LOCUS       NM_198996               1653 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens lipase I (LIPI), transcript variant 2, mRNA.
ACCESSION   NM_198996 XM_351374
VERSION     NM_198996.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Willier,S., Butt,E. and Grunewald,T.G.
  TITLE     Lysophosphatidic acid (LPA) signalling in cell migration and cancer
            invasion: a focussed review and analysis of LPA receptor gene
            expression on the basis of more than 1700 cancer microarrays
  JOURNAL   Biol Cell 105 (8), 317-333 (2013)
   PUBMED   23611148
  REMARK    Review article
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Schmiedel,B.J., Hutter,C., Hesse,M. and Staege,M.S.
  TITLE     Expression of multiple membrane-associated phospholipase A1 beta
            transcript variants and lysophosphatidic acid receptors in Ewing
            tumor cells
  JOURNAL   Mol Biol Rep 38 (7), 4619-4628 (2011)
   PUBMED   21132378
  REMARK    GeneRIF: Different LIPI transcript variants present in Ewing family
            tumors (EFT) might be involved in the pathogenesis of EFT by
            signaling via these LPA receptors.
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Foell,J.L., Hesse,M., Volkmer,I., Schmiedel,B.J., Neumann,I. and
            Staege,M.S.
  TITLE     Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing
            tumour-associated cancer/testis antigen
  JOURNAL   Pediatr Blood Cancer 51 (2), 228-234 (2008)
   PUBMED   18435455
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Hiramatsu,T., Sonoda,H., Takanezawa,Y., Morikawa,R., Ishida,M.,
            Kasahara,K., Sanai,Y., Taguchi,R., Aoki,J. and Arai,H.
  TITLE     Biochemical and molecular characterization of two phosphatidic
            acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta
  JOURNAL   J Biol Chem 278 (49), 49438-49447 (2003)
   PUBMED   12963729
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Wen,X.Y., Hegele,R.A., Wang,J., Wang,D.Y., Cheung,J., Wilson,M.,
            Yahyapour,M., Bai,Y., Zhuang,L., Skaug,J., Young,T.K.,
            Connelly,P.W., Koop,B.F., Tsui,L.C. and Stewart,A.K.
  TITLE     Identification of a novel lipase gene mutated in lpd mice with
            hypertriglyceridemia and associated with dyslipidemia in humans
  JOURNAL   Hum Mol Genet 12 (10), 1131-1143 (2003)
   PUBMED   12719377
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF130358.2, AL078615.2,
            AP001347.1 and KC877770.1.
            
            On Apr 9, 2020 this sequence version replaced NM_198996.3.
            
            Summary: The protein encoded by this gene is a phospholipase that
            hydrolyzes phosphatidic acid to produce lysophosphatidic acid.
            Defects in this gene are a cause of susceptibility to familial
            hypertrigliceridemia. This gene is also expressed at high levels in
            Ewing family tumor cells. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY197607.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2145240,
                                           SAMEA2159931 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AF130358.2         11413-11547         c
            136-521             AL078615.2         20018-20403         c
            522-630             AL078615.2         16945-17053         c
            631-732             AL078615.2         12742-12843         c
            733-822             AP001347.1         131175-131264       c
            823-990             AP001347.1         130036-130203       c
            991-1095            AP001347.1         128232-128336       c
            1096-1207           AP001347.1         117386-117497       c
            1208-1384           KC877770.1         260-436             c
            1385-1653           AP001347.1         73625-73893         c
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q11.2"
     gene            1..1653
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /note="lipase I"
                     /db_xref="GeneID:149998"
                     /db_xref="HGNC:HGNC:18821"
                     /db_xref="MIM:609252"
     exon            1..135
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            136..521
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1472
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /EC_number="2.7.11.30"
                     /note="isoform 5 is encoded by transcript variant 2;
                     cancer/testis antigen 17; LPD lipase; membrane-associated
                     phosphatidic acid-selective phospholipase A1-beta; lipase,
                     member I"
                     /codon_start=1
                     /product="lipase member I isoform 5"
                     /protein_id="NP_945347.3"
                     /db_xref="GeneID:149998"
                     /db_xref="HGNC:HGNC:18821"
                     /db_xref="MIM:609252"
                     /translation="MMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSI
                     PLWLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHG
                     ASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKF
                     VDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMAS
                     LETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLR
                     TTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFY
                     KLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCR
                     YNIVLKDREEVFLNPNTCTPKNT"
     exon            522..630
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            631..732
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            733..822
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            823..990
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1095
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1207
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1384
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1653
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgaacttc tgatagggtc ttatttatgt tgctcaaatg tttacataat aacttgtgcc
       61 aaaaatatag tgctcatgct tttcagttct cacccagaaa tgtcctgtgg cttctagttg
      121 tgtgcctgag atcagataat aaaagaccat gccttgaatt ctctcagcta agtgtaaagg
      181 attccttcag agatttattt attccgagaa tagagaccat tctgatgatg tatacaagga
      241 acaacctaaa ctgtgctgag ccactgtttg aacaaaataa ctcacttaat gttaatttca
      301 acacacaaaa gaaaacagtc tggcttattc acggatacag accagtaggc tccatcccat
      361 tatggcttca gaacttcgta aggattttgc tgaatgaaga agatatgaat gtaattgtag
      421 tagactggag ccggggtgct acaactttta tttataatag agcagttaaa aacaccagaa
      481 aagttgctgt gagtttgagt gtgcacatta aaaatctttt gaagcatggt gcatctcttg
      541 acaattttca tttcataggt gtgagcttag gggctcatat cagtggattt gttggaaaga
      601 tatttcatgg tcaacttgga agaataacag gtcttgaccc tgctgggcca aggttctcca
      661 gaaaaccacc atatagcaga ttagattaca cggatgcaaa gtttgtggat gtcatccatt
      721 ctgactccaa tggtttaggc attcaagagc ccttgggaca tatagatttt tatccaaatg
      781 gaggaaataa acaacctggc tgtcctaaat caattttctc aggaattcaa ttcattaaat
      841 gcaaccacca gagagcagtt cacttgttca tggcatcttt agaaacaaac tgcaatttta
      901 tttcatttcc ttgtcgttca tacaaagatt acaagactag cttatgtgtg gactgtgact
      961 gttttaagga aaaatcatgt cctcggctgg gttatcaagc caagctattt aaaggtgttt
     1021 taaaagaaag gatggaagga agacctctta ggaccactgt gtttttggat acaagtggta
     1081 catatccatt ctgtacctat tattttgttc tcagtataat tgttccagat aaaactatga
     1141 tggatggctc gttttcattt aaattattaa atcagcttgg aatgattgaa gagccaaggc
     1201 tttatgaaaa gaacaaacca ttttataaac ttcaagaagt caagattctt gctcaatttt
     1261 ataatgactt tgtaaatatt tcaagcattg gtttgacata tttccagagc tcaaatctgc
     1321 agtgttccac atgcacatac aagatccaga gtctcatgtt aaaatcactt acatacccag
     1381 aaagaccacc actttgcagg tataatattg tacttaaaga cagagaggaa gtgtttctta
     1441 atccaaacac atgtacacca aagaacacat aagatgcctt cttccatcaa atgcacttgc
     1501 ttgtgaatta atggacttgt aaatgaaaca atgcaatcag tcttttataa tgcactgttc
     1561 aatttgagat tcaagtattt ctatttcttg gaaaaaattt taagaatcaa aaataaagaa
     1621 aataaaaaat gcatacagtt aaacattcca aat
//
