LOCUS       NM_014583               8284 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens LIM and cysteine rich domains 1 (LMCD1), transcript
            variant 1, mRNA.
ACCESSION   NM_014583
VERSION     NM_014583.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8284)
  AUTHORS   Bogatkevich,G.S., Atanelishvili,I., Bogatkevich,A.M. and
            Silver,R.M.
  TITLE     Critical Role of LMCD1 in Promoting Profibrotic Characteristics of
            Lung Myofibroblasts in Experimental and Scleroderma-Associated Lung
            Fibrosis
  JOURNAL   Arthritis Rheumatol 75 (3), 438-448 (2023)
   PUBMED   36103378
  REMARK    GeneRIF: Critical Role of LMCD1 in Promoting Profibrotic
            Characteristics of Lung Myofibroblasts in Experimental and
            Scleroderma-Associated Lung Fibrosis.
REFERENCE   2  (bases 1 to 8284)
  AUTHORS   Yu,R., Wu,Y., He,P., Bai,Y., Zhang,Y., Bian,X., Sun,G. and Zhang,B.
  TITLE     LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor
            beta1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2
            Cells
  JOURNAL   Lab Invest 103 (2), 100016 (2023)
   PUBMED   37039151
  REMARK    GeneRIF: LIM and Cysteine-Rich Domains 1 Promotes Transforming
            Growth Factor beta1-Induced Epithelial-Mesenchymal Transition in
            Human Kidney 2 Cells.
REFERENCE   3  (bases 1 to 8284)
  AUTHORS   Ye,Z., Chen,G., Hou,C., Jiang,Z., Wang,E. and Wang,J.
  TITLE     LMCD1 facilitates the induction of pluripotency via cell
            proliferation, metabolism, and epithelial-mesenchymal transition
  JOURNAL   Cell Biol Int 46 (9), 1409-1422 (2022)
   PUBMED   35842772
  REMARK    GeneRIF: LMCD1 facilitates the induction of pluripotency via cell
            proliferation, metabolism, and epithelial-mesenchymal transition.
REFERENCE   4  (bases 1 to 8284)
  AUTHORS   Govatati,S., Pichavaram,P., Janjanam,J., Guo,L., Virmani,R. and
            Rao,G.N.
  TITLE     Myristoylation of LMCD1 Leads to Its Species-Specific Derepression
            of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression
            During Development of Vascular Lesions
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (5), 1256-1274 (2020)
   PUBMED   32160773
  REMARK    GeneRIF: LMCD1 acts as an activator of E2F1 in humans in the
            induction of CDC6 and IL-33 expression during development of
            vascular lesions.
REFERENCE   5  (bases 1 to 8284)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8284)
  AUTHORS   Donati,C., Marseglia,G., Magi,A., Serrati,S., Cencetti,F.,
            Bernacchioni,C., Nannetti,G., Benelli,M., Brunelli,S.,
            Torricelli,F., Cossu,G. and Bruni,P.
  TITLE     Sphingosine 1-phosphate induces differentiation of mesoangioblasts
            towards smooth muscle. A role for GATA6
  JOURNAL   PLoS One 6 (5), e20389 (2011)
   PUBMED   21629665
REFERENCE   7  (bases 1 to 8284)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   8  (bases 1 to 8284)
  AUTHORS   Bian,Z.Y., Huang,H., Jiang,H., Shen,D.F., Yan,L., Zhu,L.H.,
            Wang,L., Cao,F., Liu,C., Tang,Q.Z. and Li,H.
  TITLE     LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by
            targeting calcineurin/nuclear factor of activated T cells signaling
  JOURNAL   Hypertension 55 (2), 257-263 (2010)
   PUBMED   20026769
REFERENCE   9  (bases 1 to 8284)
  AUTHORS   Rath,N., Wang,Z., Lu,M.M. and Morrisey,E.E.
  TITLE     LMCD1/Dyxin is a novel transcriptional cofactor that restricts
            GATA6 function by inhibiting DNA binding
  JOURNAL   Mol Cell Biol 25 (20), 8864-8873 (2005)
   PUBMED   16199866
REFERENCE   10 (bases 1 to 8284)
  AUTHORS   Bespalova,I.N. and Burmeister,M.
  TITLE     Identification of a novel LIM domain gene, LMCD1, and chromosomal
            localization in human and mouse
  JOURNAL   Genomics 63 (1), 69-74 (2000)
   PUBMED   10662546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN388104.1, AF169284.1,
            BU619403.1 and AC087859.3.
            
            On May 17, 2019 this sequence version replaced NM_014583.3.
            
            Summary: This gene encodes a member of the LIM-domain family of
            zinc finger proteins. The encoded protein contains an N-terminal
            cysteine-rich domain and two C-terminal LIM domains. The presence
            of LIM domains suggests involvement in protein-protein
            interactions. The protein may act as a co-regulator of
            transcription along with other transcription factors. Alternate
            splicing results in multiple transcript variants of this gene.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.63208.1,
                                           SRR1660805.150890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000157600.8/ ENSP00000157600.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                CN388104.1         17-89
            74-1736             AF169284.1         61-1723
            1737-1741           BU619403.1         502-506             c
            1742-8284           AC087859.3         3508-10050          c
FEATURES             Location/Qualifiers
     source          1..8284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..8284
                     /gene="LMCD1"
                     /note="LIM and cysteine rich domains 1"
                     /db_xref="GeneID:29995"
                     /db_xref="HGNC:HGNC:6633"
                     /db_xref="MIM:604859"
     exon            1..158
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1214
                     /gene="LMCD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dyxin"
                     /codon_start=1
                     /product="LIM and cysteine-rich domains protein 1 isoform
                     1"
                     /protein_id="NP_055398.1"
                     /db_xref="CCDS:CCDS33688.1"
                     /db_xref="GeneID:29995"
                     /db_xref="HGNC:HGNC:6633"
                     /db_xref="MIM:604859"
                     /translation="MAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWR
                     KICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMT
                     NPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQ
                     LPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKP
                     EGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCA
                     KCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFV
                     CEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS"
     exon            159..247
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..503
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..839
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1055
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..8284
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      1708
                     /gene="LMCD1"
                     /note="major polyA site"
     regulatory      1715..1720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      1736
                     /gene="LMCD1"
                     /note="major polyA site"
     regulatory      2203..2208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      2226
                     /gene="LMCD1"
     regulatory      8264..8269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      8284
                     /gene="LMCD1"
ORIGIN      
        1 gcacagagct ccctcccagg cccgcgaact tggccattca gccgccgctg tccccgctgc
       61 gcgccctcgc gcctctgcct gagaagccag gcgctgttcc cccaccccag aagaggatgg
      121 caaaggtggc taaggacctc aacccaggag ttaaaaagat gtccctgggc cagctgcagt
      181 cagcaagagg tgtggcatgt ttgggatgca aggggacgtg ttcgggcttc gagccacatt
      241 catggaggaa aatatgcaag tcttgcaaat gcagccaaga ggaccactgc ctaacatctg
      301 acctagaaga cgatcggaaa attggccgct tgctgatgga ctccaagtat tccaccctca
      361 ctgctcgggt gaaaggcggg gacggcatcc ggatttacaa gaggaaccgg atgatcatga
      421 ccaaccctat tgctactggg aaagatccca cttttgacac catcacctac gagtgggctc
      481 cccctggagt cacccagaaa ctgggactgc agtacatgga gctcatcccc aaggagaagc
      541 agccagtgac aggcacagag ggtgcctttt accgccgccg ccagctcatg caccagctcc
      601 ccatctatga ccaggatccc tcgcgctgcc gtggactttt ggagaatgag ttgaaactga
      661 tggaagaatt tgtcaagcaa tataagagcg aggccctcgg cgtgggagaa gtggccctcc
      721 cggggcaggg tggcttgccc aaggaggagg ggaagcagca ggaaaagcca gagggggcag
      781 agaccactgc tgctaccacc aacggcagtc tcagtgaccc gtccaaagaa gtggaatacg
      841 tctgcgagct ctgcaaggga gcggcccctc ctgacagccc cgtggtctac tcggacaggg
      901 caggctacaa caagcagtgg caccccacct gctttgtgtg tgccaagtgc tccgagccgc
      961 tggtggacct catctacttc tggaaggatg gtgcaccctg gtgcggccgc cattactgcg
     1021 agagtctgcg gccccggtgc tccggctgcg atgagataat attcgctgag gactaccagc
     1081 gtgtggaaga tctggcctgg caccgaaagc actttgtctg tgagggttgt gagcagctgc
     1141 tgagcggccg ggcgtacatc gtcaccaagg gtcagcttct gtgcccaact tgcagcaagt
     1201 ccaaacgctc ctgaagggct gcccacccac agccagaatc cacaggatcc caccgagaag
     1261 gagagccagg tgtgccgaga ccatcctaag ggtccgatgt gacagcaagc aagtgaaata
     1321 aacaatgatt tgcttttcag tgagaatata tatatgagat atatatagat atatattcta
     1381 ggttgggtgg tggtagatcc ttgagggtca gtagtttcaa aaccaaaaat attctaagaa
     1441 gtcttaggat ggagttcctt ttctttctgt tgttgtttcc cagctacaac caactaaaga
     1501 cacaaatggc gttctgcaag gggactctgg gaggagtttt ccagaatgca attccgagtg
     1561 agcaaatcgc atagctgtag aatgtgcgtg cttttttgtg gacacaggag ctcctccagg
     1621 agcaggctgg gatcccaact atcgcttgtt gcctcttttt caagtggaat ttgaatttta
     1681 aataaacaac tttttttggc atgataaaca gatcaataaa agttttgtga attccacata
     1741 cacccttatc taattattta caccatggca gtgattttgc aacacccagt gctggcagaa
     1801 aatatagtaa aatactaatg agcctctcta tcaatgtatc tcatcagact tccactggga
     1861 gtgtaggctt tgggacagaa cccccgcccc acctgcctat tccagatact cccagatcac
     1921 taatgtaaca aaggtatcat gttttatggt acactgaaaa gtggcctgct gggaactgat
     1981 gagcttctct ttagccaggg acctgactca gctgccctca gagcccagga aaatagcgaa
     2041 tgaacccctc tgggaataag accagtactg ggaaaccact gaacaggggc cacctaagct
     2101 ccaccaatgg gtgccacatg ggatgtggtg actaatgtgg gcagatcttt aaaaatacag
     2161 cactttttca aatgccaaaa caatcagaaa caaaattttt tcaataaaaa ttaatctaaa
     2221 atttaacaat gccactttta tgagaaatct caatttttaa tgttgccaac taaacattga
     2281 atgagtcacg tagaataggt ctttgggcca aattgtatct ccattttatg gtctctctga
     2341 acattttcag ctcttaaatt aatttctttc ccacagtttc taagaaaaac atatttttct
     2401 actgggagta taaggatgaa aaagacacaa gtcctaggag cttacggtct ggtcgccagt
     2461 ggttttcttt cttgaacttc ctcatctgct gccagttttc tttaacctca ccatccaaat
     2521 ttcactctga ccatctcgta cctagaaaac ccccattcat gtgctttata agtttcacca
     2581 aagccattgc tatatcctcc caaggcagtg gttttctgct cccagctcct ttctctagtc
     2641 accctcagtt tcctcgtcat gttcatcttc tcaaagataa gtttcaagtg tgtcatttcc
     2701 ttcactcaat ctccatggct cttcattgcc tgccaagtta acaaccaagt cctcatggac
     2761 atttgaatcc ttccaaaact tggcttatgt ctttctggcc ttggagccct ttatttccct
     2821 agatttctag ttccctattt cttcctaagc atgcagaagc tccctctgat caagcccttc
     2881 cctttgcttt tgctagttga agactggcta cctgaagacc aactctggct gttgaaattc
     2941 tattcatcct ataaggtgct tctcaagcat aacctgcttc tctggcactt tcctgaagca
     3001 ccagtgaaat attcaccaat tcatcattca ttcatccatt ccacaagtat ttcagtgagc
     3061 acggcaaagt tccaattccc atgctgaata taggggatgc ggggtgcaca aaaagaacag
     3121 tgacccctac gcccatagat gttacggtct gtgggggaga tgggcctcaa gcaaatattc
     3181 tcacaagtca atgcaaaatt acactactgt gcatgctata aaaggaagat ttgtgttact
     3241 ataatgcatg taaactggac ttaggaatat cgagagaggt gcccctggga aagtgatgct
     3301 tgaactgggc tgtaaaggat gagtagcctt gccaggcata gtggctcagg cctgtattct
     3361 cagcactttg ggaggccaaa gcgggtggat cacttgagcc taggagttcg agaccggcct
     3421 gggcaacatg gcaaaactcc acccctacaa aaaatacaaa aactatctgg catggtggca
     3481 cacctgtagt atcagttact ctagaggata acctgagccc agtaagtcaa ggctgcagtg
     3541 agctgtgatc atgccacagc actccagcct gggtgacaga gtgagaccct gtttccaaaa
     3601 aaaaaaaaaa aggataggtt gcctctaagt tggcaaagag aggaaggaca atggttaaag
     3661 atggatacat gaatgcatgt gcaaaggccc tgtggtggaa gccccaccag tttattcaac
     3721 acctatttgc tggtgttgga gatacagtgg tgaacatggc ccatggatgg aactgaaaga
     3781 aaactggtgt ggcaggagca cagagcatgg tgaggagggt gggcctgggg catgagaggc
     3841 aggcatggcc agcctgctcc agttctgggg caattcaaaa gactggtctc tgttctagga
     3901 gcaaggggga gccttcaaac agctttaagg agggggtggt gatggctgga cagggagatc
     3961 atgagatacg tcatctcttc tctgttgaaa ccccagcaca atgcatgatt gacttggtcc
     4021 actgggtcac accatcatgg atgggcatta tctcccacaa cagtccccat ggggcaccac
     4081 ccagcacctg cccctgcctt tctcatgtct attaatgaca cccacccttg catttggagc
     4141 acctgaatca tctctgccac ttgccttcat atctgatggg tcactcagtc cagtcctttc
     4201 tctccatcct cgctttcact ccatccccaa agtcatatct caccttgaac attttctgct
     4261 cagactgaca agtctccccg acgggaactc accctctcca cccaccactt ccagatgaat
     4321 tgctcagaaa cacaccctca tcttgcactc tcctcttcaa gaacaatcag gggctccctg
     4381 ttgcacacac agaaaaaaat tgaaactgtt ttaccttgca gtcgagtttc ttatttttcc
     4441 tgccccaacc ctccttcctt cctgttatcc tttcagaagc caaatgggca gtttacagtc
     4501 acagtgtgtg cccctgcttt cctcacctct gtaccatcac tcacgctgtg ctttttgcct
     4561 gcaattcccc acactgtgtt taattgctgc ctctgctggg gggctgcaat agctgagtgg
     4621 gattctgtac cagaattgga aagatccatg ttaactcttg cctgattcta tctcccatgt
     4681 cagcaggaag aggggctgcc atccccaccc ctcccactct ctaggaagac tttcctccct
     4741 cacccttccc ttggggtgtt ttaggtgccc tttatctgta agttcataat atcccaggct
     4801 tacagtaatt cttccaaggc ctttattgtg ctataattat ttattcatga aagccttccc
     4861 ctatgaactt ctaaagaata atcgtattat ctttatttcc ccaactctta gtacaaatcc
     4921 tggcaactaa atgaaagaac aaacaacctg gggttctggg atggttcgtc tttgctgatg
     4981 gcactgtgtt ccaaaatggc caaggtcaaa tataaaaatt tcagactgag gtagacactg
     5041 ctggcagcct acacattgcc accacacccc acttccttct tcctagtggc aaggaagcag
     5101 tgggtggaga gggtgagttc ctgtcaggga gacttgtcag tctgagcaga aaatgttcaa
     5161 agtgagatat gactttgggg atggagacaa agggaggatg gagagaaacg actggactga
     5221 gagaagagcc cactcccctt tatgtaaatt ggctttgcca acctggtctg cagctggaga
     5281 aaggccatgc gcctctatta ccagccagtg gggcttccgc cttaggaggg tcttagaaaa
     5341 gtgtttttcc ttaatgaaag gagatactgt gcagtaaata gccctgctgt tgttttcttt
     5401 tcttttgata gaatgtcaaa cttacgaaaa aagttacaag aagagaacaa agagctatta
     5461 gagggtgttg ctgacacaat gctttatcac tcttgaatat tttcgtgtgt aattcctaca
     5521 aataaggaca ttctcccaca tagccacaat acaaccatca aaatcaggaa gttaacgctg
     5581 atgtgtttct accatgtaat cctcagatcc aattcaagtg tcaccagctg tcccaataat
     5641 gtcttttata acaaaaacat tcagtctaag atcactcatt ctatttagtt atcttgtcta
     5701 ttcttcaatt tggaagtgtt ctttgttctt tcctgaatgt tcatgacctt gacatcttag
     5761 aagattaaag gttatttaaa gttgttgagt taaatatcca ttaaattagg tttgtcagat
     5821 atttcctcga aattagattc agcttatgca ttttttggaa ggaataccac agaagtgatg
     5881 ttgttttctt tctgttgcat ccaatcagat gatacaggat tttgatttgt tccattactg
     5941 ttgacatgaa ttttgaacat ttgataatgc cagtatcagc cagatttttc cattgtaaag
     6001 tcattccttt gtcctttgta tttaataagt atgtttaggg actttgagac tatgtcaatg
     6061 tcctgttctt catcaaaatt ccactcactc attcttagta ttcattgacg tttactgatc
     6121 gaactaatta ttattatgat agttgccaaa tgttggtttt tctaattcaa tcatttcttt
     6181 agtgtttatt agcattctac tataaggaaa agcactatct tctccccatt tattaattca
     6241 catatttaca tcagcttgga gttattgatt tctattttat taaatagttt ataattgatt
     6301 accatcctta tttattttaa tgctcaaatt gtcccaaatt atggccaaag aaagctcctt
     6361 caaactggtt gctatgtcct tttgacatgg cccatcattc tttaaacaca ttttacatct
     6421 ggcacaataa cgtgctacat acccatcttg tatttttcct gccccatctt tgaaatcagc
     6481 cattctcaag gggttccttc ttaatctggc tgttgttgtg ttggaactcc tggtaccatc
     6541 ttagaacctt aaggagacaa gcgaaccaag ccaataagct ttccatgatg ctgcttagag
     6601 ttaaacagag cccaggtact aagttatgtc atggagacag tgaactaacc tctggactgc
     6661 ttgctacatg agacaattga ttttcttatt ttctatgtag ggtggtacat ttcctcattt
     6721 tgagatattt cttcaacata tagcttttca ttagtgggga ttttgtcaat tataaccaaa
     6781 aacaatgtga cggataccca agatgtttca tgttgtagct tgggtgaatt acacatttct
     6841 gaagccatta cacttcctag tttatttgga tttaagttga caaataaaaa ttgcatatgt
     6901 ttatggtcta taacatggtg tttcgatata tgtatacatc gtggaatggc taaatcaagc
     6961 taacatatcc attacctcac atagttattt tttgtggtga gaacatttta aaaatattgt
     7021 cttagcaatt ttcaatcaag cctgtcccat ggagacacaa gcaatagtga catgagcact
     7081 tgactcgctg ggttatcagg ctttggctcc aaatgtttgg cttcaaatat gaaaaagtta
     7141 catgaaagat gaaactatgc aatggcatgg ctgttggtca ttcacatctc tctctgccaa
     7201 gaatggggat gacgctgttg aaggaagaaa tgtgttttct cctttttctc aagtgatatt
     7261 tgccttaggt cagattctac tagtttaaag caaaacgatc tcctggtctg attcctttgg
     7321 gtctctaata atggaaactg caaggatcag cataaagtgt tcctttgttc tgacgttggt
     7381 ataacattgc ttcttgaaaa atgaaagtat ttggacatac agacagaagc aatattattc
     7441 aggtcttcct tgttgcaagt gagggaaatc caattaaaac tggtttaaac ctaaaaaaaa
     7501 aaaaaagaag aaaagaaaag aaaaaatatg agaggggttt tgctttctgg aatctgcttt
     7561 ctagtcagaa agtgcagaag aagggctagc ttcaggaaca attggatgca gtagttcaaa
     7621 tcacaagtta agtctctgct tcttttctcc atctctcttc tgtcttcctc cacactggct
     7681 ttattcttag gtaggcttac ccagatagtc ataaacacag ccaccagtgg cagctgggct
     7741 cacttttgtc cttggagcca gtgagcccat gaaaaaggag cttctctttc tggagcttcc
     7801 caggggtaac tttgatcagc caacaagggt cagtcctatg cttatccctt gaccaatctc
     7861 tgtgcccaga gggcagggta ctctgattgg caataccttc atcgtgggcc aaccactgtg
     7921 gggaaggggg agggattaga aaagacagcc acacccaaat ctcatgaagc agtccccttt
     7981 attttaaaaa agtccctgtg agagcaacag gagcaaagca tggagaagaa gcaatcttgg
     8041 agaagctgga agagaactga cccaaagaat ccaagagact aagactgtgc agggttgggg
     8101 aacggaagct cacacaggag gcctggacag agctgcagca gagccaggag agaagccaag
     8161 tggcacagct catcttgaag taattataat gccactaaaa ttctcatttg tattaatttt
     8221 ttttaattac tggcaagata aggcaaatgt ttttaaaggc ctaaataaaa tgatattccc
     8281 tgaa
//
