LOCUS       NM_153713               3991 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens limb and CNS expressed 1 like (LIX1L), mRNA.
ACCESSION   NM_153713
VERSION     NM_153713.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3991)
  AUTHORS   Nakamura,S., Kahyo,T., Tao,H., Shibata,K., Kurabe,N., Yamada,H.,
            Shinmura,K., Ohnishi,K. and Sugimura,H.
  TITLE     Novel roles for LIX1L in promoting cancer cell proliferation
            through ROS1-mediated LIX1L phosphorylation
  JOURNAL   Sci Rep 5, 13474 (2015)
   PUBMED   26310847
  REMARK    GeneRIF: LIX1L is an RNA-binding protein, with implications for
            therapeutic approaches for targeting LIX1L in LIX1L-expressing
            cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3991)
  AUTHORS   Mao,Y., Kucuk,B. and Irvine,K.D.
  TITLE     Drosophila lowfat, a novel modulator of Fat signaling
  JOURNAL   Development 136 (19), 3223-3233 (2009)
   PUBMED   19710173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK128733.1, BC035727.1 and AC243547.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153713.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR627381.1, SRR18074969.3019264.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000604000.4/ ENSP00000474487.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AK128733.1         3-197
            196-1417            BC035727.1         180-1401
            1418-2840           AK128733.1         1261-2683
            2841-3990           AK128733.1         2685-3834
            3991-3991           AC243547.1         101797-101797
FEATURES             Location/Qualifiers
     source          1..3991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..3991
                     /gene="LIX1L"
                     /note="limb and CNS expressed 1 like"
                     /db_xref="GeneID:128077"
                     /db_xref="HGNC:HGNC:28715"
     exon            1..382
                     /gene="LIX1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1104
                     /gene="LIX1L"
                     /note="Lix1 homolog-like"
                     /codon_start=1
                     /product="LIX1-like protein"
                     /protein_id="NP_714924.1"
                     /db_xref="CCDS:CCDS72873.1"
                     /db_xref="GeneID:128077"
                     /db_xref="HGNC:HGNC:28715"
                     /translation="METMRAQRLQPGVGTSGRGTLRALRPGVTGAAAATATPPAGPPP
                     APPPPAPPPPPLLLSGAPGLPLPPGAAGSPAVLREAVEAVVRSFAKHTQGYGRVNVVE
                     ALQEFWQMKQSRGADLKNGALVVYEMVPSNSPPYVCYVTLPGGSCFGSFQFCPTKAEA
                     RRSAAKIALMNSVFNEHPSRRITDEFIEKSVSEALASFNGNREEADNPNTGIGAFRFM
                     LESNKGKSMLEFQELMTVFQLLHWNGSLKAMRERQCSRQEVLAHYSHRALDDDIRHQM
                     ALDWVSREQSVPGALSRELASTERELDEARLAGKELRFHKEKKDILVLAAGQLGNMHS
                     SNC"
     exon            383..546
                     /gene="LIX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            547..687
                     /gene="LIX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            688..783
                     /gene="LIX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            784..861
                     /gene="LIX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            862..3991
                     /gene="LIX1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3966..3971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIX1L"
                     /note="hexamer: ATTAAA"
     polyA_site      3991
                     /gene="LIX1L"
                     /note="major polyA site"
ORIGIN      
        1 gagtccccag gcgctagctg actggggtgg ttgggaccgt tagctcggca ggctggcagg
       61 ctccggggcg ctactccatt ggcggccggg atggagacta tgcgagcgca gcggctgcag
      121 cctggtgtgg gcaccagcgg gaggggcact ctccgagcgc tgcggcccgg agtgactggg
      181 gccgcggccg ccaccgccac accccctgcg ggccccccgc ctgccccgcc gcctcccgca
      241 ccgcccccgc cgccgctgct cctgtctggg gccccaggac tacccctgcc ccccggcgcc
      301 gccggcagcc cggcagtgct gcgagaggcc gtggaggccg tggtgaggag cttcgccaag
      361 cacacgcagg gctatggccg agtgaatgtg gtggaggcac ttcaggaatt ctggcagatg
      421 aagcagtccc gtggtgctga cttaaagaat ggggctctag tggtttatga gatggttccc
      481 tccaacagcc ctccttatgt ctgctatgtc accctgcctg ggggaagctg ctttgggagt
      541 ttccagtttt gccccacaaa agctgaggcc cggaggagtg ctgcaaagat tgcgctaatg
      601 aattctgtgt ttaatgaaca tccttcccga agaatcactg atgagttcat cgagaagagt
      661 gtctctgagg ccctggcatc ttttaatggc aacagggagg aagctgacaa cccaaataca
      721 gggattggtg ccttccgatt catgctggaa tccaacaagg gcaaatcaat gttggagttc
      781 caggagctaa tgacagtttt tcaactgcta cactggaatg gcagccttaa ggccatgagg
      841 gaacgacaat gctctcggca ggaggtgttg gctcattatt cgcaccgggc cctggatgat
      901 gatattcgcc accaaatggc cttggactgg gtgagccggg agcagagtgt gccgggggca
      961 ctgtctagag agctggcctc tactgagcgg gagctggatg aagcccgact ggcaggcaag
     1021 gagctgcgct tccacaagga gaagaaagat attcttgtgc tggctgctgg gcagttgggc
     1081 aatatgcatt cttccaactg ctaggcatcc acccacataa ctccccaggc tttccacagc
     1141 ctttttttat gtctcctttc taagatttag gatgattttt tgtacatact ttctcatttt
     1201 tatactttaa aaaatatata tgtgtataaa ttctacacct agattcctat ttgctaagag
     1261 atcccttttc ttactaccag tttttggatg tagttttatt tgaaacatct tcagtccact
     1321 ttacaacaaa gagcagcttg tctttgcagc tttgttagct cttaaacttc cagattaact
     1381 gtgtagccat ttcagtagca ctaaaagatt aactctagtg ttcatgtgtc cttcttttca
     1441 aatatcaggt aacttgaata aggattatgt gccccaccct tactctcatt cctgcttcct
     1501 cttggactca aacagggtat gagtatgaag attttgcctt tagttcctga actgaacctg
     1561 cttgctatcc ctttcctccc caccactacc ttattccttc tctgcctcca aattgccact
     1621 ttgttttgag gcttccttcc ctaccttatt attctgaagg aagtagagat cttgcttctg
     1681 aaacccctcc taagaaactg cccagggaca agataaatta caaacaattc atgggagttt
     1741 actacctaag ttgcttctag ggcatatgta taccatacta gtagtctaga tttctggata
     1801 tactctacag tagatggggg ttatggttga aactgattct ctttcagtat tccctctaaa
     1861 catctcccct actcccccag cttagttaaa ccctgcgttt ggaccttcct gcctgcagct
     1921 attagtagaa agtaaaacat atttccatat ttcccttcac ctaacatttt attttttgga
     1981 agcgttatca gtcctatttg gttagtgaga accatgttcc ccttattccc gctaagttgc
     2041 tgctgtttac taccttagat tctcatttgt tttctctttc tttcctctcc ttccacatta
     2101 attattagaa cataagttga tcaggaaaat taaatgagac tttagtattt tggcacttcc
     2161 taattgacac cttgggagac tgcaggaagg gaaagagaat caatgatcag ttatttgtgt
     2221 gtgtgtgtgg tttttttttt tttttggaag acagagtctc acacttttgc ccaggctgga
     2281 gtgcagtggc gtgatctcgg ctcactgcaa cctctgcctc cagggttcaa gcgattctct
     2341 tgcctcagct tcccgagtag ctgggattac aggcacacgc cacaacgcct ggctaatttt
     2401 tatattttta gtagagacag ggtttcacca tgttggccag gctgttcttg aactcctgac
     2461 ataaggtaat ccacccgcct cagcctccca aagtgctggg attacaggcg tgaggcactg
     2521 agcctggcct atttgtggtt tttttttggt tttgtttttg tttttgtttt tgagacggag
     2581 tcttgctctg tcgcccaggc tagagtgcag tggcgcgatc tcggctcact gcaacctccg
     2641 cctcccagat tcacaccatt ctcctgcctc agcctcccga gtagctggga ttacaggtgc
     2701 ccaccaccac gcccagctaa ttttttgtat ttttagtaga gacggggttt caccatgtta
     2761 gccaggacgg tctccatctc ctgacctcgt gatccacctg cctcggcctc ccaaactatt
     2821 tgtgtgtttt tttttttttt gagacggagt ctcgctctgt cgcccaggct ggagtgcagt
     2881 ggcgctatct cggctcactg caagctccgc ctcccgggtt cacgccactc tcctgcctca
     2941 gcctccttag tagctgggac tacaggcgcc cgccaccatg cctggctaat ttttttgtat
     3001 ttttagtaga gacggggttt caccgtgttt gacaggatgg tctcgatttc ctgacttcgt
     3061 gatccgcccg cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgcccgg
     3121 cactatttgt gtttttaaca ccattctccc ccacttctct cctgggtgac ataagagaga
     3181 aataacctgt agtacagcag ctaaagtatt ctcctttcag agaatttttt tggaggtctc
     3241 taatatatat ttcccccttg tctctgtgat ctcttattta tactatatta ttgtcccatg
     3301 tactttctaa actgagcttg gaacatttag tattcctgca attggacttc ccacttaaca
     3361 attatacaga ctttgctttt agaaatagat taggttccaa acagaaagtt caagtgtaac
     3421 aacaacaata aaaatagatt atgaaacagg ctataattgg ctcttttgga tttgataggg
     3481 gcaagatgaa aggcaacttt cttgcttttg aaatcatgtt gggtaagagg taaggaatcc
     3541 agctacaatt ttattagtgc ttgaaacggg cttccttgaa ttctccaggc cctatcattt
     3601 tttttttctt actaatcaga agagagctgg ggtagaagcc ccatgtttgt attccatgaa
     3661 acacgtcggg ttggagtaaa ggcaaaaaca gctagacaca ccaggtgtgt ctgtttgaca
     3721 tttataagct ggcactcatc aacactcctg tttctccttt ctctgggacg tgtggattaa
     3781 ggggtgtgag ttgtgggaag aattgccctc gtacctcctg gatttattat ttttctcaaa
     3841 taccaaccag taagatccca aataacttga gaaaaattgt ttcctgatct gtccacttct
     3901 ggtgtcaaag attttactca tcttcttagt acattctatg tattttatat gtataatttt
     3961 atacaattaa aaatagattt ttgtctagtg a
//
