LOCUS       NM_021819               1750 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lectin, mannose binding 1 like (LMAN1L), mRNA.
ACCESSION   NM_021819 NM_024695
VERSION     NM_021819.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Naba,A., Pearce,O.M.T., Del Rosario,A., Ma,D., Ding,H., Rajeeve,V.,
            Cutillas,P.R., Balkwill,F.R. and Hynes,R.O.
  TITLE     Characterization of the Extracellular Matrix of Normal and Diseased
            Tissues Using Proteomics
  JOURNAL   J Proteome Res 16 (8), 3083-3091 (2017)
   PUBMED   28675934
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Cornelis,M.C., Monda,K.L., Yu,K., Paynter,N., Azzato,E.M.,
            Bennett,S.N., Berndt,S.I., Boerwinkle,E., Chanock,S.,
            Chatterjee,N., Couper,D., Curhan,G., Heiss,G., Hu,F.B.,
            Hunter,D.J., Jacobs,K., Jensen,M.K., Kraft,P., Landi,M.T.,
            Nettleton,J.A., Purdue,M.P., Rajaraman,P., Rimm,E.B., Rose,L.M.,
            Rothman,N., Silverman,D., Stolzenberg-Solomon,R., Subar,A.,
            Yeager,M., Chasman,D.I., van Dam,R.M. and Caporaso,N.E.
  TITLE     Genome-wide meta-analysis identifies regions on 7p21 (AHR) and
            15q24 (CYP1A2) as determinants of habitual caffeine consumption
  JOURNAL   PLoS Genet 7 (4), e1002033 (2011)
   PUBMED   21490707
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
REFERENCE   5  (bases 1 to 1750)
  AUTHORS   Nyfeler,B., Reiterer,V., Wendeler,M.W., Stefan,E., Zhang,B.,
            Michnick,S.W. and Hauri,H.P.
  TITLE     Identification of ERGIC-53 as an intracellular transport receptor
            of alpha1-antitrypsin
  JOURNAL   J Cell Biol 180 (4), 705-712 (2008)
   PUBMED   18283111
  REMARK    GeneRIF: The results reveal ERGIC-53 to be an intracellular
            transport receptor of alpha1-AT and provide direct evidence for
            active receptor-mediated ER export of a soluble secretory protein
            in higher eukaryotes
REFERENCE   6  (bases 1 to 1750)
  AUTHORS   Kawasaki,N., Ichikawa,Y., Matsuo,I., Totani,K., Matsumoto,N.,
            Ito,Y. and Yamamoto,K.
  TITLE     The sugar-binding ability of ERGIC-53 is enhanced by its
            interaction with MCFD2
  JOURNAL   Blood 111 (4), 1972-1979 (2008)
   PUBMED   18056485
  REMARK    GeneRIF: Binding of ERGIC-53 to sugar is enhanced by its
            interaction with MCFD2, and defects in this interaction in factor V
            and VIII deeficient patients may be the cause for reduced secretion
            of factors V and VIII.
REFERENCE   7  (bases 1 to 1750)
  AUTHORS   Anelli,T., Ceppi,S., Bergamelli,L., Cortini,M., Masciarelli,S.,
            Valetti,C. and Sitia,R.
  TITLE     Sequential steps and checkpoints in the early exocytic compartment
            during secretory IgM biogenesis
  JOURNAL   EMBO J 26 (19), 4177-4188 (2007)
   PUBMED   17805346
  REMARK    GeneRIF: ERGIC-53 provides a platform that receives micro(2)L(2)
            subunits from the BiP-dependent checkpoint, assisting
            polymerization. In this process, ERp44 couples thiol-dependent
            assembly and quality control.
REFERENCE   8  (bases 1 to 1750)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1750)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
REFERENCE   10 (bases 1 to 1750)
  AUTHORS   Yerushalmi,N., Keppler-Hafkemeyer,A., Vasmatzis,G., Liu,X.F.,
            Olsson,P., Bera,T.K., Duray,P., Lee,B. and Pastan,I.
  TITLE     ERGL, a novel gene related to ERGIC-53 that is highly expressed in
            normal and neoplastic prostate and several other tissues
  JOURNAL   Gene 265 (1-2), 55-60 (2001)
   PUBMED   11255007
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091230.23, AY358724.1 and
            AF303398.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_021819.2.
            
            Summary: This gene encodes a mannose-binding type 1 transmembrane
            protein that contains an N-terminal lectin-like carbohydrate
            recognition domain. The encoded protein is similar in structure to
            lectins found in leguminous plants. This lectin is thought to
            transport newly synthesized glycoproteins from the endoplasmic
            reticulum (ER) to the ER-Golgi intermediate compartment. [provided
            by RefSeq, Jan 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291819.1, AF303398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2150585
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309664.10/ ENSP00000310431.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC091230.23        61115-61132         c
            19-575              AY358724.1         1-557
            576-1750            AF303398.1         594-1768
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..1750
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /note="lectin, mannose binding 1 like"
                     /db_xref="GeneID:79748"
                     /db_xref="HGNC:HGNC:6632"
                     /db_xref="MIM:609548"
     exon            1..195
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1601
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /note="protein ERGIC-53-like; LMAN1-like protein;
                     ERGIC53-like protein"
                     /codon_start=1
                     /product="protein ERGIC-53-like precursor"
                     /protein_id="NP_068591.2"
                     /db_xref="CCDS:CCDS10270.1"
                     /db_xref="GeneID:79748"
                     /db_xref="HGNC:HGNC:6632"
                     /db_xref="MIM:609548"
                     /translation="MPAVSGPGPLFCLLLLLLDPHSPETGCPPLRRFEYKLSFKGPRL
                     ALPGAGIPFWSHHGDAILGLEEVRLTPSMRNRSGAVWSRASVPFSAWEVEVQMRVTGL
                     GRRGAQGMAVWYTRGRGHVGSVLGGLASWDGIGIFFDSPAEDTQDSPAIRVLASDGHI
                     PSEQPGDGASQGLGSCHWDFRNRPHPFRARITYWGQRLRMSLNSGLTPSDPGEFCVDV
                     GPLLLVPGGFFGVSAATGTLADDHDVLSFLTFSLSEPSPEVPPQPFLEMQQLRLARQL
                     EGLWARLGLGTREDVTPKSDSEAQGEGERLFDLEETLGRHRRILQALRGLSKQLAQAE
                     RQWKKQLGPPGQARPDGGWALDASCQIPSTPGRGGHLSMSLNKDSAKVGALLHGQWTL
                     LQALQEMRDAAVRMAAEAQVSYLPVGIEHHFLELDHILGLLQEELRGPAKAAAKAPRP
                     PGQPPRASSCLQPGIFLFYLLIQTVGFFGYVHFRQELNKSLQECLSTGSLPLGPAPHT
                     PRALGILRRQPLPASMPA"
     exon            196..350
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            351..458
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            459..517
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            518..617
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            618..738
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            739..794
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            795..927
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1079
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1151
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1219
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1343
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1471
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1750
                     /gene="LMAN1L"
                     /gene_synonym="ERGIC-53L; ERGL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacttcagg cgccttcacg atgccggcgg tcagtggtcc aggtccctta ttctgccttc
       61 tcctcctgct cctggacccc cacagccctg agacggggtg tcctcctcta cgcaggtttg
      121 agtacaagct cagcttcaaa ggcccaaggc tggcattgcc tggggctgga atacccttct
      181 ggagccatca tggagacgcc atcctgggcc tggaggaagt gcggctgacg ccatccatga
      241 ggaaccggag tggcgccgtg tggagcaggg cctctgtccc cttctctgcc tgggaagtag
      301 aggtgcagat gagggtgacg ggactggggc gccggggagc ccagggcatg gccgtgtggt
      361 acacccgggg caggggccat gtaggctctg tccttggggg gctggcttcg tgggacggca
      421 tcgggatctt ctttgactct ccggcagagg atactcagga cagtcctgcc atccgtgtgc
      481 tggccagcga cgggcacatc ccctctgagc agcctgggga tggagctagc caagggctgg
      541 gctcctgtca ttgggacttc cggaaccggc cacacccctt cagagcacgg atcacctact
      601 gggggcagag gctgcgcatg tccttgaaca gtggcctcac tcccagtgat ccaggtgagt
      661 tctgtgtgga tgtggggccc ctgcttttgg tccctggagg tttctttggg gtctcagcag
      721 ccaccggcac cctggcagat gatcatgatg tcctgtcctt cctgaccttc agcctgagtg
      781 agcccagccc agaggttccc cctcagccct tcctggagat gcagcagctc cgcctggcga
      841 ggcagctgga agggctgtgg gcaaggctgg gcttgggcac cagggaggat gtaactccaa
      901 aatcagactc tgaagctcaa ggagaagggg aaaggctctt tgacctggag gagacgctgg
      961 gcagacaccg ccggatcctg caggctctgc ggggtctctc caagcagctg gcccaggctg
     1021 agagacaatg gaagaagcag ctggggcccc caggccaagc caggcctgac ggaggctggg
     1081 ccctggatgc ttcctgccag attccatcca ccccagggag gggtggccac ctctccatgt
     1141 cactcaataa ggactctgcc aaggtcggtg ccctgctcca tggacagtgg actctgctcc
     1201 aggccctgca agagatgagg gatgcagctg tccgcatggc tgcagaagcc caggtctcct
     1261 acctgcctgt gggcattgag catcatttct tagagctgga ccacatcctg ggcctcctgc
     1321 aggaggagct tcggggcccg gcgaaggcag cagccaaggc cccccgccca cctggccagc
     1381 ccccaagggc ctcctcgtgc ctgcagcctg gcatcttcct gttctacctc ctcattcaga
     1441 ctgtaggctt cttcggctac gtgcacttca ggcaggagct gaacaagagc cttcaggagt
     1501 gtctgtccac aggcagcctt cctctgggtc ctgcaccaca cacccccagg gccctgggga
     1561 ttctgaggag gcagcctctc cctgccagca tgcctgcctg acccacctca gagcctgctt
     1621 tgcatcactg ggaagcaggc agtgtcttgg gtgggggctt ggtcagtatc ctctccgtct
     1681 gggtgcccag ctcccacgca cacctgagct ttcggcatgc tcccacctcg ttaaaggtga
     1741 tttccctctc
//
