LOCUS       NM_001080518            1303 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens lipase family member K (LIPK), transcript variant 1,
            mRNA.
ACCESSION   NM_001080518 XM_011540077 XM_926746
VERSION     NM_001080518.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1303)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL358532.11.
            
            On or before Jan 28, 2020 this sequence version replaced
            XM_011540077.1, NM_001080518.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: EF426482.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2145893, SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404190.3/ ENSP00000383900.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AL358532.11        60865-60936
            73-188              AL358532.11        79149-79264
            189-306             AL358532.11        81411-81528
            307-505             AL358532.11        85599-85797
            506-615             AL358532.11        86794-86903
            616-752             AL358532.11        87031-87167
            753-899             AL358532.11        92251-92397
            900-971             AL358532.11        94612-94683
            972-1043            AL358532.11        97866-97937
            1044-1303           AL358532.11        107133-107392
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..1303
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /note="lipase family member K"
                     /db_xref="GeneID:643414"
                     /db_xref="HGNC:HGNC:23444"
                     /db_xref="MIM:613922"
     exon            1..72
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            73..188
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1283
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lipase member K; lipase-like, ab-hydrolase
                     domain containing 2; lipase K; lipase-like abhydrolase
                     domain-containing protein 2"
                     /codon_start=1
                     /product="lipase member K isoform 1 precursor"
                     /protein_id="NP_001073987.1"
                     /db_xref="CCDS:CCDS44455.1"
                     /db_xref="GeneID:643414"
                     /db_xref="HGNC:HGNC:23444"
                     /db_xref="MIM:613922"
                     /translation="MWQLLAAACWMLLLGSMYGYDKKGNNANPEANMNISQIISYWGY
                     PYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWICNLPNNSL
                     AFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIEK
                     TGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKKLTTLS
                     RRVVKVLFGDKMFHPHTLFDQFIATKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLD
                     VYLSHNPAGTSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVP
                     TAIWNGGQDIVADPKDVENLLPQIANLIYYKLIPHYNHVDFYLGEDAPQEIYQDLIIL
                     MEEYLQN"
     exon            189..306
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            307..505
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..615
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..752
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..899
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..971
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1043
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1303
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1279..1284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /note="hexamer: ATTAAA"
     polyA_site      1303
                     /gene="LIPK"
                     /gene_synonym="bA186O14.2; LIPL2"
                     /note="major polyA site"
ORIGIN      
        1 gcctctggaa ggatctggaa tgcacctgaa gctcccagga cttgaagaca gacctccaaa
       61 gacttggatc aggcagatcc caaatgtggc agcttttagc agcagcatgc tggatgcttc
      121 ttcttggatc tatgtatggt tatgacaaga aaggaaacaa tgcaaaccct gaagctaata
      181 tgaatattag ccagattatt tcttactggg gttatcctta tgaagagtat gatgttacaa
      241 caaaagatgg ttatatcctt ggaatttata ggattccaca tggaagagga tgcccaggga
      301 ggacagctcc aaagcctgct gtgtatttgc agcatggctt aattgcatct gccagtaact
      361 ggatttgcaa cctgcccaac aacagtttgg ctttccttct ggcagatagt ggttatgacg
      421 tgtggttggg gaacagccga ggaaacactt ggtccagaaa acaccttaaa ttgtcaccga
      481 aatcaccgga atactgggcc ttcagtttgg atgagatggc taaatatgac cttccagcca
      541 caatcaattt tatcatagag aaaactggac agaagcgact ctactacgtg ggccactcac
      601 aaggcaccac catagctttt atagcatttt ctacaaaccc agaactggct aaaaagatta
      661 agatattttt tgcactggct ccagttgtca cagttaaata cacccaaagt cctatgaaaa
      721 aactaacaac cctttccagg cgagtagtta aggtgttgtt tggtgacaaa atgttccacc
      781 ctcatacatt gtttgaccaa ttcattgcca ccaaagtgtg caatcgaaag ctattccgtc
      841 gtatttgcag caacttccta tttactctga gtggatttga tccgcaaaac ttaaatatga
      901 gtcgcttgga tgtttatttg tcacacaatc ctgcgggaac atctgttcag aatatgctgc
      961 actgggctca ggctgttaat tctggtcagc tccaagcttt tgattgggga aactctgatc
     1021 agaacatgat gcacttccat cagcttacac ctcctttata caacattact aagatggaag
     1081 ttccaacagc aatatggaat ggtggacagg acattgtggc tgatcccaag gatgttgaaa
     1141 atttacttcc tcaaattgct aaccttattt attacaagct gattccacac tacaatcatg
     1201 tggattttta ccttggagag gatgcacctc aggaaattta ccaagaccta attatattga
     1261 tggaagaata tttacaaaat taaatgcact ttactttctc taa
//
