LOCUS       NM_139248               4001 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens lipase H (LIPH), mRNA.
ACCESSION   NM_139248
VERSION     NM_139248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4001)
  AUTHORS   Yi,D., Zhang,D., Zeng,Z., Zhang,S., Song,B., He,C., Li,M. and He,J.
  TITLE     Circular RNA eukaryotic translation initiation factor 6 facilitates
            TPC-1 cell proliferation and invasion through the
            microRNA-138-5p/lipase H axis
  JOURNAL   Funct Integr Genomics 23 (4), 313 (2023)
   PUBMED   37776372
  REMARK    GeneRIF: Circular RNA eukaryotic translation initiation factor 6
            facilitates TPC-1 cell proliferation and invasion through the
            microRNA-138-5p/lipase H axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4001)
  AUTHORS   Zhuang,H., Chen,X., Wang,Y., Huang,S., Chen,B., Zhang,C. and Hou,B.
  TITLE     Identification of LIPH as an unfavorable biomarkers correlated with
            immune suppression or evasion in pancreatic cancer based on RNA-seq
  JOURNAL   Cancer Immunol Immunother 71 (3), 601-612 (2022)
   PUBMED   34279685
  REMARK    GeneRIF: Identification of LIPH as an unfavorable biomarkers
            correlated with immune suppression or evasion in pancreatic cancer
            based on RNA-seq.
REFERENCE   3  (bases 1 to 4001)
  AUTHORS   Zhang,Y., Zhu,X., Qiao,X., Gu,X., Xue,J., Han,Y., Sun,L., Cui,M.
            and Liu,C.
  TITLE     LIPH promotes metastasis by enriching stem-like cells in
            triple-negative breast cancer
  JOURNAL   J Cell Mol Med 24 (16), 9125-9134 (2020)
   PUBMED   32618099
  REMARK    GeneRIF: LIPH promotes metastasis by enriching stem-like cells in
            triple-negative breast cancer.
REFERENCE   4  (bases 1 to 4001)
  AUTHORS   Malki,L., Sarig,O., Cesarato,N., Mohamad,J., Canter,T., Assaf,S.,
            Pavlovsky,M., Vodo,D., Anis,Y., Bihari,O., Malovitski,K., Gat,A.,
            Thiele,H., White,B.E.P., Samuelov,L., Nanda,A., Paller,A.S.,
            Betz,R.C. and Sprecher,E.
  TITLE     Loss-of-function variants in C3ORF52 result in localized autosomal
            recessive hypotrichosis
  JOURNAL   Genet Med 22 (7), 1227-1234 (2020)
   PUBMED   32336749
REFERENCE   5  (bases 1 to 4001)
  AUTHORS   Yu,X., Lu,J., Li,J., Guan,W., Deng,S., Deng,Q., Ye,H., Han,W.,
            Yu,Y. and Zhang,R.
  TITLE     Serum Triglyceride Lipase Concentrations are Independent Risk
            Factors for Coronary Artery Disease and In-Stent Restenosis
  JOURNAL   J Atheroscler Thromb 26 (9), 762-774 (2019)
   PUBMED   30651409
  REMARK    GeneRIF: High LIPH expression is associated with Coronary Artery
            Disease.
REFERENCE   6  (bases 1 to 4001)
  AUTHORS   Aslam,M., Chahrour,M.H., Razzaq,A., Haque,S., Yan,K., Leal,S.M. and
            Ahmad,W.
  TITLE     A novel locus for autosomal recessive form of hypotrichosis maps to
            chromosome 3q26.33-q27.3
  JOURNAL   J Med Genet 41 (11), 849-852 (2004)
   PUBMED   15520410
REFERENCE   7  (bases 1 to 4001)
  AUTHORS   Hiramatsu,T., Sonoda,H., Takanezawa,Y., Morikawa,R., Ishida,M.,
            Kasahara,K., Sanai,Y., Taguchi,R., Aoki,J. and Arai,H.
  TITLE     Biochemical and molecular characterization of two phosphatidic
            acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta
  JOURNAL   J Biol Chem 278 (49), 49438-49447 (2003)
   PUBMED   12963729
REFERENCE   8  (bases 1 to 4001)
  AUTHORS   Wen,X.Y., Hegele,R.A., Wang,J., Wang,D.Y., Cheung,J., Wilson,M.,
            Yahyapour,M., Bai,Y., Zhuang,L., Skaug,J., Young,T.K.,
            Connelly,P.W., Koop,B.F., Tsui,L.C. and Stewart,A.K.
  TITLE     Identification of a novel lipase gene mutated in lpd mice with
            hypertriglyceridemia and associated with dyslipidemia in humans
  JOURNAL   Hum Mol Genet 12 (10), 1131-1143 (2003)
   PUBMED   12719377
REFERENCE   9  (bases 1 to 4001)
  AUTHORS   Sonoda,H., Aoki,J., Hiramatsu,T., Ishida,M., Bandoh,K., Nagai,Y.,
            Taguchi,R., Inoue,K. and Arai,H.
  TITLE     A novel phosphatidic acid-selective phospholipase A1 that produces
            lysophosphatidic acid
  JOURNAL   J Biol Chem 277 (37), 34254-34263 (2002)
   PUBMED   12063250
  REMARK    GeneRIF: PA-selective PLA(1) has a role in LPA production.
REFERENCE   10 (bases 1 to 4001)
  AUTHORS   Jin,W., Broedl,U.C., Monajemi,H., Glick,J.M. and Rader,D.J.
  TITLE     Lipase H, a new member of the triglyceride lipase family
            synthesized by the intestine
  JOURNAL   Genomics 80 (3), 268-273 (2002)
   PUBMED   12213196
  REMARK    GeneRIF: mRNA expressed in intestine, lung, and pancreas. Lipase H
            protein was also detected in human intestine.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099661.11, AK122651.1,
            BC064941.1 and BI965988.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_139248.2.
            
            Summary: This gene encodes a membrane-bound member of the mammalian
            triglyceride lipase family. It catalyzes the production of 2-acyl
            lysophosphatidic acid (LPA), which is a lipid mediator with diverse
            biological properties that include platelet aggregation, smooth
            muscle contraction, and stimulation of cell proliferation and
            motility. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.208729.1, BC064941.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296252.9/ ENSP00000296252.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC099661.11        140838-140844       c
            8-20                AK122651.1         1-13
            21-2457             BC064941.1         1-2437
            2458-2481           BI965988.1         5-28                c
            2482-4001           AC099661.11        94518-96037         c
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..4001
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /note="lipase H"
                     /db_xref="GeneID:200879"
                     /db_xref="HGNC:HGNC:18483"
                     /db_xref="MIM:607365"
     exon            1..166
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1473
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /EC_number="2.7.11.30"
                     /note="membrane-bound phosphatidic acid-selective
                     phospholipase A1; mPA-PLA1 alpha; LPD lipase-related
                     protein; lipase, member H; membrane-associated
                     phosphatidic acid-selective phospholipase A1-alpha;
                     phospholipase A1 member B; phospholipase A(1)"
                     /codon_start=1
                     /product="lipase member H precursor"
                     /protein_id="NP_640341.1"
                     /db_xref="CCDS:CCDS3272.1"
                     /db_xref="GeneID:200879"
                     /db_xref="HGNC:HGNC:18483"
                     /db_xref="MIM:607365"
                     /translation="MLRFYLFISLLCLSRSDAEETCPSFTRLSFHSAVVGTGLNVRLM
                     LYTRKNLTCAQTINSSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMN
                     VVVVDWNRGATTLIYTHASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGVSLGAHIS
                     GFVGEMYDGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLG
                     NIDFYPNGGLDQPGCPKTILGGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDY
                     RNGKCVSCGTSQKESCPLLGYYADNWKDHLRGKDPPMTKAFFDTAEESPFCMYHYFVD
                     IITWNKNVRRGDITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAI
                     SLMFSTGSLIGPRYKLRILRMKLRSLAHPERPQLCRYDLVLMENVETVFQPILCPELQ
                     L"
     exon            167..534
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            535..643
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            644..745
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            746..835
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1003
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1099
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1211
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1385
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..4001
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3197..3202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /note="hexamer: ATTAAA"
     polyA_site      3218
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
     regulatory      3980..3985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /note="hexamer: AATAAA"
     polyA_site      4001
                     /gene="LIPH"
                     /gene_synonym="AH; ARWH2; HYPT7; LAH2; LPDLR; mPA-PLA1;
                     PLA1B"
                     /note="major polyA site"
ORIGIN      
        1 accacacctc tgagtcgtct gagctcactg tgagcaaaat cccacagtgg aaactcttaa
       61 gcctctgcga agtaaatcat tcttgtgaat gtgacacacg atctctccag tttccatatg
      121 ttgagattct acttattcat cagtttgttg tgcttgtcaa gatcagacgc agaagaaaca
      181 tgtccttcat tcaccaggct gagctttcac agtgcagtgg ttggtacggg actaaatgtg
      241 aggctgatgc tctacacaag gaaaaacctg acctgcgcac aaaccatcaa ctcctcagct
      301 tttgggaact tgaatgtgac caagaaaacc accttcattg tccatggatt caggccaaca
      361 ggctcccctc ctgtttggat ggatgactta gtaaagggtt tgctctctgt tgaagacatg
      421 aacgtagttg ttgttgattg gaatcgagga gctacaactt taatatatac ccatgcctct
      481 agtaagacca gaaaagtagc catggtcttg aaggaattta ttgaccagat gttggcagaa
      541 ggagcttctc ttgatgacat ttacatgatc ggagtaagtc taggagccca catatctggg
      601 tttgttggag agatgtacga tggatggctg gggagaatta caggcctcga ccctgcaggc
      661 cctttattca acgggaaacc tcaccaagac agattagatc ccagtgatgc gcagtttgtt
      721 gatgtcatcc attccgacac tgatgcactg ggctacaagg agccattagg aaacatagac
      781 ttctacccaa atggaggatt ggatcaacct ggctgcccca aaacaatatt gggaggattt
      841 cagtatttta aatgtgacca ccagaggtct gtatacctgt acctgtcttc cctgagagag
      901 agctgcacca tcactgcgta tccctgtgac tcctaccagg attataggaa tggcaagtgt
      961 gtcagctgcg gcacgtcaca aaaagagtcc tgtccccttc tgggctatta tgctgataat
     1021 tggaaagacc atctaagggg gaaagatcct ccaatgacga aggcattctt tgacacagct
     1081 gaggagagcc cattctgcat gtatcattac tttgtggata ttataacatg gaacaagaat
     1141 gtaagaagag gggacattac catcaaattg agagacaaag ctggaaacac cacagaatcc
     1201 aaaatcaatc atgaacccac cacatttcag aaatatcacc aagtgagtct acttgcaaga
     1261 tttaatcaag atctggataa agtggctgca atttccttga tgttctctac aggatctcta
     1321 ataggcccaa ggtacaagct caggattctc cgaatgaagt taaggtccct tgcccatccg
     1381 gagaggcctc agctgtgtcg gtatgatctt gtcctgatgg aaaacgttga aacagtcttc
     1441 caacctattc tttgcccaga gttgcagttg taactgttgc caggacacat ggccataaat
     1501 aatagaaaga aagctacaac cacaggctgt ttgaaagctt cacctcacct ttctgcaagg
     1561 cagaaaaagt atgaaaaaaa ccaaggcttt tttcagtagc gtcctatgga tgtcacattg
     1621 tacatcaaac aaccttgtga ttataaaacg atcctgggaa ggagccccta actagggcaa
     1681 gtcagaaata gccaggctcg cagcagcgca gcgctgtgtc tgctgtgtcc tggggcctcc
     1741 cttgttccga cctgtcaatt ctgctgcctg tcacgcgggt ggttctgccc atcgcggctg
     1801 cgggtcaagc atcttcaagg gaaggacgga ctggaggcct caccgtggac tcaactctgc
     1861 attctccgtg ccacattcct ccagttccca cacgtagaag ggaacgaaac tgacgtctac
     1921 ctcatggggc tgctgtgtgg gtttgggagg caaaaatcta tgaagggttt tttgaaatcc
     1981 cataggtgcc acatctatga gatgtttgat aaatgtgaat atgcttttac atttgggctt
     2041 atctaatttg caataagaga gcctctctct atcaacacca gcttctctct cgggctgttt
     2101 gctcagggaa ggcaagaaag ccacgtgctg gccctctgcc ttctctaaag tgctgttgga
     2161 gcatggagga gctggaggag atggggatgg actgacagct aagagggcgg ctgctgggac
     2221 tagatagtgg atgaagaaag aaggacgagg aagccgtggg gcagcctctt cacatgggga
     2281 caggggatgg agcatgaggc aagggaagga aaagcagagc ttatttttca cctaaggtgg
     2341 agaaggatca ctttacaggc aacgctcatt ttaagcaacc cttaagaaat gtttatgttt
     2401 ctttattacc aatgtaatct atgattattg aaggaaattt agaaaatgcg tagatacaaa
     2461 attaaaaaaa aatactgtcc acgatcctat tagaggtaat taatgttagc cttttggaac
     2521 aaggctgtca cctattttgc caacacgtga attcaaaaca tgaaccggtt tgcttttgga
     2581 gaatctgaag actccagttt gaggaatcct ttgcttccct ggaggtagat gctgtctgca
     2641 aatctagaat gacagcagga gtccagtcaa gaggtcctgt caggccaagg ccagaaagaa
     2701 gggaggacaa tccctggggc cagatgccca gtgtgagggg aggcatgatc tgtcccatgg
     2761 ctgtggccac tgcaggaagg tctgtgaaaa ggaggtgaca ggcccagtca cctcctcttc
     2821 acccaagtga ttgctccttc aactgctatc tgtgaaaata gcctttgtta tgaagaaatt
     2881 gactctctct ctcttttttt ttttttggag ttgcctaggc tggagtgcaa tggtacgatc
     2941 tcagctcact gcaacctcca cctcccaggt tcaattgatt ctcctgcctc agcctcctga
     3001 gtagctggga ttacaggcat gtgccaccac acccggctaa tttttgtatt tttattagag
     3061 acagggtttc accacgttag ccaggctcgt ctcgaactcc tgtcctcagg tgactacccg
     3121 tctcggcctc ccaaagtgct gggattacag gcatgagcca ccacacccgg ccaaaaatgg
     3181 attctctatg tcataaatta aagaaatcta taaatgtatt cctgtgtggc acatcttctt
     3241 acagatttac atttgcagca aatacagagt ctgttttatt taagtgaggg atgactgaac
     3301 tctgagtgga acaagctctt ggacatgtta ccatccttcc tcctccttct cacatttcct
     3361 cagcaattgt ggatagagag atcagtgtgc tgtaggccct ggtttttttt tttttttttt
     3421 tttttttttt ttagatggag tctccttctg ttacccaggc tggagtgcag tggcacgatc
     3481 ttggctcact gcaacctctg cctcccgggt tcaagcaatt ctctgcctca gcctcccaag
     3541 tagctgggat tacaggcgcc cccaccatgc ctggctaatt tttgtatttt tagtagagac
     3601 ctggtttcac catcttggcc ttgaactcct gaccttgtga tccactggcc ttggcctctc
     3661 aaagttctgg gattacaggt gtgagccatc gtacccggca gccctggttt cttcttagtt
     3721 ttattggtct gtgttttgat cagcacagtc acttttttgt tctctttcct ggtaagcagg
     3781 gagtcaaaac aatagcaaga aaatgccaga aatagaattt ctactacttt gtaaactcta
     3841 ggctcgtggg tctcctagct ctcagtacct ggctcactgt aggatgggta gatgggtgaa
     3901 tgaatggata aagaaaggaa gtttgttcac cggagaggag atgaatttca gtaagtttca
     3961 tgtaacagtg atcaggagaa ataaaggcag ttataactgt g
//
