LOCUS       NM_001258282           14226 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens leucine rich repeat and Ig domain containing 2
            (LINGO2), transcript variant 2, mRNA.
ACCESSION   NM_001258282
VERSION     NM_001258282.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14226)
  AUTHORS   Huang,X., Liang,W., Yang,R., Jin,L., Zhao,K., Chen,J., Shang,X.,
            Zhou,Y., Wang,X. and Yu,H.
  TITLE     Variations in the LINGO2 and GLIS3 Genes and Gene-Environment
            Interactions Increase Gestational Diabetes Mellitus Risk in Chinese
            Women
  JOURNAL   Environ Sci Technol 58 (26), 11596-11605 (2024)
   PUBMED   38888423
  REMARK    GeneRIF: Variations in the LINGO2 and GLIS3 Genes and
            Gene-Environment Interactions Increase Gestational Diabetes
            Mellitus Risk in Chinese Women.
REFERENCE   2  (bases 1 to 14226)
  AUTHORS   Su,T., Ren,Q., Lu,Y., Tai,W., Zhu,Y., Li,Z., Wen,J., Hu,L.,
            Zhang,L. and Ma,J.
  TITLE     A genetic variant in LINGO2 contributes to the risk of gestational
            diabetes mellitus in a Chinese population
  JOURNAL   J Cell Physiol 234 (5), 7012-7018 (2019)
   PUBMED   30426492
  REMARK    GeneRIF: LINGO2 rs824248 may serve as a susceptibility marker for
            gestational diabetes mellitus in Chinese females.
REFERENCE   3  (bases 1 to 14226)
  AUTHORS   Jo,J.H., Park,S.B., Park,S., Lee,H.S., Kim,C., Jung,D.E. and
            Song,S.Y.
  TITLE     Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated
            with Cancer Cell Phenotype and Patient Outcome
  JOURNAL   Int J Mol Sci 20 (3), 555 (2019)
   PUBMED   30696080
  REMARK    GeneRIF: These indicate the involvement of LINGO2 in gastric cancer
            initiation and progression by altering cell motility, stemness, and
            tumorigenicity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14226)
  AUTHORS   Rask-Andersen,M., Almen,M.S., Lind,L. and Schioth,H.B.
  TITLE     Association of the LINGO2-related SNP rs10968576 with body mass in
            a cohort of elderly Swedes
  JOURNAL   Mol Genet Genomics 290 (4), 1485-1491 (2015)
   PUBMED   25711307
  REMARK    GeneRIF: Data indicate that rs10968576, an intronic single
            nucleotide polymorphism (SNP) within the leucine rich repeat and Ig
            domain containing 2 LINGO2 (LERN3, LRRN6C) gene was associated with
            body mass in elderly Swedes at age 70.
REFERENCE   5  (bases 1 to 14226)
  AUTHORS   Kapoor,M., Wang,J.C., Wetherill,L., Le,N., Bertelsen,S.,
            Hinrichs,A.L., Budde,J., Agrawal,A., Almasy,L., Bucholz,K.,
            Dick,D.M., Harari,O., Xiaoling,X., Hesselbrock,V., Kramer,J.,
            Nurnberger,J.I. Jr., Rice,J., Schuckit,M., Tischfield,J.,
            Porjesz,B., Edenberg,H.J., Bierut,L., Foroud,T. and Goate,A.
  TITLE     Genome-wide survival analysis of age at onset of alcohol dependence
            in extended high-risk COGA families
  JOURNAL   Drug Alcohol Depend 142, 56-62 (2014)
   PUBMED   24962325
REFERENCE   6  (bases 1 to 14226)
  AUTHORS   Vilarino-Guell,C., Wider,C., Ross,O.A., Jasinska-Myga,B.,
            Kachergus,J., Cobb,S.A., Soto-Ortolaza,A.I., Behrouz,B.,
            Heckman,M.G., Diehl,N.N., Testa,C.M., Wszolek,Z.K., Uitti,R.J.,
            Jankovic,J., Louis,E.D., Clark,L.N., Rajput,A. and Farrer,M.J.
  TITLE     LINGO1 and LINGO2 variants are associated with essential tremor and
            Parkinson disease
  JOURNAL   Neurogenetics 11 (4), 401-408 (2010)
   PUBMED   20369371
  REMARK    GeneRIF: LINGO1 and LINGO2 variants are associated with essential
            tremor and Parkinson disease
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 14226)
  AUTHORS   Ichikawa,S., Koller,D.L., Padgett,L.R., Lai,D., Hui,S.L.,
            Peacock,M., Foroud,T. and Econs,M.J.
  TITLE     Replication of previous genome-wide association studies of bone
            mineral density in premenopausal American women
  JOURNAL   J Bone Miner Res 25 (8), 1821-1829 (2010)
   PUBMED   20200978
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 14226)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 14226)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene
            with enriched expression in limbic system and neocortex
  JOURNAL   Eur J Neurosci 18 (12), 3167-3182 (2003)
   PUBMED   14686891
REFERENCE   10 (bases 1 to 14226)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162388.8, AL158072.9, AL592206.5, AL353683.7, AL596323.10,
            AL353746.6 and BX538226.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001258282.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803614.86983.1, DN991981.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000698399.1/ ENSP00000513694.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-680               AL162388.8         76973-77652         c
            681-777             AL158072.9         182267-182363       c
            778-858             AL592206.5         44854-44934         c
            859-944             AL353683.7         173986-174071       c
            945-977             AL353683.7         70882-70914         c
            978-1136            AL596323.10        82749-82907         c
            1137-13971          AL353746.6         63555-76389         c
            13972-14226         BX538226.1         6629-6883
FEATURES             Location/Qualifiers
     source          1..14226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2-p21.1"
     gene            1..14226
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /note="leucine rich repeat and Ig domain containing 2"
                     /db_xref="GeneID:158038"
                     /db_xref="HGNC:HGNC:21207"
                     /db_xref="MIM:609793"
     exon            1..680
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /inference="alignment:Splign:2.1.0"
     exon            681..777
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /inference="alignment:Splign:2.1.0"
     exon            778..858
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /inference="alignment:Splign:2.1.0"
     exon            859..944
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /inference="alignment:Splign:2.1.0"
     exon            945..977
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1136
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..14226
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /inference="alignment:Splign:2.1.0"
     CDS             1172..2992
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /note="leucine rich repeat neuronal 6C; leucine-rich
                     repeat and immunoglobulin-like domain-containing nogo
                     receptor-interacting protein 2; leucine-rich repeat
                     neuronal protein 3; leucine-rich repeat neuronal protein
                     6C"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2
                     precursor"
                     /protein_id="NP_001245211.1"
                     /db_xref="CCDS:CCDS6524.1"
                     /db_xref="GeneID:158038"
                     /db_xref="HGNC:HGNC:21207"
                     /db_xref="MIM:609793"
                     /translation="MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCH
                     RRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFN
                     NLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV
                     GDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPV
                     YAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLT
                     HLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLE
                     TLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRERS
                     FKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR
                     FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRF
                     LYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVW
                     SRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI"
     regulatory      3734..3739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /note="hexamer: AATAAA"
     polyA_site      3765
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /note="major polyA site"
     regulatory      14205..14210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /note="hexamer: AATAAA"
     polyA_site      14226
                     /gene="LINGO2"
                     /gene_synonym="LERN3; LRRN6C"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgtgtgc gcagcccgag ctctgagccc ggctgccaag ccccagccgg ctatcctgcg
       61 tcccgccttg cagccgcctc ctcaaagcct cctcacctgg cgccgccgcc cgccgcccgc
      121 ccagccccgc accggcgctg cctcccctga aagtttcccc agcgtagaca ccttcgcgct
      181 gcagcagccc agggagacgg tgttccgaag ctgtgccttg gagtggctct tcttacacct
      241 ttccgcctca tccccaccta attcgggcag ggagtagaaa tttttccaaa ttaaggggag
      301 aaagggggga ggggcattat cgagagaaag caagaggagc ggccgcaact gagaatatcc
      361 tgcctgatgc cagggaattg actgacgtgt ctgtggggtt acggaagaaa actgaatagg
      421 cagccaagtt ggcccaggag gggctgggag gcttccgggt gccgggaagg tggtcccggt
      481 ctccatttcc actggtacga aggcttggag gcgcctctat ggtgagggct tttgaaccgc
      541 catcccctcc tgatcccttg gaaaggagga gccttcagag ctgaggaggg ggaagtccag
      601 gaaaagcccc tggacttgtg tgcgtcgcat ccttggcttg ggattttaag gacacgaagg
      661 agaattaaca gcgcctcaag gaaatccact ggagatggtt tcaagatata ggatccttat
      721 atgtgaagta tcccaaatga agttggagca tccatgttga aattgcttca tgttgtggaa
      781 ttgatgagtg ccatcagaaa gctgtatcat gagctgcctg cacttctaaa gtgtccagtg
      841 gatttttaat cacatgagcc tggaaatagg gttatgagaa gaagctcaga gcagagcacc
      901 gaaagtggcc actaccagca tgaagagccc aacaattcaa actggtgaag tgagaaaaac
      961 agaatgcagc tttcaaggtt cgtttcaagc agttggcttg tgggactctg agagatgctg
     1021 ctgcccatga catgcgggaa ttatcatgat caactaccca gcttggattt cacccagtgg
     1081 ccaagagctt tgtgtgggag acggcaaggg ttggattttt caaaagagta aaccagaccc
     1141 gtgaccaagg tgtagactaa gaagtggagt catgcttcac acggccatat catgctggca
     1201 gccattcctg ggtctggctg tggtgttaat cttcatggga tccaccattg gctgccccgc
     1261 tcgctgtgag tgctctgccc agaacaaatc tgttagctgt cacagaaggc gattgatcgc
     1321 catcccagag ggcattccca tcgaaaccaa aatcttggac ctcagtaaaa acaggctaaa
     1381 aagcgtcaac cctgaagaat tcatatcata tcctctgctg gaagagatag acttgagtga
     1441 caacatcatt gccaatgtgg aaccaggagc attcaacaat ctctttaacc tgcgttccct
     1501 ccgcctaaaa ggcaatcgtc taaagctggt ccctttggga gtattcacgg ggctgtccaa
     1561 tctcactaag cttgacatta gtgagaataa gattgtcatt ttactagact acatgttcca
     1621 agatctacat aacctgaagt ctctagaagt gggggacaat gatttggttt atatatcaca
     1681 cagggcattc agtgggcttc ttagcttgga gcagctcacc ctggagaaat gcaacttaac
     1741 agcagtacca acagaagccc tctcccacct ccgcagcctc atcagcctgc atctgaagca
     1801 tctcaatatc aacaatatgc ctgtgtatgc ctttaaaaga ttgttccacc tgaaacacct
     1861 agagattgac tattggcctt tactggatat gatgcctgcc aatagcctct acggtctcaa
     1921 cctcacatcc ctttcagtca ccaacaccaa tctgtctact gtacccttcc ttgcctttaa
     1981 acacctggta tacctgactc accttaacct ctcctacaat cccatcagca ctattgaagc
     2041 aggcatgttc tctgacctga tccgccttca ggagcttcat atagtggggg cccagcttcg
     2101 caccattgag cctcactcct tccaagggct ccgcttccta cgcgtgctca atgtgtctca
     2161 gaacctgctg gaaactttgg aagagaatgt cttctcctcc cctagggctc tggaggtctt
     2221 gagcattaac aacaaccctc tggcctgtga ctgccgcctt ctctggatct tgcagcgaca
     2281 gcccaccctg cagtttggtg gccagcaacc tatgtgtgct ggcccagaca ccatccgtga
     2341 gaggtctttc aaggatttcc atagcactgc cctttctttt tactttacct gcaaaaaacc
     2401 caaaatccgt gaaaagaagt tgcagcatct gctagtagat gaagggcaga cagtccagct
     2461 agaatgcagt gcagatggag acccgcagcc tgtgatttcc tgggtgacac cccgaaggcg
     2521 tttcatcacc accaagtcca atggaagagc caccgtgttg ggtgatggca ccttggaaat
     2581 ccgctttgcc caggatcaag acagcgggat gtatgtttgc atcgctagca atgctgctgg
     2641 gaatgatacc ttcacagcct ccttaactgt gaaaggattc gcttcagatc gttttcttta
     2701 tgcgaacagg acccctatgt acatgaccga ctccaatgac accatttcca atggcaccaa
     2761 tgccaatact ttttccctgg accttaaaac aatactggtg tctacagcta tgggctgctt
     2821 cacattcctg ggagtggttt tattttgttt tcttctcctt tttgtgtgga gccgagggaa
     2881 aggcaagcac aaaaacagca ttgaccttga gtatgtgccc agaaaaaaca atggtgctgt
     2941 tgtggaaggg gaggtagctg gacccaggag gttcaacatg aaaatgattt gaaggcccac
     3001 ccctcacatt actgtctctt tgtcaatgtg ggtaatcagt aagacagtat ggcacagtaa
     3061 attactagat taagaggcag ccatgtgcag ctgcccctgt atcaaaagca gggtctatgg
     3121 aagcaggagg acttccaatg gagactctcc atcgaaaggc aggcaggcag gcatgtgtca
     3181 gagcccttca cacagtggga tactaagtgt ttgcgttgca aatattggcg ttctggggat
     3241 ctcagtaatg aacctgaata tttggctcac actcacggac aattattcag cattttctac
     3301 cactgcaaaa aacaaaagaa aaaataaaaa agaacaacct acagtgtagg atttacatat
     3361 taaaaagaca catttgtcta aaacatactc tacagaaaaa tttgtatcta tgattatcat
     3421 ttgttaaagc cttgcatcat accatattgt tggttcagta ccacaaagag atcaatatat
     3481 tcttttcttc cttttttgaa acatatatgc tgtacatgtt ttaaagcaat atgaatgaga
     3541 ggttgtgctt ttagttactc accactatag atccaagtgt gatttcacct tccgttacct
     3601 acagatgacc ctgagactag atccctggag ttatgggcgg agatattttg agagatgtgt
     3661 ttgtctgatg taggatgcca agaaacagga cccaaggcaa aactgctcaa ctctgttaac
     3721 ttctgttact ataaataaag gcatgtgcct agttttgata cagaatggaa tattttttat
     3781 acttgtaata atatcacact ggaccagttt actgtaaaca aagcccttgg tttctccaga
     3841 aggtggtaca ccactagatg tacctgtaaa atgcaaggta ggtgttaata atgaaaatga
     3901 ttcatttaat cactccttga ttttactttc cacagtcact attagcgggt taatagaaaa
     3961 tggaagaaga ggtaatggtt acaaataacc ataggataat attcaccagt ggctaagatc
     4021 aagaattcag atgttcaaaa gctctctgaa taagaaagag ttcttctcag atgccaacac
     4081 aaaccagggt gatacataca taacatgatg ttaatgcaaa caacgatttg tttaaaacat
     4141 gatagctgcc tgcatgctag attgctgcta gtcaagggaa catctagcta ctgccactct
     4201 gatgttctct acttgaatac tgtacacaca atattacctt gaatagacaa cttcagggtt
     4261 tcttcctgct tccttaccaa ttagattttg gttttttctt tgaaaattat cttgtataat
     4321 aaagaggaat ttgtcttgtt ttctaagaac tgagaaaaaa caaggtggat taaaaaccat
     4381 ttagtgtttt ttttctccac tgaggaaaaa gcaaggttat agccccataa atatgtcaag
     4441 ttgtgctgat tttttttcct ctctctgacc caaggatact tatccaattc agtttgtatt
     4501 aatgactgtt actcaaagtt aaacatccca gtttttaaaa actgatgtca tgccgtgacc
     4561 accagtcatc tggttcagag caggcatagt ttcatttggc taaatgttca gtgaatgact
     4621 ttcaaagcat atggttatgt gatctgagaa agaattgaat gtggactgtg ttcatgcaat
     4681 gtcaaatatt taatcagcat agaactgata ggaaatatct atacttttcc tatttcaaga
     4741 gggatctgaa aataggtcat gtttttaata acatgtaagc tggagtagaa agtctctggg
     4801 gtttgcttct tgacatattg gattggcggg ttgacattca aaaggctggc tttttagttt
     4861 gaaatttgaa aatttgaaat tttgaagaac tttaataaaa ttaaattgac cccaataaaa
     4921 gtaggataag cccagaaatt attttgccaa tcagatagca acagagttaa acccatttct
     4981 cccctaataa agggtggaaa atatgatgaa agattgaaga attgcctgtt caagccattt
     5041 ttcatttgac ttttctgatg actatcatag atcttttaga attttatttt ccatttgtgc
     5101 caaatacctt atatcaaaca atgcaaatca agctctgctg caaactctat cacaaatcca
     5161 acttgtgtgc aaatggaatg gggtctttca aatttaaaaa tgaactgtta gagatttcaa
     5221 aaaaacttcc aaaagttaat agaaactatt ttgcagcatt gtgtgaagtg tagtattcaa
     5281 ctaattgtca taaaagagaa acattgagca attaataaga gggctttgtg attttcactg
     5341 ctcttttgtc aaaataaaag ttggccaaaa acagctgagt gaaatgaaat tggattaaaa
     5401 tgtacccatc catgaaaaag atttagttaa aagattttgt tactattcat tttattggaa
     5461 gaaaagagaa tggattttct cagcggtccc atactctgat ctatggaata atagttattt
     5521 aagatatttc taagcattct tccaaaaaag tcctgttgac cagtctatca gggaaatgca
     5581 ttctgtaacc acctttagag attcaaaatc tatatgagcc taataaatcc tctgaaaagt
     5641 cctgtaaaca ggaatcctgt ttaatattgt ttatcttcag gcttcactaa tttatatgag
     5701 cagaaagcac ttcttttcgt gctataactg ttaacatttt caaaaactag agctccatag
     5761 aaccccggtt ggtctacttc agactagagt aatactcttg tgacgtattc ctaaacctaa
     5821 tgtttccaat aagagtaaaa ttactgtttg aattggcctc cgatagacta ccaaaaaaat
     5881 attgactgtg tcagtgctta gatcataaaa gtatattgac cagatatttt caggggaatt
     5941 ggctactttt tgcctgaagc atccatcata gcaatggatt aagaggtaat tgaatagaca
     6001 tttaattttc tacactctca ctatctgagc agatcttggg ttctttttgt gcgtgcaaag
     6061 ctctggtatc cattgagtga aacgctggtg ctttagtact cagtttcaca aaagggttaa
     6121 tgaattttcc ctcatggctt ctgattacct ctttgttata tcaactagac catggtagag
     6181 cataacagct cataccagca caggggccaa ctactcactt aaatatgaca tctctgagtc
     6241 attttcttcc cagaggcttt gtttcaaagt atcccagaaa gaaatactgt tgtttgactc
     6301 agcatttcac tccagttggt tttcattcca ctctggtttt gctcaacttt ctcagaaatt
     6361 ttgcttgtta ctgacaactc cctagtagga aaaacacatt cagaagttgc cctacagtat
     6421 ttaggatgga ttcttttttc attattctgt caaatattct gtgttcctca gttcttacag
     6481 gagtccagaa gttgcagtct tctgtgactc tttaaaaaat gattatttaa atgtcatttg
     6541 cattgaggcc tgacttttgt cactttactc tggtacaaac acatgtattt ttatatcaga
     6601 ggaacaaaag agagaatgtg atcttggaga aataaaattg agtaaagtcc catgtaaatt
     6661 aacttgtatt tccagggtct ctcttcatct ctgtgtcaag acatttgttt taacttcagg
     6721 ggatgtactc agaagccatt caacactgca tatgtcttga gggtttctag gaaagaaaaa
     6781 aattacataa ttttcagctt agaagtctaa gaccaaacat aaagatatat caagacttta
     6841 aagaaggttg gaggcagaca cttgacccat gttaatcctg ttttctttct tgccaatttt
     6901 tgtagttatc tcctacctga agaagaatca gagattatgt tcttccttga ctttcactga
     6961 agtccttttt ataccttttt tctatgaccc agtcacctat atctcacatg agctatccca
     7021 aatggattct gtggcatctg aatctagtaa caaaaccttt gggaccaaag gcattcattc
     7081 tactcagcac ttaggtaaag acttattatc tctattacta taattaacat tccctgtttg
     7141 ttagactcat acatcatgtg cctggttatt tccattgatt ttccaccgtt ggctttggga
     7201 gcacctttta attcctttca gctagaaccc ttgatgtttt tctgattgag gagtttggga
     7261 attattctgc ctttgggtat agaaagtttt gaggaatgaa atattatttg tttgattttt
     7321 gaattttcta ttttcgttag gcaacagagg gtgttttctg gtactttggc aaacacttga
     7381 catgaatctc tcagtgatgc tccccttttc accttcaaaa gccattccca aaagagcctt
     7441 ctcatttaca ttccagctgg gaaaggacag ctttacaaca taggtgtaca ggataaaatg
     7501 atagctgatt gctgtgctct ttagctcaat taacctaata aacactgggt ccaggggcca
     7561 tatgtctagg cttgcaaggt ttagccaagt aaacaaggtt ttaaatcaac aattaatgac
     7621 aggttttcga ctctgaagtt ggtttgcctg tttggagaac agtatgtgta actgcatgtc
     7681 ttctcaaaaa ggtagggact agaacttcct tatcttatgt gagattttta acaaatggtc
     7741 taggataaaa tgtgtccaac aacaacaaaa tacataatta agatgtttgt aaaaggttta
     7801 tttttctaaa ataggattgg ggctgatgtt actctttcca aatttgggag tttgatcagg
     7861 acaagcttgc atgtgcccca gactgccctt tctcaagttt accaaggtct ttaatacctc
     7921 ttctccctcc ctgatcccct tctccctgga gaacatcctg aataggaagg agaaaaagag
     7981 caggaactaa agtcccctga gacagcccac agaaggagaa aagctttggt attcccccac
     8041 attcttgcct cctttcctga tgcagcaatt gaaatgatcc ttcactctct gcctacttac
     8101 cactgtcact tctcagctgc tgccatcctc atcaatgaac gctctctcca gggataagtc
     8161 ttctttcatt ggtaactgag attcttgggt aattgttaaa ctggaaattg ctttaaaaaa
     8221 aaaaaaccct ccagctatct cacataacac tttaaaagtt aagacttacc attcacataa
     8281 tcacaagctg acagcaatct gcaggttgag tgattctgat tttttttcct ctcccttcca
     8341 gaagcaggtg ggttgatata atgccagcct taaatagaaa gctttattta tagccttagc
     8401 agaatgagaa aagagctggc ataatcaaga gagtacttca cattttaaag aagactttac
     8461 ctttaatatg caaaatagtc attagaagac aacaaaaatg caaatttatg ttttactaaa
     8521 ttgcttaact atattccaat aaagttcaaa agataactgt ccatactgaa gatgggtcag
     8581 ccaaagactt tatgcctgtt ctaaaaggac caaaaaaaag cagaaatttg gttgccatgt
     8641 taactttatg ttgttgcaca cctcctattc taaattgctt taatatcttt acactgcaat
     8701 atattgagta aaatcaacaa tataagataa ataataaaca ggagattaat tcagacttgc
     8761 aaaaaaaatt tttcattctt tacaatgtat gtccagcagc aaaatgatgt atatacatat
     8821 ctgtgtgata acaagagatt ggaattggca tgaacaaact ttgcatagag gctgtttgga
     8881 agaaaacatg ctgtttttct ccccagttac aaaatcaggt atatcataaa aacctgagtt
     8941 gcttcataac aagacagttg ttttcaggtt ttttccatgt ggtatagaat accccaaatc
     9001 ataattaatt tctattgttt atatatacat atataaatat gtggggaagg gtggttagat
     9061 ttttttgtgt ttaaattata accgttttaa aagttgataa gcctgagcag gagaaaaaga
     9121 gacagaatgt gtatctgtgt tttcctttaa tgtcttttat caaaatccta ttttgagaat
     9181 atcccatgat tgaaagttaa taaccaagaa cctaacaaaa cttttcgtaa aaaatgcctg
     9241 aaagtttttg ttttcaaaaa attaatgcta atgacaaaag tatcttgatt taggtttgca
     9301 tctctttagc tattggttaa ttgttgtggg catgtttttt ttaacatgta aaaacaaatt
     9361 aacttattaa catgtaaaat aagttaagaa aacatgtttt cttttcggat gaaagggctt
     9421 aagcatctga catctcagtt aaattcactg aagtattaat aagaaatgca atatgagaca
     9481 atcggagtcg tataaaaata ttttcttatt gagagaagta ggttatatga gtctcacagg
     9541 gaacgtgagg tatcactgta ttaattagta atccccaata ctgtcagaga tgaagcaggt
     9601 ccagtggaat ctcattcaaa tgctaaggtg agtggagata actcacagag gaatcaaaag
     9661 acaggctatc cagttacata aagttacaaa ggggtcatag ttcaacctga tgggcatcca
     9721 aatttatgta atatcaacca cactctaaag atattctact tttgtggagt taaatcctgt
     9781 atcacttgca aaagtatccc aaattcatgt gacttaataa cataagcaag taatgggcat
     9841 aacttaaggc gtaagatcta tttgagcaag aactgaaggg ttcagcaagc catacataca
     9901 acaccaccct ctagtttttc tttctgagtt agccttcact cagccaaatg attcaaaaca
     9961 ttgtgtcaag taggaagcca caaaaaaaat aaaaagagaa acaactttag tcttcaagca
    10021 aattgaaaaa agggaaagag aaaattgtct agtgttaaag aggaaatgaa ttgaaaattt
    10081 ttaaactcct cttgggctga gagtgaaggt gccctctctt tacctttcgt acttgaggga
    10141 atgggcttta gagagatgtg ttcaggcagg tgtcatcatc tagggtatca tctttactcc
    10201 ctgtggctca ttagatggct tccagtgaag gaggaggagg tagagaagga agcagaaagc
    10261 tgacagtcat ggtacctgaa agtcacattg ttagagaaca agaaagtccg ggattcatct
    10321 ccaggaagca ataaacacac aaatactgag actgttagca agaaaccaga aaaggtccct
    10381 ttgctattct tcttttcttt tcttttcttt tttgagtctc actctgtcaa caggctggag
    10441 tacagtggca caatctcggc tcactgcaac ctccccgtcc cgggttcaag agattctcct
    10501 gcctcagcct ccccagtagc tgggattaca ggcacccacc accacacccg gctaattttt
    10561 gtattttttt agtagagaca gggtttcacc atgttggcca ggatggtctc gatctcctga
    10621 cctcgtgatc cgcccacctc ggcttcccaa agtgcaggga ttacagacat gagtcactgc
    10681 acccggcctg ctgctattta attgcaaaat gaaaagcttg cccctagaga gagaatttct
    10741 tgaaaatgtt ctgttaatgc cagagctgct ctggtcagag tcacatctct aacagtgggc
    10801 ttttatttta tgctagtaaa tcagtaagac taaaacaaag ggccatttcc cataagcata
    10861 gttttgaatg tgttgggtag acatctcgcc aattaatatt aggagttagc ttgtccagta
    10921 aactcaccaa tcagggataa gatgatccca atacttcaga acttgtactt aaacaatggg
    10981 aagaagataa tataatgaac tcgaagctaa acatactttt aactcagtgg cctggcttct
    11041 agctctgcac cttaaagact ttctggtcat gtattacttc ataaatttag aagttcttca
    11101 tagttctgtg tttctgtttc tgtttggttt cttcttcctt tcatttttct cagtcatgag
    11161 catactgccc ttgctagatg gctgttaatg tttttgtgtt gtttgataca gtcgaaataa
    11221 aaattaggag tttctaccga ctcccttcaa ggcagataag cttattgtac aaccctatat
    11281 tcttttctta attacttcat tatcagacct aaaacacagg acatgaagat taatgtggaa
    11341 taaagccaag ttaaggagaa aagtgagaaa cctgagggga aatttaccta ctatttctgc
    11401 cactgactgg tggaaaatct gaaaacactg gcttctaggg cttgtcacac tggtgccttt
    11461 catcaactct tataaataac taaatgcaaa aattatgacc ctctatcaaa aaataaagga
    11521 ttgggaagga gatcgcttat tacagctatg caggtattgt tttattctat aacgctgtca
    11581 ttggcaaatc aggacatgtc aataaatctc tcaaagtagt atatgtatat taatggcaga
    11641 atgacacgta tatacatatc tattactaag aaccatctgg ggaaaaaaat aagaaaattt
    11701 aaaaaataaa aaaagataag gcaggtggaa aatatgtgga ttctccctat tctatttgtc
    11761 tgctaaaaaa actaagacct cacctgaatc accagagtca gggtctcaga aatgaaaacc
    11821 caaggagagt ctctacaaaa agaacagact gctagagagg atacctcttt gattaaaata
    11881 cctaaatctt ttatgtgatt gtgaaagtta tatctatagt gaataatttt gtattgtcac
    11941 attgggagat aaatttgttt accagatccc catctaaggc agaaataaca tttatgtgaa
    12001 cccttttcta actgcagcat cactattcat attatttcca agcacaagag atcaagtatg
    12061 ctagtaccat agcacagagg caattcacca catctagcct attcctttag ccatgggcta
    12121 ttagctggat gtacaaaaga ctaacaggtt acatccattc tatacatgca gggatttcat
    12181 aaaagttaaa cacttcttca aacctgcaca cacaaatcca tactgtggca tccagagttt
    12241 ctttaagcct cacactgtat cagtacaaac atcctacagg gaattaattc actgagcaca
    12301 gaacaaatgt gtaatgcaaa gagattacca agtcacctcc accaccttga tttatataag
    12361 ctcttctgtt ttagcaacac ctggagaatc cagtggtctg tgcttcagtg gtctcaagag
    12421 ctcttcatgg cagttctgta agaaagttgc tggctttaac gcagggctgg tttcaatata
    12481 gggcagctgt tttctgctgt gagtcttctg gaggaaaaag aatgggttca cggaaactga
    12541 aagtaactga aaaatgtatc ctggctggtg agtgtaggaa gagtagttca ttgttctaat
    12601 ggttgaatat atttcaaaag aacatttaat aagaattgga gaacacaagc atttcaaata
    12661 aatggcaatg atcatatgag catgtgtaag agaatttaat tgcagaggaa aatggatgat
    12721 tatgcatatc acactgcctc taatattgat cttgagttgg tttccaaatt gataagtaaa
    12781 tacattctat attgaaaatc attttaaatg tctatttata tcttttaaat attgccaata
    12841 attagcttaa atacatgccc tcaaaatatt caggaatcta ctcggtcctt tccttctcat
    12901 ccttgattag aagttaaaaa tcagatttct ctagctttgt tttaaaagat acagaaaatt
    12961 taattttcca attatccaag cacaatctcc tttcattcat ttactcattt aattatgcaa
    13021 catctactga gtatccatta tcatagtaat cgagctgccc gtcactgaag tcattatcaa
    13081 actgtggttt aaaccttagc tctgtgtttc tccacattaa ctcctttggc ttccatattg
    13141 attgcaactt gtgtctcatt ctgtcatcta aatcatgtgg tttagagata ggccttagtg
    13201 tccacctggc caggcacaag tctggcgtta aggacctacc tgctttaatg atccactctc
    13261 agggagtcag aacagttaag tactaaaaag acaaggatct ggagtgagag tccctagggc
    13321 tatgtcactg gattcatgtt tctttatggg caagctactt aacatctctg catccccatc
    13381 tctcaaaata accataacac tacctacctc acaagggtgc tgtgaggctt accatgaaaa
    13441 gcatgaggaa atggtatata gaattgggga cctagtagaa aggtgctaca ggattagagt
    13501 aactagatat cattgagtat gaaccctgct ttccctggga gccccaggtt tgccagaata
    13561 tgtctaatct ctttacggct agaatctaaa atggtgttgg ccatcgattg gcttaggtta
    13621 tctttaatgt cattgacttt tacaaaattc gtaacgacac ctctttctca gagagatgct
    13681 ggattggaaa aattattaaa ttaattttaa caaaggagaa caaaaatgat tcacttccag
    13741 gtgctgggtg tggcggaaca gttatttatt tcaatatgaa acaagagttt gaatggatat
    13801 cttcaagggg atgcatttta ttggagacat ttattgcctg gggctttctg ttttcagtct
    13861 gactccccag ctttctgtat cattgtttta acatacatcc ccttttctcc tttattggaa
    13921 gagaagctat aattctcctc atttcatgat aatccttttc agtctgtttt gctcaaagga
    13981 caaattcttt tcaacaacta ttgtaattat tttcttagag ggccattttt aattgccgta
    14041 ttgtttagct aagccctatt gtcttggtgt ccttcaaaac tgtcagttgc attaaaatat
    14101 aggggtggga ggggagctga taagcacatt gttgtaattg atttgtatgt ttgaattgtc
    14161 ttatcagaaa acaaggttat gaatttcatc tgttgagaca caaaaataaa atactttctt
    14221 aaaaaa
//
