LOCUS       NM_018362               4842 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens lin-7 homolog C, crumbs cell polarity complex
            component (LIN7C), mRNA.
ACCESSION   NM_018362
VERSION     NM_018362.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4842)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4842)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4842)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4842)
  AUTHORS   Uzawa,K., Kasamatsu,A., Shimizu,T., Saito,Y., Baba,T., Sakuma,K.,
            Fushimi,K., Sakamoto,Y., Ogawara,K., Shiiba,M. and Tanzawa,H.
  TITLE     Suppression of metastasis by mirtazapine via restoration of the
            Lin-7C/beta-catenin pathway in human cancer cells
  JOURNAL   Sci Rep 4, 5433 (2014)
   PUBMED   24961284
  REMARK    GeneRIF: Data show that mirtazapine caused substantial
            up-regulation of the Lin-7C/beta-catenin pathway in a metastatic
            squamous cell carcinomas (hSCCs) cell line and melanoma-derived
            cell line.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4842)
  AUTHORS   Kemp,J.P., Medina-Gomez,C., Estrada,K., St Pourcain,B., Heppe,D.H.,
            Warrington,N.M., Oei,L., Ring,S.M., Kruithof,C.J., Timpson,N.J.,
            Wolber,L.E., Reppe,S., Gautvik,K., Grundberg,E., Ge,B., van der
            Eerden,B., van de Peppel,J., Hibbs,M.A., Ackert-Bicknell,C.L.,
            Choi,K., Koller,D.L., Econs,M.J., Williams,F.M., Foroud,T.,
            Zillikens,M.C., Ohlsson,C., Hofman,A., Uitterlinden,A.G., Davey
            Smith,G., Jaddoe,V.W., Tobias,J.H., Rivadeneira,F. and Evans,D.M.
  TITLE     Phenotypic dissection of bone mineral density reveals skeletal site
            specificity and facilitates the identification of novel loci in the
            genetic regulation of bone mass attainment
  JOURNAL   PLoS Genet 10 (6), e1004423 (2014)
   PUBMED   24945404
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4842)
  AUTHORS   Leonoudakis,D., Conti,L.R., Anderson,S., Radeke,C.M., McGuire,L.M.,
            Adams,M.E., Froehner,S.C., Yates,J.R. 3rd and Vandenberg,C.A.
  TITLE     Protein trafficking and anchoring complexes revealed by proteomic
            analysis of inward rectifier potassium channel (Kir2.x)-associated
            proteins
  JOURNAL   J Biol Chem 279 (21), 22331-22346 (2004)
   PUBMED   15024025
REFERENCE   7  (bases 1 to 4842)
  AUTHORS   Leonoudakis,D., Conti,L.R., Radeke,C.M., McGuire,L.M. and
            Vandenberg,C.A.
  TITLE     A multiprotein trafficking complex composed of SAP97, CASK, Veli,
            and Mint1 is associated with inward rectifier Kir2 potassium
            channels
  JOURNAL   J Biol Chem 279 (18), 19051-19063 (2004)
   PUBMED   14960569
REFERENCE   8  (bases 1 to 4842)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
REFERENCE   9  (bases 1 to 4842)
  AUTHORS   Becamel,C., Alonso,G., Galeotti,N., Demey,E., Jouin,P., Ullmer,C.,
            Dumuis,A., Bockaert,J. and Marin,P.
  TITLE     Synaptic multiprotein complexes associated with 5-HT(2C) receptors:
            a proteomic approach
  JOURNAL   EMBO J 21 (10), 2332-2342 (2002)
   PUBMED   12006486
REFERENCE   10 (bases 1 to 4842)
  AUTHORS   Jo,K., Derin,R., Li,M. and Bredt,D.S.
  TITLE     Characterization of MALS/Velis-1, -2, and -3: a family of mammalian
            LIN-7 homologs enriched at brain synapses in association with the
            postsynaptic density-95/NMDA receptor postsynaptic complex
  JOURNAL   J Neurosci 19 (11), 4189-4199 (1999)
   PUBMED   10341223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA231006.1, BC053907.1, AK025540.1 and BC039459.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018362.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.233621.1,
                                           SRR1803615.47110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03568911 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278193.7/ ENSP00000278193.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA231006.1         11-23
            14-3100             BC053907.1         1-3087
            3101-4479           AK025540.1         831-2209
            4480-4842           BC039459.1         810-1172
FEATURES             Location/Qualifiers
     source          1..4842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..4842
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="lin-7 homolog C, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:55327"
                     /db_xref="HGNC:HGNC:17789"
                     /db_xref="MIM:612332"
     exon            1..54
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..611
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="LIN-7 protein 3; veli-3; vertebrate lin-7 homolog
                     3; mammalian lin-seven protein 3"
                     /codon_start=1
                     /product="protein lin-7 homolog C"
                     /protein_id="NP_060832.1"
                     /db_xref="CCDS:CCDS7864.1"
                     /db_xref="GeneID:55327"
                     /db_xref="HGNC:HGNC:17789"
                     /db_xref="MIM:612332"
                     /translation="MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQS
                     EFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEG
                     LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELL
                     KAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT"
     exon            55..173
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            174..245
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            246..455
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..4842
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4343..4348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="hexamer: AATAAA"
     polyA_site      4374
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="major polyA site"
     regulatory      4666..4671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="hexamer: AATAAA"
     polyA_site      4684
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="major polyA site"
     regulatory      4786..4791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="hexamer: AATGAA"
     polyA_site      4805
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
     regulatory      4823..4828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
                     /note="hexamer: CATAAA"
     polyA_site      4842
                     /gene="LIN7C"
                     /gene_synonym="LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3"
ORIGIN      
        1 gtaggttaag ggagaagatg gcggcgctag gggaacccgt gcggctggag agagatattt
       61 gtagagcaat tgaattattg gaaaaactac aaaggagtgg agaagtacca ccacagaaac
      121 ttcaggcttt gcaaagagtc cttcaaagtg aattctgcaa tgctgtgaga gaggtatatg
      181 aacatgtcta tgagactgtg gacatcagta gcagtcctga agtgagagcg aacgctactg
      241 caaaggctac tgttgctgca tttgctgcca gtgaaggaca ttctcatcct cgagttgttg
      301 agctaccaaa aacagaagag ggccttggat tcaatattat gggaggcaaa gaacaaaact
      361 ctccaatcta tatatcccga ataattccag gtggaattgc tgatagacat gggggcctca
      421 aacgtggaga tcaactcctc tctgttaatg gagtgagtgt tgaaggagaa catcatgaaa
      481 aagctgtaga actgctgaaa gccgcacaag gaaaggttaa attagtggta cgatacacac
      541 ccaaagtctt agaagaaatg gagtcgcgct ttgaaaaaat gagatcagca aaacgcaggc
      601 aacagaccta atacatttca aaacttgata tttcattttg cgttttagct agagaagttt
      661 tccttgtgac ttactaatgg ctgcaatgcc aatgattgta agaaaacaaa caaatttatc
      721 atgaaattct ccttgtcatt ttataaatgc ctattttaac atcatttatg gttccagaga
      781 tgcatacact tttttctgac aagaaaaagt aaaaggtgat gagggcaatt ctgtcctact
      841 gtttttacag gcctttttca aatgcagatt ttgtcataaa gttgttatag attttttaaa
      901 atgctttttt aatattaaaa tgtactttta cattcttaat ctttttttag aaaggaaaag
      961 ttttcttcat ttagctgctg atttaaaagt aaagttctcc aattcttttt ttttgcttac
     1021 tctatttttt ttaacctgtg aaatttcttt acagttttcc aagaaattaa gcataacagt
     1081 ctcatctacg gcagttcatt acactgtcaa tgttaacatc attgctgcat tttgtacttt
     1141 gaacacacac ataatatata taaccagtgg taaatcatga ctcagtacag tgcaagtttt
     1201 ttcactttta cttaaacata atatataatg gatattcatt tatactgatt tatgaaagta
     1261 agtttttaaa cactgaaaca atcattgcta aaatacatat tcttaatatt tgagcattga
     1321 ggcaagagga tgtaattgat agcattactt attacatccc tatttatgtt caaccgtaca
     1381 tcaaattata aatgcaaaac aggttcagat ttcatctttt gtgatttctt ttaaatacta
     1441 ttcattttta tttaaatgca cagtatttcc cctatatttt agtccttcca ttcctagaga
     1501 caaaccagtt atttggtggt gggaagtagc tgaagcaaag aaggaaaagt aataccttta
     1561 acctcactag cttcaagagt agacattctt actagctcaa tttaaataat tgattttaaa
     1621 taggaagaaa agaggatata tttaagatac atagaaatta tgatgtgaag tattcatgag
     1681 aatctgtaga ttccatcaaa ataagtagga actcatacta aaattgttgg atttaaagag
     1741 gcaacttttg tttatgattc aaatatggga atttgagaaa tatttcattt gtccactgga
     1801 tgtcactatt ttactaaaag gcagctatta gtgtgggact gtgactgagg tcttaaagac
     1861 tgaaagagtt ggggttcatt ttctgttaca acttacagga acatttgtac tttaagaaaa
     1921 atttaagtga caaatgttag aagatgatgg attgaaaaat ataagtaatt tggcatattg
     1981 accctatata aaaaagtggg cattttgtaa cattccttca ggaagaatag aattgtatgc
     2041 ttttttctgc atgtttgtga tcactgtgag tctcagatga ttattccagt tttcaatgat
     2101 ttttcaaaat aaaagtcaat cagcattgtt atttatcatt aaggtattga acactggatt
     2161 gcatggttga atgtgtcttt aatccactac aaaatgtgct tgttattgat aggatcatgt
     2221 tgttaaattg taaattttca aaattaattg atgttttaaa aatgttgaga ccaaagtagt
     2281 atagaagtat ggacttaatt taattgtaaa attattagag gtatttgttg tagagcttta
     2341 tatattaaag agaggtattg gtgcatataa aaacagtaat attattgtta tgcttgtatt
     2401 cttgcatttc agggtaagta aaccctgaag aaatcttatt ttagtatagc tacagctgca
     2461 gtagctttta agtatgtatc aacatttcat tataaattat agcttcctgg ttctgtgtct
     2521 cagctgtttc agaactttca gccaagttaa atcttttttg gtgttgaaac ttttagtaag
     2581 ttgagtaagc tatttttttc cctacggtaa tccacaatct gttctttgtg tgggttgaca
     2641 cctatttata attcttaaaa taagggtagc tcaaaggagc caagtacagt agtttagctt
     2701 gctactgttg agcatgaata gcagtaggtt gttttcatta atgcagtttt cataatgtat
     2761 cccagaattt taaatcttga ccatagaaaa atacagtcat tcattggcaa agatgtacag
     2821 tggtggttta gtgcagtgag gaaatgatgg gaatttttat cttagaaatg gatgattcgt
     2881 gaataaaact aggtacatag taagtgtatg atagatgttt gatttgtaaa ttacaaatat
     2941 aaattatcac ccccatttcc atttattttc ttgatatatc aaaatgtgtt gacttagtga
     3001 ttctcaatct tagctacata ttagcctggc agagctttaa aaaattgata cctgggtcct
     3061 attccataac aactaaatca aaatcaccct tttttttttt tttgtaaagc tttccaggtg
     3121 gttctaaagg acacctaggg tcaataaccc attataaaat gatctgatta cactggacac
     3181 tcttaggaag tatcaaaata gaacagttca atttgcagct acttaatgat taattacatt
     3241 tcttaggttt tttttttgtt ttttttttgg tttgtttgtt ttttgtttta aaagagacag
     3301 gatcttgctt tgtctcccag gctggaacac agtggtgtga tcatagctca ctgcagcctg
     3361 aaactccttg gcttccacct cagcctccca aagcattagg attataggcg tgagccactg
     3421 cacctggcca agtaatttct tttaggaata aaaggtactt ggcattcctt atttgggaag
     3481 taattacagt cttatctttt tttttctttt ttcttttttt taataaaatc taccagtaat
     3541 ttaaatgtga gctttttatg tctgtcatca ttctgccccc tttgccttta aaacttacaa
     3601 aaatacgtgt ttgttatttg agaaagcatg tttaaaaatt gcagatgaga aatattgtcg
     3661 ttaataatta tgtactgtct taatgtgggc acttcatttg ttagtataat actagataat
     3721 agcagcctag ttctttagga tttgacgatt caaatttttt ttttgttttt tgtttttgtt
     3781 tttttttgag acagagtctt gctctgttgc ccaggctggc gtgcagtggt gtgatctcgg
     3841 ctcacttcag cctccgccac ctcaaggcag ttcaagcaat tctcctgcct cagcctcccg
     3901 agtagctagg actacaggcg tgtgccacct ctcccggcta atttttttgt atttttagta
     3961 gagacggggt ttcaccgtgt tagccaggat gatctcgatc tcctgacctc gtgattcgcc
     4021 cgcctcggcc tcccaaagtg ctggaattac tggcgtgagc caccatgccc agcctcaaat
     4081 atgtttttaa aaaatatcat tgtcctcctc ctcttaagat ttttttaagt tattttgctc
     4141 aagtacttaa gtagtctggc tcaagtactt tgtttacaat taaaatggat attatagcat
     4201 ttaatagaag aaatggttat ggcttatcca aaaagaatgt cagcatgacc tggtgtagac
     4261 ttaaaaaact acatgtttgt gaatatttta taatgtggaa tgatcattga aatatcaagg
     4321 attctagtaa ttgtatttcc tgaataaatg tatgtttatg aattttctaa cttacatttt
     4381 gttgtgtcct ctgccaacaa tctggtttta taattgttgt ctaaagtttg ctagtagtgt
     4441 ttcttcaaag gttattccag gtatggttaa gtagtgagaa aaatcactta ttaattttca
     4501 agaactttga gactaatttg tattgactcg gttttttaaa ataactggca aatgctatgc
     4561 ttctactttt aaaatttgtg gtaataccca gaatggatgt aaaataacat ttttcaatag
     4621 attacttcat ttatcaattt aattctgatt ttaaggctta tttaaaataa atttgtatga
     4681 gttatgtcct cgttctttgg atttgaaaaa agttgatata actacacaat agataacgtt
     4741 tatgaaaggt atgtataaaa aaacataatt cctggtggct gctgaaatga aactttgaat
     4801 ttctatattt tgctttgtct ttcataaaat ttaaagaaaa ca
//
