LOCUS       NM_001382496             788 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens LLLL and CFNLAS motif containing 1 (LLCFC1),
            transcript variant 3, mRNA.
ACCESSION   NM_001382496
VERSION     NM_001382496.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 788)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   2  (bases 1 to 788)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245136.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014596.1, AB083484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000409607.5/
                                                ENSP00000386450.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC245136.2         148750-149020       c
            272-788             AC245136.2         147636-148152       c
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..788
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /note="LLLL and CFNLAS motif containing 1"
                     /db_xref="GeneID:135927"
                     /db_xref="HGNC:HGNC:21750"
                     /db_xref="MIM:618946"
     exon            1..271
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..507
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /note="MSSP-binding protein CTM-1; uncharacterized protein
                     C7orf34; LLLL and CFNLAS motif-containing protein 1;
                     sperm-oocyte fusion required protein 1; sperm-egg fusion
                     protein LLCFC1"
                     /codon_start=1
                     /product="sperm-egg fusion protein LLCFC1 precursor"
                     /protein_id="NP_001369425.1"
                     /db_xref="CCDS:CCDS5876.3"
                     /db_xref="GeneID:135927"
                     /db_xref="HGNC:HGNC:21750"
                     /db_xref="MIM:618946"
                     /translation="MPPLAPQLCRAVFLVPILLLLQVKPLNGSPGPKDGSQTEKTPSA
                     DQNQEQFEEHFVASSVGEMWQVVDMAQQEEDQSSKTAAVHKHSFHLSFCFSLASVMVF
                     SGGPLRRTFPNIQLCFMLTH"
     exon            272..788
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      759..764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /note="hexamer: AATAAA"
     regulatory      770..775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /note="hexamer: GATAAA"
     polyA_site      785
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /note="major polyA site"
     polyA_site      788
                     /gene="LLCFC1"
                     /gene_synonym="C7orf34; ctm-1; SOF1"
                     /note="major polyA site"
ORIGIN      
        1 agaggtccta tggaaggtga ggggagaaaa tgcccctgga aagggttaag ggccaggaca
       61 ggaatggggc aggaggtgca cggatcctgc tgggcactgg gagcaggggg cggccaaagg
      121 cagtgggtgg gcaggtccat gcctcccctg gccccccagc tctgcagggc agtgttcctg
      181 gttcctatct tgctgctgct gcaggtgaag cctctgaacg ggagcccagg ccccaaagat
      241 gggagccaga cagagaaaac gccctctgca gaccagaatc aagaacagtt cgaagagcac
      301 tttgtggcct cctcagtggg tgagatgtgg caggtggtgg acatggccca gcaggaagaa
      361 gaccagtcgt ccaagacggc agctgttcac aagcactctt tccacctcag cttctgcttt
      421 agtctggcca gtgtcatggt tttctcagga gggccattga ggcggacatt cccaaatatc
      481 caactctgct tcatgctcac tcactgaccc tccctccctc ctgggctcca ggtcacaact
      541 cccaaaggag atgcaggcat ggctctctgc ctctgatcac catcactgta tctcaaggtt
      601 cagcagcaga gataccagtt gccatcagtg ctaactgact gcctctccag gttcggagtt
      661 tcatctccca gggccagaga cagcagaccc acatccttct ctcccacacc tctcctggtt
      721 ttgttcagga cagcagatta gaggcaggag gcaatgacaa taaaataacg ataaaatcct
      781 gagaacaa
//
