LOCUS       NM_001353425             823 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens LKAAEAR motif containing 1 (LKAAEAR1), transcript
            variant 2, mRNA.
ACCESSION   NM_001353425
VERSION     NM_001353425.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 823)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590548.22.
            
            On Sep 17, 2020 this sequence version replaced NM_001353425.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY217507.1, HY243695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03568911 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302096.5/ ENSP00000302763.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               AL590548.22        22263-22843         c
            582-704             AL590548.22        22028-22150         c
            705-823             AL590548.22        21821-21939         c
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..823
                     /gene="LKAAEAR1"
                     /gene_synonym="C20orf201"
                     /note="LKAAEAR motif containing 1"
                     /db_xref="GeneID:198437"
                     /db_xref="HGNC:HGNC:33718"
     exon            1..581
                     /gene="LKAAEAR1"
                     /gene_synonym="C20orf201"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..764
                     /gene="LKAAEAR1"
                     /gene_synonym="C20orf201"
                     /note="isoform 2 is encoded by transcript variant 2;
                     LKAAEAR motif-containing protein 1; protein LKAAEAR1"
                     /codon_start=1
                     /product="protein LKAAEAR1 isoform 2"
                     /protein_id="NP_001340354.1"
                     /db_xref="CCDS:CCDS86972.1"
                     /db_xref="GeneID:198437"
                     /db_xref="HGNC:HGNC:33718"
                     /translation="MPPPAKEGGRKGPRERSGKSAPGTAQGEERAKGAPATEPPKPGW
                     ALTPQGLAAMLPAQRHRHLLFGDLLEDVGAAASTFPCGSVEPGYRMPDPRPWTQSLEL
                     PAERQNRLLGVLKAAEARGRVRALRLRYTRMRAEEIALLIQRQKSARAAIRLELFLPP
                     QLKPARIPDPLDRQERRRVETILEENVDGTIFPR"
     exon            582..704
                     /gene="LKAAEAR1"
                     /gene_synonym="C20orf201"
                     /inference="alignment:Splign:2.1.0"
     exon            705..823
                     /gene="LKAAEAR1"
                     /gene_synonym="C20orf201"
                     /inference="alignment:Splign:2.1.0"
     regulatory      802..807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LKAAEAR1"
                     /gene_synonym="C20orf201"
                     /note="hexamer: CATAAA"
     polyA_site      823
                     /gene="LKAAEAR1"
                     /gene_synonym="C20orf201"
                     /note="major polyA site"
ORIGIN      
        1 ggagagggag agcgcctggg caaagctcag aggctggggg tgcggaactc aaaaccgact
       61 gcggagagcc cagcgggcgg gagctggggc gcacgttggg gccctgccga ggggcgggca
      121 gggcccggtg ccagccccgg caccgacggg acgccctcct ccctccgcag ggcgggagga
      181 tgccgccgcc agcgaaggag ggcgggcgca agggcccgcg ggagcgaagc gggaagagcg
      241 cgccaggcac ggcgcagggt gaggagcgtg ccaagggggc gcccgcgaca gagcccccca
      301 agccgggctg ggccctgacg ccgcagggac tggcggccat gctccctgcg cagcgccacc
      361 gccatctgct cttcggcgac ctgctggagg acgtgggcgc ggcggcctcc accttcccgt
      421 gcgggtcggt ggaaccgggg taccgcatgc ccgacccgcg cccgtggacg cagtcgctcg
      481 agctgcccgc cgagcgccag aaccggctcc tcggcgtcct caaggcagcg gaggcccgcg
      541 ggcgagtccg cgccctgcgg ctgcgctaca cccgcatgcg ggccgaggag atcgcgctgc
      601 tcatccagcg gcagaagtcc gcgcgcgccg ccatccggct ggagctgttc ctgccgccgc
      661 agctgaagcc cgcgcggatc ccggaccccc tggaccgcca agagcggagg cgcgtggaga
      721 ccatcctgga ggagaacgtg gatggcacca tcttcccgcg gtgacggcga ctgagagtgt
      781 gcgacgcgcc ccagcctccc acataaagtt ataattctcc gaa
//
