LOCUS       NM_032338               7728 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LLP homolog, long-term synaptic facilitation factor
            (LLPH), mRNA.
ACCESSION   NM_032338
VERSION     NM_032338.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7728)
  AUTHORS   Gupta,N., Sahar,T., Khowal,S., Ganaie,I.A., Mughees,M., Khullar,D.,
            Jain,S.K. and Wajid,S.
  TITLE     Differential levels of CHMP2B, LLPH, and SLC25A51 proteins in
            secondary renal amyloidosis
  JOURNAL   Expert Rev Proteomics 18 (1), 65-73 (2021)
   PUBMED   33583303
  REMARK    GeneRIF: Differential levels of CHMP2B, LLPH, and SLC25A51 proteins
            in secondary renal amyloidosis.
REFERENCE   2  (bases 1 to 7728)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7728)
  AUTHORS   Yu,N.K., Kim,H.F., Shim,J., Kim,S., Kim,D.W., Kwak,C., Sim,S.E.,
            Choi,J.H., Ahn,S., Yoo,J., Choi,S.L., Jang,D.J., Lim,C.S.,
            Lee,Y.S., Kang,C., Choi,S.Y. and Kaang,B.K.
  TITLE     A transducible nuclear/nucleolar protein, mLLP, regulates neuronal
            morphogenesis and synaptic transmission
  JOURNAL   Sci Rep 6, 22892 (2016)
   PUBMED   26961175
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7728)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 7728)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 7728)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091568.1, BM996194.1, AC078927.20 and KF455664.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032338.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG484691.1, SRR1803611.102187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733, SAMEA2163105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266604.7/ ENSP00000266604.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1152              AK091568.1         4-1155
            1153-1214           BM996194.1         18-79               c
            1215-4714           AC078927.20        85732-89231
            4715-5091           KF455664.1         1-377               c
            5092-7728           AC078927.20        89609-92245
FEATURES             Location/Qualifiers
     source          1..7728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.3"
     gene            1..7728
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /note="LLP homolog, long-term synaptic facilitation
                     factor"
                     /db_xref="GeneID:84298"
                     /db_xref="HGNC:HGNC:28229"
                     /db_xref="MIM:616998"
     exon            1..46
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            47..264
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..443
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /note="human LAPS18-like protein; LLP homolog, long-term
                     synaptic facilitation (Aplysia)"
                     /codon_start=1
                     /product="protein LLP homolog"
                     /protein_id="NP_115714.1"
                     /db_xref="CCDS:CCDS8974.1"
                     /db_xref="GeneID:84298"
                     /db_xref="HGNC:HGNC:28229"
                     /db_xref="MIM:616998"
                     /translation="MAKSLRSKWKRKMRAEKRKKNAPKEASRLKSILKLDGDVLMKDV
                     QEIATVVVPKPKHCQEKMQCEVKDEKDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQR
                     KRLKAKREKRKGKSKAKAVKVAKGLAW"
     exon            265..7728
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1193..1198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /note="hexamer: AATAAA"
     polyA_site      1214
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /note="major polyA site"
     regulatory      7707..7712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
                     /note="hexamer: AATAAA"
     polyA_site      7728
                     /gene="LLPH"
                     /gene_synonym="C12orf31; hLLP"
ORIGIN      
        1 gacttccggt cggcgtgagc gtgaggtgtg ggtgttcgtt tctcaggtaa aacatggcta
       61 aaagcttacg gagtaagtgg aaaagaaaga tgcgtgctga aaagagaaaa aagaatgccc
      121 caaaggaggc cagcaggctt aaaagtattc tcaaactaga cggtgatgtt ttaatgaaag
      181 atgttcaaga gatagcaact gtggtggtac ccaaacccaa acattgccaa gagaaaatgc
      241 aatgtgaggt aaaagatgaa aaagatgaca tgaaaatgga gactgatatt aagagaaaca
      301 aaaagactct tctagaccag catggacagt acccaatatg gatgaaccaa aggcaaagaa
      361 aaaggctgaa ggcaaagcga gagaaaagaa aggggaaaag caaagcaaaa gcagtgaaag
      421 tggcaaaggg tttggcctgg tagactctta aaaccttgga aaatgccaca tgggatagat
      481 gacggattag aatgtataca catgtatact ttgatttcaa ctgccaccaa atgaaaacca
      541 tttgttttcc tattttaact tggccttttt tcttcaattc aaacccagca taactcctca
      601 agtttgtttt gggaacttga ataaaatatt ttctttgata catccaagct ctactgatac
      661 tttaactgga tgctacccaa tatccagtta taatcaggcc tcaacgttct gtcaggtatt
      721 aatatggtta gaattgttct tacaactggt aattatagtc aatagagata aaacagatga
      781 tgtactgaca aatttttgtg aacttagatt ttaaagaaag ttgttgtata atcatatcat
      841 ttaaaaatac tacattaggg ctgggcatgg tggctcacac ctgtaatccc agcactttgg
      901 gaggccgagg caggtggatc acgaggtcag ttcgagacta gcctggctaa tacagtgaaa
      961 ccccatctct actaaaaata caaaattagc cgggcatggg ggcgcgcacc tgtagttcca
     1021 gctactcggg aggctgaggc aggataattg cttgaaccca ggagatggag gttgcagtga
     1081 gccaagattg ccccactgca ctccaccctg ggcaatggag taggactctg tctcaaaaaa
     1141 aaaaaaaata atggatctta taaagtactt gtgtggagct ttgattccac agaataaaag
     1201 atattttgtg tgtagatctt caagtctgat ttttttttct ttcatgtatg cttaaggttt
     1261 tttagtccta gagaagacca gatttcaatt aaatgttttc ttatcttaat tttaggtaga
     1321 atattaacat atacaaatca gtatgctttt taggaaatta gaacatttca ggtttttcat
     1381 ggaaactgat ttaatgttct ttagtgttaa tattgtgtgg cctaatatag tatcatgcag
     1441 cattccccgg agtgtgttct tcagtatcag tttcctctgg atgcttggtt aaaaaaaata
     1501 aattgtgttc acatcgattt gggaaatgct acatacttga agatttacaa aagattttag
     1561 tttaggatta gaatagtcct acagggttcc agcagcaaag aaacctgttt agcgtctact
     1621 ctttgaaact agttttctga gaaatgattt ttagttaaat ctgtcttact acagtttgct
     1681 aaattcattt ttattttact tttagttaag caatctaaac ttagcattcc ctctgaattt
     1741 cactataatc agattaacca tctcatatgt taactggaac aaccaaatac ttactgagtg
     1801 cctagtatgt gggccaggga ctttccagat gcttgggaca gattgaataa gataagattt
     1861 ctgctctcat agggctgaga gctgtgtatc tgtttagaag aagatgttaa cttcccagga
     1921 gaactcaagt aaaatgtgaa atagaataag gccacttggt catgaggtca caaactttgt
     1981 gccaggcaca ctgctaaatt ggggcacaat acatggacat gtattgtaat aaagaggaca
     2041 tgacccaaat gtttcagaaa atttaagctt ataaaatttg atgccagtaa actcttggaa
     2101 ttgtttaaat atagtagact tttcttattt ttctcaatag tttattgaaa agttggtaga
     2161 taactttaaa tgcttaaaat ttcttaacag ctaagaaaga tatgaattga aagatgtcat
     2221 tcatgatctt tgttgccttt ggtgtaggta tgaataacac tagcatttgt gagggaaaag
     2281 tgaatatgta catttttatt cataaaataa aaaaaattgc aaacaaccag ttaagccact
     2341 gacaatatca gcctaaatac agtagctgaa ttatttatgt tttttttttt tttttttttg
     2401 agatggggtc tcactctgtc acccaggctg gagtgattgg cacaagtgtg gctccgctgc
     2461 aacctccacc tcccaggctg aagcgattct cccacctcag cctccccagt agctgggact
     2521 acaggtgggt gccaccacgc ccagctaatt tttgtatttt tgtagagaca gggtttcgcc
     2581 atgttgccca ggctggtctc aaactcctgg actcaagtaa tccacctgcc ccagcctccc
     2641 aaagtggtgg gattacatgc gtgagccacc acacccggcc taatgtagac attttttatg
     2701 atttttggaa aagggggcca ggcaccaaat tctaacaatt tgggaggctg aggcagatgg
     2761 atcacctgag gtcaggagtt tgagaccagc ctgaccaaca tggtgaaacc ctgtctctac
     2821 taaaaataca aagttagctg ggcatggtgg caggtgcctg taatcccagc tacttgggag
     2881 gctgaggaag gagaatcgct tgaacctggg aggcagaggt tgcagtgagt caagaccaca
     2941 ccattgcact ccagcctgag caagaagagc gaaactccat ctcaaaaaaa aaaaaaaaaa
     3001 aagtctacat tcgtgatatt acacagttgg cacttattta cattttggca gcattgtcag
     3061 gtagagacca atgccagggt tatgttcatg ttttctgtgg ctgataacct ctaatttgat
     3121 tctgttgata gtagctttga gctttcatcc agagcctctc tgatgttagg attttcactt
     3181 cattgtgtcc agtcatgaag tttgtccatt caggatttaa cttgaaagtt aacaaaatca
     3241 aaaatcaaag caccattacc agaaaacata tttgggaatc atgttctcaa gtgtcacatg
     3301 gcctctggaa aggcgactgc tgaagagaag tttactgaca cagtgttgtc agtaccctct
     3361 aaggcactga gttcctgaac actaccagca agattctccc cacctccaaa tattggcagg
     3421 aaatttagac tagcatttca aaattagtgc aggggtatgg tcacatcttt ggcactttat
     3481 ttttaaagat tacaaatcga gaagtatagc atagtccttt tatcttttaa ataattagct
     3541 tatttttttg aaatttgtca tctttttgac tgacattttc cagagaattg ctgtaaagcc
     3601 acaagatgga gctcaagcta agcaccaaat cattttggaa ttagattgag tgagctaaat
     3661 cacattagga attgaatgta acactttttg tgttttaaga aattaagtct gaaatcaaaa
     3721 tataatttaa agatgatcaa aactgcttca agtattaact catttaatct gcccagcaat
     3781 ctcatgagtt tggtactaat gttatctgag tttggtacta atgtaatctc tgtttacaca
     3841 tggggaaact gaggcacaca ggccatacaa ctaaaactga aatctgggat tcaaatttag
     3901 gcagtgtggc tctagagcct atactcttac aatgccattc tgcctctcaa ggatgtgcaa
     3961 actcttgcta agagagaaag gtgattttag gatagaatac ctatttttgg gtcaacctgt
     4021 gatagattgg gttcatgtgg gctcaggatc agataaagag caggtttaag tagaataatg
     4081 atgtacagaa ccctcctcaa atctctaggc ctaaggcaga ctggatttcc tcaggtgaca
     4141 cttcattagg aatgggctga ccaatccaaa aggggaaggt gtaggccatg atcagtagtt
     4201 gcccaaggta ctaatcagag aagaaatgca aactgcagtt gaagctctaa ggtagaatca
     4261 agtagtggtt ttgaccacat cctattttct actgtcacat tagtgtagat atctcttccc
     4321 actatgtaat tcacatgcta catcaaataa ggatgcagca gtatatattt gcttattagg
     4381 aaattcagat attttcaaaa tttggatccg tgtttctgga atatggctta agagttggag
     4441 aagaaaaata gctataaatg acttgaatca aatatctgaa atggactggt ggtgatggtg
     4501 aggggcagca atgtgtaatt tagggaagtg ctgaccacaa cataaaattg ggaggaatct
     4561 aaggcattgc caaatttata aatactacaa tagaaatgca gatgctaagc tgttggctaa
     4621 tcttactagt taagtgacta acttctgatg ccatctggca gagtgattca aatttgtgct
     4681 aaacacaaaa tatatgtctt tttccctcta tttgcctgca tgtattaata aaaacactgt
     4741 tgcagtagac acataccaat tttacaagga aatgtttagg ggtgaggtgg gactgttaaa
     4801 tacttacatc aggtcaaagg tcactctgct gtttccagag gactgtcagg tagccaggag
     4861 gcccagggcc acttttgggc ctgcttacaa aaccctaaat tttccgcagt tgaatgccaa
     4921 gagtcttttg cagttatttt agagcagggg agaaaataca atgtgttgcc aaataagctt
     4981 aatttggtag gcaagcagta aaaataaccc aacagccaac atttagagaa tgcgtactct
     5041 cttaaatgct ttatgtatat tatttaatct ttaaaacact gtgggatcaa tactttaatt
     5101 atccctattt tcagatgaga aaacagtttg aaaggttaac taaatttacc caaagtcatg
     5161 caactgctaa gtagtgagca agccgcctgt cccagagtat agaatgaata cctatgatgg
     5221 aaagctacag agagacagac ttttatttga tttaaggaag cgccttctaa ccaagatttt
     5281 gggagctgaa atgggcacct tgggatcctt gaggtgtcag tctaaggtgg acaggcattt
     5341 ggttggaatg tagcaaaatg gattcaaaca ctgtagagtt atccttcaga atctatcggg
     5401 gattggtgcc aggatcttca cagataccaa aatccacaga tgctcgaatc gcttacataa
     5461 actggtgaaa tatttgcata taacccatgc ccatcctccc atatatagtc atatgtcact
     5521 aaatgactgg gatgtgttct gagaagtgtg tcactaggta atatcgttaa tcattgtgtg
     5581 aatatcatag actgtactta cacaaatcta gagggtatcg tctactacac ttaggctatg
     5641 tgatatagcc tattgcttct aggctacaaa ttggtcaagc aagttactgt actgagtact
     5701 gtaggcaatt gtatcacaat gggaagtatt tgtgtatcta aacatagaaa aggtacagta
     5761 aaaatacagt ataaaagata aaaaaatggt acacctgtac cacttatgaa tagtgcttgg
     5821 aggactcgtg cttggggtga gtcaatgagt aagccatgag tgaatgtgaa ggcctcagac
     5881 atgactgtat actgctgtat attttttttt tttttttttg agacggagtt tcactcttgt
     5941 tgcccaggct ggagtacaat ggcgcaatct cagctcacct caacctccac ctcctgggtt
     6001 caagcaattc ttctgcctca acctcccgac tagctaggat tacaggcatg caccaccacg
     6061 gccggctaat tttgtatttt tggtagagat gaggtttctc catgttggtc aggctggcct
     6121 tgaactcctg acctcaggtg atccacctgc ctcagcctcc caaagtgctg cgattacagg
     6181 cgtgagccac tgtactcggc ctgctgtagg ctttatatac actgtgcact taggctacat
     6241 aaacttataa aaaactttct tcaataataa attaacttta gcttcctgta acttttttac
     6301 cttataaacg ttttaatttt ttaaactgta taaccctttt atcataacac ttaccttaaa
     6361 acacaaatac attgtacaac tgtacacaaa tattttatat ttttataagc ttttttctat
     6421 ttccacaatt tttaattttt taatttcttt ttttacttct taagtttttt tgttaaaaac
     6481 taagacacaa acacattagc ctccatctac actgtcttcc acctccacag cttgtcccac
     6541 tgcaaggcct tcaggggcaa taacaggcat ggagttgcca tctcctatga gagcaacacc
     6601 ttcttgtgca ataccttctg gaggacctgc ctgaggctgt tcacagtcaa ctttttcttt
     6661 aagtagaagg agtacactct aaaataaaaa gtatagtaaa gccataaacc gtagtcatta
     6721 ttatcaagta ttatgaactg tacataattg tatgtgctat acctttatat gactgacagc
     6781 acagtaggtt tgtttacacc agcatcacca caaacacgtg agtaatgcat tgcactgtga
     6841 tgttaagatg gctacagtgt cactgggcca taggaatgtt tcagctctac tgtaatctta
     6901 tgggaccact gcctatattg actgaaatgt catcatgcaa tgcatgactg tactttaaat
     6961 catctctaga ttacttataa tacaatgaaa atgctatgta aatagttgtt atactgtatt
     7021 tagggaataa tgataagaaa aaaagtcggt acatgttcag tacagatgca actgtagttt
     7081 tcttttgaat attttttatc tcaggacgaa gccccaaatg cagaattcat agatacagag
     7141 ggccaactgt tcttggaatt tgggttgaaa gctgttaaag ttcttttcag ccaaaaaaaa
     7201 atgcctcgta ataaattgtc atgtttgaaa tgtatcatgc ttgttttgct ctacatagtt
     7261 ttttggtact acataactgt agacttaagt atctttttgg tggaaataaa atatgaaatc
     7321 tctttaattt tgttaatgtt aggtctggta ttcgttccat taagttccac tttaaagtat
     7381 ggaaaaatgt tataaacatc tgctttaaac aatgaatggt actgcaatag tcctgtaaag
     7441 aaaaatgaat ggagtaaagt ccttcaagtt ttcatttaaa gaatggcata gctttataat
     7501 acattaagtt tttaatatgc ggaatgtatt taatatccta aagcgatgaa ttgtcttggc
     7561 attatgctat cttatgaaac actttcttac tctcacattg tgtctttata gttttcaata
     7621 tcagcaaaac ctttaaatag tcttagttgg gtgttgtgta tcattgtaca gcaactgtta
     7681 gtacatgtgg tatttctgat ccatgtaata aagtacattt gtcatgta
//
