LOCUS       NM_001101391            4738 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens leucine rich repeat and Ig domain containing 3
            (LINGO3), mRNA.
ACCESSION   NM_001101391 XM_928228 XM_939777
VERSION     NM_001101391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4738)
  AUTHORS   Zullo,K.M., Douglas,B., Maloney,N.M., Ji,Y., Wei,Y., Herbine,K.,
            Cohen,R., Pastore,C., Cramer,Z., Wang,X., Wei,W., Somsouk,M.,
            Hung,L.Y., Lengner,C., Kohanski,M.H., Cohen,N.A. and Herbert,D.R.
  TITLE     LINGO3 regulates mucosal tissue regeneration and promotes TFF2
            dependent recovery from colitis
  JOURNAL   Scand J Gastroenterol 56 (7), 791-805 (2021)
   PUBMED   33941035
  REMARK    GeneRIF: LINGO3 regulates mucosal tissue regeneration and promotes
            TFF2 dependent recovery from colitis.
REFERENCE   2  (bases 1 to 4738)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene
            with enriched expression in limbic system and neocortex
  JOURNAL   Eur J Neurosci 18 (12), 3167-3182 (2003)
   PUBMED   14686891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005258.2 and AC004152.1.
            
            On Apr 29, 2021 this sequence version replaced NM_001101391.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2819827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000698372.1/ ENSP00000513689.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC005258.2         10709-10787         c
            80-4738             AC004152.1         32362-37020         c
FEATURES             Location/Qualifiers
     source          1..4738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4738
                     /gene="LINGO3"
                     /gene_synonym="LERN2; LRRN6B"
                     /note="leucine rich repeat and Ig domain containing 3"
                     /db_xref="GeneID:645191"
                     /db_xref="HGNC:HGNC:21206"
                     /db_xref="MIM:609792"
     exon            1..79
                     /gene="LINGO3"
                     /gene_synonym="LERN2; LRRN6B"
                     /inference="alignment:Splign:2.1.0"
     exon            80..4738
                     /gene="LINGO3"
                     /gene_synonym="LERN2; LRRN6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1904
                     /gene="LINGO3"
                     /gene_synonym="LERN2; LRRN6B"
                     /note="leucine rich repeat neuronal 6B; leucine-rich
                     repeat and immunoglobulin-like domain-containing nogo
                     receptor-interacting protein 3; leucine-rich repeat
                     neuronal protein 2; leucine-rich repeat neuronal protein
                     6B"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 3
                     precursor"
                     /protein_id="NP_001094861.1"
                     /db_xref="CCDS:CCDS45905.1"
                     /db_xref="GeneID:645191"
                     /db_xref="HGNC:HGNC:21206"
                     /db_xref="MIM:609792"
                     /translation="MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRR
                     LTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLP
                     RLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDN
                     DLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNF
                     RRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLN
                     LSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLE
                     ESTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRN
                     LPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVT
                     ATSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPG
                     EAHNETLAALRAPLDLTTILVSTAMGCITFLGVVLFCFVLLFVWSRGRGQHKNNFSVE
                     YSFRKVDGPAAAAGQGGARKFNMKMI"
     regulatory      4710..4715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINGO3"
                     /gene_synonym="LERN2; LRRN6B"
                     /note="hexamer: AATAAA"
     polyA_site      4738
                     /gene="LINGO3"
                     /gene_synonym="LERN2; LRRN6B"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gctgctcgtg tcggctccgg gcggcccccg cgccgcagcc cgcgccgtgt
       61 ccgcggcgga gccgcccagg tgcgcaggag gatggtggcg cggccctagg cccacgctcc
      121 gcaccatgac ctgctggctg tgcgtcctga gcctgcccct gctcctgctg cccgcggcgc
      181 cgcccccggc tggaggctgc ccggcccgct gcgagtgcac cgtgcagacc cgcgcggtgg
      241 cctgcacgcg ccgccgcctg accgccgtgc ccgacggcat cccggccgag acccgcctgc
      301 tggagctcag ccgcaaccgc atccgctgcc tgaacccggg cgacctggcc gcgctgcccg
      361 cgctggagga gctggacctg agcgagaacg ccatcgcgca cgtggagccc ggcgccttcg
      421 ccaacctgcc gcgcctgcgc gtcctgcgtc tccgtggcaa ccagctgaag ctcatcccgc
      481 ccggggtctt cacgcgcctg gacaacctca cgctgctgga cctgagcgag aacaagctgg
      541 taatcctgct ggactacact ttccaggacc tgcacagcct gcgccggctg gaagtgggcg
      601 acaacgacct ggtattcgtc tcgcgccgcg ccttcgcggg gctgctggcc ctggaggagc
      661 tgaccctgga gcgctgcaac ctcacggctc tgtccgggga gtcgctgggc catctgcgca
      721 gcctgggcgc cctgcggctg cgccacctgg ccatcgcctc cctggaggac cagaacttcc
      781 gcaggctgcc cgggctgctg cacctggaga ttgacaactg gccgctgctg gaggaggtgg
      841 cggcgggcag cctgcggggc ctgaacctga cctcgctgtc ggtcacccac accaacatca
      901 ccgccgtgcc ggccgccgcg ctgcggcacc aggcgcacct cacctgcctc aatctgtcgc
      961 acaaccccat cagcacggtg ccgcgggggt cgttccggga cctggtccgc ctgcgcgagc
     1021 tgcacctggc cggggccctg ctggctgtgg tggagccgca ggccttcctg ggcctgcgcc
     1081 agatccgcct gctcaacctc tccaacaacc tgctctccac gttggaggag agcaccttcc
     1141 actcggtgaa cacgctagag acgctgcgcg tggacgggaa cccgctggcc tgcgactgtc
     1201 gcctgctgtg gatcgtgcag cgtcgcaaga ccctcaactt cgacgggcgg ctgccggcct
     1261 gcgccacccc ggccgaggtg cgcggcgacg cgctgcgaaa cctgccggac tccgtgctgt
     1321 tcgagtactt cgtgtgccgc aaacccaaga tccgggagcg gcggctgcag cgcgtcacgg
     1381 ccaccgcggg cgaagacgtc cgcttcctct gccgcgccga gggcgagccg gcgcccaccg
     1441 tggcctgggt gaccccccag caccggccgg tgacggccac cagcgcgggc cgggcgcgcg
     1501 tgctccccgg ggggacgctg gagatccagg acgcgcggcc gcaggacagc ggcacctaca
     1561 cgtgcgtggc cagcaacgcg ggcggcaacg acacctactt cgccacgctg accgtgcgcc
     1621 ccgagccggc cgccaaccgg accccgggcg aggcccacaa cgagacgctg gcggccctgc
     1681 gcgcgccgct cgacctcacc accatcctgg tgtccaccgc catgggctgc atcaccttcc
     1741 tgggcgtggt cctcttctgc ttcgtgctgc tgttcgtgtg gagccgcggc cgcgggcagc
     1801 acaaaaacaa cttctcggtg gagtactcct tccgcaaggt ggatgggccg gccgccgcgg
     1861 cgggccaggg aggcgcgcgc aagttcaaca tgaagatgat ctgaggggtc cccagggcgg
     1921 accctcccct cccctccccc gcgggccggc cgctcgcgtg tccacctatg catttcccgg
     1981 aggggaaggg gacggctgca cggcgctccc caggcagaac ttcccctttt tttgtagacg
     2041 cccaaccgca ggactgtttt tcatcagcat gcgtcttttt tgcagtttct caagcgtttt
     2101 ctaaagattt caacccgtct tcctgtccct gctatggtgg ctgagctggg gggtgggggt
     2161 gcgggctgca aggatggggg gatgggctcc cgtctaccaa cccggggtgg ctgggggcgc
     2221 tcagagaccc caggatcctc agggcccgca attcacaccc aggaggcaca agactgctgc
     2281 ccccaagccc tgggcttccg ctcccccagc cctttgtaca cagatcgcat cggggagacg
     2341 gtggacaccc gggtcccaca aagggcccca cagccccaag gggagggtgc gcagaaagtc
     2401 tgcattgctc acacctggcc gtcctacacc tcacacccag agacacactc acacctggaa
     2461 cccaatcaca caggtgcaac acacctcaca cccagccgac actaaaacca gacccggggc
     2521 accagagctg accgcagggg gcaggcaggg ctctcgtgag agcaaagctc acacccggga
     2581 caggcgcaac tcacacccgg gacacacagc tcacacccag gacacacaca gctcacaccc
     2641 agaacacaca gctcacaccc gggacacaca gcttacaccc gggaaacaca gctcacaccc
     2701 gggacacaca gctcacaccc ggaacacaga gctcacaccc gggacacaca gctcatacgc
     2761 aggacacact cagctcacac ctgatacaag gacagctcac agtggaacac acagctcaca
     2821 cccgggatac agctcacacc caggacacac tcagctcaca ctggaacaca cagctcacac
     2881 ccagaacaca gaactcacat ctgggacaca cacagctcac acccgagaca cacaccctca
     2941 cacccagctg acactaaaac caagccctgg gcaccagagc tgaccacaga ggcaggcagg
     3001 gctctcgtga gagcacagct cacaccaggg acatgctcag ttcacacctg ggacaggcac
     3061 aacgcataac tgagacacag ctcacacctg ggacacagag cccaccccag cgcctgctca
     3121 gctgagcatc tcccagccga cctcggggcc tgggctcagg tcttgctgag gacccagcac
     3181 acacggtggt cacagtcagg ggtccacacg ccctgtcctc cgtcctcccc acagcccagc
     3241 agggctgtcc acaagaagga gccatcaccc cagccctccg cctccctccg ctgccacgtg
     3301 cttcccagaa cagcaggcaa gagagggcca ccccacaagg gagaggtggc caccctgccc
     3361 cggcccagaa ccatggcttc tggggtgctg agtgtccttc caaatgggtc tactggaggg
     3421 acttttgccc ctaggtacac atgacctctg agccggcctc agacaagccc tgagcgtggc
     3481 cccatcatgg ccggccctgc tgacccgtgg ctcaggtggg gaacgagacc aaagagcaca
     3541 gggggttccc ggggatcccg gctacgtgcg gtgcagtgta gtgacaagaa caaggccgga
     3601 acaagggctt caccctgcag ggaggcctgg acccgggtcc tcgggagaag gtgatggagg
     3661 aagctgggtc tctgcacctg cagaggtggg gcagatccag gaccaaagct ggggtcacag
     3721 gccgactgca gctctggtca aggaagagct tccctgaggt caccgcccgg ttgctctgca
     3781 gatggtgggc atcctgtcac ggggggcaaa caagcaggag ctgaggtttt gcagaaggat
     3841 tcaggcacca gaccgggacc acagggacca tctgtgacct ggcctcctca cagccagttc
     3901 ttgcccctcc cctccacatc ctccagagga cagttaggac attgctgggg gcagggacag
     3961 gaaccactgt tgggccaaaa cctcagccag aaaggggctt ggctgccaac caagaggtta
     4021 ggacagaccc tccaggactt tgcgggaagg gctcaaaagc agctctgctc ctgcccggct
     4081 atgtgatctc agctggtgac tgaagaccac ctagaccatc agtgtcctca tctgtaaaat
     4141 gggtctgagg gtcaaaccta ttaccctgta ttcagaggcc aggcctgcag atgagcttga
     4201 tggcttgact tggatcctgg atccctgaag actgctctga gatcgatcag ccagagagaa
     4261 acagagagaa agctggctca gccctgaagg ctttgagcaa aagtttcaga aggagctgga
     4321 aggagacaac agcccgttct ccctgagctg tggccgggag ggcccaggcc agcaccacga
     4381 tgtacagatg gcccaggggg ctcgacatga gtgagggctg aagttcgtgc aaccccaacc
     4441 gccacccctg aattgggcag aaccaatttt tttcttagca cctgtctgac tctgcttacc
     4501 atgacaaccc caagggcccc ccagaattga tatccaagtg cctttagcct atcaaagaca
     4561 ggagggggtg cattctcggc caggttaggg ttcacagagc atccgtatat taggatttcc
     4621 cagccccctg agccccccac cccatcccaa catgaactaa gacccctcag cacccccacc
     4681 cctcatcctg ctgtatttgg ttcaaatcca ataaaaatgg aaccgattta ataacaaa
//
