LOCUS       NM_022165                746 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lin-7 homolog B, crumbs cell polarity complex
            component (LIN7B), transcript variant 1, mRNA.
ACCESSION   NM_022165
VERSION     NM_022165.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 746)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 746)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 746)
  AUTHORS   Mizuno,M., Matsumoto,A., Hamada,N., Ito,H., Miyauchi,A.,
            Jimbo,E.F., Momoi,M.Y., Tabata,H., Yamagata,T. and Nagata,K.
  TITLE     Role of an adaptor protein Lin-7B in brain development: possible
            involvement in autism spectrum disorders
  JOURNAL   J Neurochem 132 (1), 61-69 (2015)
   PUBMED   25196215
  REMARK    GeneRIF: functional deficiency in Lin-7B could be implicated in
            clinical phenotypes in some autism spectrum disorders patients
            through bringing about abnormal cortical architecture
REFERENCE   4  (bases 1 to 746)
  AUTHORS   Zucker,B., Kama,J.A., Kuhn,A., Thu,D., Orlando,L.R., Dunah,A.W.,
            Gokce,O., Taylor,D.M., Lambeck,J., Friedrich,B., Lindenberg,K.S.,
            Faull,R.L., Weiller,C., Young,A.B. and Luthi-Carter,R.
  TITLE     Decreased Lin7b expression in layer 5 pyramidal neurons may
            contribute to impaired corticostriatal connectivity in huntington
            disease
  JOURNAL   J Neuropathol Exp Neurol 69 (9), 880-895 (2010)
   PUBMED   20720508
  REMARK    GeneRIF: Data suggest that decreased cortical LIN7b expression may
            contribute to abnormal corticostriatal connectivity in Huntington
            disease.
REFERENCE   5  (bases 1 to 746)
  AUTHORS   Lanktree,M., Squassina,A., Krinsky,M., Strauss,J., Jain,U.,
            Macciardi,F., Kennedy,J.L. and Muglia,P.
  TITLE     Association study of brain-derived neurotrophic factor (BDNF) and
            LIN-7 homolog (LIN-7) genes with adult
            attention-deficit/hyperactivity disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (6), 945-951 (2008)
   PUBMED   18286632
  REMARK    GeneRIF: Allelic and haplotype association was found between both
            BDNF and adult ADHD, and LIN-7 and adult ADHD.
REFERENCE   6  (bases 1 to 746)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 746)
  AUTHORS   Coussen,F., Normand,E., Marchal,C., Costet,P., Choquet,D.,
            Lambert,M., Mege,R.M. and Mulle,C.
  TITLE     Recruitment of the kainate receptor subunit glutamate receptor 6 by
            cadherin/catenin complexes
  JOURNAL   J Neurosci 22 (15), 6426-6436 (2002)
   PUBMED   12151522
REFERENCE   8  (bases 1 to 746)
  AUTHORS   Olsen,O., Liu,H., Wade,J.B., Merot,J. and Welling,P.A.
  TITLE     Basolateral membrane expression of the Kir 2.3 channel is
            coordinated by PDZ interaction with Lin-7/CASK complex
  JOURNAL   Am J Physiol Cell Physiol 282 (1), C183-C195 (2002)
   PUBMED   11742811
REFERENCE   9  (bases 1 to 746)
  AUTHORS   Jo,K., Derin,R., Li,M. and Bredt,D.S.
  TITLE     Characterization of MALS/Velis-1, -2, and -3: a family of mammalian
            LIN-7 homologs enriched at brain synapses in association with the
            postsynaptic density-95/NMDA receptor postsynaptic complex
  JOURNAL   J Neurosci 19 (11), 4189-4199 (1999)
   PUBMED   10341223
REFERENCE   10 (bases 1 to 746)
  AUTHORS   Butz,S., Okamoto,M. and Sudhof,T.C.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358744.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022165.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358744.1, SRR5189661.15876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221459.7/ ENSP00000221459.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               AY358744.1         10-755
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..746
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /note="lin-7 homolog B, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:64130"
                     /db_xref="HGNC:HGNC:17788"
                     /db_xref="MIM:612331"
     exon            1..72
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..659
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein lin-7 homolog B; hLin7B; hVeli2; veli-2;
                     vertebrate lin-7 homolog 2; mammalian lin-seven protein 2"
                     /codon_start=1
                     /product="protein lin-7 homolog B isoform 1"
                     /protein_id="NP_071448.1"
                     /db_xref="CCDS:CCDS12757.1"
                     /db_xref="GeneID:64130"
                     /db_xref="HGNC:HGNC:17788"
                     /db_xref="MIM:612331"
                     /translation="MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQS
                     RFCSAIREVYEQLYDTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEG
                     LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELL
                     KAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG"
     exon            73..191
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..263
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            264..473
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..637
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..746
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      746
                     /gene="LIN7B"
                     /gene_synonym="LIN-7B; MALS-2; MALS2; VELI2"
                     /note="major polyA site"
ORIGIN      
        1 agggcaggcg ggcggctggc agctgtggcg ccgacatggc tgcgctggtg gagccgctgg
       61 ggctggagcg ggacgtgtcc cgggcggttg agctcctcga gcggctccag cgcagcgggg
      121 agctgccgcc gcagaagctg caggccctcc agcgagttct gcagagccgc ttctgctccg
      181 ctatccgaga ggtgtatgag cagctttatg acacgctgga catcaccggc agcgccgaga
      241 tccgagccca tgccacagcc aaggccacag tggctgcctt cacagccagc gagggccacg
      301 cacatcccag ggtagtggag ctacccaaga cggatgaggg cctaggcttc aacatcatgg
      361 gtggcaaaga gcaaaactcg cccatctaca tctcccgggt catcccaggg ggtgtggctg
      421 accgccatgg aggcctcaag cgtggggatc aactgttgtc ggtgaacggt gtgagcgttg
      481 agggtgagca gcatgagaag gcggtggagc tgctgaaggc ggcccagggc tcggtgaagc
      541 tggttgtccg ttacacaccg cgagtgctgg aggagatgga ggcccggttc gagaagatgc
      601 gctctgcccg ccggcgccaa cagcatcaga gctactcgtc cttggagtct cgaggttgaa
      661 accacagatc tggacgttca cgtgcactct cttcctgtac agtatttatt gttcctggca
      721 ctttatttaa agatatttga ccctca
//
