LOCUS       NM_001366245            2998 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens lin-9 DREAM MuvB core complex component (LIN9),
            transcript variant 9, mRNA.
ACCESSION   NM_001366245
VERSION     NM_001366245.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2998)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2998)
  AUTHORS   Roberts,M.S., Sahni,J.M., Schrock,M.S., Piemonte,K.M.,
            Weber-Bonk,K.L., Seachrist,D.D., Avril,S., Anstine,L.J., Singh,S.,
            Sizemore,S.T., Varadan,V., Summers,M.K. and Keri,R.A.
  TITLE     LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be
            Therapeutically Targeted to Overcome Taxane Resistance
  JOURNAL   Cancer Res 80 (8), 1693-1706 (2020)
   PUBMED   32054769
  REMARK    GeneRIF: LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That
            Can Be Therapeutically Targeted to Overcome Taxane Resistance.
REFERENCE   3  (bases 1 to 2998)
  AUTHORS   Sahni,J.M., Gayle,S.S., Webb,B.M., Weber-Bonk,K.L., Seachrist,D.D.,
            Singh,S., Sizemore,S.T., Restrepo,N.A., Bebek,G., Scacheri,P.C.,
            Varadan,V., Summers,M.K. and Keri,R.A.
  TITLE     Mitotic Vulnerability in Triple-Negative Breast Cancer Associated
            with LIN9 Is Targetable with BET Inhibitors
  JOURNAL   Cancer Res 77 (19), 5395-5408 (2017)
   PUBMED   28807940
  REMARK    GeneRIF: High LIN9 expression is associated with Triple-negative
            breast cancers.
REFERENCE   4  (bases 1 to 2998)
  AUTHORS   Wolter,P., Hanselmann,S., Pattschull,G., Schruf,E. and Gaubatz,S.
  TITLE     Central spindle proteins and mitotic kinesins are direct
            transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer
            cell lines and are potential targets for therapy
  JOURNAL   Oncotarget 8 (7), 11160-11172 (2017)
   PUBMED   28061449
  REMARK    GeneRIF: The MuvB multiprotein complex, together with B-MYB and
            FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in
            breast cancer cells.
REFERENCE   5  (bases 1 to 2998)
  AUTHORS   Eckerdt,F., Perez-Neut,M. and Colamonici,O.R.
  TITLE     LIN-9 phosphorylation on threonine-96 is required for
            transcriptional activation of LIN-9 target genes and promotes cell
            cycle progression
  JOURNAL   PLoS One 9 (1), e87620 (2014)
   PUBMED   24475316
  REMARK    GeneRIF: LIN-9 phosphorylation on threonine-96 is required for
            transcriptional activation of LIN-9 target genes and promotes cell
            cycle progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2998)
  AUTHORS   Osterloh,L., von Eyss,B., Schmit,F., Rein,L., Hubner,D., Samans,B.,
            Hauser,S. and Gaubatz,S.
  TITLE     The human synMuv-like protein LIN-9 is required for transcription
            of G2/M genes and for entry into mitosis
  JOURNAL   EMBO J 26 (1), 144-157 (2007)
   PUBMED   17159899
  REMARK    GeneRIF: human LIN-9, together with B-MYB, has a critical role in
            the activation of genes that are essential for progression into
            mitosis
REFERENCE   7  (bases 1 to 2998)
  AUTHORS   Pilkinton,M., Sandoval,R., Song,J., Ness,S.A. and Colamonici,O.R.
  TITLE     Mip/LIN-9 regulates the expression of B-Myb and the induction of
            cyclin A, cyclin B, and CDK1
  JOURNAL   J Biol Chem 282 (1), 168-175 (2007)
   PUBMED   17098733
  REMARK    GeneRIF: Mip/LIN-9 is required for the expression of B-Myb, and
            both proteins collaborate in the control of the cell cycle
            progression via the regulation of S phase and cyclin A, cyclin B,
            and CDK1
REFERENCE   8  (bases 1 to 2998)
  AUTHORS   Sandoval,R., Xue,J., Tian,X., Barrett,K., Pilkinton,M., Ucker,D.S.,
            Raychaudhuri,P., Kineman,R.D., Luque,R.M., Baida,G., Zou,X.,
            Valli,V.E., Cook,J.L., Kiyokawa,H. and Colamonici,O.R.
  TITLE     A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by
            releasing the repression on E2F-regulated genes
  JOURNAL   Exp Cell Res 312 (13), 2465-2475 (2006)
   PUBMED   16730350
  REMARK    GeneRIF: Mutation of BARA/LIN-9 restores the expression of E2F
            target genes.
REFERENCE   9  (bases 1 to 2998)
  AUTHORS   Gagrica,S., Hauser,S., Kolfschoten,I., Osterloh,L., Agami,R. and
            Gaubatz,S.
  TITLE     Inhibition of oncogenic transformation by mammalian Lin-9, a
            pRB-associated protein
  JOURNAL   EMBO J 23 (23), 4627-4638 (2004)
   PUBMED   15538385
  REMARK    GeneRIF: Human Lin-9 has tumor-suppressing activities and the
            ability of hLin-9 to inhibit transformation is mediated through its
            association with pRB.
REFERENCE   10 (bases 1 to 2998)
  AUTHORS   White-Cooper,H., Leroy,D., MacQueen,A. and Fuller,M.T.
  TITLE     Transcription of meiotic cell cycle and terminal differentiation
            genes depends on a conserved chromatin associated protein, whose
            nuclear localisation is regulated
  JOURNAL   Development 127 (24), 5463-5473 (2000)
   PUBMED   11076766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF190324.1 and BX284931.11.
            
            On Jun 3, 2019 this sequence version replaced NM_001366245.1.
            
            Summary: This gene encodes a tumor suppressor protein that inhibits
            DNA synthesis and oncogenic transformation through association with
            the retinoblastoma 1 protein. The encoded protein also interacts
            with a complex of other cell cycle regulators to repress cell
            cycle-dependent gene expression in non-dividing cells.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Jul
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043444.2, SRR11853561.2946.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681046.1/ ENSP00000505590.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               AF190324.1         9-458
            451-451             BX284931.11        61347-61347         c
            452-2997            AF190324.1         460-3005
            2998-2998           BX284931.11        6073-6073           c
FEATURES             Location/Qualifiers
     source          1..2998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..2998
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /note="lin-9 DREAM MuvB core complex component"
                     /db_xref="GeneID:286826"
                     /db_xref="HGNC:HGNC:30830"
                     /db_xref="MIM:609375"
     exon            1..56
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1654
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /note="isoform 8 is encoded by transcript variant 9; rb
                     related pathway actor; protein lin-9 homolog; type I
                     interferon receptor beta chain-associated protein;
                     pRB-associated protein; TUDOR gene similar protein; beta
                     subunit-associated regulator of apoptosis"
                     /codon_start=1
                     /product="protein lin-9 homolog isoform 8"
                     /protein_id="NP_001353174.1"
                     /db_xref="CCDS:CCDS91165.1"
                     /db_xref="GeneID:286826"
                     /db_xref="HGNC:HGNC:30830"
                     /db_xref="MIM:609375"
                     /translation="MAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKG
                     RNTSSAVEMPFRNSKRSRLFSDEDDRQINTRSPKRNQRVAMVPQKFTATMSTPDKKAS
                     QKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTR
                     VEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPL
                     PLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRTGLGTHTIPDYEVLSNEP
                     HETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPIIDNDPLLGQSPWRSKISGSDTET
                     LGGFPVEFLIQVTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPISIEFQRRYATIV
                     LELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSST
                     GQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNIS
                     CFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD"
     exon            57..89
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            90..184
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            185..289
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..423
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..549
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..707
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..841
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..961
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1063
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1144
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1270
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1450
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1548
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..2998
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /note="hexamer: AATAAA"
     polyA_site      2998
                     /gene="LIN9"
                     /gene_synonym="BARA; BARPsv; Lin-9; TGS; TGS1; TGS2"
                     /note="major polyA site"
ORIGIN      
        1 gaaaaagcgg cgcggctcgt tcaagatggc ggagctcgac cagttgcctg acgagagctc
       61 ttcagcaaaa gcccttgtca gtttaaaaga aggaagctta tctaacacgt ggaatgaaaa
      121 gtacagttct ttacagaaaa cacctgtttg gaaaggcagg aatacaagct ctgctgtgga
      181 aatgcctttc agaaattcaa aacgaagtcg acttttttct gatgaagatg ataggcaaat
      241 aaatacaagg tcacctaaaa gaaaccagag ggttgcaatg gttccacaga aatttacagc
      301 aacaatgtca acaccagata agaaagcttc acagaagatt ggttttcgat tacgtaatct
      361 gctcaagctt cctaaagcac ataaatggtg tatatacgag tggttctatt caaatataga
      421 taaaccactt tttgaaggtg ataatgactt ctgtgtatgt ctaaaggaat cttttcctaa
      481 tttgaaaaca agaaagttaa caagagtaga atggggaaaa attcggcggc ttatgggaaa
      541 accacggaga tgttcttctg cattttttga ggaagagaga tcagcattaa aacagaaacg
      601 gcagaaaata aggctcttac aacaaaggaa agttgcagat gtttcacaat tcaaagatct
      661 cccagatgaa attcctttgc ctctggttat tggaacgaaa gttacagcac gattacgtgg
      721 tgttcatgat ggtttgttca ctggacaaat agatgctgtg gatactctta atgctactta
      781 tagagtaact tttgatagga cagggcttgg aacccatacc atccctgact atgaagttct
      841 cagtaatgaa cctcatgaga caatgccaat tgctgccttt ggacaaaaac agcggccttc
      901 tcgatttttt atgaccccac cacggttaca ttatactcct cctctccagt caccaattat
      961 agataatgat cctttattag gacagtcgcc gtggagaagt aaaatttctg gctctgacac
     1021 tgaaacatta ggtggttttc cagtagaatt tcttatccaa gtgaccagat tatcaaaaat
     1081 tctcatgatt aaaaaggaac atatcaagaa attaagggaa atgaacacag aagcagaaaa
     1141 attgaaatca tattccatgc ccatcagcat tgaatttcag cggagatatg caacaattgt
     1201 tctggagctt gaacagctga acaaggacct aaacaaagtt ttgcataaag ttcaacagta
     1261 ttgctatgag cttgctccag accaggggct ccagcctgca gatcagccaa cagatatgag
     1321 acgcaggtgt gaggaagaag cacaggaaat tgttcggcat gcaaattcct caacaggaca
     1381 gccctgcgtt gaaaatgaaa atctgacaga cttaatttcc aggcttacag ctattttgtt
     1441 acaaattaag tgtctagcag aaggaggaga cctgaattcc tttgaattca aatcacttac
     1501 agactcatta aatgatatca agagtacaat agacgcttct aatatcagtt gctttcagaa
     1561 taatgtagaa atccatgttg cacatattca gagtggcctg agccagatgg gaaacttaca
     1621 tgcctttgca gcaaataaca ccaacagaga ctgagtaaag atttcattat tccaactgca
     1681 cgggacattg tttttgagaa gttcttttcc tttatatagg cttccaacac caaataacct
     1741 aactgctgga aaacaaggga aatttaaatc tccaaataag gcattttaat agactgtact
     1801 gcttcttaaa ccagcattgc tgaccagcat tatatttatt tttcttttat tattcagatg
     1861 cagtagcatt gcttatgtta catatgttta tattcacaaa tatttttaaa ctgaaatatc
     1921 tgaacataat ataatttcgt ggaagaatac attgaccatt ttttttaatg tgcatgaatt
     1981 caccgcaaca catgcagaca actgctgcaa tggagagtat gaagaaacct ggtcttttta
     2041 ttcatgtcgg tggcagtgtg gaaattccat ccagaaaatt acaactccac ttgatttagt
     2101 tgatcaccat ctcagtcttc aaaagataac atcatgaggt gtgggaagtc ctagttttaa
     2161 ggaaaccact gaaatataga tgggaaatgt ggactttaca agtatatgtt atatatactt
     2221 gcaatgtgac atggttctgt agatcatttt ataataataa atattttaat ttatcataac
     2281 atataaaaga aacctttgtt gtttgttgaa agaaaatgaa ggaacagggg gaaaaaaggt
     2341 gcaaaatgct aaatttctaa aaatggattt ggcatgtctt cccatcagtt caggtcaaaa
     2401 gtgcattgtt gtgagattta ttaaaaaaaa aatgataaca cactattttc atattttttt
     2461 gtttatttgc acaactttta aaccagatta ctggttaaaa tccaacagta cacaatttat
     2521 aaagtaaaaa gattttataa ggaaaacaaa tataataacc agtgctgtga aatgcagaag
     2581 aaaggcttgt tttggttgtt tttctttttt aggaaaacgc tgcctaaaat gttaatcttg
     2641 taaaaagtat gtatttggaa ttttcttcgt tttaatagaa tattataaac tcaaaatata
     2701 aatttttttc aaatttggag tttaagatat agctgtagag gtggttttaa ttcctttaga
     2761 tgtctcataa aatgagactt tttatatgtt aatgtataat aaaactgaaa caagattatt
     2821 ttccatttga aatttttgta tagtttaaaa aggcttccgt attctttgtt ggtattgtgc
     2881 cactgcagaa ctttagtgca gagtttatat ttagctaaac tgttatgtta attaagaaat
     2941 gcataaatct tctattctta atatttgtaa ttctaaataa attgatctat gaaaatta
//
