LOCUS       NM_001303001            1384 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens lipase I (LIPI), transcript variant deltaE8, mRNA.
ACCESSION   NM_001303001 XM_005260924
VERSION     NM_001303001.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1384)
  AUTHORS   Willier,S., Butt,E. and Grunewald,T.G.
  TITLE     Lysophosphatidic acid (LPA) signalling in cell migration and cancer
            invasion: a focussed review and analysis of LPA receptor gene
            expression on the basis of more than 1700 cancer microarrays
  JOURNAL   Biol Cell 105 (8), 317-333 (2013)
   PUBMED   23611148
  REMARK    Review article
REFERENCE   2  (bases 1 to 1384)
  AUTHORS   Schmiedel,B.J., Hutter,C., Hesse,M. and Staege,M.S.
  TITLE     Expression of multiple membrane-associated phospholipase A1 beta
            transcript variants and lysophosphatidic acid receptors in Ewing
            tumor cells
  JOURNAL   Mol Biol Rep 38 (7), 4619-4628 (2011)
   PUBMED   21132378
  REMARK    GeneRIF: Different LIPI transcript variants present in Ewing family
            tumors (EFT) might be involved in the pathogenesis of EFT by
            signaling via these LPA receptors.
REFERENCE   3  (bases 1 to 1384)
  AUTHORS   Foell,J.L., Hesse,M., Volkmer,I., Schmiedel,B.J., Neumann,I. and
            Staege,M.S.
  TITLE     Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing
            tumour-associated cancer/testis antigen
  JOURNAL   Pediatr Blood Cancer 51 (2), 228-234 (2008)
   PUBMED   18435455
REFERENCE   4  (bases 1 to 1384)
  AUTHORS   Hiramatsu,T., Sonoda,H., Takanezawa,Y., Morikawa,R., Ishida,M.,
            Kasahara,K., Sanai,Y., Taguchi,R., Aoki,J. and Arai,H.
  TITLE     Biochemical and molecular characterization of two phosphatidic
            acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta
  JOURNAL   J Biol Chem 278 (49), 49438-49447 (2003)
   PUBMED   12963729
REFERENCE   5  (bases 1 to 1384)
  AUTHORS   Wen,X.Y., Hegele,R.A., Wang,J., Wang,D.Y., Cheung,J., Wilson,M.,
            Yahyapour,M., Bai,Y., Zhuang,L., Skaug,J., Young,T.K.,
            Connelly,P.W., Koop,B.F., Tsui,L.C. and Stewart,A.K.
  TITLE     Identification of a novel lipase gene mutated in lpd mice with
            hypertriglyceridemia and associated with dyslipidemia in humans
  JOURNAL   Hum Mol Genet 12 (10), 1131-1143 (2003)
   PUBMED   12719377
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF130358.2, JN387916.1,
            AY918476.1 and AY197607.1.
            
            On Aug 6, 2019 this sequence version replaced NM_001303001.1.
            
            Summary: The protein encoded by this gene is a phospholipase that
            hydrolyzes phosphatidic acid to produce lysophosphatidic acid.
            Defects in this gene are a cause of susceptibility to familial
            hypertrigliceridemia. This gene is also expressed at high levels in
            Ewing family tumor cells. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: JN387916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159931 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AF130358.2         15490-15553         c
            65-586              JN387916.1         1-522
            587-651             AY918476.1         115-179
            652-1152            JN387916.1         588-1088
            1153-1384           AY197607.1         1405-1636
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q11.2"
     gene            1..1384
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /note="lipase I"
                     /db_xref="GeneID:149998"
                     /db_xref="HGNC:HGNC:18821"
                     /db_xref="MIM:609252"
     exon            1..156
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1238
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /EC_number="2.7.11.30"
                     /note="isoform 4 precursor is encoded by transcript
                     variant deltaE8; cancer/testis antigen 17; LPD lipase;
                     membrane-associated phosphatidic acid-selective
                     phospholipase A1-beta; lipase, member I"
                     /codon_start=1
                     /product="lipase member I isoform 4 precursor"
                     /protein_id="NP_001289930.1"
                     /db_xref="CCDS:CCDS93079.1"
                     /db_xref="GeneID:149998"
                     /db_xref="HGNC:HGNC:18821"
                     /db_xref="MIM:609252"
                     /translation="MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFIPRIETI
                     LMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRILLN
                     EEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVSL
                     GAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI
                     QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCR
                     SYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPF
                     CNHHFAGIILYLKTERKCFLIQTHVHQRTHKMPSSIKCTCL"
     exon            157..542
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            543..651
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            652..753
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            754..843
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1011
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1116
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1384
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaagaac ctgccagcct gtgatgatcc taccaaagag aaacctcaat gagttacgga
       61 atttcctttt tggtgaattg agtgctgttt ttgcttttct cagattccaa atgagagtat
      121 acatttttct ttgtttgatg tgctgggtga gatctgataa taaaagacca tgccttgaat
      181 tctctcagct aagtgtaaag gattccttca gagatttatt tattccgaga atagagacca
      241 ttctgatgat gtatacaagg aacaacctaa actgtgctga gccactgttt gaacaaaata
      301 actcacttaa tgttaatttc aacacacaaa agaaaacagt ctggcttatt cacggataca
      361 gaccagtagg ctccatccca ttatggcttc agaacttcgt aaggattttg ctgaatgaag
      421 aagatatgaa tgtaattgta gtagactgga gccggggtgc tacaactttt atttataata
      481 gagcagttaa aaacaccaga aaagttgctg tgagtttgag tgtgcacatt aaaaatcttt
      541 tgaagcatgg tgcatctctt gacaattttc atttcatagg tgtgagctta ggggctcata
      601 tcagtggatt tgttggaaag atatttcatg gtcaacttgg aagaataaca ggtcttgacc
      661 ctgctgggcc aaggttctcc agaaaaccac catatagcag attagattac acggatgcaa
      721 agtttgtgga tgtcatccat tctgactcca atggtttagg cattcaagag cccttgggac
      781 atatagattt ttatccaaat ggaggaaata aacaacctgg ctgtcctaaa tcaattttct
      841 caggaattca attcattaaa tgcaaccacc agagagcagt tcacttgttc atggcatctt
      901 tagaaacaaa ctgcaatttt atttcatttc cttgtcgttc atacaaagat tacaagacta
      961 gcttatgtgt ggactgtgac tgttttaagg aaaaatcatg tcctcggctg ggttatcaag
     1021 ccaagctatt taaaggtgtt ttaaaagaaa ggatggaagg aagacctctt aggaccactg
     1081 tgtttttgga tacaagtggt acatatccat tctgtaacca ccactttgca ggtataatat
     1141 tgtacttaaa gacagagagg aagtgtttct taatccaaac acatgtacac caaagaacac
     1201 ataagatgcc ttcttccatc aaatgcactt gcttgtgaat taatggactt gtaaatgaaa
     1261 caatgcaatc agtcttttat aatgcactgt tcaatttgag attcaagtat ttctatttct
     1321 tggaaaaaat tttaagaatc aaaaataaag aaaataaaaa atgcatacag ttaaacattc
     1381 caaa
//
