LOCUS       NM_005357               3768 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lipase E, hormone sensitive type (LIPE), transcript
            variant 11, mRNA.
ACCESSION   NM_005357
VERSION     NM_005357.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Zambrano,C., Kulyte,A., Lujan,J., Rivero-Gutierrez,B., Sanchez de
            Medina,F., Martinez-Augustin,O., Ryden,M., Scheer,F.A.J.L. and
            Garaulet,M.
  TITLE     Habitual nappers and non-nappers differ in circadian rhythms of
            LIPE expression in abdominal adipose tissue explants
  JOURNAL   Front Endocrinol (Lausanne) 14, 1166961 (2023)
   PUBMED   37361522
  REMARK    GeneRIF: Habitual nappers and non-nappers differ in circadian
            rhythms of LIPE expression in abdominal adipose tissue explants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Sommerer,Y., Dobricic,V., Schilling,M., Ohlei,O., Sabet,S.S.,
            Wesse,T., Fuss,J., Franzenburg,S., Franke,A., Parkkinen,L.,
            Lill,C.M. and Bertram,L.
  TITLE     Entorhinal cortex epigenome-wide association study highlights four
            novel loci showing differential methylation in Alzheimer's disease
  JOURNAL   Alzheimers Res Ther 15 (1), 92 (2023)
   PUBMED   37149695
  REMARK    GeneRIF: Entorhinal cortex epigenome-wide association study
            highlights four novel loci showing differential methylation in
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Zareie,R., Yuzbashian,E., Rahimi,H., Asghari,G., Zarkesh,M.,
            Hedayati,M., Djazayery,A., Movahedi,A., Mirmiran,P. and Khalaj,A.
  TITLE     Dietary fat content and adipose triglyceride lipase and
            hormone-sensitive lipase gene expressions in adults' subcutaneous
            and visceral fat tissues
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 165, 102244 (2021)
   PUBMED   33445064
  REMARK    GeneRIF: Dietary fat content and adipose triglyceride lipase and
            hormone-sensitive lipase gene expressions in adults' subcutaneous
            and visceral fat tissues.
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Shajari,S., Saeed,A., Smith-Cortinez,N.F., Heegsma,J., Sydor,S. and
            Faber,K.N.
  TITLE     Hormone-sensitive lipase is a retinyl ester hydrolase in human and
            rat quiescent hepatic stellate cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (9), 1258-1267
            (2019)
   PUBMED   31150775
  REMARK    GeneRIF: HSL regulates vitamin A metabolism in quiescent hepatic
            stellate cells.
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Anthonsen,M.W., Ronnstrand,L., Wernstedt,C., Degerman,E. and
            Holm,C.
  TITLE     Identification of novel phosphorylation sites in hormone-sensitive
            lipase that are phosphorylated in response to isoproterenol and
            govern activation properties in vitro
  JOURNAL   J Biol Chem 273 (1), 215-221 (1998)
   PUBMED   9417067
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Holst,L.S., Langin,D., Mulder,H., Laurell,H., Grober,J., Bergh,A.,
            Mohrenweiser,H.W., Edgren,G. and Holm,C.
  TITLE     Molecular cloning, genomic organization, and expression of a
            testicular isoform of hormone-sensitive lipase
  JOURNAL   Genomics 35 (3), 441-447 (1996)
   PUBMED   8812477
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Levitt,R.C., Liu,Z., Nouri,N., Meyers,D.A., Brandriff,B. and
            Mohrenweiser,H.M.
  TITLE     Mapping of the gene for hormone sensitive lipase (LIPE) to
            chromosome 19q13.1-->q13.2
  JOURNAL   Cytogenet Cell Genet 69 (3-4), 211-214 (1995)
   PUBMED   7698015
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Langin,D., Laurell,H., Holst,L.S., Belfrage,P. and Holm,C.
  TITLE     Gene organization and primary structure of human hormone-sensitive
            lipase: possible significance of a sequence homology with a lipase
            of Moraxella TA144, an antarctic bacterium
  JOURNAL   Proc Natl Acad Sci U S A 90 (11), 4897-4901 (1993)
   PUBMED   8506334
REFERENCE   10 (bases 1 to 3768)
  AUTHORS   Holm,C., Kirchgessner,T.G., Svenson,K.L., Fredrikson,G.,
            Nilsson,S., Miller,C.G., Shively,J.E., Heinzmann,C., Sparkes,R.S.,
            Mohandas,T. et al.
  TITLE     Hormone-sensitive lipase: sequence, expression, and chromosomal
            localization to 19 cent-q13.3
  JOURNAL   Science 241 (4872), 1503-1506 (1988)
   PUBMED   3420405
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070041.1 and AK292482.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005357.3.
            
            Summary: The protein encoded by this gene has a long and a short
            form, generated by use of alternative translational start codons.
            The long form is expressed in steroidogenic tissues such as testis,
            where it converts cholesteryl esters to free cholesterol for
            steroid hormone production. The short form is expressed in adipose
            tissue, among others, where it hydrolyzes stored triglycerides to
            free fatty acids. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U40002.1, BC070041.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244289.9/ ENSP00000244289.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1695              BC070041.1         39-1733
            1696-3485           AK292482.1         1714-3503
            3486-3768           BC070041.1         3524-3806
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3768
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /note="lipase E, hormone sensitive type"
                     /db_xref="GeneID:3991"
                     /db_xref="HGNC:HGNC:6621"
                     /db_xref="MIM:151750"
     exon            1..1122
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..3470
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /EC_number="3.1.1.79"
                     /EC_number="3.1.1.23"
                     /note="isoform 11 is encoded by transcript variant 11;
                     lipase, hormone-sensitive; retinyl ester hydrolase;
                     monoacylglycerol lipase LIPE; hormone-sensitive lipase"
                     /codon_start=1
                     /product="hormone-sensitive lipase isoform 11"
                     /protein_id="NP_005348.2"
                     /db_xref="CCDS:CCDS12607.1"
                     /db_xref="GeneID:3991"
                     /db_xref="HGNC:HGNC:6621"
                     /db_xref="MIM:151750"
                     /translation="MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQG
                     SNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQ
                     RVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQ
                     AKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRS
                     ALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSG
                     TSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRL
                     SGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSR
                     YVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLT
                     ADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAAS
                     SLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSR
                     LLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIK
                     SNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISID
                     YSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAA
                     YGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNS
                     DQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSE
                     AALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLP
                     PEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSP
                     LLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLA
                     ALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH"
     exon            1123..1658
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1749
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1895
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2081
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2376
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2604
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2781
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..3206
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3768
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3751..3756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /note="hexamer: AATAAA"
     polyA_site      3768
                     /gene="LIPE"
                     /gene_synonym="AOMS4; FPLD6; HSL; LHS; REH"
                     /note="major polyA site"
ORIGIN      
        1 attcctaatc ctcccaccaa agaaagaggc acagagttca ttacttagtg ggggccagct
       61 gtgatcggcc aactgccagc tgccttaaaa aggaagacca gtgatgctag gatggagtga
      121 aacccaagag gaagtgccat catgaggaat caatgagaga tctgtgaaga gagagggctg
      181 ggtgggagcc cagaaggata gaacctggaa gatcaatatc tcccgtgagg gaaataacaa
      241 tggagccagg ttctaagtca gtgtctaggt cagactggca acctgaacca caccagaggc
      301 ctataacccc gctagagcct gggccagaaa agacacccat agcccagcca gaatcgaaga
      361 ctctgcaggg atccaatacc caacagaagc ctgcttcaaa ccaaagaccc ctcacccagc
      421 aggagacccc tgcacaacat gatgctgaat cccagaagga acctagagcc caacaaaaat
      481 ctgcttcaca agaggaattt cttgccccac agaagcccgc accacagcaa tcaccttaca
      541 tccaaagggt gctgctcact caacaggaag ctgcctccca gcagggacct gggctaggaa
      601 aagaatctat aactcaacag gagccagcat tgagacaaag acatgtagcc cagccagggc
      661 ctgggccagg agagccacct ccagctcaac aagaagctga atcaacacct gcggcccagg
      721 ctaaacctgg agccaaaagg gagccatctg ccccgactga atctacgtcc caagagacac
      781 ctgaacagtc agacaagcaa acaacgccag tccagggagc caaatccaag cagggatctt
      841 tgacagagct gggatttcta acaaaacttc aggaactatc catacagcga tcagccctag
      901 agtggaaggc actttctgag tgggtcacag attctgagtc agaatcagat gtgggatcat
      961 cttcagacac agattctcca gccacgatgg gtggaatggt ggcccaggga gtgaagctag
     1021 gcttcaaagg aaaatctggt tataaagtga tgtcaggata cagtgggacg tcgccacatg
     1081 agaaaaccag tgctcggaat cacagacact accaggatac agcctcaagg ctcatccaca
     1141 acatggacct gcgcacaatg acacagtcgc tggtgactct ggcggaggac aacatagcct
     1201 tcttctcgag ccagggtcct ggggaaacgg cccagcggct gtcaggcgtt tttgccggtg
     1261 tacgggagca ggcgctgggg ctggagccgg ccctgggccg cctgctgggt gtggcgcacc
     1321 tctttgacct ggacccagag acaccggcca acgggtaccg cagcctagtg cacacagccc
     1381 gctgctgcct ggcgcacctc ctgcacaaat cccgctatgt ggcctccaac cgccgcagca
     1441 tcttcttccg caccagccac aacctggccg agctggaggc ctacctggct gccctcaccc
     1501 agctccgcgc tctggtctac tacgcccagc gcctgctggt taccaatcgg ccgggggtac
     1561 tcttctttga gggcgacgag gggctcaccg ccgacttcct ccgggagtat gtcacgctgc
     1621 ataagggatg cttctatggc cgctgcctgg gcttccagtt cacgcctgcc atccggccat
     1681 tcctgcagac catctccatt gggctggtgt ccttcgggga gcactacaaa cgcaacgaga
     1741 caggcctcag tgtggccgcc agctctctct tcaccagcgg ccgctttgcc atcgaccccg
     1801 agctgcgtgg ggctgagttt gagcggatca cacagaacct ggacgtgcac ttctggaaag
     1861 ccttctggaa catcaccgag atggaagtgc tatcgtctct ggccaacatg gcatcggcca
     1921 ccgtgagggt aagccgcctg ctcagcctgc cacccgaagc ctttgagatg ccactgactg
     1981 ccgaccccac gctcacggtc accatctcac ccccactggc ccacacaggc cctgggcccg
     2041 tcctcgtcag gctcatctcc tatgacctgc gtgaaggaca ggacagtgag gagctcagca
     2101 gcctgataaa gtccaacggc caacggagcc tggagctgtg gccgcgcccc cagcaggcac
     2161 cccgctcgcg gtccctgata gtgcacttcc acggcggtgg ctttgtggcc cagacctcca
     2221 gatcccacga gccctacctc aagagctggg cccaggagct gggcgccccc atcatctcca
     2281 tcgactactc cctggcccct gaggccccct tcccccgtgc gctggaggag tgcttcttcg
     2341 cctactgctg ggccatcaag cactgcgccc tccttggctc aacaggggaa cgaatctgcc
     2401 ttgcggggga cagtgcaggc gggaacctct gcttcaccgt ggctcttcgg gcagcagcct
     2461 acggggtgcg ggtgccagat ggcatcatgg cagcctaccc ggccacaatg ctgcagcctg
     2521 ccgcctctcc ctcccgcctg ctgagcctca tggacccctt gctgcccctc agtgtgctct
     2581 ccaagtgtgt cagcgcctat gctggtgcaa agacggagga ccactccaac tcagaccaga
     2641 aagccctcgg catgatgggg ctggtgcggc gggacacagc cctgctcctc cgagacttcc
     2701 gcctgggtgc ctcctcatgg ctcaactcct tcctggagtt aagtgggcgc aagtcccaga
     2761 agatgtcgga gcccatagca gagccgatgc gccgcagtgt gtctgaagca gcactggccc
     2821 agccccaggg cccactgggc acggattccc tcaagaacct gaccctgagg gacttgagcc
     2881 tgaggggaaa ctccgagacg tcgtcggaca cccccgagat gtcgctgtca gctgagacac
     2941 ttagcccctc cacaccctcc gatgtcaact tcttattacc acctgaggat gcaggggaag
     3001 aggctgaggc caaaaatgag ctgagcccca tggacagagg cctgggcgtc cgtgccgcct
     3061 tccccgaggg tttccacccc cgacgctcca gccagggtgc cacacagatg cccctctact
     3121 cctcacccat agtcaagaac cccttcatgt cgccgctgct ggcacccgac agcatgctca
     3181 agagcctgcc acctgtgcac atcgtggcgt gcgcgctgga ccccatgctg gacgactcgg
     3241 tcatgctcgc gcggcgactg cgcaacctgg gccagccggt gacgctgcgc gtggtggagg
     3301 acctgccgca cggcttcctg accctagcgg cgctgtgccg cgagacgcgc caggccgcag
     3361 agctgtgcgt ggagcgcatc cgcctcgtcc tcactcctcc cgccggagcc gggccgagcg
     3421 gggagacggg ggctgcgggg gtagacgggg gctgcggggg gcgacactaa aagcctgttg
     3481 ttcccatctg cgccggcctc cgtcatgaat gccttccggg ccgggcggaa ggggacgcgg
     3541 gctgtgcctt acttaagtcg ggggtggcaa gggggcgggg cgggggcccg aaagctgaga
     3601 ccctcgccac ggggaggggg acgcgcacac acaccggtca ccgagacggc tggacctgca
     3661 cgccaccgct gccttttgct gctgctgctg cggcgaccgc cgcagggacg gggactggcc
     3721 ctcccttgca ggtcggtttg gtttgttgta aataaaagta tttaatta
//
