LOCUS       NM_032808               3477 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens leucine rich repeat and Ig domain containing 1
            (LINGO1), transcript variant 1, mRNA.
ACCESSION   NM_032808
VERSION     NM_032808.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3477)
  AUTHORS   Andrews,J.L., Zalesky,A., Nair,S., Sullivan,R.P., Green,M.J.,
            Pantelis,C., Newell,K.A. and Fernandez,F.
  TITLE     Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive
            Function and White Matter Microstructure in a Case-Control Study
            for Schizophrenia
  JOURNAL   Int J Mol Sci 24 (21), 15624 (2023)
   PUBMED   37958608
  REMARK    GeneRIF: Genetic and Epigenetic Regulation in Lingo-1: Effects on
            Cognitive Function and White Matter Microstructure in a
            Case-Control Study for Schizophrenia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3477)
  AUTHORS   Kalafatakis,I., Papagianni,F., Theodorakis,K. and Karagogeos,D.
  TITLE     Nogo-A and LINGO-1: Two Important Targets for Remyelination and
            Regeneration
  JOURNAL   Int J Mol Sci 24 (5), 4479 (2023)
   PUBMED   36901909
  REMARK    GeneRIF: Nogo-A and LINGO-1: Two Important Targets for
            Remyelination and Regeneration.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3477)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     LINGO-1 shRNA protects the brain against ischemia/reperfusion
            injury by inhibiting the activation of NF-kappaB and JAK2/STAT3
  JOURNAL   Hum Cell 34 (4), 1114-1122 (2021)
   PUBMED   33830473
  REMARK    GeneRIF: LINGO-1 shRNA protects the brain against
            ischemia/reperfusion injury by inhibiting the activation of
            NF-kappaB and JAK2/STAT3.
REFERENCE   4  (bases 1 to 3477)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3477)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3477)
  AUTHORS   Satoh,J., Tabunoki,H., Yamamura,T., Arima,K. and Konno,H.
  TITLE     TROY and LINGO-1 expression in astrocytes and macrophages/microglia
            in multiple sclerosis lesions
  JOURNAL   Neuropathol Appl Neurobiol 33 (1), 99-107 (2007)
   PUBMED   17239012
  REMARK    GeneRIF: the ternary complex of NgR/TROY/LINGO-1 expressed on
            astrocytes, macrophages/microglia and neurones, by interacting with
            Nogo-A on oligodendrocytes, might modulate glial-neuronal
            interactions in demyelinating lesions of multiple sclerosis
REFERENCE   7  (bases 1 to 3477)
  AUTHORS   Mosyak,L., Wood,A., Dwyer,B., Buddha,M., Johnson,M., Aulabaugh,A.,
            Zhong,X., Presman,E., Benard,S., Kelleher,K., Wilhelm,J.,
            Stahl,M.L., Kriz,R., Gao,Y., Cao,Z., Ling,H.P., Pangalos,M.N.,
            Walsh,F.S. and Somers,W.S.
  TITLE     The structure of the Lingo-1 ectodomain, a module implicated in
            central nervous system repair inhibition
  JOURNAL   J Biol Chem 281 (47), 36378-36390 (2006)
   PUBMED   17005555
  REMARK    GeneRIF: the Lingo-1 ectodomain is a module implicated in central
            nervous system repair inhibition
REFERENCE   8  (bases 1 to 3477)
  AUTHORS   Mi,S., Lee,X., Shao,Z., Thill,G., Ji,B., Relton,J., Levesque,M.,
            Allaire,N., Perrin,S., Sands,B., Crowell,T., Cate,R.L., McCoy,J.M.
            and Pepinsky,R.B.
  TITLE     LINGO-1 is a component of the Nogo-66 receptor/p75 signaling
            complex
  JOURNAL   Nat Neurosci 7 (3), 221-228 (2004)
   PUBMED   14966521
REFERENCE   9  (bases 1 to 3477)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene
            with enriched expression in limbic system and neocortex
  JOURNAL   Eur J Neurosci 18 (12), 3167-3182 (2003)
   PUBMED   14686891
  REMARK    GeneRIF: The LERN1 expression pattern is specific to the central
            nervous system, highly and broadly expressed during early stages of
            development and gradually restricted to forebrain structures as
            development proceeds(LERN1)
REFERENCE   10 (bases 1 to 3477)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC046168.12, BI523562.1, BC011057.1 and AK027500.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032808.6.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY324320.1, BC011057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355300.7/ ENSP00000347451.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AC046168.12        145968-146352       c
            386-545             BI523562.1         31-190
            546-2821            BC011057.1         1-2276
            2822-3477           AK027500.1         1370-2025
FEATURES             Location/Qualifiers
     source          1..3477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.3"
     gene            1..3477
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="leucine rich repeat and Ig domain containing 1"
                     /db_xref="GeneID:84894"
                     /db_xref="HGNC:HGNC:21205"
                     /db_xref="MIM:609791"
     exon            1..603
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..2460
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; leucine-rich repeat neuronal protein 1; leucine
                     rich repeat neuronal 6A; leucine-rich repeat and
                     immunoglobulin-like domain-containing nogo
                     receptor-interacting protein 1; leucine-rich repeat and
                     immunoglobulin domain-containing protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     isoform a precursor"
                     /protein_id="NP_116197.4"
                     /db_xref="CCDS:CCDS45313.1"
                     /db_xref="GeneID:84894"
                     /db_xref="HGNC:HGNC:21205"
                     /db_xref="MIM:609791"
                     /translation="MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPP
                     RCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELEL
                     NENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLD
                     YMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLI
                     VLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLT
                     AVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGL
                     NYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQ
                     QPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADG
                     DPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSM
                     PAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFI
                     SFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI"
     exon            604..3477
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2743..2748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="hexamer: AATAAA"
     polyA_site      2771
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="major polyA site"
     regulatory      2814..2819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="hexamer: AATAAA"
     polyA_site      2834
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
     polyA_site      3477
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="major polyA site"
ORIGIN      
        1 agtgctccct ccccgcgccg ctgcagagcg cggagcccga gcgggagccg gcgcgggagc
       61 cggagcgggc ggcgggcgac agcgcaggcg gcggcggcgg cggtgggtcc tggtcccggc
      121 cccggagggc gcggagtccc cacccgcgcc gctccggccc ctctcccgac gcggggcgcc
      181 gagcagcatg cgcggccgct gcccgccggc cccggccccg cggcggagcg cgcccggcct
      241 cgaccccggc cccagcggca gaggcggcgg cggcggctcc gggccggccc agggggcaga
      301 agcaggctcg cgcagcccct gtcccgcggc ctgagcgcgc ccgcccatcc gcccgccggg
      361 gccgcggcct cccgcctccc cactcccgag ccccggcccc ggctccggct cggctcccgc
      421 ccgcgcgggg cggacagacg gacagccagc cccgcgaggg cgcgcggact gccgggcgga
      481 ggtgtcggag gaggaggaaa cggaggaggg ggctgggcag gggctggggc ctggtcgggc
      541 cggctggaga gacatgcgat tggtgaccga gccgagcgga ccgaaggcgc gcccgagatg
      601 caggtgagca agaggatgct ggcggggggc gtgaggagca tgcccagccc cctcctggcc
      661 tgctggcagc ccatcctcct gctggtgctg ggctcagtgc tgtcaggctc ggccacgggc
      721 tgcccgcccc gctgcgagtg ctccgcccag gaccgcgctg tgctgtgcca ccgcaagcgc
      781 tttgtggcag tccccgaggg catccccacc gagacgcgcc tgctggacct aggcaagaac
      841 cgcatcaaaa cgctcaacca ggacgagttc gccagcttcc cgcacctgga ggagctggag
      901 ctcaacgaga acatcgtgag cgccgtggag cccggcgcct tcaacaacct cttcaacctc
      961 cggacgctgg gtctccgcag caaccgcctg aagctcatcc cgctaggcgt cttcactggc
     1021 ctcagcaacc tgaccaagct ggacatcagc gagaacaaga tcgttatcct actggactac
     1081 atgtttcagg acctgtacaa cctcaagtca ctggaggttg gcgacaatga cctcgtctac
     1141 atctctcacc gcgccttcag cggcctcaac agcctggagc agctgacgct ggagaaatgc
     1201 aacctgacct ccatccccac cgaggcgctg tcccacctgc acggcctcat cgtcctgagg
     1261 ctccggcacc tcaacatcaa tgccatccgg gactactcct tcaagaggct gtaccgactc
     1321 aaggtcttgg agatctccca ctggccctac ttggacacca tgacacccaa ctgcctctac
     1381 ggcctcaacc tgacgtccct gtccatcaca cactgcaatc tgaccgctgt gccctacctg
     1441 gccgtccgcc acctagtcta tctccgcttc ctcaacctct cctacaaccc catcagcacc
     1501 attgagggct ccatgttgca tgagctgctc cggctgcagg agatccagct ggtgggcggg
     1561 cagctggccg tggtggagcc ctatgccttc cgcggcctca actacctgcg cgtgctcaat
     1621 gtctctggca accagctgac cacactggag gaatcagtct tccactcggt gggcaacctg
     1681 gagacactca tcctggactc caacccgctg gcctgcgact gtcggctcct gtgggtgttc
     1741 cggcgccgct ggcggctcaa cttcaaccgg cagcagccca cgtgcgccac gcccgagttt
     1801 gtccagggca aggagttcaa ggacttccct gatgtgctac tgcccaacta cttcacctgc
     1861 cgccgcgccc gcatccggga ccgcaaggcc cagcaggtgt ttgtggacga gggccacacg
     1921 gtgcagtttg tgtgccgggc cgatggcgac ccgccgcccg ccatcctctg gctctcaccc
     1981 cgaaagcacc tggtctcagc caagagcaat gggcggctca cagtcttccc tgatggcacg
     2041 ctggaggtgc gctacgccca ggtacaggac aacggcacgt acctgtgcat cgcggccaac
     2101 gcgggcggca acgactccat gcccgcccac ctgcatgtgc gcagctactc gcccgactgg
     2161 ccccatcagc ccaacaagac cttcgctttc atctccaacc agccgggcga gggagaggcc
     2221 aacagcaccc gcgccactgt gcctttcccc ttcgacatca agaccctcat catcgccacc
     2281 accatgggct tcatctcttt cctgggcgtc gtcctcttct gcctggtgct gctgtttctc
     2341 tggagccggg gcaagggcaa cacaaagcac aacatcgaga tcgagtatgt gccccgaaag
     2401 tcggacgcag gcatcagctc cgccgacgcg ccccgcaagt tcaacatgaa gatgatatga
     2461 ggccggggcg gggggcaggg acccccgggc ggccgggcag gggaaggggc ctggccgcca
     2521 cctgctcact ctccagtcct tcccacctcc tccctaccct tctacacacg ttctctttct
     2581 ccctcccgcc tccgtcccct gctgcccccc gccagccctc accacctgcc ctccttctac
     2641 caggacctca gaagcccaga cctggggacc ccacctacac aggggcattg acagactgga
     2701 gttgaaagcc gacgaaccga cacgcggcag agtcaataat tcaataaaaa agttacgaac
     2761 tttctctgta acttgggttt caataattat ggatttttat gaaaacttga aataataaaa
     2821 agagaaaaaa actatttcct atagctagtc ggaatgcaaa cttttgacgt cctgattgct
     2881 ccagggccct cttccaactc agtttcttgt ttttctcttc ctcctcctcc tcttcttcct
     2941 cctttctctt ctcttcccca gtggggaggg atcactcagg aaaacaggaa aggaggttcc
     3001 agccccaccc acctgcccac cccgccccag gcaccatcag gagcaggcta gggggcaggc
     3061 ctgggcccag ctccgggctg gctttttgca gggcgcaggt ggaggggaca ggtctgccga
     3121 tgggggtggg agcctgtctg ctgggctgcc aggcggcacc actgcaaggg gtgggagcct
     3181 ggcttgggtg tggctgagac tctggacaga ggctggggtc ctcctggggg acagcacagt
     3241 cagtggagag agccaggggc tggaggtggg gcccacccca gcctctggtc ccagctctgc
     3301 tgctcacttg ctgtgtggcc tcaagcaggt cactggcctc tctgggcctc agtctccaca
     3361 tctgtacaaa tgggaacatt accccctgcc ctgcctacct cacagggctg ttgtgaggaa
     3421 ttgatgagat gatgtatgtg aaacactttg taacctgtaa agcgctgtgc acacgtg
//
