LOCUS       NM_001301186            3377 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat and Ig domain containing 1
            (LINGO1), transcript variant 2, mRNA.
ACCESSION   NM_001301186
VERSION     NM_001301186.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3377)
  AUTHORS   Andrews,J.L., Zalesky,A., Nair,S., Sullivan,R.P., Green,M.J.,
            Pantelis,C., Newell,K.A. and Fernandez,F.
  TITLE     Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive
            Function and White Matter Microstructure in a Case-Control Study
            for Schizophrenia
  JOURNAL   Int J Mol Sci 24 (21), 15624 (2023)
   PUBMED   37958608
  REMARK    GeneRIF: Genetic and Epigenetic Regulation in Lingo-1: Effects on
            Cognitive Function and White Matter Microstructure in a
            Case-Control Study for Schizophrenia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3377)
  AUTHORS   Kalafatakis,I., Papagianni,F., Theodorakis,K. and Karagogeos,D.
  TITLE     Nogo-A and LINGO-1: Two Important Targets for Remyelination and
            Regeneration
  JOURNAL   Int J Mol Sci 24 (5), 4479 (2023)
   PUBMED   36901909
  REMARK    GeneRIF: Nogo-A and LINGO-1: Two Important Targets for
            Remyelination and Regeneration.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3377)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     LINGO-1 shRNA protects the brain against ischemia/reperfusion
            injury by inhibiting the activation of NF-kappaB and JAK2/STAT3
  JOURNAL   Hum Cell 34 (4), 1114-1122 (2021)
   PUBMED   33830473
  REMARK    GeneRIF: LINGO-1 shRNA protects the brain against
            ischemia/reperfusion injury by inhibiting the activation of
            NF-kappaB and JAK2/STAT3.
REFERENCE   4  (bases 1 to 3377)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3377)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3377)
  AUTHORS   Satoh,J., Tabunoki,H., Yamamura,T., Arima,K. and Konno,H.
  TITLE     TROY and LINGO-1 expression in astrocytes and macrophages/microglia
            in multiple sclerosis lesions
  JOURNAL   Neuropathol Appl Neurobiol 33 (1), 99-107 (2007)
   PUBMED   17239012
  REMARK    GeneRIF: the ternary complex of NgR/TROY/LINGO-1 expressed on
            astrocytes, macrophages/microglia and neurones, by interacting with
            Nogo-A on oligodendrocytes, might modulate glial-neuronal
            interactions in demyelinating lesions of multiple sclerosis
REFERENCE   7  (bases 1 to 3377)
  AUTHORS   Mosyak,L., Wood,A., Dwyer,B., Buddha,M., Johnson,M., Aulabaugh,A.,
            Zhong,X., Presman,E., Benard,S., Kelleher,K., Wilhelm,J.,
            Stahl,M.L., Kriz,R., Gao,Y., Cao,Z., Ling,H.P., Pangalos,M.N.,
            Walsh,F.S. and Somers,W.S.
  TITLE     The structure of the Lingo-1 ectodomain, a module implicated in
            central nervous system repair inhibition
  JOURNAL   J Biol Chem 281 (47), 36378-36390 (2006)
   PUBMED   17005555
  REMARK    GeneRIF: the Lingo-1 ectodomain is a module implicated in central
            nervous system repair inhibition
REFERENCE   8  (bases 1 to 3377)
  AUTHORS   Mi,S., Lee,X., Shao,Z., Thill,G., Ji,B., Relton,J., Levesque,M.,
            Allaire,N., Perrin,S., Sands,B., Crowell,T., Cate,R.L., McCoy,J.M.
            and Pepinsky,R.B.
  TITLE     LINGO-1 is a component of the Nogo-66 receptor/p75 signaling
            complex
  JOURNAL   Nat Neurosci 7 (3), 221-228 (2004)
   PUBMED   14966521
REFERENCE   9  (bases 1 to 3377)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene
            with enriched expression in limbic system and neocortex
  JOURNAL   Eur J Neurosci 18 (12), 3167-3182 (2003)
   PUBMED   14686891
  REMARK    GeneRIF: The LERN1 expression pattern is specific to the central
            nervous system, highly and broadly expressed during early stages of
            development and gradually restricted to forebrain structures as
            development proceeds(LERN1)
REFERENCE   10 (bases 1 to 3377)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA150164.1, DA232085.1, BC011057.1 and AK027500.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001301186.1.
            
            Transcript Variant: This variant (2) contains alternate 5' exon
            structure and thus differs in the 5' UTR, lacks a portion of the 5'
            coding region, and initiates translation at a downstream in-frame
            start codon, compared to variant 1. The encoded isoform (b) is
            shorter at the N-terminus, compared to isoform a. Variants 2
            through 12 all encode isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA150164.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2145743,
                                           SAMEA2148093 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               DA150164.1         1-319
            320-358             DA232085.1         347-385
            359-456             DA150164.1         359-456
            457-503             DA232085.1         484-530
            504-2721            BC011057.1         59-2276
            2722-3377           AK027500.1         1370-2025
FEATURES             Location/Qualifiers
     source          1..3377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.3"
     gene            1..3377
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="leucine rich repeat and Ig domain containing 1"
                     /db_xref="GeneID:84894"
                     /db_xref="HGNC:HGNC:21205"
                     /db_xref="MIM:609791"
     exon            1..58
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            59..173
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            174..235
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            236..417
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            418..503
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            504..3377
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..2360
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; leucine-rich repeat neuronal protein 1; leucine
                     rich repeat neuronal 6A; leucine-rich repeat and
                     immunoglobulin-like domain-containing nogo
                     receptor-interacting protein 1; leucine-rich repeat and
                     immunoglobulin domain-containing protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     isoform b precursor"
                     /protein_id="NP_001288115.1"
                     /db_xref="CCDS:CCDS73766.1"
                     /db_xref="GeneID:84894"
                     /db_xref="HGNC:HGNC:21205"
                     /db_xref="MIM:609791"
                     /translation="MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSA
                     QDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVS
                     AVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDL
                     YNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRH
                     LNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA
                     VRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVL
                     NVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCAT
                     PEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAI
                     LWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV
                     RSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVV
                     LFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI"
     regulatory      2643..2648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="hexamer: AATAAA"
     polyA_site      2671
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="major polyA site"
     regulatory      2714..2719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="hexamer: AATAAA"
     polyA_site      2734
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
     polyA_site      3377
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /note="major polyA site"
ORIGIN      
        1 acctcgttcc ctggtttccc tgatgaggca gttggaagga ggaggcagac cagtcctgcc
       61 tccggcaccc acaggccctg aggctccagt gcccacaggc agagagggcg actgagtcca
      121 gcccaggctg agccctgccc agctgtactc cccagacacc cacccaaccc gaggtgtccc
      181 accgaggagg ccctgatctt gagcccggag ccctgagccc tgagacgatg cttgaggatc
      241 ttatgaccat gacctggcta ccttgagtct gtggggctac acagccttca gcctgcatct
      301 ccagggctct gactctatcc agctcctgga ccagctccca agtctactcc tgaccccagc
      361 ctgggccaag gggacttctc aagctttggg acccagcagg acacagcagc agtcaggtgc
      421 atgctgggac cgcgacggac aggctgccgc accccaggcc cccagaggcc agtctgtttg
      481 cctcccaacg ccatctgacc caggtgagca agaggatgct ggcggggggc gtgaggagca
      541 tgcccagccc cctcctggcc tgctggcagc ccatcctcct gctggtgctg ggctcagtgc
      601 tgtcaggctc ggccacgggc tgcccgcccc gctgcgagtg ctccgcccag gaccgcgctg
      661 tgctgtgcca ccgcaagcgc tttgtggcag tccccgaggg catccccacc gagacgcgcc
      721 tgctggacct aggcaagaac cgcatcaaaa cgctcaacca ggacgagttc gccagcttcc
      781 cgcacctgga ggagctggag ctcaacgaga acatcgtgag cgccgtggag cccggcgcct
      841 tcaacaacct cttcaacctc cggacgctgg gtctccgcag caaccgcctg aagctcatcc
      901 cgctaggcgt cttcactggc ctcagcaacc tgaccaagct ggacatcagc gagaacaaga
      961 tcgttatcct actggactac atgtttcagg acctgtacaa cctcaagtca ctggaggttg
     1021 gcgacaatga cctcgtctac atctctcacc gcgccttcag cggcctcaac agcctggagc
     1081 agctgacgct ggagaaatgc aacctgacct ccatccccac cgaggcgctg tcccacctgc
     1141 acggcctcat cgtcctgagg ctccggcacc tcaacatcaa tgccatccgg gactactcct
     1201 tcaagaggct gtaccgactc aaggtcttgg agatctccca ctggccctac ttggacacca
     1261 tgacacccaa ctgcctctac ggcctcaacc tgacgtccct gtccatcaca cactgcaatc
     1321 tgaccgctgt gccctacctg gccgtccgcc acctagtcta tctccgcttc ctcaacctct
     1381 cctacaaccc catcagcacc attgagggct ccatgttgca tgagctgctc cggctgcagg
     1441 agatccagct ggtgggcggg cagctggccg tggtggagcc ctatgccttc cgcggcctca
     1501 actacctgcg cgtgctcaat gtctctggca accagctgac cacactggag gaatcagtct
     1561 tccactcggt gggcaacctg gagacactca tcctggactc caacccgctg gcctgcgact
     1621 gtcggctcct gtgggtgttc cggcgccgct ggcggctcaa cttcaaccgg cagcagccca
     1681 cgtgcgccac gcccgagttt gtccagggca aggagttcaa ggacttccct gatgtgctac
     1741 tgcccaacta cttcacctgc cgccgcgccc gcatccggga ccgcaaggcc cagcaggtgt
     1801 ttgtggacga gggccacacg gtgcagtttg tgtgccgggc cgatggcgac ccgccgcccg
     1861 ccatcctctg gctctcaccc cgaaagcacc tggtctcagc caagagcaat gggcggctca
     1921 cagtcttccc tgatggcacg ctggaggtgc gctacgccca ggtacaggac aacggcacgt
     1981 acctgtgcat cgcggccaac gcgggcggca acgactccat gcccgcccac ctgcatgtgc
     2041 gcagctactc gcccgactgg ccccatcagc ccaacaagac cttcgctttc atctccaacc
     2101 agccgggcga gggagaggcc aacagcaccc gcgccactgt gcctttcccc ttcgacatca
     2161 agaccctcat catcgccacc accatgggct tcatctcttt cctgggcgtc gtcctcttct
     2221 gcctggtgct gctgtttctc tggagccggg gcaagggcaa cacaaagcac aacatcgaga
     2281 tcgagtatgt gccccgaaag tcggacgcag gcatcagctc cgccgacgcg ccccgcaagt
     2341 tcaacatgaa gatgatatga ggccggggcg gggggcaggg acccccgggc ggccgggcag
     2401 gggaaggggc ctggccgcca cctgctcact ctccagtcct tcccacctcc tccctaccct
     2461 tctacacacg ttctctttct ccctcccgcc tccgtcccct gctgcccccc gccagccctc
     2521 accacctgcc ctccttctac caggacctca gaagcccaga cctggggacc ccacctacac
     2581 aggggcattg acagactgga gttgaaagcc gacgaaccga cacgcggcag agtcaataat
     2641 tcaataaaaa agttacgaac tttctctgta acttgggttt caataattat ggatttttat
     2701 gaaaacttga aataataaaa agagaaaaaa actatttcct atagctagtc ggaatgcaaa
     2761 cttttgacgt cctgattgct ccagggccct cttccaactc agtttcttgt ttttctcttc
     2821 ctcctcctcc tcttcttcct cctttctctt ctcttcccca gtggggaggg atcactcagg
     2881 aaaacaggaa aggaggttcc agccccaccc acctgcccac cccgccccag gcaccatcag
     2941 gagcaggcta gggggcaggc ctgggcccag ctccgggctg gctttttgca gggcgcaggt
     3001 ggaggggaca ggtctgccga tgggggtggg agcctgtctg ctgggctgcc aggcggcacc
     3061 actgcaaggg gtgggagcct ggcttgggtg tggctgagac tctggacaga ggctggggtc
     3121 ctcctggggg acagcacagt cagtggagag agccaggggc tggaggtggg gcccacccca
     3181 gcctctggtc ccagctctgc tgctcacttg ctgtgtggcc tcaagcaggt cactggcctc
     3241 tctgggcctc agtctccaca tctgtacaaa tgggaacatt accccctgcc ctgcctacct
     3301 cacagggctg ttgtgaggaa ttgatgagat gatgtatgtg aaacactttg taacctgtaa
     3361 agcgctgtgc acacgtg
//
