LOCUS       NM_001302998            1673 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens lipase I (LIPI), transcript variant fl, mRNA.
ACCESSION   NM_001302998
VERSION     NM_001302998.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1673)
  AUTHORS   Willier,S., Butt,E. and Grunewald,T.G.
  TITLE     Lysophosphatidic acid (LPA) signalling in cell migration and cancer
            invasion: a focussed review and analysis of LPA receptor gene
            expression on the basis of more than 1700 cancer microarrays
  JOURNAL   Biol Cell 105 (8), 317-333 (2013)
   PUBMED   23611148
  REMARK    Review article
REFERENCE   2  (bases 1 to 1673)
  AUTHORS   Schmiedel,B.J., Hutter,C., Hesse,M. and Staege,M.S.
  TITLE     Expression of multiple membrane-associated phospholipase A1 beta
            transcript variants and lysophosphatidic acid receptors in Ewing
            tumor cells
  JOURNAL   Mol Biol Rep 38 (7), 4619-4628 (2011)
   PUBMED   21132378
  REMARK    GeneRIF: Different LIPI transcript variants present in Ewing family
            tumors (EFT) might be involved in the pathogenesis of EFT by
            signaling via these LPA receptors.
REFERENCE   3  (bases 1 to 1673)
  AUTHORS   Foell,J.L., Hesse,M., Volkmer,I., Schmiedel,B.J., Neumann,I. and
            Staege,M.S.
  TITLE     Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing
            tumour-associated cancer/testis antigen
  JOURNAL   Pediatr Blood Cancer 51 (2), 228-234 (2008)
   PUBMED   18435455
REFERENCE   4  (bases 1 to 1673)
  AUTHORS   Hiramatsu,T., Sonoda,H., Takanezawa,Y., Morikawa,R., Ishida,M.,
            Kasahara,K., Sanai,Y., Taguchi,R., Aoki,J. and Arai,H.
  TITLE     Biochemical and molecular characterization of two phosphatidic
            acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta
  JOURNAL   J Biol Chem 278 (49), 49438-49447 (2003)
   PUBMED   12963729
REFERENCE   5  (bases 1 to 1673)
  AUTHORS   Wen,X.Y., Hegele,R.A., Wang,J., Wang,D.Y., Cheung,J., Wilson,M.,
            Yahyapour,M., Bai,Y., Zhuang,L., Skaug,J., Young,T.K.,
            Connelly,P.W., Koop,B.F., Tsui,L.C. and Stewart,A.K.
  TITLE     Identification of a novel lipase gene mutated in lpd mice with
            hypertriglyceridemia and associated with dyslipidemia in humans
  JOURNAL   Hum Mol Genet 12 (10), 1131-1143 (2003)
   PUBMED   12719377
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF130358.2, JN387910.1,
            AY918476.1 and AY197607.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 7, 2019 this sequence version replaced NM_001302998.1.
            
            Summary: The protein encoded by this gene is a phospholipase that
            hydrolyzes phosphatidic acid to produce lysophosphatidic acid.
            Defects in this gene are a cause of susceptibility to familial
            hypertrigliceridemia. This gene is also expressed at high levels in
            Ewing family tumor cells. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: JN387910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2159931
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000681601.1/
                                                ENSP00000505323.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AF130358.2         15490-15553         c
            65-586              JN387910.1         1-522
            587-651             AY918476.1         115-179
            652-1441            JN387910.1         588-1377
            1442-1673           AY197607.1         1405-1636
FEATURES             Location/Qualifiers
     source          1..1673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q11.2"
     gene            1..1673
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /note="lipase I"
                     /db_xref="GeneID:149998"
                     /db_xref="HGNC:HGNC:18821"
                     /db_xref="MIM:609252"
     exon            1..156
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1493
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /EC_number="2.7.11.30"
                     /note="isoform 1 precursor is encoded by transcript
                     variant fl; cancer/testis antigen 17; LPD lipase;
                     membrane-associated phosphatidic acid-selective
                     phospholipase A1-beta; lipase, member I"
                     /codon_start=1
                     /product="lipase member I isoform 1 precursor"
                     /protein_id="NP_001289927.1"
                     /db_xref="CCDS:CCDS93080.1"
                     /db_xref="GeneID:149998"
                     /db_xref="HGNC:HGNC:18821"
                     /db_xref="MIM:609252"
                     /translation="MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFIPRIETI
                     LMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRILLN
                     EEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVSL
                     GAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI
                     QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCR
                     SYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPF
                     CTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYN
                     DFVNISSIGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCRYNIVLKDREEVFL
                     NPNTCTPKNT"
     exon            157..542
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            543..651
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            652..753
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            754..843
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1011
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1116
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1228
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1405
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1673
                     /gene="LIPI"
                     /gene_synonym="CT17; LPDL; mPA-PLA1 beta; PLA1C; PRED5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaagaac ctgccagcct gtgatgatcc taccaaagag aaacctcaat gagttacgga
       61 atttcctttt tggtgaattg agtgctgttt ttgcttttct cagattccaa atgagagtat
      121 acatttttct ttgtttgatg tgctgggtga gatctgataa taaaagacca tgccttgaat
      181 tctctcagct aagtgtaaag gattccttca gagatttatt tattccgaga atagagacca
      241 ttctgatgat gtatacaagg aacaacctaa actgtgctga gccactgttt gaacaaaata
      301 actcacttaa tgttaatttc aacacacaaa agaaaacagt ctggcttatt cacggataca
      361 gaccagtagg ctccatccca ttatggcttc agaacttcgt aaggattttg ctgaatgaag
      421 aagatatgaa tgtaattgta gtagactgga gccggggtgc tacaactttt atttataata
      481 gagcagttaa aaacaccaga aaagttgctg tgagtttgag tgtgcacatt aaaaatcttt
      541 tgaagcatgg tgcatctctt gacaattttc atttcatagg tgtgagctta ggggctcata
      601 tcagtggatt tgttggaaag atatttcatg gtcaacttgg aagaataaca ggtcttgacc
      661 ctgctgggcc aaggttctcc agaaaaccac catatagcag attagattac acggatgcaa
      721 agtttgtgga tgtcatccat tctgactcca atggtttagg cattcaagag cccttgggac
      781 atatagattt ttatccaaat ggaggaaata aacaacctgg ctgtcctaaa tcaattttct
      841 caggaattca attcattaaa tgcaaccacc agagagcagt tcacttgttc atggcatctt
      901 tagaaacaaa ctgcaatttt atttcatttc cttgtcgttc atacaaagat tacaagacta
      961 gcttatgtgt ggactgtgac tgttttaagg aaaaatcatg tcctcggctg ggttatcaag
     1021 ccaagctatt taaaggtgtt ttaaaagaaa ggatggaagg aagacctctt aggaccactg
     1081 tgtttttgga tacaagtggt acatatccat tctgtaccta ttattttgtt ctcagtataa
     1141 ttgttccaga taaaactatg atggatggct cgttttcatt taaattatta aatcagcttg
     1201 gaatgattga agagccaagg ctttatgaaa agaacaaacc attttataaa cttcaagaag
     1261 tcaagattct tgctcaattt tataatgact ttgtaaatat ttcaagcatt ggtttgacat
     1321 atttccagag ctcaaatctg cagtgttcca catgcacata caagatccag agtctcatgt
     1381 taaaatcact tacataccca gaaagaccac cactttgcag gtataatatt gtacttaaag
     1441 acagagagga agtgtttctt aatccaaaca catgtacacc aaagaacaca taagatgcct
     1501 tcttccatca aatgcacttg cttgtgaatt aatggacttg taaatgaaac aatgcaatca
     1561 gtcttttata atgcactgtt caatttgaga ttcaagtatt tctatttctt ggaaaaaatt
     1621 ttaagaatca aaaataaaga aaataaaaaa tgcatacagt taaacattcc aaa
//
