LOCUS       NM_004140               4212 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LLGL scribble cell polarity complex component 1
            (LLGL1), mRNA.
ACCESSION   NM_004140
VERSION     NM_004140.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4212)
  AUTHORS   Tocan,V., Hayase,J., Kamakura,S., Kohda,A., Ohga,S., Kohjima,M. and
            Sumimoto,H.
  TITLE     Hepatocyte polarity establishment and apical lumen formation are
            organized by Par3, Cdc42, and aPKC in conjunction with Lgl
  JOURNAL   J Biol Chem 297 (6), 101354 (2021)
   PUBMED   34717957
  REMARK    GeneRIF: Hepatocyte polarity establishment and apical lumen
            formation are organized by Par3, Cdc42, and aPKC in conjunction
            with Lgl.
REFERENCE   2  (bases 1 to 4212)
  AUTHORS   Abedrabbo,M. and Ravid,S.
  TITLE     Scribble, Lgl1, and myosin II form a complex in vivo to promote
            directed cell migration
  JOURNAL   Mol Biol Cell 31 (20), 2234-2248 (2020)
   PUBMED   32697665
  REMARK    GeneRIF: Scribble, Lgl1, and myosin II form a complex in vivo to
            promote directed cell migration.
REFERENCE   3  (bases 1 to 4212)
  AUTHORS   Liu,R., Zhang,L., Xu,Z. and Cui,Y.
  TITLE     [MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer
            by Targeting LLGL1]
  JOURNAL   Zhongguo Fei Ai Za Zhi 23 (4), 223-232 (2020)
   PUBMED   32222154
  REMARK    GeneRIF: [MiR-665 Promotes the Biological Behavior of Small Cell
            Lung Cancer by Targeting LLGL1].
REFERENCE   4  (bases 1 to 4212)
  AUTHORS   Zhu,Y.X., Li,C.H., Li,G., Feng,H., Xia,T., Wong,C.H., Fung,F.K.C.,
            Tong,J.H., To,K.F., Chen,R. and Chen,Y.
  TITLE     LLGL1 Regulates Gemcitabine Resistance by Modulating the
            ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma
  JOURNAL   Cell Mol Gastroenterol Hepatol 10 (4), 811-828 (2020)
   PUBMED   32615164
  REMARK    GeneRIF: LLGL1 Regulates Gemcitabine Resistance by Modulating the
            ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma.
REFERENCE   5  (bases 1 to 4212)
  AUTHORS   Desuki,A., Staib,F., Gockel,I., Moehler,M., Lang,H.,
            Biesterfeld,S., Maderer,A., Galle,P.R., Berger,M.R. and
            Schimanski,C.C.
  TITLE     Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and
            Distant Peritoneal Metastases
  JOURNAL   Can J Gastroenterol Hepatol 2019, 2920493 (2019)
   PUBMED   31058107
  REMARK    GeneRIF: LLGL1 is coexpressed with E-cadherin; loss of expression
            of either protein is associated with diffuse gastric cancer and
            peritoneal metastases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4212)
  AUTHORS   Bi,W., Yan,J., Stankiewicz,P., Park,S.S., Walz,K., Boerkoel,C.F.,
            Potocki,L., Shaffer,L.G., Devriendt,K., Nowaczyk,M.J., Inoue,K. and
            Lupski,J.R.
  TITLE     Genes in a refined Smith-Magenis syndrome critical deletion
            interval on chromosome 17p11.2 and the syntenic region of the mouse
  JOURNAL   Genome Res 12 (5), 713-728 (2002)
   PUBMED   11997338
REFERENCE   7  (bases 1 to 4212)
  AUTHORS   Ludford-Menting,M.J., Thomas,S.J., Crimeen,B., Harris,L.J.,
            Loveland,B.E., Bills,M., Ellis,S. and Russell,S.M.
  TITLE     A functional interaction between CD46 and DLG4: a role for DLG4 in
            epithelial polarization
  JOURNAL   J Biol Chem 277 (6), 4477-4484 (2002)
   PUBMED   11714708
REFERENCE   8  (bases 1 to 4212)
  AUTHORS   Campbell,H.D., Fountain,S., Young,I.G., Claudianos,C.,
            Hoheisel,J.D., Chen,K.S. and Lupski,J.R.
  TITLE     Genomic structure, evolution, and expression of human FLII, a
            gelsolin and leucine-rich-repeat family member: overlap with LLGL
  JOURNAL   Genomics 42 (1), 46-54 (1997)
   PUBMED   9177775
REFERENCE   9  (bases 1 to 4212)
  AUTHORS   Koyama,K., Fukushima,Y., Inazawa,J., Tomotsune,D., Takahashi,N. and
            Nakamura,Y.
  TITLE     The human homologue of the murine Llglh gene (LLGL) maps within the
            Smith-Magenis syndrome region in 17p11.2
  JOURNAL   Cytogenet Cell Genet 72 (1), 78-82 (1996)
   PUBMED   8565641
REFERENCE   10 (bases 1 to 4212)
  AUTHORS   Strand,D., Unger,S., Corvi,R., Hartenstein,K., Schenkel,H.,
            Kalmes,A., Merdes,G., Neumann,B., Krieg-Schneider,F., Coy,J.F. et
            al.
  TITLE     A human homologue of the Drosophila tumour suppressor gene l(2)gl
            maps to 17p11.2-12 and codes for a cytoskeletal protein that
            associates with nonmuscle myosin II heavy chain
  JOURNAL   Oncogene 11 (2), 291-301 (1995)
   PUBMED   7542763
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109515.6 and AC127537.8.
            
            On Nov 23, 2018 this sequence version replaced NM_004140.3.
            
            Summary: This gene encodes a protein that is similar to a tumor
            suppressor in Drosophila. The protein is part of a cytoskeletal
            network and is associated with nonmuscle myosin II heavy chain and
            a kinase that specifically phosphorylates this protein at serine
            residues. The gene is located within the Smith-Magenis syndrome
            region on chromosome 17. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151838.1, SRR1660803.213199.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316843.9/ ENSP00000321537.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC109515.6         13864-13992         c
            130-227             AC109515.6         9589-9686           c
            228-309             AC109515.6         7051-7132           c
            310-440             AC109515.6         6825-6955           c
            441-599             AC109515.6         5691-5849           c
            600-762             AC109515.6         5452-5614           c
            763-898             AC109515.6         5219-5354           c
            899-953             AC109515.6         4924-4978           c
            954-1108            AC109515.6         4634-4788           c
            1109-1332           AC109515.6         4315-4538           c
            1333-1400           AC109515.6         4090-4157           c
            1401-1554           AC109515.6         2867-3020           c
            1555-1659           AC109515.6         2688-2792           c
            1660-1952           AC109515.6         1854-2146           c
            1953-2100           AC109515.6         1413-1560           c
            2101-2254           AC109515.6         1018-1171           c
            2255-2550           AC127537.8         14817-15112
            2551-2815           AC127537.8         15690-15954
            2816-2930           AC127537.8         16124-16238
            2931-3043           AC127537.8         16405-16517
            3044-3164           AC127537.8         16747-16867
            3165-3244           AC127537.8         16982-17061
            3245-4212           AC127537.8         18147-19114
FEATURES             Location/Qualifiers
     source          1..4212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..4212
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /note="LLGL scribble cell polarity complex component 1"
                     /db_xref="GeneID:3996"
                     /db_xref="HGNC:HGNC:6628"
                     /db_xref="MIM:600966"
     exon            1..129
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3243
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /note="human homolog to the D-lgl gene protein; lethal
                     giant larvae homolog 1, scribble cell polarity complex
                     component; LLGL1, scribble cell polarity complex
                     component"
                     /codon_start=1
                     /product="lethal(2) giant larvae protein homolog 1"
                     /protein_id="NP_004131.4"
                     /db_xref="CCDS:CCDS32586.1"
                     /db_xref="GeneID:3996"
                     /db_xref="HGNC:HGNC:6628"
                     /db_xref="MIM:600966"
                     /translation="MMKFRFRRQGADPQREKLKQELFAFNKTVEHGFPNQPSALAFDP
                     ELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAATVTQMHFLTGQGRLLSLLDDSSLHLW
                     EIVHHNGCAHLEEALSFQLPSRPGFDGASAPLSLTRVTVVLLVAASDIAALGTEGSSV
                     FFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKALGPVESLQGHLRDPTKILIGYSRG
                     LLVIWNQASQCVDHIFLGNQQLESLCWGRDSSTVVSSHSDGSYAVWSVDAGSFPTLQP
                     TVATTPYGPFPCKAINKILWRNCESGGHFIIFSGGMPRASYGDRHCVSVLRAETLVTL
                     DFTSRIIDFFTVHSTRPEDEFDDPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHS
                     SAITCSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGGRNLAQEPSQRGLLLT
                     GHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAAEDDWPPFRKVGCFDP
                     YSDDPRLGVQKVALCKYTAQMVVAGTAGQVLVLELSDVPVEQAVSVAIIDLLQDREGF
                     TWKGHERLSPRTGPLPWPAGFQPRVLVQCLPPAAVTAVTLHTEWSLVAFGTSHGFGLF
                     DYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRAANAS
                     SKLQEANAQLAEQACPHDVEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDGAHHG
                     PTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDG
                     RGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCR
                     VRKVALATFASVACEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDISGIAS
                     CVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQASYRIRESPKLSQ
                     ANGTPSILLAPQSLDGSPDPAHSMGPDTPEPPEAALSPMSIDSATSADTTLDTTGDVT
                     VEDVKDFLGSSEESEKNLRNLAEDEAHACAILIK"
     exon            130..227
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..309
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..440
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..599
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            600..762
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..898
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..953
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1108
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1332
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1400
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1554
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1659
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1952
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2100
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2254
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2550
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2815
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2930
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3043
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3164
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3244
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..4212
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4187..4192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /note="hexamer: AATAAA"
     polyA_site      4212
                     /gene="LLGL1"
                     /gene_synonym="DLG4; HUGL; HUGL-1; HUGL1; Lgl1; LLGL;
                     Mgl1"
                     /note="major polyA site"
ORIGIN      
        1 atcctgcggg cggcggcggc gggcgaggcg cctgcagccg ggcgcaagat gatgaagttt
       61 cggttccggc ggcagggcgc cgacccgcag cgcgagaagc tcaagcagga gcttttcgcc
      121 ttcaacaaga ctgtggagca tggcttcccc aatcagccca gcgccctggc cttcgacccg
      181 gaacttcgca tcatggccat cggcaccagg tctggggctg tcaagatcta tggtgcacct
      241 ggcgtggagt tcacaggcct gcaccgggat gcagccactg tcacacagat gcacttcttg
      301 accggccagg gccgcctcct gtccctgctt gatgacagca gtctgcatct ctgggagatt
      361 gtccaccata atggctgtgc ccacctggaa gaagcactca gtttccagct gcccagccgg
      421 cccggctttg atggtgccag tgctccgctc agccttaccc gagtcacagt ggtcctgctg
      481 gtggctgcca gcgacatagc agccctgggc actgagggca gcagtgtctt cttcctggat
      541 gttaccaccc tgaccctgct cgaggggcag acgcttgccc caggcgaggt tctgcgcagc
      601 gtgccagacg actaccgctg tgggaaggca ctgggccccg tggagtcact ccagggacac
      661 ctgcgggacc ccacaaagat tctcattggc tacagccggg gcctgctggt catctggaac
      721 caggcctcgc agtgtgtgga ccacatcttc ctggggaacc agcagctgga gagcctatgc
      781 tgggggcgtg atagcagcac tgtggtcagc tcacacagcg atggcagcta tgctgtctgg
      841 tctgtggatg ccggcagctt cccaacgctg cagcccacgg tagccaccac accttacggc
      901 ccctttccct gcaaggccat taacaagatt ctgtggcgga actgtgaatc tgggggccac
      961 tttatcatct tcagcggtgg catgccccgt gccagctatg gtgaccgcca ctgtgtaagt
     1021 gtgcttcgag ccgagacatt ggtgacgctg gacttcactt cccgcatcat cgacttcttc
     1081 acagtgcaca gcacacggcc cgaggatgaa tttgatgacc cccaggccct ggctgtgctg
     1141 ctggaagagg agctggtggt gctggacctg cagactcctg gctggccagc tgtgcctgcc
     1201 ccatacctgg ccccgctgca ctcctctgca atcacttgct cggcccacgt ggccagtgtc
     1261 cccgccaagc tgtgggcccg cattgtgagc gctggcgagc agcagagccc ccagcctgtc
     1321 tccagtgcct tgagctggcc catcactggg ggccgaaacc tggcccagga gccgtcacag
     1381 cgagggctgc tgctgacggg ccatgaggac ggcaccgtga ggttctggga tgcctcgggt
     1441 gtggcgctgc ggccgctcta taagctgagc acagctggcc tcttccagac agactgtgag
     1501 cacgctgaca gcctggccca ggctgccgag gacgactggc cacccttccg caaggtgggc
     1561 tgcttcgatc cctacagtga cgatccccgg cttggcgtgc agaaggttgc tctctgcaag
     1621 tatacagccc agatggtggt ggctggcact gcaggccagg tgctggtact ggagcttagt
     1681 gatgtgccgg tggagcaggc ggtcagcgtg gccatcatag acctcctcca ggaccgcgag
     1741 ggcttcacat ggaagggcca cgagcggctg agcccacgca cggggccgct gccctggcct
     1801 gctggcttcc agccccgtgt cctggtgcag tgcctgccgc cagctgctgt aaccgctgtc
     1861 acactccaca ccgagtggag cctcgtggct tttggcacca gtcatggctt tggcctcttc
     1921 gactaccagc gcaagagccc tgtgctggcc aggtgcactc ttcaccccaa tgactccctg
     1981 gccatggagg gtccgctctc ccgggtgaag tctctcaaga agtcactgcg ccagtctttc
     2041 cggcgcattc gcaagagtcg tgtctctggc aagaagcggg ctgctaatgc cagcagcaag
     2101 ttgcaggaag ccaatgcaca gctggctgag caggcctgcc cccacgacgt ggagatgacg
     2161 cccgtgcagc gccgcattga gccccgctct gccgatgact ccttgtcggg tgtcgtgcgt
     2221 tgcctatact ttgccgacac attccttcga gatggggccc accacgggcc caccatgtgg
     2281 gctggcacca actcaggctc tgtgttcgcc tatgcactgg aggtgccggc agcagcagtg
     2341 ggtggtgaga agcggcctga gcaagcggtg gaggccgtgc tgggcaagga ggtgcagctg
     2401 atgcaccggg cgcctgtggt ggccattgcc gtgttggacg ggcgtggccg cccactgccc
     2461 gagccctacg aggcctcacg ggacctggcg caggcacctg acatgcaggg tggtcacgct
     2521 gtgctcatcg catctgagga gcagttcaag gtgttcacac tgcccaaggt gagcgcgaag
     2581 accaagttca agctgacggc ccatgagggc tgtcgtgtgc gcaaggtggc actggccacg
     2641 tttgccagtg tggcctgcga ggactatgct gagacctgcc tggcctgcct caccaacctg
     2701 ggtgacgtcc acgtcttctc ggtgcctggc ctgcggcccc aggtgcacta ttcctgcatc
     2761 cggaaggagg acatcagcgg catcgcttcg tgcgtcttta cgcgccatgg ccagggcttt
     2821 tacctgatat ccccatcaga atttgaacgc ttctccctaa gtgcccggaa catcacagag
     2881 ccgctctgct ctctggacat taactggccc cgcgatgcca cccaggccag ttacaggatc
     2941 cgagagtcac ccaagctgag ccaggctaac gggaccccaa gcatcctgct ggccccacag
     3001 agccttgatg gaagccctga tccagcccac agcatgggac ctgacacccc ggagccaccc
     3061 gaggctgcac tctcacccat gtccatcgac tcagccacca gtgctgacac cacgctggac
     3121 acgacagggg acgtcacagt ggaagatgtg aaggatttcc tgggctcctc tgaggagtca
     3181 gagaagaacc tgaggaacct ggcagaagac gaggcccacg cctgtgccat cctgatcaaa
     3241 tgaggaaggc cagaactatc ccgacctcca cctgccctgc tcggagctgg agtgctggat
     3301 ccctggcacc tgcctggccc cttaacatag aaccacgcct gctaacctgt aggctccact
     3361 gggacctgct gtcctgtccc gcctgaccct gggccctgga gcagcaccag ccccagggtg
     3421 tgggcctggg acctgggcca gaactgagcc ctcctgcagg catttggctg ccctgggggc
     3481 ccactgccta gggaagagga caggtggggc ccagcacctg tgccacctcc ccccctccac
     3541 acaccatcct tccccctcac tttgcagagt atttttcctt tttttttttt ttcttaaaga
     3601 cggagtcttg ctctgtcgcc caggctggag tgcagtggcc ccatctctgc tcactgcaag
     3661 ccccgccttc tgggttcccg ccattcttct gcctcagcct cccaagtagc tgggactaca
     3721 ggcgcccacc accacgccca gctaattttt tctgtatttt tagtagagat ggggtttcac
     3781 catgttagcc aggatggtct cgatctcctg acctcgtgat ccacccacct cagcctccca
     3841 aagtgctggg attacaggcg tgagccacca tgcccagccc tgcaaagagt atttttctag
     3901 cgcctgggct ggacagttgt ttctaaaact aaactatttt ggtacctgct tctgggccag
     3961 tccccagcct gtcatgagtg tgtgtgtgcg ggcatggatg tgactgggag ctctgctggg
     4021 cacccacatc tggggcctag tcaggtgtgt gtgtccggcg gggggggggg gcaggggggg
     4081 gggtcaagat gagtttccct gtagattgta ccttggggtt tttttctgtc gttttgttaa
     4141 aattagcgcc attttaatat taaaaatact gatttttaat attgaaaata aaagcattta
     4201 atatctctta aa
//
