LOCUS       NM_006033              10418 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens lipase G, endothelial type (LIPG), transcript variant
            1, mRNA.
ACCESSION   NM_006033
VERSION     NM_006033.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10418)
  AUTHORS   Zhang,Q., Du,Z., Zhou,W., Li,W., Yang,Q., Yu,H. and Liu,T.
  TITLE     ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via
            IGF2BP1 Palmitoylation
  JOURNAL   Cancer Gene Ther 31 (9), 1427-1437 (2024)
   PUBMED   39069526
  REMARK    GeneRIF: ZDHHC1 downregulates LIPG and inhibits colorectal cancer
            growth via IGF2BP1 Palmitoylation.
REFERENCE   2  (bases 1 to 10418)
  AUTHORS   Sylvers-Davie,K.L., Bierstedt,K.C., Schnieders,M.J. and
            Davies,B.S.J.
  TITLE     Endothelial lipase variant T111I does not alter inhibition by
            angiopoietin-like proteins
  JOURNAL   Sci Rep 14 (1), 4246 (2024)
   PUBMED   38379026
  REMARK    GeneRIF: Endothelial lipase variant T111I does not alter inhibition
            by angiopoietin-like proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10418)
  AUTHORS   Huang,J., Liu,R., Zhang,Y. and Sheng,X.
  TITLE     Mechanistic analysis of endothelial lipase G promotion of the
            occurrence and development of cervical carcinoma by activating the
            phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase
            B/mechanistic target of rapamycin kinase signalling pathway
  JOURNAL   J Obstet Gynaecol 43 (1), 2151353 (2023)
   PUBMED   36606668
  REMARK    GeneRIF: Mechanistic analysis of endothelial lipase G promotion of
            the occurrence and development of cervical carcinoma by activating
            the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase
            B/mechanistic target of rapamycin kinase signalling pathway.
REFERENCE   4  (bases 1 to 10418)
  AUTHORS   Yi,J., Wu,M., Zheng,Z., Zhou,Q., Li,X., Lu,Y. and Liu,P.
  TITLE     Integrated analysis of DNA methylome and transcriptome reveals
            SFRP1 and LIPG as potential drivers of ovarian cancer metastasis
  JOURNAL   J Gynecol Oncol 34 (6), e71 (2023)
   PUBMED   37417299
  REMARK    GeneRIF: Integrated analysis of DNA methylome and transcriptome
            reveals SFRP1 and LIPG as potential drivers of ovarian cancer
            metastasis.
REFERENCE   5  (bases 1 to 10418)
  AUTHORS   Gago-Dominguez,M., Redondo,C.M., Calaza,M., Matabuena,M.,
            Bermudez,M.A., Perez-Fernandez,R., Torres-Espanol,M., Carracedo,A.
            and Castelao,J.E.
  TITLE     LIPG endothelial lipase and breast cancer risk by subtypes
  JOURNAL   Sci Rep 11 (1), 10436 (2021)
   PUBMED   34001944
  REMARK    GeneRIF: LIPG endothelial lipase and breast cancer risk by
            subtypes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10418)
  AUTHORS   Cohen,J.C.
  TITLE     Endothelial lipase: direct evidence for a role in HDL metabolism
  JOURNAL   J Clin Invest 111 (3), 318-321 (2003)
   PUBMED   12569156
  REMARK    GeneRIF: Endothelial lipase has a role in HDL metabolism [review]
            Review article
REFERENCE   7  (bases 1 to 10418)
  AUTHORS   Strauss,J.G., Zimmermann,R., Hrzenjak,A., Zhou,Y., Kratky,D.,
            Levak-Frank,S., Kostner,G.M., Zechner,R. and Frank,S.
  TITLE     Endothelial cell-derived lipase mediates uptake and binding of
            high-density lipoprotein (HDL) particles and the selective uptake
            of HDL-associated cholesterol esters independent of its enzymic
            activity
  JOURNAL   Biochem J 368 (Pt 1), 69-79 (2002)
   PUBMED   12164779
  REMARK    GeneRIF: EDL mediates both HDL binding and uptake, and the
            selective uptake of HDL-CE, independently of lipolysis and CLA-1.
REFERENCE   8  (bases 1 to 10418)
  AUTHORS   McCoy,M.G., Sun,G.S., Marchadier,D., Maugeais,C., Glick,J.M. and
            Rader,D.J.
  TITLE     Characterization of the lipolytic activity of endothelial lipase
  JOURNAL   J Lipid Res 43 (6), 921-929 (2002)
   PUBMED   12032167
REFERENCE   9  (bases 1 to 10418)
  AUTHORS   Hirata,K., Dichek,H.L., Cioffi,J.A., Choi,S.Y., Leeper,N.J.,
            Quintana,L., Kronmal,G.S., Cooper,A.D. and Quertermous,T.
  TITLE     Cloning of a unique lipase from endothelial cells extends the
            lipase gene family
  JOURNAL   J Biol Chem 274 (20), 14170-14175 (1999)
   PUBMED   10318835
REFERENCE   10 (bases 1 to 10418)
  AUTHORS   Jaye,M., Lynch,K.J., Krawiec,J., Marchadier,D., Maugeais,C.,
            Doan,K., South,V., Amin,D., Perrone,M. and Rader,D.J.
  TITLE     A novel endothelial-derived lipase that modulates HDL metabolism
  JOURNAL   Nat Genet 21 (4), 424-428 (1999)
   PUBMED   10192396
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF118767.1, BC060825.1,
            AI861822.1 and AC091170.15.
            
            On Nov 23, 2018 this sequence version replaced NM_006033.3.
            
            Summary: The protein encoded by this gene has substantial
            phospholipase activity and may be involved in lipoprotein
            metabolism and vascular biology. This protein is designated a
            member of the TG lipase family by its sequence and characteristic
            lid region which provides substrate specificity for enzymes of the
            TG lipase family. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF118767.1, BC060825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261292.9/ ENSP00000261292.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3927              AF118767.1         1-3927
            3928-4135           BC060825.1         3925-4132
            4136-4141           AI861822.1         3-8                 c
            4142-10418          AC091170.15        20815-27091         c
FEATURES             Location/Qualifiers
     source          1..10418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..10418
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /note="lipase G, endothelial type"
                     /db_xref="GeneID:9388"
                     /db_xref="HGNC:HGNC:6623"
                     /db_xref="MIM:603684"
     exon            1..349
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1755
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.32"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; endothelial cell-derived lipase; endothelial
                     lipase; lipoprotein lipase H; lipase, endothelial;
                     phospholipase A1"
                     /codon_start=1
                     /product="endothelial lipase isoform 1 precursor"
                     /protein_id="NP_006024.1"
                     /db_xref="CCDS:CCDS11938.1"
                     /db_xref="GeneID:9388"
                     /db_xref="HGNC:HGNC:6623"
                     /db_xref="MIM:603684"
                     /translation="MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTE
                     VKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWL
                     HKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSL
                     GNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDV
                     LHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHER
                     AVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKM
                     YLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQ
                     NATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIR
                     VKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP"
     exon            350..531
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            532..711
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            712..823
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1045
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1288
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1409
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1628
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1733
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..10418
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3478
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /note="major polyA site"
     regulatory      4118..4123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /note="hexamer: AATAAA"
     polyA_site      4136
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /note="major polyA site"
     regulatory      10393..10398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /note="hexamer: AATAAA"
     polyA_site      10418
                     /gene="LIPG"
                     /gene_synonym="EDL; EL; PRO719"
                     /note="major polyA site"
ORIGIN      
        1 agcagcgagt ccttgcctcc cggcggctca ggacgagggc agatctcgtt ctggggcaag
       61 ccgttgacac tcgctccctg ccaccgcccg ggctccgtgc cgccaagttt tcattttcca
      121 ccttctctgc ctccagtccc ccagcccctg gccgagagaa gggtcttacc ggccgggatt
      181 gctggaaaca ccaagaggtg gtttttgttt tttaaaactt ctgtttcttg ggagggggtg
      241 tggcggggca ggatgagcaa ctccgttcct ctgctctgtt tctggagcct ctgctattgc
      301 tttgctgcgg ggagccccgt accttttggt ccagagggac ggctggaaga taagctccac
      361 aaacccaaag ctacacagac tgaggtcaaa ccatctgtga ggtttaacct ccgcacctcc
      421 aaggacccag agcatgaagg atgctacctc tccgtcggcc acagccagcc cttagaagac
      481 tgcagtttca acatgacagc taaaaccttt ttcatcattc acggatggac gatgagcggt
      541 atctttgaaa actggctgca caaactcgtg tcagccctgc acacaagaga gaaagacgcc
      601 aatgtagttg tggttgactg gctccccctg gcccaccagc tttacacgga tgcggtcaat
      661 aataccaggg tggtgggaca cagcattgcc aggatgctcg actggctgca ggagaaggac
      721 gatttttctc tcgggaatgt ccacttgatc ggctacagcc tcggagcgca cgtggccggg
      781 tatgcaggca acttcgtgaa aggaacggtg ggccgaatca caggtttgga tcctgccggg
      841 cccatgtttg aaggggccga catccacaag aggctctctc cggacgatgc agattttgtg
      901 gatgtcctcc acacctacac gcgttccttc ggcttgagca ttggtattca gatgcctgtg
      961 ggccacattg acatctaccc caatgggggt gacttccagc caggctgtgg actcaacgat
     1021 gtcttgggat caattgcata tggaacaatc acagaggtgg taaaatgtga gcatgagcga
     1081 gccgtccacc tctttgttga ctctctggtg aatcaggaca agccgagttt tgccttccag
     1141 tgcactgact ccaatcgctt caaaaagggg atctgtctga gctgccgcaa gaaccgttgt
     1201 aatagcattg gctacaatgc caagaaaatg aggaacaaga ggaacagcaa aatgtaccta
     1261 aaaacccggg caggcatgcc tttcagagtt taccattatc agatgaaaat ccatgtcttc
     1321 agttacaaga acatgggaga aattgagccc accttttacg tcacccttta tggcactaat
     1381 gcagattccc agactctgcc actggaaata gtggagcgga tcgagcagaa tgccaccaac
     1441 accttcctgg tctacaccga ggaggacttg ggagacctct tgaagatcca gctcacctgg
     1501 gagggggcct ctcagtcttg gtacaacctg tggaaggagt ttcgcagcta cctgtctcaa
     1561 ccccgcaacc ccggacggga gctgaatatc aggcgcatcc gggtgaagtc tggggaaacc
     1621 cagcggaaac tgacattttg tacagaagac cctgagaaca ccagcatatc cccaggccgg
     1681 gagctctggt ttcgcaagtg tcgggatggc tggaggatga aaaacgaaac cagtcccact
     1741 gtggagcttc cctgagggtg cccgggcaag tcttgccagc aaggcagcaa gacttcctgc
     1801 tatccaagcc catggaggaa agttactgct gaggacccac ccaatggaag gattcttctc
     1861 agccttgacc ctggagcact gggaacaact ggtctcctgt gatggctggg actcctcgcg
     1921 ggaggggact gcgctgctat agctcttgct gcctctcttg aatagctcta actccaaacc
     1981 tctgtccaca cctccagagc accaagtcca gatttgtgtg taagcagctg ggtgcctggg
     2041 gcctctcgtg cacactggat tggtttctca gttgctgggc gagcctgtac tctgcctgac
     2101 gaggaacgct ggctccgaag aggccctgtg tagaaggctg tcagctgctc agcctgcttt
     2161 gagcctcagt gagaagtcct tccgacagga gctgactcat gtcaggatgg caggcctggt
     2221 atcttgctcg ggccctagct gttggggttc tcatgggttg cactgaccat actgcttacg
     2281 tcttagccat tccgtcctgc tccccagctc actctctgaa gcacacatca ttggctttcc
     2341 tatttttctg ttcatttttt aattgagcaa atgtctattg aacacttaaa attaattaga
     2401 atgtggtaat ggacatatta ctgagcctct ccatttggaa cccagtggag ttgggatttc
     2461 tagaccctct ttctgtttgg atggtgtatg tgtatatgca tggggaaagg cacctggggc
     2521 ctgggggagg ctataggata taagcattag ggaccctgag gctttaagtg gtttctattt
     2581 cttcttagtt attatgtgcc accttcttag ttattatgtg ccacctcccc tatgagtgac
     2641 gtgtttgatc actagcagaa tagcaagcag agtatcattc atgctggggc cagaatgatg
     2701 gccggttgcc agatataact gctttggagc aaatctcttc tgtttagaga gatagaagtt
     2761 atgacatatg taatacacat ctgtgtacac agaaaccggc acctgccaga cagagctggt
     2821 tctaagattt aatacagtgc tttttttcct ctttgaaata ttttacttta ataccagtgc
     2881 cttttcttgt tgaacttctt ggaaaagcca ccaattctag atcttgattt gaattaatac
     2941 acacaatatc tgagacactt acacttttca aaagatttgt gtatgcattg cctaattaga
     3001 gtagggggag aagggcaact attattatcc ctattttaca aaactgaggc ttagtgaggt
     3061 tcagccacat gcctagactt atatactagt tagtggtgca gccagggaga ggactcagat
     3121 ttcctggagg caaagtctat ctctgaaact ccatgaagac ttttgcagcc agttcccacc
     3181 aatatgcccc agacgtgaga caaacaagga cttttttttt tatatagagc catccataaa
     3241 atcctaagcc cttttattaa tgtataacca ggagaacatc tgtgccaacg gttggacttt
     3301 ttatggctga gattcgggag gaagtgtgac accaagcagg agaggaagaa tgattttctt
     3361 tgtacttagg ttttctaagg acattgtttt aatctgtatc gtgccaaagt tgtatcactg
     3421 ttaaacttct gaagacataa ccagttgagt cttatttcaa gatatgttct caagccaatt
     3481 gtgtgcttct cttgtttctg tgattgcttt ctagccaaag cgaagcttgt acaggttgag
     3541 tatcccttat ccaaaatgct tggaaccaga agtgtttcaa attttagatt attttcagat
     3601 tttggaatgt ttgcatatac ataatgagat attttgggaa taggacccga gcctaaacac
     3661 aaaattcatt gatgtgtcag ttacacctta tccacatagc ctgagggtaa ttttatacga
     3721 tattttaaat agttgtgtac atgaagcatg gtttgtggta acttatgtga ggggttttcc
     3781 cattttttgt cttgttggtg ctcaaaaagt tttggatttt ggagcatttc ggattttgga
     3841 tttttggatt agggttgctc aacccatatt attggctgta catcctggtc acttctgact
     3901 tctgttttta ctaatggaag ctttgcaaat tgaattctca gtgagttgta tatttataca
     3961 cctggcttga agccttaatt gtatataatg atgcttttta aaaaatgcta tttggaagac
     4021 tatttatttc tcgtgtatat aatgtatata aaaaaatatg gttagtgttt acctaaggtt
     4081 aaccaatttc aagattaaaa tttttaaata gtaaaataat aaaaaattat aaagttctta
     4141 atggtctgac aactcaattt tttttttttt tttttttttt tttgagacag agcctctctc
     4201 tgtcacccag gctggagtgc agtggcaatc ttggctcact acaacctctg cctcctgggc
     4261 tcaggtggtc ctcccacctc agccttctga gtagctggga ttacagagat gcgtcaccat
     4321 gtctggctaa tttttgtatt tttagtagag atggggtttc gccatgttgg ccaggctggt
     4381 caggctgggt tcgaactcct ggcctcaagt gatccgcctg cctcagcctc tgaaagttct
     4441 gagattatag gtgtgagcca ccgtgcctgg ccaattctta aagtttgaaa gaatatagct
     4501 gccccaacct agagtctgac aaaaagttac tctaatataa ggcatattct ttatttgaca
     4561 ctcatcgtta gcagaagtgg acagcaattc actaaagaac cagaacaaga acatcatttc
     4621 actgaagacg agaagaaaaa ttatttcaat tgtagcagct tgaaggcctg aaggtggatg
     4681 ttaggaagaa cagggagcat ggctggacac tggggagcat tagtgagatt attaggtttg
     4741 gttgaattgg aactagatat cagtgactta gaccagaggg aagctgattt ctctattggt
     4801 taaagtccca gctggtagta aggttctatt ctacaggcca agagggctgc aggttcttag
     4861 tttttcactg tgccattcat ggggtattcc tcgcatcccc acagcccagg ggtcccctac
     4921 cagccaatgg aaagccagaa aagggaaggg atgaacagtc tcctcttaaa gacatgactg
     4981 agaagttgct tacattctat tggccagaaa taaatccatg gtcacatgac aggctgggaa
     5041 atacagtctt tatttagggt gcccatgggc cctgctgaag atccaattac tatttattta
     5101 aaattgacat ataataattg tacatatttg tggggaaaat agtgatgttt cgatacatac
     5161 aaggtatagt gatcatgttg gaataattag catacccatc ctttcaaaca tgtatcattt
     5221 ctttgtgttg ggaacattca atatcctcct tctagttact tgaaaccata ttttattaac
     5281 tctagtttta cccttcagtg gtataggaca ctagaattta ttcctcctgt ctagctgtaa
     5341 tcttgtttgt ttcgtttggt gttttttgtt tttttgtttt tttttgagat ggagtcttgc
     5401 tctgtagccc aggctggagt gcaggggcat gatcttggcc cactgcaacc tccgcctcct
     5461 gggttcaagt gattctcctg cctcagcctc ccaagtagct gggattacag gcatgcacca
     5521 ccacacccag ctaatttttg tatttttagt agagacaagg tttcaccatg ttggccaggc
     5581 tggtcttgaa ctcctgacct caagtgatcc acctacctca gccttccaaa ctgtcgggat
     5641 taccggtgtg agccaccggg cccagccact agctgtaatt ttgtatcttt taacaattcc
     5701 gtccctattt cccctttccc cctaccaatt actatttatt aaaagggaaa ttggatcttg
     5761 ccatccgttt atcaggaatt agttttttct ctgctaaagc cagcgagata gaccagagta
     5821 ccctttaaat gattaaatcc tgtagtcaat ttttagtaat cttaaattga tctatgacta
     5881 tgaagtataa tgcattacat cagtttgact ttatttctgg tcttaagtgt gaaaacattt
     5941 ctaaatgaca aggaagctct ttataaaggg ctttagtgat ggtggaaact ccactgtcca
     6001 tctctaccag gacattctga aaccaggctt gataatggct gtagggagtt gggttagaca
     6061 ataagagata agttcttaac ttggttcaga tgtcagagga aagcagaaaa tggtgtctct
     6121 ggcatagtaa agaaaattgt tgaaatttcc caaaggaaga gtcatagcct ggatgactgc
     6181 aagtgccttc tttggcttgg gggttcagtt actagttaga gtcaggggaa cttccacagg
     6241 acttcctttg actctccaaa caagctgaag ccccagaccc cttggaagga tggatacaaa
     6301 gtaggtacta gaacagtctt tgtcatcaaa tatggtattt ctcaggtgtc acctctgtgt
     6361 tcagagctac cctgagccct ctgccatgta agctctctga tggcacagat ttttatctgg
     6421 cttgttttct gccgttatct tagaagctag aatagtgtct ggaacatcat gggtattcaa
     6481 tgaatattta aataaataga tgaaattaga tataagaaac taggtgctta aacaggcagg
     6541 aggtaatctg ggaaaagagc agttagtttg gaatcagaat tcttggtgtg tcatccagca
     6601 ttatgtgagt tttaggctaa atacagcctt tctgagtctc tatctgctca tttaagaaac
     6661 agagacaata ctgctcaggg ttgttgtgaa tgttaaaggt acatggtaaa aaagaaagta
     6721 tttgtgtttt gtaaacattt gaattgataa gaggacagtg tgagacaaaa ataaaatcct
     6781 gggtgggcac ggtggctcac ccctgtaatc tcagcacttt gggaggctga gatgggagga
     6841 tcacgaggtc aggagtgcga gaccagcctg gccaatatgg tgaaaccacg tctctgctaa
     6901 aaatacaaaa attagctggg cgtggtggca cgtgcctgta gtcccagcta cgccggaggc
     6961 tgaggcagaa gaatcgctcg aacctgggag atggagtttg cagtgagctg agatcacgcc
     7021 actgcactcc agcctaggca actgagtgag actccatctc aaaataaaat aaaatagaat
     7081 agaataaaat aaaatccttt ccacatatat gcggaaattt tatgtatgat aaaaggggcc
     7141 tattagtctt tgggaaagga atggatggat gatgagaaag taggctcatt tgacaaagag
     7201 aaacaaaatt agattcctat tttaacacgc aacaaagatg aattccaaaa tacctattgg
     7261 gtactatgct tattacctga gtgacgaaat aatctgtaca gcaaactcct gtgacacacc
     7321 atttaactac ataacaaacc tgcatacgta cccctgaaac taaagtagaa gttaaaacca
     7381 tcaacccccc caaaacaaaa atgaattcca tctgaataaa aggtataaat gtgaaagtca
     7441 tcatgctaat agatattatg aaatataaat tcaaaacctg tataaaaact gaaaaaatgt
     7501 aaaacgtcac aattagaata agaaaattta aatagaacaa tgaatattaa ataaactaaa
     7561 atgctaataa aatgtactcc ttagggccag gtgcggtggc tcacacctgt aatcccagca
     7621 ctttgggagg ccgaggtggg tggatcacct gaggtcagga gtttgagacc agcctggcca
     7681 atgtggtgaa accctgtctc tactaaaaat acaaaaagtt agccaggtgt gatggtgggc
     7741 acctgtaatc ccagctactt gggaggctga ggtaggaaaa tcacttgaac ccagaaggca
     7801 gaagttgcag tgagcctaga tcacggcact acactccagc ctgggcaaca agagcaaatc
     7861 tctatctcaa aaaaaaaaaa aaaaaaaaaa aggccacaga aatgtccatc cagcaggtgg
     7921 acaattaccc ttttgtcagc cgttcctctg ttgctgacca ttagatccac atttcttttc
     7981 tgtccgccct ggtcccctgg tgcccccttt cctggcccct gtgacatatt gtcatgtagc
     8041 tccaagtatt tccccccctc atatccctca agtgctccat tttccaaatg catttgactt
     8101 cctactctct tagccccagc tctctggtat tctgtgtagc tgacttccac aagggatctg
     8161 ttgggagctt gtaactgaac tgaagtcatg cacattgtca atggctagta gacctttacc
     8221 tggtccagag ttgtctgcat tgtttaaaga agacgtttgt taatccaaat taatctttga
     8281 tttgcatgga ggcagtaggt caaatcaaaa ggaaattttc ctctccctag caagcaaact
     8341 cagaaacaaa caaacaaacg aaaaccaaga aacaaaagga aaggttcctg ttgggataga
     8401 gaaacagtgg agcagggcag ccaccttaca cataggctag atctgcttgg gaatctttct
     8461 tctaatcgag gcccctaaaa tattcctgat tttcacagtt gatttcattt cttccctcct
     8521 gaacttacag agcctttcag taaacaccag tatttgtccc tccccgtgta tgcccagtgg
     8581 tttccatggc agcaacggtt gccatagaga ggtgaagaga ggtgtcggtg ccctcttttg
     8641 taactgtggg ttatctatag attgggggtg gcctctccta aaaaagacta atatgtaaat
     8701 aaaaggaata agaatcaaac aaatataaat cagggctcaa gtcatttgtt ttcctaaacc
     8761 tttgtggtta tccataccat ttaaccttga ctttccttaa atcataccgg tgcgtgtgtg
     8821 tgtgcagagg gaaagggctg caagaagact ctggaagcta ggacaggtct cagcaggtga
     8881 gggctcaggc ccagaggcca gctggggcag cagggagcag agttatctgg gccatttgct
     8941 aattatctca gcccagacga gtctgcacgc tatgtggttt aataccttca ccagaggcaa
     9001 atggttttgg actcacaaga attgctcatg gccagaggca atggacagat gccatatgag
     9061 aaagggctga ggccaggaac agaggcaggg ttatctcact ggaatggaga agctaaaatg
     9121 acattatctt tacttctgcc ctggttatta tcccaaggca acttcagtgg gcttgttttg
     9181 aagtcaaagc ctcaactatt tattgtgagg gagataattc attttcattt tcctgccaga
     9241 gatgtcagtc ttactattca tcctgtatcc tctattagat acacagagct tcttccttct
     9301 gcttaggctg ccccaaattc catataggat tctttttgaa gaatatatat catccaaaaa
     9361 gaggtcctag gaaatgtggc ttcacaaccc tggggtttgt ttccctggct gctgtctctc
     9421 tctctctctt ttttaatttt ttttggagac acggtatcac tgtgtggccc aggctggagt
     9481 gtggtggcgc catcactgct cactgcagcc tcgacctcct gggctcaagc agtcctccca
     9541 cttcagcctc ccaaatagct gggactacag gtgtactcca ctatgcctgg ctacattttg
     9601 aattttttgt agagatgggg ttttgccatg ttgctcaggt tggtctcaaa ctcctgggct
     9661 caagcaatcc acccaacttg gcctcccaaa gtgctgggat tagaggcatg agccatcagg
     9721 cctggccatg ctgcctctct ctccttcaag gtagacttcc tctttccttc cccttctccc
     9781 tgcttctttc tccttctcct ctccttctcc tcttctcctt cttcttctca cagcttttta
     9841 ttgacttata acaggcacac aataaactgc acacaggtaa atcatataat ttgacatttt
     9901 ggtacaggaa atcatcatga aactgaaagc attaccacat cgagattgtg aacataccac
     9961 caccagaagt tttcttgtgc ccctttgtaa ttcttcccac tgccctctcc ccaggttgtc
    10021 cctgatctgc tttttgtcct tgtagattag ttgcattttc tagaattttg tataagtgga
    10081 gtgtatctac agtatgttct cttttgtgtc tgccttcttg tactcagcat aattattttg
    10141 agattcatcc acgtctttgc atggatcagt catctgttcc attttattgc taagcagtat
    10201 tccactgtat agataaataa cattttgttt atccgtttac ttgttgatga actttaagtt
    10261 gtttccagtt ttgagttatt agagtaatgc tactatgaac atttgcatat gaatccttgt
    10321 atggacatga actttcattt cttttgggag taggatagct ggatcatatg gaatgtatat
    10381 gtttaacttt taaataaact gccaaactgt tttccaaa
//
