LOCUS       NM_018113               2295 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens limb development membrane protein 1 like (LMBR1L),
            transcript variant 1, mRNA.
ACCESSION   NM_018113
VERSION     NM_018113.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Liu,W., Jiang,X., Li,X., Sun,K., Yang,Y., Yang,M., Li,S. and Zhu,X.
  TITLE     LMBR1L regulates the proliferation and migration of endothelial
            cells through Norrin/beta-catenin signaling
  JOURNAL   J Cell Sci 135 (6) (2022)
   PUBMED   35146515
  REMARK    GeneRIF: LMBR1L regulates the proliferation and migration of
            endothelial cells through Norrin/beta-catenin signaling.
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Choi,J.H., Zhong,X., McAlpine,W., Liao,T.C., Zhang,D., Fang,B.,
            Russell,J., Ludwig,S., Nair-Gill,E., Zhang,Z., Wang,K.W.,
            Misawa,T., Zhan,X., Choi,M., Wang,T., Li,X., Tang,M., Sun,Q.,
            Yu,L., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073040
  REMARK    GeneRIF: LMBR1L has an essential function during lymphopoiesis and
            lymphoid activation, acting as a negative regulator of the
            Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2295)
  AUTHORS   Hesselink,R.W. and Findlay,J.B.
  TITLE     Expression, characterization and ligand specificity of lipocalin-1
            interacting membrane receptor (LIMR)
  JOURNAL   Mol Membr Biol 30 (5-6), 327-337 (2013)
   PUBMED   23964685
  REMARK    GeneRIF: LIMR was shown to be highly specific for Lcn1, binding the
            lipocalin with low micromolar to high nanomolar affinity
REFERENCE   5  (bases 1 to 2295)
  AUTHORS   Dartt,D.A.
  TITLE     Tear lipocalin: structure and function
  JOURNAL   Ocul Surf 9 (3), 126-138 (2011)
   PUBMED   21791187
  REMARK    GeneRIF: The receptor to which lipocalin binds is termed tear
            lipocalin-interacting membrane receptor and it appears to work by
            endocytosis.
            Review article
REFERENCE   6  (bases 1 to 2295)
  AUTHORS   Fluckinger,M., Merschak,P., Hermann,M., Haertle,T. and Redl,B.
  TITLE     Lipocalin-interacting-membrane-receptor (LIMR) mediates cellular
            internalization of beta-lactoglobulin
  JOURNAL   Biochim Biophys Acta 1778 (1), 342-347 (2008)
   PUBMED   17991420
  REMARK    GeneRIF: Human LIMR, known to act as an endocytic receptor for
            lipocalin-1, also binds bovine BLG and mediates its cellular
            uptake.
REFERENCE   7  (bases 1 to 2295)
  AUTHORS   Zhang,Z., Kim,S.J., Chowdhury,B., Wang,J., Lee,Y.C., Tsai,P.C.,
            Choi,M. and Mukherjee,A.B.
  TITLE     Interaction of uteroglobin with lipocalin-1 receptor suppresses
            cancer cell motility and invasion
  JOURNAL   Gene 369, 66-71 (2006)
   PUBMED   16423471
REFERENCE   8  (bases 1 to 2295)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2295)
  AUTHORS   Wojnar,P., Lechner,M. and Redl,B.
  TITLE     Antisense down-regulation of lipocalin-interacting membrane
            receptor expression inhibits cellular internalization of
            lipocalin-1 in human NT2 cells
  JOURNAL   J Biol Chem 278 (18), 16209-16215 (2003)
   PUBMED   12591932
  REMARK    GeneRIF: LIMR mediating internalization of lipocalin-1 (Lcn-1) in
            NT2 cells, leading to its degradation.
REFERENCE   10 (bases 1 to 2295)
  AUTHORS   Wojnar,P., Lechner,M., Merschak,P. and Redl,B.
  TITLE     Molecular cloning of a novel lipocalin-1 interacting human cell
            membrane receptor using phage display
  JOURNAL   J Biol Chem 276 (23), 20206-20212 (2001)
   PUBMED   11287427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001651.1, BC015015.1 and AC011603.37.
            
            On Aug 11, 2020 this sequence version replaced NM_018113.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031550.1, AY358572.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267102.13/ ENSP00000267102.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AK001651.1         4-221
            219-1233            BC015015.1         1-1015
            1234-1234           AC011603.37        57380-57380
            1235-2295           BC015015.1         1017-2077
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2295
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /note="limb development membrane protein 1 like"
                     /db_xref="GeneID:55716"
                     /db_xref="HGNC:HGNC:18268"
                     /db_xref="MIM:610007"
     exon            1..364
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1762
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lipocalin-interacting membrane receptor; protein LMBR1L;
                     lipocalin-1 interacting membrane receptor; limb region 1
                     protein homolog-like; limb region 1 homolog-like; limb
                     region 1-like protein -like; limb development membrane
                     protein 1 like-protein"
                     /codon_start=1
                     /product="protein LMBR1L isoform 1"
                     /protein_id="NP_060583.2"
                     /db_xref="CCDS:CCDS8780.2"
                     /db_xref="GeneID:55716"
                     /db_xref="HGNC:HGNC:18268"
                     /db_xref="MIM:610007"
                     /translation="MEAPDYEVLSVREQLFHERIRECIISTLLFATLYILCHIFLTRF
                     KKPAEFTTVDDEDATVNKIALELCTFTLAIALGAVLLLPFSIISNEVLLSLPRNYYIQ
                     WLNGSLIHGLWNLVFLFSNLSLIFLMPFAYFFTESEGFAGSRKGVLGRVYETVVMLML
                     LTLLVLGMVWVASAIVDKNKANRESLYDFWEYYLPYLYSCISFLGVLLLLVCTPLGLA
                     RMFSVTGKLLVKPRLLEDLEEQLYCSAFEEAALTRRICNPTSCWLPLDMELLHRQVLA
                     LQTQRVLLEKRRKASAWQRNLGYPLAMLCLLVLTGLSVLIVAIHILELLIDEAAMPRG
                     MQGTSLGQVSFSKLGSFGAVIQVVLIFYLMVSSVVGFYSSPLFRSLRPRWHDTAMTQI
                     IGNCVCLLVLSSALPVFSRTLGLTRFDLLGDFGRFNWLGNFYIVFLYNAAFAGLTTLC
                     LVKTFTAAVRAELIRAFGLDRLPLPVSGFPQASRKTQHQ"
     exon            365..449
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            450..483
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            484..623
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            624..727
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            728..854
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            855..923
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            924..988
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1061
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1145
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1222
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1300
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1374
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1465
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1532
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1694
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..2295
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /note="hexamer: AATAAA"
     polyA_site      2295
                     /gene="LMBR1L"
                     /gene_synonym="LIMR"
                     /note="major polyA site"
ORIGIN      
        1 gtagcgagcc tagtggcggg tgtttgcatt gaaacgtgag cgcgacccga ccttaaagag
       61 tggggagcaa agggaggaca gagcccttta aaacgaggcg ggtggtgcct gcccctttaa
      121 gggcggggcg tccggacgac tgtatctgag ccccagactg ccccgagttt ctgtcgcagg
      181 ctgcgaggaa aggcccctag gctgggtctg ggtgcttggc ggcggcggct tcctccccgc
      241 tcgtcctccc cgggcccaga ggcacctcgg cttcagtcat gctgagcaga gtatggaagc
      301 acctgactac gaagtgctat ccgtgcgaga acagctattc cacgagagga tccgcgagtg
      361 tattatatca acacttctgt ttgcaacact gtacatcctc tgccacatct tcctgacccg
      421 cttcaagaag cctgctgagt tcaccacagt ggatgatgaa gatgccaccg tcaacaagat
      481 tgcgctcgag ctgtgcacct ttaccctggc aattgccctg ggtgctgtcc tgctcctgcc
      541 cttctccatc atcagcaatg aggtgctgct ctccctgcct cggaactact acatccagtg
      601 gctcaacggc tccctcatcc atggcctctg gaaccttgtt tttctcttct ccaacctgtc
      661 cctcatcttc ctcatgccct ttgcatattt cttcactgag tctgagggct ttgctggctc
      721 cagaaagggt gtcctgggcc gggtctatga gacagtggtg atgttgatgc tcctcactct
      781 gctggtgcta ggtatggtgt gggtggcatc agccattgtg gacaagaaca aggccaacag
      841 agagtcactc tatgactttt gggagtacta tctcccctac ctctactcat gcatctcctt
      901 ccttggggtt ctgctgctcc tggtgtgtac tccactgggt ctcgcccgca tgttctccgt
      961 cactgggaag ctgctagtca agccccggct gctggaagac ctggaggagc agctgtactg
     1021 ctcagccttt gaggaggcag ccctgacccg caggatctgt aatcctactt cctgctggct
     1081 gcctttagac atggagctgc tacacagaca ggtcctggct ctgcagacac agagggtcct
     1141 gctggagaag aggcggaagg cttcagcctg gcaacggaac ctgggctacc ccctggctat
     1201 gctgtgcttg ctggtgctga cgggcctgtc tgtgctcatt gtggccatcc acatcctgga
     1261 gctgctcatc gatgaggctg ccatgccccg aggcatgcag ggtacctcct taggccaggt
     1321 ctccttctcc aagctgggct cctttggtgc cgtcattcag gttgtactca tcttttacct
     1381 aatggtgtcc tcagttgtgg gcttctatag ctctccactc ttccggagcc tgcggcccag
     1441 atggcacgac actgccatga cgcagataat tgggaactgt gtctgtctcc tggtcctaag
     1501 ctcagcactt cctgtcttct ctcgaaccct ggggctcact cgctttgacc tgctgggtga
     1561 ctttggacgc ttcaactggc tgggcaattt ctacattgtg ttcctctaca acgcagcctt
     1621 tgcaggcctc accacactct gtctggtgaa gaccttcact gcagctgtgc gggcagagct
     1681 gatccgggcc tttgggctgg acagactgcc gctgcccgtc tccggtttcc cccaggcatc
     1741 taggaagacc cagcaccagt gacctccagc tgggggtggg aaggaaaaaa ctggacactg
     1801 ccatctgctg cctaggcctg gagggaagcc caaggctact tggacctcag gacctggaat
     1861 ctgagagggt gggtggcaga ggggagcaga gccatctgca ctattgcata atctgagcca
     1921 gagtttggga ccaggacctc ctgcttttcc atacttaact gtggcctcag catggggtag
     1981 ggctgggtga ctgggtctag cccctgatcc caaatctgtt tacacatcaa tctgcctcac
     2041 tgctgttctg ggccatcccc atagccatgt ttacatgatt tgatgtgcaa tagggtgggg
     2101 taggggcagg gaaaggactg ggccagggca ggctcgggag atagattgtc tcccttgcct
     2161 ctggcccagc agagcctaag cactgtgcta tcctggaggg gctttggacc acctgaaaga
     2221 ccaaggggat agggaggagg aggcttcagc catcagcaat aaagttgatc ccagggtttg
     2281 ctttgttttt ttaaa
//
