LOCUS       NM_001004432            2644 bp    mRNA    linear   PRI 15-SEP-2020
DEFINITION  Homo sapiens leucine rich repeat and Ig domain containing 4
            (LINGO4), mRNA.
ACCESSION   NM_001004432 XM_291387
VERSION     NM_001004432.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Liang H, Zheng W, Xu H, Lei J, Song Z, Jiang X, Zeng Z and Deng H.
  TITLE     No evidence of association between the LINGO4 gene and essential
            tremor in Chinese Han patients
  JOURNAL   Parkinsonism Relat. Disord. 18 (3), 303-305 (2012)
   PUBMED   22104011
  REMARK    GeneRIF: variants in coding region of the LINGO4 gene may play
            little or no role in the risk of Essential tremor susceptibility
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
            Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
            Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
            Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
            Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
            Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
            K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
            A, Wood WI, Godowski P and Gray A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589765.19.
            
            On Aug 5, 2019 this sequence version replaced NM_001004432.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.25781.1,
                                           SRR1803615.246381.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368820.4/ ENSP00000357810.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AL589765.19        127605-127794       c
            191-2644            AL589765.19        122639-125092       c
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2644
                     /gene="LINGO4"
                     /gene_synonym="DAAT9248; LRRN6D; PRO34002"
                     /note="leucine rich repeat and Ig domain containing 4"
                     /db_xref="GeneID:339398"
                     /db_xref="HGNC:HGNC:31814"
                     /db_xref="MIM:609794"
     exon            1..190
                     /gene="LINGO4"
                     /gene_synonym="DAAT9248; LRRN6D; PRO34002"
                     /inference="alignment:Splign:2.1.0"
     exon            191..2644
                     /gene="LINGO4"
                     /gene_synonym="DAAT9248; LRRN6D; PRO34002"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1985
                     /gene="LINGO4"
                     /gene_synonym="DAAT9248; LRRN6D; PRO34002"
                     /note="leucine-rich repeat neuronal protein 6D;
                     leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 4"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 4
                     precursor"
                     /protein_id="NP_001004432.1"
                     /db_xref="CCDS:CCDS30855.1"
                     /db_xref="GeneID:339398"
                     /db_xref="HGNC:HGNC:31814"
                     /db_xref="MIM:609794"
                     /translation="MDAATAPKQAWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAV
                     LCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPG
                     AFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQK
                     LEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGR
                     LPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLS
                     FLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADN
                     ALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQ
                     GKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRP
                     HGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPN
                     GTLSDPNITVPGIPGPFFLDSRGVAMVLAVGFLPFLTSVTLCFGLIALWSKGKGRVKH
                     HMTFDFVAPRPSGDKNSGGNRVTAKLF"
     polyA_site      2644
                     /gene="LINGO4"
                     /gene_synonym="DAAT9248; LRRN6D; PRO34002"
                     /note="major polyA site"
ORIGIN      
        1 agtcttggca gcagcggccg cagcagcaac agcagcagca gcagcggcag gcagcagccg
       61 ggcagccagg cagcgggggt tgaggcacac agggaaggtg caggggcctg aggtgcagct
      121 cgaatgggac agggccccca gcgctggaca gatgcagtgc caaacttgat gccaccttcc
      181 agcttctccg gactgaagag ggaatggatg cagccacagc tccaaagcaa gcctggcccc
      241 catggccccc gctccttttc ctcctcctcc tacctggagg gagcggtggc agctgccctg
      301 ctgtgtgtga ctgcacctcc cagccccagg ctgtgctctg tggccacagg caactggagg
      361 ctgtacctgg aggactccca ctggacactg agctcctgga cctgagtggg aaccgcctgt
      421 gggggctcca gcagggaatg ctctcccgcc tgagcctgct ccaggaattg gacctcagct
      481 acaaccagct ctcaaccctt gagcctgggg ccttccatgg cctacaaagc ctactcaccc
      541 tgaggctgca gggcaatcgg ctcagaatca tggggcctgg ggtcttctca ggcctctctg
      601 ctctgaccct gctggacctc cgcctcaacc agattgttct cttcctagat ggagcttttg
      661 gggagctagg cagcctccag aagctggagg ttggggacaa ccacctggta tttgtggctc
      721 cgggggcctt tgcagggcta gccaagttga gcaccctcac cctggagcgc tgcaacctca
      781 gcacagtgcc tggcctagcc cttgcccgtc tcccggcact agtggcccta aggcttagag
      841 aactggatat tgggaggctg ccagctgggg ccctgcgggg gctggggcag ctcaaggagc
      901 tggagatcca cctctggcca tctctggagg ctctggaccc tgggagcctg gttgggctca
      961 atctcagcag cctggccatc actcgctgca atctgagctc ggtgcccttc caagcactgt
     1021 accacctcag cttcctcagg gtcctggatc tgtcccagaa tcccatctca gccatcccag
     1081 cccgaaggct cagccccctg gtgcggctcc aggagctacg cctgtcaggg gcatgcctca
     1141 cctccattgc tgcccatgcc ttccatggct tgactgcctt ccacctcctg gatgtggcag
     1201 ataacgccct tcagacacta gaggaaacag ctttcccttc tccagacaaa ctggtcacct
     1261 tgaggctgtc tggcaacccc ctaacctgtg actgccgcct cctctggctg ctccggctcc
     1321 gccgccacct ggactttggc atgtcccccc ctgcctgtgc tggcccccat catgtccagg
     1381 ggaagagcct gaaggagttt tcagacatcc tgcctccagg gcacttcacc tgcaaaccag
     1441 ccctgatccg aaagtcgggg cctcgatggg tcattgcaga ggagggcggg catgcggttt
     1501 tctcctgctc tggagatgga gacccagccc ccactgtctc ctggatgagg cctcatgggg
     1561 cttggctggg cagggctggg agagtaaggg tcctagagga tgggacactg gagatccgct
     1621 cagtgcagct acgggacaga ggggcctatg tctgtgtggt tagcaatgtc gctgggaatg
     1681 actccctgag gacctggctg gaagtcatcc aggtggaacc accaaacggc acactttctg
     1741 accccaacat caccgtgcca gggatcccag ggcctttttt tctggatagc agaggtgtgg
     1801 ccatggtgct ggcagtcggc ttcctcccct tcctcacctc agtgaccctc tgctttggcc
     1861 tgattgccct ttggagcaag ggcaaaggtc gggtcaaaca tcacatgacc tttgactttg
     1921 tggcacctcg gccctctggg gataaaaact ctgggggtaa ccgggtcact gccaagctct
     1981 tctgaccttt ccttccccag tggggaaccc accaagtccg cttcagatac caaaggggaa
     2041 gacagaacca aggctgcttg aaccagaacc tagtcccgag cagcaccgct ctcctgcacc
     2101 tcccgcctgc gttgtgcctc ctgccggaga gtctgcttcc tgagcttttc cggtctgagg
     2161 atagcattgt catttcttct ctgagggtcc cagggagctg cagatgcaga ccccgtcgtt
     2221 agtccagccc ctgcttcacc ccctccacac acaaaacagg aaacataatc aaagcgctag
     2281 tcagctagtc taaccactag gctttcttca cacatgctta tatcctttaa taaccaattg
     2341 ccaaccacgg ctataagatt atttcagagg tggggctggg aagtgccact tgctccttag
     2401 agtctgtttg tcaaccaggc agagtccctt tcttttctgc tccccacccc aaccctgccc
     2461 ctatgtacag gaataagagc aaaggaccca caggctacag agaagaggat ggggacagag
     2521 tgtgggatgg agaggacaga ccatatactg cactgtgttt gcatgagcct ctaccacctt
     2581 cctctatcta ccagatcatt aaacctgctg tcaaagggcc acaacagtag cagccaaaac
     2641 taaa
//
