LOCUS       NM_001303016            2522 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens LINC02210-CRHR1 readthrough (LINC02210-CRHR1),
            transcript variant 6, mRNA.
ACCESSION   NM_001303016
VERSION     NM_001303016.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Hollenstein K, Kean J, Bortolato A, Cheng RK, Dore AS, Jazayeri A,
            Cooke RM, Weir M and Marshall FH.
  TITLE     Structure of class B GPCR corticotropin-releasing factor receptor 1
  JOURNAL   Nature 499 (7459), 438-443 (2013)
   PUBMED   23863939
REFERENCE   2  (bases 1 to 2522)
  AUTHORS   Dunn HA, Walther C, Godin CM, Hall RA and Ferguson SS.
  TITLE     Role of SAP97 protein in the regulation of corticotropin-releasing
            factor receptor 1 endocytosis and extracellular signal-regulated
            kinase 1/2 signaling
  JOURNAL   J. Biol. Chem. 288 (21), 15023-15034 (2013)
   PUBMED   23576434
REFERENCE   3  (bases 1 to 2522)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS ONE 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2522)
  AUTHORS   Pioszak AA, Parker NR, Suino-Powell K and Xu HE.
  TITLE     Molecular recognition of corticotropin-releasing factor by its
            G-protein-coupled receptor CRFR1
  JOURNAL   J. Biol. Chem. 283 (47), 32900-32912 (2008)
   PUBMED   18801728
REFERENCE   5  (bases 1 to 2522)
  AUTHORS   Tao J, Hildebrand ME, Liao P, Liang MC, Tan G, Li S, Snutch TP and
            Soong TW.
  TITLE     Activation of corticotropin-releasing factor receptor 1 selectively
            inhibits CaV3.2 T-type calcium channels
  JOURNAL   Mol. Pharmacol. 73 (6), 1596-1609 (2008)
   PUBMED   18292205
REFERENCE   6  (bases 1 to 2522)
  AUTHORS   Sakai K, Yamada M, Horiba N, Wakui M, Demura H and Suda T.
  TITLE     The genomic organization of the human corticotropin-releasing
            factor type-1 receptor
  JOURNAL   Gene 219 (1-2), 125-130 (1998)
   PUBMED   9757017
REFERENCE   7  (bases 1 to 2522)
  AUTHORS   Vita N, Laurent P, Lefort S, Chalon P, Lelias JM, Kaghad M, Le Fur
            G, Caput D and Ferrara P.
  TITLE     Primary structure and functional expression of mouse pituitary and
            human brain corticotrophin releasing factor receptors
  JOURNAL   FEBS Lett. 335 (1), 1-5 (1993)
   PUBMED   8243652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FJ543100.1, AK297590.1 and AC217771.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between neighboring genes CRHR1-IT1, CRHR1 intronic
            transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing
            hormone receptor 1 (Gene ID: 1394) on chromosome 17. The
            readthrough transcript encodes a protein that shares sequence
            identity with the product of the CRHR1 gene. [provided by RefSeq,
            Dec 2016].
            
            Transcript Variant: This variant (6) encodes the longer isoform
            (6).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297590.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 1394, 147081
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               FJ543100.1         30-312
            284-1595            AK297590.1         266-1577
            1596-2522           AC217771.1         70020-70946         c
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2522
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /note="LINC02210-CRHR1 readthrough"
                     /db_xref="GeneID:104909134"
                     /db_xref="HGNC:HGNC:51483"
     exon            1..134
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..389
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..465
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..553
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..673
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             650..1507
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     CRHR1-IT1-CRHR1 readthrough"
                     /codon_start=1
                     /product="CRHR1-IT1-CRHR1 protein isoform 6"
                     /protein_id="NP_001289945.1"
                     /db_xref="GeneID:104909134"
                     /db_xref="HGNC:HGNC:51483"
                     /translation="MVSATIPQKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLR
                     SIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNF
                     FWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFG
                     KRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRASLCLCSTV
                     SSIVRSVLPSGRGGTGGRTSTRSVPEWPVPCPSPPPQPVSAFTASSSPQQSELAGHGA
                     APKELWLGG"
     exon            674..780
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..901
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1055
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1116
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1189
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1275
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1317
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..2522
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /note="hexamer: AATAAT"
     polyA_site      2522
                     /gene="LINC02210-CRHR1"
                     /gene_synonym="CRHR1-IT1-CRHR1; MGC57346-CRHR1"
                     /note="major polyA site"
ORIGIN      
        1 ataccttctc gaaacaaaag attttcctac ctgcttatac ttggtaaccg agggaatttc
       61 taagacttct tgctcatttc tgagtattgt ctttatatcc tgacactatg aatgctactt
      121 ggatgcctct taagggtctc ttctgcaggg tccccatgaa ttgtggctga agttgtgcac
      181 aaacaagtat ctccagtgac aggagtgcct tctgaggcag ccattgcatc ttcatctgct
      241 gacactctgc taggctgact tctgtagttt tcaccactga tcttcagtcc acctcacaga
      301 gctctataaa acgcttaaat cctctttaca tcatagactt tcagctactt gaagatagcc
      361 atcagccgct acgtgactct tttctccagg aacgaggggt ccctgaggga aaggactggg
      421 gctccttcat ctctatgatc ctagtgcagt gtctgaaggc atcaggccct tctccttctg
      481 gggctgaacc ccgtctctgc ctccctccag gaccagcact gcgagagcct gtccctggcc
      541 agcaacatct caggactgca gtgcaacgca tccgtggacc tcattggcac ctgctggccc
      601 cgcagccctg cggggcagct agtggttcgg ccctgccctg cctttttcta tggtgtccgc
      661 tacaatacca caaaaaaaaa gcaaggtgca ctaccatgtc gcagtcatca tcaactacct
      721 gggccactgt atctccctgg tggccctcct ggtggccttt gtcctctttc tgcggctcag
      781 gagcatccgg tgcctgcgaa acatcatcca ctggaacctc atctccgcct tcatcctgcg
      841 caacgccacc tggttcgtgg tccagctaac catgagcccc gaggtccacc agagcaacgt
      901 gggctggtgc aggttggtga cagccgccta caactacttc catgtgacca acttcttctg
      961 gatgttcggc gagggctgct acctgcacac agccatcgtg ctcacctact ccactgaccg
     1021 gctgcgcaaa tggatgttca tctgcattgg ctggggtgtg cccttcccca tcattgtggc
     1081 ctgggccatt gggaagctgt actacgacaa tgagaagtgc tggtttggca aaaggcctgg
     1141 ggtgtacacc gactacatct accagggccc catgatcctg gtcctgctga tcaatttcat
     1201 cttccttttc aacatcgtcc gcatcctcat gaccaagctc cgggcatcca ccacgtctga
     1261 gaccattcag tacagggctt ctttgtgtct gtgttctact gtttcctcaa tagtgaggtc
     1321 cgttctgcca tccggaagag gtggcaccgg tggcaggaca agcactcgat ccgtgcccga
     1381 gtggcccgtg ccatgtccat ccccacctcc ccaacccgtg tcagctttca cagcatcaag
     1441 cagtccacag cagtctgagc tggcaggtca tggagcagcc cccaaagagc tgtggctggg
     1501 gggatgacgg ccaggctccc tgaccaccct gcctgtggag gtgacctgtt aggtctcatg
     1561 cccactcccc caggagcagc tggcactgac agcctggggg ggccgctctc cccctgcagc
     1621 cgtgcaggac tctagctcat gagtggaaag tcacctacag gactgggccg ggcccagggc
     1681 ctctggcttc cctgcccaat cctccctgga gaagggacat gggaatgaat tgaaatgggg
     1741 cgctggacac ctacagcagc acgcatgtcc ctccaaggct gtcttctccc agagcacaag
     1801 aaggccagcc cactgggccc tggggctgcc ctcggcaacc gtggggaggc catttgctgc
     1861 cctggggcat catgggcaac tcgtgacagc ctctgactca ccacgatgac gcctctggac
     1921 ctcggtgatg ccttccgaca ccactgggaa ccaagggccc tcactcagga accctggaga
     1981 cagaagtcag gtgtcatcat cagacttgcg gccacagcac tagagtcacc cccccaggcc
     2041 tccagaacct tactggcact gtggcactgc caccagcaat gccctgcctt gctgccttca
     2101 ccctgaacat ttagtaccct gcaggccagg ccagcttccc ctcacttaac caccccatac
     2161 cagtcacctc ctgctccttt tcctcttttg tgagaagatg ggggctggag ggggcagagt
     2221 ggcctgtgag caagagccag gggtgtccca gtcccagcct ctggggcaga gcttgtagcc
     2281 ctggatggcc tctggggcag gaccactagc taagcaagcc aggagaagac ccctgcccaa
     2341 gtggctcttg ggacaacgtg ctgcttacac tccaggtgtg gaccggccgc agcccccact
     2401 gacctgccca tgtccagagg gactggacag ccagggcagg gctttggggg gcactagaag
     2461 atgagggtgt cggctgtgag gcgggtggct ggtataaata atatttatct tttcaaccag
     2521 ca
//
