LOCUS       NM_006816               1611 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lectin, mannose binding 2 (LMAN2), mRNA.
ACCESSION   NM_006816
VERSION     NM_006816.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Zhang,D., Ye,L., Hu,S., Zhu,Q., Li,C. and Zhu,C.
  TITLE     Comprehensive Analysis of the Expression and Prognostic Value of
            LMAN2 in HER2+ Breast Cancer
  JOURNAL   J Immunol Res 2022, 7623654 (2022)
   PUBMED   35707004
  REMARK    GeneRIF: Comprehensive Analysis of the Expression and Prognostic
            Value of LMAN2 in HER2+ Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Bettencourt,C., Foti,S.C., Miki,Y., Botia,J., Chatterjee,A.,
            Warner,T.T., Revesz,T., Lashley,T., Balazs,R., Vire,E. and
            Holton,J.L.
  TITLE     White matter DNA methylation profiling reveals deregulation of
            HIP1, LMAN2, MOBP, and other loci in multiple system atrophy
  JOURNAL   Acta Neuropathol 139 (1), 135-156 (2020)
   PUBMED   31535203
  REMARK    GeneRIF: White matter DNA methylation profiling reveals
            deregulation of HIP1, LMAN2, MOBP, and other loci in multiple
            system atrophy.
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Kwon,S.H., Oh,S., Nacke,M., Mostov,K.E. and Lipschutz,J.H.
  TITLE     Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome
            Cargo Protein Trafficking through the Golgi Complex
  JOURNAL   J Biol Chem 291 (49), 25462-25475 (2016)
   PUBMED   27765817
  REMARK    GeneRIF: data thus reveal a Golgi-traversing pathway for exosomal
            release of the cargo protein GPRC5B in which CD2AP facilitates the
            entry and LMAN2 impedes the exit of the flux, respectively.
            Erratum:[J Biol Chem. 2017 Oct 6;292(40):16523. doi:
            10.1074/jbc.A116.729202.. PMID: 28986432]
REFERENCE   4  (bases 1 to 1611)
  AUTHORS   Takeda,Y., Seko,A., Sakono,M., Hachisu,M., Koizumi,A., Fujikawa,K.
            and Ito,Y.
  TITLE     Parallel quantification of lectin-glycan interaction using
            ultrafiltration
  JOURNAL   Carbohydr Res 375, 112-117 (2013)
   PUBMED   23701871
REFERENCE   5  (bases 1 to 1611)
  AUTHORS   Arshad,N., Ballal,S. and Visweswariah,S.S.
  TITLE     Site-specific N-linked glycosylation of receptor guanylyl cyclase C
            regulates ligand binding, ligand-mediated activation and
            interaction with vesicular integral membrane protein 36, VIP36
  JOURNAL   J Biol Chem 288 (6), 3907-3917 (2013)
   PUBMED   23269669
  REMARK    GeneRIF: Interaction with VIP36 is dependent on glycosylation at
            the same sites that allow GC-C to fold and bind ligand.
REFERENCE   6  (bases 1 to 1611)
  AUTHORS   Kawasaki,N., Matsuo,I., Totani,K., Nawa,D., Suzuki,N.,
            Yamaguchi,D., Matsumoto,N., Ito,Y. and Yamamoto,K.
  TITLE     Detection of weak sugar binding activity of VIP36 using
            VIP36-streptavidin complex and membrane-based sugar chains
  JOURNAL   J Biochem 141 (2), 221-229 (2007)
   PUBMED   17169971
REFERENCE   7  (bases 1 to 1611)
  AUTHORS   Kamiya,Y., Yamaguchi,Y., Takahashi,N., Arata,Y., Kasai,K.,
            Ihara,Y., Matsuo,I., Ito,Y., Yamamoto,K. and Kato,K.
  TITLE     Sugar-binding properties of VIP36, an intracellular animal lectin
            operating as a cargo receptor
  JOURNAL   J Biol Chem 280 (44), 37178-37182 (2005)
   PUBMED   16129679
REFERENCE   8  (bases 1 to 1611)
  AUTHORS   Neve,E.P., Svensson,K., Fuxe,J. and Pettersson,R.F.
  TITLE     VIPL, a VIP36-like membrane protein with a putative function in the
            export of glycoproteins from the endoplasmic reticulum
  JOURNAL   Exp Cell Res 288 (1), 70-83 (2003)
   PUBMED   12878160
REFERENCE   9  (bases 1 to 1611)
  AUTHORS   Nufer,O., Mitrovic,S. and Hauri,H.P.
  TITLE     Profile-based data base scanning for animal L-type lectins and
            characterization of VIPL, a novel VIP36-like endoplasmic reticulum
            protein
  JOURNAL   J Biol Chem 278 (18), 15886-15896 (2003)
   PUBMED   12609988
REFERENCE   10 (bases 1 to 1611)
  AUTHORS   Dahm,T., White,J., Grill,S., Fullekrug,J. and Stelzer,E.H.
  TITLE     Quantitative ER <--> Golgi transport kinetics and protein
            separation upon Golgi exit revealed by vesicular integral membrane
            protein 36 dynamics in live cells
  JOURNAL   Mol Biol Cell 12 (5), 1481-1498 (2001)
   PUBMED   11359937
  REMARK    GeneRIF: Live imaging of the canine homologous protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC404202.1, BC017263.2 and
            AK222609.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006816.2.
            
            Summary: This gene encodes a type I transmembrane lectin that
            shuttles between the endoplasmic reticulum, the Golgi apparatus and
            the plasma membrane. The encoded protein binds high mannose type
            glycoproteins and may facilitate their sorting, trafficking and
            quality control. [provided by RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.170632.1,
                                           SRR3476690.790902.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303127.12/ ENSP00000303366.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DC404202.1         217-220
            5-1224              BC017263.2         1-1220
            1225-1611           AK222609.1         1207-1593
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1611
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /note="lectin, mannose binding 2"
                     /db_xref="GeneID:10960"
                     /db_xref="HGNC:HGNC:16986"
                     /db_xref="MIM:609551"
     exon            1..217
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1092
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /note="vesicular integral protein of 36 kDa; vesicular
                     integral-membrane protein VIP36; glycoprotein GP36b;
                     vesicular integral-membrane protein 36; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="vesicular integral-membrane protein VIP36
                     precursor"
                     /protein_id="NP_006807.1"
                     /db_xref="CCDS:CCDS4417.1"
                     /db_xref="GeneID:10960"
                     /db_xref="HGNC:HGNC:16986"
                     /db_xref="MIM:609551"
                     /translation="MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTA
                     DITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRLTPDERSKEGSIW
                     NHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIF
                     LDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVR
                     YSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQL
                     MVEHTPDEESIDWTKIEPSVNFLKSPKDNVDDPTGNFRSGPLTGWRVFLLLLCALLGI
                     VVCAVVGAVVFQKRQERNKRFY"
     exon            218..336
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     exon            337..454
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     exon            455..534
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     exon            535..696
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     exon            697..811
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     exon            812..931
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1611
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /note="hexamer: AATAAA"
     polyA_site      1224
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /note="hexamer: AATAAA"
     polyA_site      1611
                     /gene="LMAN2"
                     /gene_synonym="C5orf8; GP36B; VIP36"
                     /note="major polyA site"
ORIGIN      
        1 agtggccgag aggagaggag aatggcggcg gaaggctgga tttggcgttg gggctggggc
       61 cggcggtgcc tgggaaggcc tgggcttctc ggccccggcc ctggccccac tacacctctc
      121 tttcttcttt tgttgttggg gtctgtgact gcggatataa ctgacggcaa cagtgaacat
      181 ctcaagcggg agcattcgct cattaagccc taccaagggg tcggttccag ctctatgccc
      241 ctctgggact tccagggcag cactatgctc acgagccagt acgtacgtct gacccctgac
      301 gagcgcagca aagagggctc tatctggaac caccagccgt gcttcctcaa agactgggaa
      361 atgcacgtcc acttcaaagt ccacggcaca gggaagaaga acctccatgg agacggcatc
      421 gccttgtggt acacccggga ccgcctcgtg ccagggcctg tgtttggaag caaagataac
      481 ttccacggct tagccatctt cctggacacc taccccaatg atgagaccac tgagcgcgtg
      541 ttcccgtaca tctcggtgat ggtgaacaat ggctccctgt cctacgacca cagcaaggat
      601 gggcgctgga ccgagctggc gggctgcacg gctgacttcc gcaaccgcga tcacgacacc
      661 ttcctggctg tgcgctactc ccggggccgt ctgacggtga tgaccgacct ggaggacaag
      721 aacgagtgga agaactgcat tgacatcacg ggagtgcgcc tgcccaccgg ctactacttc
      781 ggggcctccg ccggcaccgg cgacctgtct gacaatcatg acatcatctc catgaagctg
      841 ttccagctga tggtggagca cacgcccgac gaggagagca tcgactggac caagatcgag
      901 cccagcgtca acttcctcaa gtcgcccaaa gacaacgtgg acgaccccac ggggaacttc
      961 cgcagcgggc ccctgacggg gtggcgggtg ttcctgctgc tgctgtgcgc tctcctgggc
     1021 atcgttgtct gcgccgtggt gggggccgtg gtgttccaga agcggcagga gcggaacaag
     1081 cgcttctact gagtggcgcc tccggcgggg cctgtccctg ggcccaggag ccaatgtgaa
     1141 cttttttttt taccgggatt ataaaagaac aacaagatga ccttatttct taactgtttc
     1201 aaataaatga ttaaagtatt ttcatacatt ttgcttcttg cccagcaggg acaggtggca
     1261 gagccgaggc ttagggtctg gcacccccca cagctggaga cggaggctct cctggggctg
     1321 gtgtctcagg agcaggggtc tgtgtctaca gatgggctgt ggcccctgca ggcagctgtt
     1381 gaacactgga gggtcccccg gaccacactg gggtgggctc ctgaggacgt ggggaagtga
     1441 ttttgttttg tggtgtgtgg cacgtgtggc gacggataag gcctgaactg ggaaacccag
     1501 gccttcctgt tcaccctgag ctgcttcctg agacagatgc tcaagtgagg ctgcaggcgc
     1561 ggtgtggtgg ggccgagtgt gaccgtttgc taaataaagt gaaataccca a
//
