LOCUS       NM_001278234            8028 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens LIM and cysteine rich domains 1 (LMCD1), transcript
            variant 3, mRNA.
ACCESSION   NM_001278234
VERSION     NM_001278234.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8028)
  AUTHORS   Bogatkevich,G.S., Atanelishvili,I., Bogatkevich,A.M. and
            Silver,R.M.
  TITLE     Critical Role of LMCD1 in Promoting Profibrotic Characteristics of
            Lung Myofibroblasts in Experimental and Scleroderma-Associated Lung
            Fibrosis
  JOURNAL   Arthritis Rheumatol 75 (3), 438-448 (2023)
   PUBMED   36103378
  REMARK    GeneRIF: Critical Role of LMCD1 in Promoting Profibrotic
            Characteristics of Lung Myofibroblasts in Experimental and
            Scleroderma-Associated Lung Fibrosis.
REFERENCE   2  (bases 1 to 8028)
  AUTHORS   Yu,R., Wu,Y., He,P., Bai,Y., Zhang,Y., Bian,X., Sun,G. and Zhang,B.
  TITLE     LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor
            beta1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2
            Cells
  JOURNAL   Lab Invest 103 (2), 100016 (2023)
   PUBMED   37039151
  REMARK    GeneRIF: LIM and Cysteine-Rich Domains 1 Promotes Transforming
            Growth Factor beta1-Induced Epithelial-Mesenchymal Transition in
            Human Kidney 2 Cells.
REFERENCE   3  (bases 1 to 8028)
  AUTHORS   Ye,Z., Chen,G., Hou,C., Jiang,Z., Wang,E. and Wang,J.
  TITLE     LMCD1 facilitates the induction of pluripotency via cell
            proliferation, metabolism, and epithelial-mesenchymal transition
  JOURNAL   Cell Biol Int 46 (9), 1409-1422 (2022)
   PUBMED   35842772
  REMARK    GeneRIF: LMCD1 facilitates the induction of pluripotency via cell
            proliferation, metabolism, and epithelial-mesenchymal transition.
REFERENCE   4  (bases 1 to 8028)
  AUTHORS   Govatati,S., Pichavaram,P., Janjanam,J., Guo,L., Virmani,R. and
            Rao,G.N.
  TITLE     Myristoylation of LMCD1 Leads to Its Species-Specific Derepression
            of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression
            During Development of Vascular Lesions
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (5), 1256-1274 (2020)
   PUBMED   32160773
  REMARK    GeneRIF: LMCD1 acts as an activator of E2F1 in humans in the
            induction of CDC6 and IL-33 expression during development of
            vascular lesions.
REFERENCE   5  (bases 1 to 8028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8028)
  AUTHORS   Donati,C., Marseglia,G., Magi,A., Serrati,S., Cencetti,F.,
            Bernacchioni,C., Nannetti,G., Benelli,M., Brunelli,S.,
            Torricelli,F., Cossu,G. and Bruni,P.
  TITLE     Sphingosine 1-phosphate induces differentiation of mesoangioblasts
            towards smooth muscle. A role for GATA6
  JOURNAL   PLoS One 6 (5), e20389 (2011)
   PUBMED   21629665
REFERENCE   7  (bases 1 to 8028)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   8  (bases 1 to 8028)
  AUTHORS   Bian,Z.Y., Huang,H., Jiang,H., Shen,D.F., Yan,L., Zhu,L.H.,
            Wang,L., Cao,F., Liu,C., Tang,Q.Z. and Li,H.
  TITLE     LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by
            targeting calcineurin/nuclear factor of activated T cells signaling
  JOURNAL   Hypertension 55 (2), 257-263 (2010)
   PUBMED   20026769
REFERENCE   9  (bases 1 to 8028)
  AUTHORS   Rath,N., Wang,Z., Lu,M.M. and Morrisey,E.E.
  TITLE     LMCD1/Dyxin is a novel transcriptional cofactor that restricts
            GATA6 function by inhibiting DNA binding
  JOURNAL   Mol Cell Biol 25 (20), 8864-8873 (2005)
   PUBMED   16199866
REFERENCE   10 (bases 1 to 8028)
  AUTHORS   Bespalova,I.N. and Burmeister,M.
  TITLE     Identification of a novel LIM domain gene, LMCD1, and chromosomal
            localization in human and mouse
  JOURNAL   Genomics 63 (1), 69-74 (2000)
   PUBMED   10662546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN388104.1, AK293849.1,
            BC000646.2, BU619403.1 and AC087859.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001278234.1.
            
            Summary: This gene encodes a member of the LIM-domain family of
            zinc finger proteins. The encoded protein contains an N-terminal
            cysteine-rich domain and two C-terminal LIM domains. The presence
            of LIM domains suggests involvement in protein-protein
            interactions. The protein may act as a co-regulator of
            transcription along with other transcription factors. Alternate
            splicing results in multiple transcript variants of this gene.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (3) lacks an alternate exon and
            initiates translation at an alternate start codon, compared to
            variant 1. The encoded isoform (3) has a distinct N-terminus and is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2571717.1,
                                           SRR14038196.1066756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CN388104.1         17-81
            66-1124             AK293849.1         3-1061
            1125-1452           BC000646.2         1367-1694
            1453-1485           BU619403.1         502-534             c
            1486-8028           AC087859.3         3508-10050          c
FEATURES             Location/Qualifiers
     source          1..8028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..8028
                     /gene="LMCD1"
                     /note="LIM and cysteine rich domains 1"
                     /db_xref="GeneID:29995"
                     /db_xref="HGNC:HGNC:6633"
                     /db_xref="MIM:604859"
     exon            1..158
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..247
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..958
                     /gene="LMCD1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     dyxin"
                     /codon_start=1
                     /product="LIM and cysteine-rich domains protein 1 isoform
                     3"
                     /protein_id="NP_001265163.1"
                     /db_xref="CCDS:CCDS63533.1"
                     /db_xref="GeneID:29995"
                     /db_xref="HGNC:HGNC:6633"
                     /db_xref="MIM:604859"
                     /translation="MFGMQGDVFGLRATFMEGLQYMELIPKEKQPVTGTEGAFYRRRQ
                     LMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQ
                     QEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTC
                     FVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHR
                     KHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS"
     exon            248..583
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..799
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..8028
                     /gene="LMCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      1452
                     /gene="LMCD1"
                     /note="major polyA site"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      1480
                     /gene="LMCD1"
                     /note="major polyA site"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      1970
                     /gene="LMCD1"
     regulatory      8008..8013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMCD1"
                     /note="hexamer: AATAAA"
     polyA_site      8028
                     /gene="LMCD1"
ORIGIN      
        1 gcacagagct ccctcccagg cccgcgaact tggccattca gccgccgctg tccccgctgc
       61 gcgccctcgc gcctctgcct gagaagccag gcgctgttcc cccaccccag aagaggatgg
      121 caaaggtggc taaggacctc aacccaggag ttaaaaagat gtccctgggc cagctgcagt
      181 cagcaagagg tgtggcatgt ttgggatgca aggggacgtg ttcgggcttc gagccacatt
      241 catggaggga ctgcagtaca tggagctcat ccccaaggag aagcagccag tgacaggcac
      301 agagggtgcc ttttaccgcc gccgccagct catgcaccag ctccccatct atgaccagga
      361 tccctcgcgc tgccgtggac ttttggagaa tgagttgaaa ctgatggaag aatttgtcaa
      421 gcaatataag agcgaggccc tcggcgtggg agaagtggcc ctcccggggc agggtggctt
      481 gcccaaggag gaggggaagc agcaggaaaa gccagagggg gcagagacca ctgctgctac
      541 caccaacggc agtctcagtg acccgtccaa agaagtggaa tacgtctgcg agctctgcaa
      601 gggagcggcc cctcctgaca gccccgtggt ctactcggac agggcaggct acaacaagca
      661 gtggcacccc acctgctttg tgtgtgccaa gtgctccgag ccgctggtgg acctcatcta
      721 cttctggaag gatggtgcac cctggtgcgg ccgccattac tgcgagagtc tgcggccccg
      781 gtgctccggc tgcgatgaga taatattcgc tgaggactac cagcgtgtgg aagatctggc
      841 ctggcaccga aagcactttg tctgtgaggg ttgtgagcag ctgctgagcg gccgggcgta
      901 catcgtcacc aagggtcagc ttctgtgccc aacttgcagc aagtccaaac gctcctgaag
      961 ggctgcccac ccacagccag aatccacagg atcccaccga gaaggagagc caggtgtgcc
     1021 gagaccatcc taagggtccg atgtgacagc aagcaagtga aataaacaat gatttgcttt
     1081 tcagtgagaa tatatatatg agatatatat agatatatat tctaggttgg gtggtggtag
     1141 atccttgagg gtcagtagtt tcaaaaccaa aaatattcta agaagtctta ggatggagtt
     1201 ccttttcttt ctgttgttgt ttcccagcta caaccaacta aagacacaaa tggcgttctg
     1261 caaggggact ctgggaggag ttttccagaa tgcaattccg agtgagcaaa tcgcatagct
     1321 gtagaatgtg cgtgcttttt tgtggacaca ggagctcctc caggagcagg ctgggatccc
     1381 aactatcgct tgttgcctct ttttcaagtg gaatttgaat tttaaataaa caactttttt
     1441 tggcatgata aacagatcaa taaaagtttt gtgaattcca catacaccct tatctaatta
     1501 tttacaccat ggcagtgatt ttgcaacacc cagtgctggc agaaaatata gtaaaatact
     1561 aatgagcctc tctatcaatg tatctcatca gacttccact gggagtgtag gctttgggac
     1621 agaacccccg ccccacctgc ctattccaga tactcccaga tcactaatgt aacaaaggta
     1681 tcatgtttta tggtacactg aaaagtggcc tgctgggaac tgatgagctt ctctttagcc
     1741 agggacctga ctcagctgcc ctcagagccc aggaaaatag cgaatgaacc cctctgggaa
     1801 taagaccagt actgggaaac cactgaacag gggccaccta agctccacca atgggtgcca
     1861 catgggatgt ggtgactaat gtgggcagat ctttaaaaat acagcacttt ttcaaatgcc
     1921 aaaacaatca gaaacaaaat tttttcaata aaaattaatc taaaatttaa caatgccact
     1981 tttatgagaa atctcaattt ttaatgttgc caactaaaca ttgaatgagt cacgtagaat
     2041 aggtctttgg gccaaattgt atctccattt tatggtctct ctgaacattt tcagctctta
     2101 aattaatttc tttcccacag tttctaagaa aaacatattt ttctactggg agtataagga
     2161 tgaaaaagac acaagtccta ggagcttacg gtctggtcgc cagtggtttt ctttcttgaa
     2221 cttcctcatc tgctgccagt tttctttaac ctcaccatcc aaatttcact ctgaccatct
     2281 cgtacctaga aaacccccat tcatgtgctt tataagtttc accaaagcca ttgctatatc
     2341 ctcccaaggc agtggttttc tgctcccagc tcctttctct agtcaccctc agtttcctcg
     2401 tcatgttcat cttctcaaag ataagtttca agtgtgtcat ttccttcact caatctccat
     2461 ggctcttcat tgcctgccaa gttaacaacc aagtcctcat ggacatttga atccttccaa
     2521 aacttggctt atgtctttct ggccttggag ccctttattt ccctagattt ctagttccct
     2581 atttcttcct aagcatgcag aagctccctc tgatcaagcc cttccctttg cttttgctag
     2641 ttgaagactg gctacctgaa gaccaactct ggctgttgaa attctattca tcctataagg
     2701 tgcttctcaa gcataacctg cttctctggc actttcctga agcaccagtg aaatattcac
     2761 caattcatca ttcattcatc cattccacaa gtatttcagt gagcacggca aagttccaat
     2821 tcccatgctg aatatagggg atgcggggtg cacaaaaaga acagtgaccc ctacgcccat
     2881 agatgttacg gtctgtgggg gagatgggcc tcaagcaaat attctcacaa gtcaatgcaa
     2941 aattacacta ctgtgcatgc tataaaagga agatttgtgt tactataatg catgtaaact
     3001 ggacttagga atatcgagag aggtgcccct gggaaagtga tgcttgaact gggctgtaaa
     3061 ggatgagtag ccttgccagg catagtggct caggcctgta ttctcagcac tttgggaggc
     3121 caaagcgggt ggatcacttg agcctaggag ttcgagaccg gcctgggcaa catggcaaaa
     3181 ctccacccct acaaaaaata caaaaactat ctggcatggt ggcacacctg tagtatcagt
     3241 tactctagag gataacctga gcccagtaag tcaaggctgc agtgagctgt gatcatgcca
     3301 cagcactcca gcctgggtga cagagtgaga ccctgtttcc aaaaaaaaaa aaaaaggata
     3361 ggttgcctct aagttggcaa agagaggaag gacaatggtt aaagatggat acatgaatgc
     3421 atgtgcaaag gccctgtggt ggaagcccca ccagtttatt caacacctat ttgctggtgt
     3481 tggagataca gtggtgaaca tggcccatgg atggaactga aagaaaactg gtgtggcagg
     3541 agcacagagc atggtgagga gggtgggcct ggggcatgag aggcaggcat ggccagcctg
     3601 ctccagttct ggggcaattc aaaagactgg tctctgttct aggagcaagg gggagccttc
     3661 aaacagcttt aaggaggggg tggtgatggc tggacaggga gatcatgaga tacgtcatct
     3721 cttctctgtt gaaaccccag cacaatgcat gattgacttg gtccactggg tcacaccatc
     3781 atggatgggc attatctccc acaacagtcc ccatggggca ccacccagca cctgcccctg
     3841 cctttctcat gtctattaat gacacccacc cttgcatttg gagcacctga atcatctctg
     3901 ccacttgcct tcatatctga tgggtcactc agtccagtcc tttctctcca tcctcgcttt
     3961 cactccatcc ccaaagtcat atctcacctt gaacattttc tgctcagact gacaagtctc
     4021 cccgacggga actcaccctc tccacccacc acttccagat gaattgctca gaaacacacc
     4081 ctcatcttgc actctcctct tcaagaacaa tcaggggctc cctgttgcac acacagaaaa
     4141 aaattgaaac tgttttacct tgcagtcgag tttcttattt ttcctgcccc aaccctcctt
     4201 ccttcctgtt atcctttcag aagccaaatg ggcagtttac agtcacagtg tgtgcccctg
     4261 ctttcctcac ctctgtacca tcactcacgc tgtgcttttt gcctgcaatt ccccacactg
     4321 tgtttaattg ctgcctctgc tggggggctg caatagctga gtgggattct gtaccagaat
     4381 tggaaagatc catgttaact cttgcctgat tctatctccc atgtcagcag gaagaggggc
     4441 tgccatcccc acccctccca ctctctagga agactttcct ccctcaccct tcccttgggg
     4501 tgttttaggt gccctttatc tgtaagttca taatatccca ggcttacagt aattcttcca
     4561 aggcctttat tgtgctataa ttatttattc atgaaagcct tcccctatga acttctaaag
     4621 aataatcgta ttatctttat ttccccaact cttagtacaa atcctggcaa ctaaatgaaa
     4681 gaacaaacaa cctggggttc tgggatggtt cgtctttgct gatggcactg tgttccaaaa
     4741 tggccaaggt caaatataaa aatttcagac tgaggtagac actgctggca gcctacacat
     4801 tgccaccaca ccccacttcc ttcttcctag tggcaaggaa gcagtgggtg gagagggtga
     4861 gttcctgtca gggagacttg tcagtctgag cagaaaatgt tcaaagtgag atatgacttt
     4921 ggggatggag acaaagggag gatggagaga aacgactgga ctgagagaag agcccactcc
     4981 cctttatgta aattggcttt gccaacctgg tctgcagctg gagaaaggcc atgcgcctct
     5041 attaccagcc agtggggctt ccgccttagg agggtcttag aaaagtgttt ttccttaatg
     5101 aaaggagata ctgtgcagta aatagccctg ctgttgtttt cttttctttt gatagaatgt
     5161 caaacttacg aaaaaagtta caagaagaga acaaagagct attagagggt gttgctgaca
     5221 caatgcttta tcactcttga atattttcgt gtgtaattcc tacaaataag gacattctcc
     5281 cacatagcca caatacaacc atcaaaatca ggaagttaac gctgatgtgt ttctaccatg
     5341 taatcctcag atccaattca agtgtcacca gctgtcccaa taatgtcttt tataacaaaa
     5401 acattcagtc taagatcact cattctattt agttatcttg tctattcttc aatttggaag
     5461 tgttctttgt tctttcctga atgttcatga ccttgacatc ttagaagatt aaaggttatt
     5521 taaagttgtt gagttaaata tccattaaat taggtttgtc agatatttcc tcgaaattag
     5581 attcagctta tgcatttttt ggaaggaata ccacagaagt gatgttgttt tctttctgtt
     5641 gcatccaatc agatgataca ggattttgat ttgttccatt actgttgaca tgaattttga
     5701 acatttgata atgccagtat cagccagatt tttccattgt aaagtcattc ctttgtcctt
     5761 tgtatttaat aagtatgttt agggactttg agactatgtc aatgtcctgt tcttcatcaa
     5821 aattccactc actcattctt agtattcatt gacgtttact gatcgaacta attattatta
     5881 tgatagttgc caaatgttgg tttttctaat tcaatcattt ctttagtgtt tattagcatt
     5941 ctactataag gaaaagcact atcttctccc catttattaa ttcacatatt tacatcagct
     6001 tggagttatt gatttctatt ttattaaata gtttataatt gattaccatc cttatttatt
     6061 ttaatgctca aattgtccca aattatggcc aaagaaagct ccttcaaact ggttgctatg
     6121 tccttttgac atggcccatc attctttaaa cacattttac atctggcaca ataacgtgct
     6181 acatacccat cttgtatttt tcctgcccca tctttgaaat cagccattct caaggggttc
     6241 cttcttaatc tggctgttgt tgtgttggaa ctcctggtac catcttagaa ccttaaggag
     6301 acaagcgaac caagccaata agctttccat gatgctgctt agagttaaac agagcccagg
     6361 tactaagtta tgtcatggag acagtgaact aacctctgga ctgcttgcta catgagacaa
     6421 ttgattttct tattttctat gtagggtggt acatttcctc attttgagat atttcttcaa
     6481 catatagctt ttcattagtg gggattttgt caattataac caaaaacaat gtgacggata
     6541 cccaagatgt ttcatgttgt agcttgggtg aattacacat ttctgaagcc attacacttc
     6601 ctagtttatt tggatttaag ttgacaaata aaaattgcat atgtttatgg tctataacat
     6661 ggtgtttcga tatatgtata catcgtggaa tggctaaatc aagctaacat atccattacc
     6721 tcacatagtt attttttgtg gtgagaacat tttaaaaata ttgtcttagc aattttcaat
     6781 caagcctgtc ccatggagac acaagcaata gtgacatgag cacttgactc gctgggttat
     6841 caggctttgg ctccaaatgt ttggcttcaa atatgaaaaa gttacatgaa agatgaaact
     6901 atgcaatggc atggctgttg gtcattcaca tctctctctg ccaagaatgg ggatgacgct
     6961 gttgaaggaa gaaatgtgtt ttctcctttt tctcaagtga tatttgcctt aggtcagatt
     7021 ctactagttt aaagcaaaac gatctcctgg tctgattcct ttgggtctct aataatggaa
     7081 actgcaagga tcagcataaa gtgttccttt gttctgacgt tggtataaca ttgcttcttg
     7141 aaaaatgaaa gtatttggac atacagacag aagcaatatt attcaggtct tccttgttgc
     7201 aagtgaggga aatccaatta aaactggttt aaacctaaaa aaaaaaaaaa gaagaaaaga
     7261 aaagaaaaaa tatgagaggg gttttgcttt ctggaatctg ctttctagtc agaaagtgca
     7321 gaagaagggc tagcttcagg aacaattgga tgcagtagtt caaatcacaa gttaagtctc
     7381 tgcttctttt ctccatctct cttctgtctt cctccacact ggctttattc ttaggtaggc
     7441 ttacccagat agtcataaac acagccacca gtggcagctg ggctcacttt tgtccttgga
     7501 gccagtgagc ccatgaaaaa ggagcttctc tttctggagc ttcccagggg taactttgat
     7561 cagccaacaa gggtcagtcc tatgcttatc ccttgaccaa tctctgtgcc cagagggcag
     7621 ggtactctga ttggcaatac cttcatcgtg ggccaaccac tgtggggaag ggggagggat
     7681 tagaaaagac agccacaccc aaatctcatg aagcagtccc ctttatttta aaaaagtccc
     7741 tgtgagagca acaggagcaa agcatggaga agaagcaatc ttggagaagc tggaagagaa
     7801 ctgacccaaa gaatccaaga gactaagact gtgcagggtt ggggaacgga agctcacaca
     7861 ggaggcctgg acagagctgc agcagagcca ggagagaagc caagtggcac agctcatctt
     7921 gaagtaatta taatgccact aaaattctca tttgtattaa ttttttttaa ttactggcaa
     7981 gataaggcaa atgtttttaa aggcctaaat aaaatgatat tccctgaa
//
