LOCUS       NM_153234               3765 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens limb and CNS expressed 1 (LIX1), mRNA.
ACCESSION   NM_153234
VERSION     NM_153234.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3765)
  AUTHORS   Golabek,K., Raczka,G., Gazdzicka,J., Miskiewicz-Orczyk,K.,
            Zieba,N., Krakowczyk,L., Hudy,D., Asman,M., Misiolek,M. and
            Strzelczyk,J.K.
  TITLE     Single Nucleotide Polymorphism and mRNA Expression of LTF in Oral
            Squamous Cell Carcinoma
  JOURNAL   Genes (Basel) 13 (11), 2085 (2022)
   PUBMED   36360322
  REMARK    GeneRIF: Single Nucleotide Polymorphism and mRNA Expression of LTF
            in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3765)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3765)
  AUTHORS   Guerin,A., Martire,D., Trenquier,E., Lesluyes,T., Sagnol,S.,
            Pratlong,M., Lefebvre,E., Chibon,F., de Santa Barbara,P. and
            Faure,S.
  TITLE     LIX1 regulates YAP activity and controls gastrointestinal cancer
            cell plasticity
  JOURNAL   J Cell Mol Med 24 (16), 9244-9254 (2020)
   PUBMED   32633461
  REMARK    GeneRIF: LIX1 regulates YAP activity and controls gastrointestinal
            cancer cell plasticity.
REFERENCE   4  (bases 1 to 3765)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3765)
  AUTHORS   Sasongko,T.H., Gunadi, Yusoff,S., Atif,A.B., Fatemeh,H., Rani,A.,
            Marini,M., Ab Aziz,C.B., Zabidi-Hussin,Z.A., Nishio,H. and
            Zilfalil,B.A.
  TITLE     Screening of the LIX1 gene in Japanese and Malaysian patients with
            SMA and/or SMA-like disorder
  JOURNAL   Brain Dev 32 (5), 385-389 (2010)
   PUBMED   19664890
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3765)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3765)
  AUTHORS   Mao,Y., Kucuk,B. and Irvine,K.D.
  TITLE     Drosophila lowfat, a novel modulator of Fat signaling
  JOURNAL   Development 136 (19), 3223-3233 (2009)
   PUBMED   19710173
REFERENCE   8  (bases 1 to 3765)
  AUTHORS   Parkinson,N.J., Baumer,D., Rose-Morris,A. and Talbot,K.
  TITLE     Candidate screening of the bovine and feline spinal muscular
            atrophy genes reveals no evidence for involvement in human motor
            neuron disorders
  JOURNAL   Neuromuscul Disord 18 (5), 394-397 (2008)
   PUBMED   18395445
  REMARK    GeneRIF: Data show that mutations in LIX1 do not contribute
            significantly to the cause of motor neuron diseases in the human
            population.
REFERENCE   9  (bases 1 to 3765)
  AUTHORS   Moeller,C., Yaylaoglu,M.B., Alvarez-Bolado,G., Thaller,C. and
            Eichele,G.
  TITLE     Murine Lix1, a novel marker for substantia nigra, cortical layer 5,
            and hindbrain structures
  JOURNAL   Brain Res Gene Expr Patterns 1 (3-4), 199-203 (2002)
   PUBMED   12638132
REFERENCE   10 (bases 1 to 3765)
  AUTHORS   Swindell,E.C., Moeller,C., Thaller,C. and Eichele,G.
  TITLE     Cloning and expression analysis of chicken Lix1, a founding member
            of a novel gene family
  JOURNAL   Mech Dev 109 (2), 405-408 (2001)
   PUBMED   11731258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098400.1, BC036467.2 and AC008865.3.
            
            On Nov 22, 2018 this sequence version replaced NM_153234.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036467.2, SRR1803611.193891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274382.9/ ENSP00000274382.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2289              AK098400.1         262-2550
            2290-3762           BC036467.2         2413-3885
            3763-3765           AC008865.3         105782-105784       c
FEATURES             Location/Qualifiers
     source          1..3765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..3765
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /note="limb and CNS expressed 1"
                     /db_xref="GeneID:167410"
                     /db_xref="HGNC:HGNC:18581"
                     /db_xref="MIM:610466"
     exon            1..117
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..884
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /note="limb expression 1; Lix1 homolog; Lowfat homolog"
                     /codon_start=1
                     /product="protein limb expression 1 homolog"
                     /protein_id="NP_694966.3"
                     /db_xref="CCDS:CCDS4088.1"
                     /db_xref="GeneID:167410"
                     /db_xref="HGNC:HGNC:18581"
                     /db_xref="MIM:610466"
                     /translation="MDRTLESLRHIIAQVLPHRDPALVFKDLNVVSMLQEFWESKQQQ
                     KAAFPSEGVVVYESLPAPGPPFVSYVTLPGGSCFGNFQCCLSRAEARRDAAKVALINS
                     LFNELPSRRITKEFIMESVQEAVASTSGTLDDADDPSTSVGAYHYMLESNMGKTMLEF
                     QELMTIFQLLHWNGSLKALRETKCSRQEVISYYSQYSLDEKMRSHMALDWIMKERDSP
                     GIVSQELRMALRQLEEARKAGQELRFYKEKKEILSLALTQICSDPDTSSPSDDQLSLT
                     ALCGYH"
     exon            118..281
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /inference="alignment:Splign:2.1.0"
     exon            282..422
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /inference="alignment:Splign:2.1.0"
     exon            423..518
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /inference="alignment:Splign:2.1.0"
     exon            519..596
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /inference="alignment:Splign:2.1.0"
     exon            597..3765
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2268..2273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /note="hexamer: AAGAAA"
     polyA_site      2293
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
     regulatory      3738..3743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /note="hexamer: AATAAA"
     polyA_site      3765
                     /gene="LIX1"
                     /gene_synonym="C5orf11; Lft"
                     /note="major polyA site"
ORIGIN      
        1 actctgtaca ggaggctcac acaggcagac ccaagatgga cagaaccttg gaatctctga
       61 gacacatcat tgcccaagtc ttgcctcaca gagatccggc tctagtcttc aaagacttga
      121 acgttgtgtc aatgttacag gaattttggg aaagcaagca gcagcagaag gctgcattcc
      181 caagtgaagg tgtggtggtc tatgagtcac tgccagctcc tgggcctccc tttgtgagtt
      241 acgtgaccct cccaggggga agctgttttg gcaactttca gtgctgctta agtagagccg
      301 aggccaggcg ggatgcagct aaagtggccc tgatcaactc cctcttcaat gagctgccct
      361 ctcgcaggat caccaaggaa ttcattatgg aaagtgttca ggaagcagta gcctccacca
      421 gcggcacctt agatgatgca gatgacccca gcaccagtgt tggggcctat cactacatgc
      481 tggagtcaaa catggggaag actatgctgg agtttcagga gctgatgacc attttccaac
      541 tattgcactg gaatggaagc ctaaaagccc ttcgtgaaac aaagtgttcc cgacaggaag
      601 tcatctccta ctattctcag tattctctag atgaaaagat gcgcagccac atggccctgg
      661 actggatcat gaaggagcgg gactcaccag gaattgtctc tcaagagcta cgaatggccc
      721 tgaggcagtt ggaggaagcc aggaaagcag gacaagaact acggttttac aaagaaaaga
      781 aagaaatatt gagcttagcc ctgactcaga tctgcagtga ccctgacact tcctcaccca
      841 gtgatgatca gctgagcctt acggccctgt gtggctatca ctagcaaggc caagccccgg
      901 gtaccctcag tgatggcaga ggccagatta acattaggaa tctcagtgca gaggtcctca
      961 gaggctccag catctctagt actacctgaa ggctctccta accctctcca cacattccat
     1021 ttacagagta tgagagtcgt aggaccctta caagacccaa caagccactc gatgcatttt
     1081 tctatcacat tctcaatagt tccagctcag gatgaaagga tagacacaaa attgtttgaa
     1141 aaacattttc caggcctggc tccaacctaa agcctgactg tcacgtgcct tgcttgattt
     1201 tatatatatt gtttcaagaa tagtccaata tagcattccc caaatgaaca gcagccagaa
     1261 ttaggtgaag tagcatgata gcagtgttta aaaatactta ggattaaata aataatatgg
     1321 attgttttaa aaaatatcca aggatcagag tctctttcta agctttgtaa gctaagcaat
     1381 agtttatgtc ctactagata cactgcaaac tacagtgggg attttatctg gacatcccac
     1441 catcaaagat cttgaaatag taatagtatg aaaatactag ataaaattaa tgtttaaaat
     1501 gtttttgtaa caataatttt taaaacccac actcttccat atatggggat aaatatcacc
     1561 tagaaaagta gcctcactct tattcctcaa gaattaatat ccaatgttta tgagtcttgc
     1621 aatcaatttt gttcattttt aatttgcaaa tcgataacct gaactaattt gttcttattt
     1681 tttgccactg caaacatata tctacagaga gaaaaattaa tggcatttta aaggttaaaa
     1741 cattttgaaa aattattagc atgtaacaaa gaatgcttgc atttgattag tttcaccagc
     1801 atttgagaga aggacccttt agctctgttt gttgttcaag aacataagca accagtagct
     1861 caaatgtagt atcattatta agtttaagtc actggaatct tctttaaagg aaggataaga
     1921 cattgccatc tctatttaac tcatccatat gggtcaatca actgattaga aaatcaaaaa
     1981 acaataaaaa cttttttttt tttttttttt ttagtagaga cgggatttca tcatgttgcc
     2041 caggctggtc ttgaactcct gggctcaagc catctgcctg cctccacctc ccaaaatgct
     2101 gagattacag gtgtgagcca ccatgcctgg cctaaactaa tttttagata gttcctggtc
     2161 actcaaattt aagaatgtca gcaatgtcaa ttttaaatgc tcataggtct ttccatatct
     2221 gtaacatgaa aatgattatt ctgcatttta ttcagtagtc caaattaaag aaaatgtttt
     2281 tctcaattta aaataatttc tttttctttt gtttatgcaa gtgcatacat gcttcactga
     2341 aagcaaaacc attataatta cattaaagtt tataaaatat gatattttaa cctcatatct
     2401 aataagtatg tacaaaggta accatcactc cttaaatcca catgaaaact actgtaactg
     2461 atcatgtatt ttggaattag acttgataat aaaagattat catgtatcac atatctcaca
     2521 ccaggggaac aattagctac ataattgtca taccttaata tcttttaaag gtaacagtaa
     2581 ttttcaacac attttatttt aaaatattat tttaacaaaa gttacattcc tctccacaat
     2641 gaggctaaat gtcacccacg aaagaacttt attcccttat attcctgaaa agaaatcaga
     2701 attaacattt ttatgttgaa taaattttaa aatttaggaa atgttctatt taaagttaat
     2761 ttctttcata aagccattac tctttacatt gtcatttcca aaaagccaca atttcccatg
     2821 ctggatgtga tgaaagttag gcacaccttt actgcattag cagcctttga caatgacttc
     2881 ctcaaactga caccatctta attagatgca gggacaggga tcagatggga caatatcaaa
     2941 tttactttgt gccctacaag ttaaaaactg cacccattct gtaaattgaa tatagaggtt
     3001 ctcccttggc cactgtcagc ttttcttgac tggccaaaac tgcccattct tcctggaatg
     3061 gtatgaaagc ttcagcaaaa taaataaaag tcagaatctt tgctggtccc tttaatgctg
     3121 atttgatagt aaatcaattt cagctgagac ataagggctg tcagtctatc atataaacat
     3181 ctttaactat agcctagaga aaagagggtt gaagagcaaa gcagattttt tttttccttt
     3241 tctatatctt gttctgaaca acacactgtg ataaagggga ctagagtgga agattcccta
     3301 tttaaacaca tgaagctctg ggtcctagcc ttttttggtt ataagccctt tgagaatctg
     3361 ataaaagctg tggatcatct cctaggaaaa tagaacaaaa catacatatt cacattacac
     3421 agttccagag tatgtggacc ccccaaagtc cagagattgc cctaggggat ctttagattc
     3481 ttgtttagaa ctgttgattt tgaacacaac atacactgtc aaactttaca tcagggatcc
     3541 aacataactc agacatagcc caggtagcct gtttctaaca caactgtcat aatcctgaaa
     3601 tccaaaattg cactgtgttt gacatgagat agtttaagtt ccacaaaatc caaatttacc
     3661 atattattgt ttttaaaaaa gcagtttaga gcaaactgtc actaaacttg gataaatggg
     3721 tcagaaagta cagatttaat aaagtcgtac ctctaatgtt cagaa
//
