LOCUS       NM_001031803            3553 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens LLGL scribble cell polarity complex component 2
            (LLGL2), transcript variant 3, mRNA.
ACCESSION   NM_001031803 XM_001134249 XM_001134251 XM_001134253
VERSION     NM_001031803.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3553)
  AUTHORS   Hong,G.L., Kim,K.H., Kim,Y.J., Lee,H.J., Cho,S.P., Han,S.Y.,
            Yang,S.W., Lee,J.S., Kang,S.K., Lim,J.S. and Jung,J.Y.
  TITLE     Novel role of LLGL2 silencing in autophagy: reversing
            epithelial-mesenchymal transition in prostate cancer
  JOURNAL   Biol Res 57 (1), 25 (2024)
   PUBMED   38720397
  REMARK    GeneRIF: Novel role of LLGL2 silencing in autophagy: reversing
            epithelial-mesenchymal transition in prostate cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3553)
  AUTHORS   Hisada,T., Kondo,N., Wanifuchi-Endo,Y., Osaga,S., Fujita,T.,
            Asano,T., Uemoto,Y., Nishikawa,S., Katagiri,Y., Terada,M., Kato,A.,
            Sugiura,H., Okuda,K., Kato,H., Komura,M., Morita,S., Takahashi,S.
            and Toyama,T.
  TITLE     Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in
            ERalpha-positive breast cancer
  JOURNAL   Sci Rep 12 (1), 16515 (2022)
   PUBMED   36192404
  REMARK    GeneRIF: Co-expression effect of LLGL2 and SLC7A5 to predict
            prognosis in ERalpha-positive breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3553)
  AUTHORS   Liu,J., Wang,H., Fang,M., Chen,X. and Zeng,X.
  TITLE     A human cell polarity protein Lgl2 regulates influenza A virus
            nucleoprotein exportation from nucleus in MDCK cells
  JOURNAL   J Biosci 45 (2020)
   PUBMED   32385218
  REMARK    GeneRIF: A human cell polarity protein Lgl2 regulates influenza A
            virus nucleoprotein exportation from nucleus in MDCK cells.
REFERENCE   4  (bases 1 to 3553)
  AUTHORS   Ufimtsev,I.S., Almagor,L., Weis,W.I. and Levitt,M.
  TITLE     Solving the structure of Lgl2, a difficult blind test of
            unsupervised structure determination
  JOURNAL   Proc Natl Acad Sci U S A 116 (22), 10819-10823 (2019)
   PUBMED   31088964
  REMARK    GeneRIF: Study and determination of the crystal structure of lethal
            giant larvae homolog 2 (Lgl2).
REFERENCE   5  (bases 1 to 3553)
  AUTHORS   Almagor,L., Ufimtsev,I.S., Ayer,A., Li,J. and Weis,W.I.
  TITLE     Structural insights into the aPKC regulatory switch mechanism of
            the human cell polarity protein lethal giant larvae 2
  JOURNAL   Proc Natl Acad Sci U S A 116 (22), 10804-10812 (2019)
   PUBMED   31088962
  REMARK    GeneRIF: The crystal structures of human lethal giant larvae
            homolog 2 (Lgl2) in both its unphosphorylated and atypical protein
            kinase C(aPKC) phosphorylated states are presented and investigated
            in this article.
REFERENCE   6  (bases 1 to 3553)
  AUTHORS   Yamada,Y., Fuku,N., Tanaka,M., Aoyagi,Y., Sawabe,M., Metoki,N.,
            Yoshida,H., Satoh,K., Kato,K., Watanabe,S., Nozawa,Y., Hasegawa,A.
            and Kojima,T.
  TITLE     Identification of CELSR1 as a susceptibility gene for ischemic
            stroke in Japanese individuals by a genome-wide association study
  JOURNAL   Atherosclerosis 207 (1), 144-149 (2009)
   PUBMED   19403135
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3553)
  AUTHORS   Zimmermann,T., Kashyap,A., Hartmann,U., Otto,G., Galle,P.R.,
            Strand,S. and Strand,D.
  TITLE     Cloning and characterization of the promoter of Hugl-2, the human
            homologue of Drosophila lethal giant larvae (lgl) polarity gene
  JOURNAL   Biochem Biophys Res Commun 366 (4), 1067-1073 (2008)
   PUBMED   18155665
  REMARK    GeneRIF: The identification and functional characterization of the
            promoter region ( approximately 1.2kb) of the Hugl-2 gene are
            reported.
REFERENCE   8  (bases 1 to 3553)
  AUTHORS   Spaderna,S., Schmalhofer,O., Wahlbuhl,M., Dimmler,A., Bauer,K.,
            Sultan,A., Hlubek,F., Jung,A., Strand,D., Eger,A., Kirchner,T.,
            Behrens,J. and Brabletz,T.
  TITLE     The transcriptional repressor ZEB1 promotes metastasis and loss of
            cell polarity in cancer
  JOURNAL   Cancer Res 68 (2), 537-544 (2008)
   PUBMED   18199550
  REMARK    GeneRIF: Retention of Lgl2 expression is critical for the
            epithelial phenotype;its loss might be involved in metastasis.
REFERENCE   9  (bases 1 to 3553)
  AUTHORS   Yasumi,M., Sakisaka,T., Hoshino,T., Kimura,T., Sakamoto,Y.,
            Yamanaka,T., Ohno,S. and Takai,Y.
  TITLE     Direct binding of Lgl2 to LGN during mitosis and its requirement
            for normal cell division
  JOURNAL   J Biol Chem 280 (8), 6761-6765 (2005)
   PUBMED   15632202
  REMARK    GeneRIF: binding between Lgl2 and LGN play a role in mitotic
            spindle organization through regulating formation of the LGN.NuMA
            complex; Lgl2 forms a Lgl2.Par-6.aPKC.LGN complex, which responds
            to mitotic signaling to establish normal cell division
REFERENCE   10 (bases 1 to 3553)
  AUTHORS   Yamanaka,T., Horikoshi,Y., Sugiyama,Y., Ishiyama,C., Suzuki,A.,
            Hirose,T., Iwamatsu,A., Shinohara,A. and Ohno,S.
  TITLE     Mammalian Lgl forms a protein complex with PAR-6 and aPKC
            independently of PAR-3 to regulate epithelial cell polarity
  JOURNAL   Curr Biol 13 (9), 734-743 (2003)
   PUBMED   12725730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100787.17, X87342.1,
            BC064994.1 and BC031842.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001031803.1.
            
            Summary: The lethal (2) giant larvae protein of Drosophila plays a
            role in asymmetric cell division, epithelial cell polarity, and
            cell migration. This human gene encodes a protein similar to lethal
            (2) giant larvae of Drosophila. In fly, the protein's ability to
            localize cell fate determinants is regulated by the atypical
            protein kinase C (aPKC). In human, this protein interacts with
            aPKC-containing complexes and is cortically localized in mitotic
            cells. Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064994.1, SRR7346977.1398993.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392550.8/ ENSP00000376333.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC100787.17        177056-177184
            130-234             AC100787.17        194756-194860
            235-332             AC100787.17        207405-207502
            333-414             AC100787.17        209514-209595
            415-530             AC100787.17        209871-209986
            531-689             AC100787.17        210611-210769
            690-852             AC100787.17        214375-214537
            853-985             AC100787.17        214690-214822
            986-1040            AC100787.17        215111-215165
            1041-1195           AC100787.17        215712-215866
            1196-3112           X87342.1           1167-3083
            3113-3182           BC064994.1         3081-3150
            3183-3552           X87342.1           3111-3480
            3553-3553           BC031842.1         1147-1147
FEATURES             Location/Qualifiers
     source          1..3553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3553
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /note="LLGL scribble cell polarity complex component 2"
                     /db_xref="GeneID:3993"
                     /db_xref="HGNC:HGNC:6629"
                     /db_xref="MIM:618483"
     exon            1..129
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..234
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..3222
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /note="isoform c is encoded by transcript variant 3; human
                     giant larvae homolog; lethal(2) giant larvae protein
                     homolog 2; LLGL2, scribble cell polarity complex
                     component; lethal giant larvae homolog 2, scribble cell
                     polarity complex component"
                     /codon_start=1
                     /product="LLGL scribble cell polarity complex component 2
                     isoform c"
                     /protein_id="NP_001026973.1"
                     /db_xref="CCDS:CCDS32733.1"
                     /db_xref="GeneID:3993"
                     /db_xref="HGNC:HGNC:6629"
                     /db_xref="MIM:618483"
                     /translation="MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSL
                     RILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSL
                     KVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPA
                     FRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDL
                     QGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYG
                     PFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIG
                     FTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHH
                     VSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFW
                     DASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQ
                     KIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAA
                     RSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFV
                     KCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAK
                     AERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGG
                     TIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHD
                     LSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRA
                     EDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLIS
                     PSEFERFSLSTKWLVEPRCLVDSAETKNHRPGNGAGPKKAPSRARNSGTQSDGEEKQP
                     GLVMERALLSDERVLKEIQSTLEGDRGSGNWRSHRAAVGCSLSNGGAE"
     exon            235..332
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..414
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..530
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..689
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..852
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..985
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1040
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1195
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1413
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1481
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1635
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1740
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2033
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2184
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2335
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2452
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2619
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2884
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3035
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3064
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3112
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3155
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3214
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3553
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /note="hexamer: AATAAA"
     polyA_site      3553
                     /gene="LLGL2"
                     /gene_synonym="HGL; Hugl-2; LGL2"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggagg tgagcaggaa ggagacggcc gcccagcagc ccgtgggcag gcgcggcgga
       61 gcgagcgggg ccggcggcgg gcgccgaggg acgccgaggc ctcgggcggg ggctggcccg
      121 gggttccagg tctccagtgg gggctgcaga ctaagcaaaa tgaggcggtt cctgaggcca
      181 gggcatgacc ctgtgcggga gaggctcaag cgggacctgt tccagtttaa caagacggtg
      241 gagcatggct tcccgcacca gcccagcgcc ctcggctaca gcccgtccct gcgcatcctg
      301 gccatcggca cccgttctgg agccatcaag ctctacggag ccccaggcgt ggagttcatg
      361 gggctgcacc aggagaacaa cgctgtgacg cagatccacc tcctgcccgg ccagtgccag
      421 ctggtcaccc tgctggatga caacagcctg cacctttgga gcctgaaggt caagggcggg
      481 gcatcggagc tgcaggagga tgagagcttc acactgcgtg gacccccagg ggctgccccc
      541 agtgccacac agatcaccgt ggtcctgcca cattcctcct gcgagctgct ctacctgggc
      601 accgagagtg gcaacgtgtt tgtggtgcag ctgccagctt ttcgtgcgct ggaggaccgg
      661 accatcagct cggacgcggt gctgcagcgg ttgccagagg aggcccgcca ccggcgtgtg
      721 ttcgagatgg tggaggcact gcaggagcac cctcgagacc ccaaccagat cctgatcggc
      781 tacagccgag gcctcgttgt catctgggac ctacagggca gccgcgtgct ctaccacttc
      841 ctcagcagcc agcaactgga gaacatctgg tggcagcggg acggccgcct gctcgtcagc
      901 tgtcactctg acggcagcta ctgccagtgg cccgtgtcca gcgaagccca gcaaccagag
      961 cccctccgca gcctcgtgcc ttacggtccc tttccttgca aagcgattac cagaatcctc
     1021 tggctgacca ctaggcaggg gttgcccttc accatcttcc agggtggcat gccacgggcc
     1081 agctacgggg accgccactg catctcagtg atccacgatg gccagcagac ggccttcgac
     1141 ttcacctccc gtgtcatcgg cttcactgtc ctcacagagg cagaccctgc agccaccttt
     1201 gacgacccct atgccctggt ggtgctggct gaggaggagc tggtggtgat tgacctgcag
     1261 acagcaggct ggccaccggt ccagctgccc tacctggctt ctctgcactg ttccgccatc
     1321 acctgctctc accacgtctc caacatcccg ctgaagctgt gggagcggat cattgccgcc
     1381 ggcagccggc agaacgcaca cttctccacc atggagtggc caattgatgg tggcaccagc
     1441 ctgaccccag ccccacccca gagggacctg ctgctcacag ggcacgagga cggcacggtg
     1501 cggttctggg atgcctcggg tgtctgcctg cggctgctct acaaactcag cactgtgcgc
     1561 gtgttcctca ccgacacgga ccccaacgag aacttcagtg cccagggcga ggacgagtgg
     1621 cccccactcc gcaaggtggg ctcctttgac ccctacagtg atgacccccg gctgggcatc
     1681 cagaagatct tcctctgcaa gtacagcggc tacctggctg tggcaggcac ggcagggcag
     1741 gtgctggtac tggaactgaa tgacgaggca gcggagcagg ctgtggagca ggtggaggcc
     1801 gacctgctgc aggaccaaga gggctaccgc tggaaggggc acgagcgcct ggcagcccgc
     1861 tcagggcccg tgcgctttga gcctggcttt cagcccttcg tgttggtgca gtgtcagccc
     1921 ccggctgtgg tcacctcctt ggccctgcac tctgagtggc ggctcgtggc cttcggcacc
     1981 agccatggct ttggcctctt tgaccaccag cagcggcggc aggtctttgt taagtgcaca
     2041 ctgcacccca gtgaccagct ggccttggag ggcccactct cccgcgtcaa gtccctcaag
     2101 aagtccttgc gtcagtcatt ccgccggatg cgtcggagcc gggtgtccag ccggaagcgg
     2161 cacccggctg gccccccagg agaggcacag gaggggagtg ccaaggctga gcggccaggc
     2221 ctccagaaca tggagctggc gcctgtgcag cgcaagatcg aggctcgctc ggcagaggac
     2281 tccttcacag gcttcgtccg gaccctgtac tttgctgaca cctacctgaa ggacagctcc
     2341 cggcactgcc cctcgctgtg ggctggcacc aatgggggca ccatctatgc cttctccctg
     2401 cgtgtgcctc ccgccgagcg gagaatggat gagcctgtgc gggcagagca ggccaaggag
     2461 atccagctga tgcaccgggc gccggtggtg ggcatcctgg tgctcgacgg acacagcgta
     2521 ccccttcccg agcccctcga agtggcccat gatctgtcga agagccctga catgcaggga
     2581 agccaccagc tgctcgtcgt atcagaggag cagttcaagg tgttcacgct gcccaaggtg
     2641 agtgccaagc tgaagttgaa gctgacggcc ctggagggct caagagtgcg gcgggtcagc
     2701 gtggcccact tcggcagtcg tcgagccgag gactacgggg agcaccacct ggcagtcctt
     2761 accaacctgg gcgacatcca ggtggtctcg ctgcccctgc tcaagcccca ggtgcgctac
     2821 agctgcatcc gccgggagga cgtcagtggc atcgcctcct gcgtcttcac caaatatggc
     2881 caaggcttct acctgatctc accctcggag tttgagcgct tctctctctc caccaagtgg
     2941 ctggtggagc cccggtgtct ggtggattca gcagaaacca agaaccaccg ccctggtaac
     3001 ggtgcgggcc ccaagaaggc cccgagccga gccaggaact cagggactca gagtgatggc
     3061 gaggagaagc agcccggcct ggtgatggag cgcgctctgc tcagtgatga gagagtcctg
     3121 aaggaaatcc agagcacact ggagggagac cgcgggagcg gcaactggcg ttcacatcga
     3181 gccgccgtgg ggtgcagcct cagcaatggc ggagcagagt gagtggctga gcgtccaggc
     3241 tgcgcgatga gcacacacta ctactgatgg cctttcgggg gtccctgccc caaccggaga
     3301 ggccggtgca cagggccccg ccaggggctg ggggcatccc ggcttccaca atgcagctgc
     3361 tctgggcctc gggagaggag agaccccagt cccctgggct gcccttcccg ggcctcgtct
     3421 gtctgggtcc tttggtcaat gttgcacagt ttttattgct cccatccctt tttgtagtgg
     3481 gctgggtttt aagttataaa tgttaactgc ctctgggtga aaaagttttt aataaacacc
     3541 tattacctct tga
//
