LOCUS       NP_919258                749 aa            linear   PRI 05-APR-2024
DEFINITION  protein lin-54 homolog isoform a [Homo sapiens].
ACCESSION   NP_919258 XP_059594
VERSION     NP_919258.2
DBSOURCE    REFSEQ: accession NM_194282.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Marceau,A.H., Felthousen,J.G., Goetsch,P.D., Iness,A.N., Lee,H.W.,
            Tripathi,S.M., Strome,S., Litovchick,L. and Rubin,S.M.
  TITLE     Structural basis for LIN54 recognition of CHR elements in cell
            cycle-regulated promoters
  JOURNAL   Nat Commun 7, 12301 (2016)
   PUBMED   27465258
  REMARK    GeneRIF: the DNA-binding properties of LIN54 and the structural
            basis for recognition of a cell cycle genes homology region
            sequence, are described.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Matsuo,T., Kuramoto,H., Kumazaki,T., Mitsui,Y. and Takahashi,T.
  TITLE     LIN54 harboring a mutation in CHC domain is localized to the
            cytoplasm and inhibits cell cycle progression
  JOURNAL   Cell Cycle 11 (17), 3227-3236 (2012)
   PUBMED   22895175
  REMARK    GeneRIF: LIN54 harboring a mutation in CHC domain is localized to
            the cytoplasm and inhibits cell cycle progression.
REFERENCE   4  (residues 1 to 749)
  AUTHORS   Litovchick,L., Florens,L.A., Swanson,S.K., Washburn,M.P. and
            DeCaprio,J.A.
  TITLE     DYRK1A protein kinase promotes quiescence and senescence through
            DREAM complex assembly
  JOURNAL   Genes Dev 25 (8), 801-813 (2011)
   PUBMED   21498570
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Schmit,F., Cremer,S. and Gaubatz,S.
  TITLE     LIN54 is an essential core subunit of the DREAM/LINC complex that
            binds to the cdc2 promoter in a sequence-specific manner
  JOURNAL   FEBS J 276 (19), 5703-5716 (2009)
   PUBMED   19725879
  REMARK    GeneRIF: the cysteine-rich CXC domain of LIN54 is a novel
            DNA-binding domain that binds to the cdc2 promoter in a
            sequence-specific manner
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Litovchick,L., Sadasivam,S., Florens,L., Zhu,X., Swanson,S.K.,
            Velmurugan,S., Chen,R., Washburn,M.P., Liu,X.S. and DeCaprio,J.A.
  TITLE     Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein
            complex represses human cell cycle-dependent genes in quiescence
  JOURNAL   Mol Cell 26 (4), 539-551 (2007)
   PUBMED   17531812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021105.13.
            
            On Mar 1, 2008 this sequence version replaced NP_919258.1.
            
            Summary: LIN54 is a component of the LIN, or DREAM, complex, an
            essential regulator of cell cycle genes (Schmit et al., 2009
            [PubMed 19725879]).[supplied by OMIM, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640966.1, SRR1660807.215599.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340417.8/ ENSP00000341947.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     Protein         1..749
                     /product="protein lin-54 homolog isoform a"
                     /note="protein lin-54 homolog; CXC domain-containing
                     protein 1"
                     /calculated_mol_wt=79363
     Region          214..>461
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Site            244
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            249
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            264
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            310
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18220336,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            314
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18220336,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Region          369..388
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Region          522..>545
                     /region_name="TCR"
                     /note="Tesmin/TSO1-like CXC domain, cysteine-rich domain;
                     pfam03638"
                     /db_xref="CDD:461001"
     Region          523..536
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:27465258"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            536
                     /site_type="other"
                     /note="Critical for interaction with target DNA.
                     /evidence=ECO:0000269|PubMed:27465258; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            574
                     /site_type="other"
                     /note="Interaction with DNA.
                     /evidence=ECO:0000269|PubMed:27465258; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Region          583..596
                     /region_name="Linker.
                     /evidence=ECO:0000269|PubMed:27465258"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Region          596..631
                     /region_name="TCR"
                     /note="Tesmin/TSO1-like CXC domain, cysteine-rich domain;
                     pfam03638"
                     /db_xref="CDD:461001"
     Region          599..612
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:27465258"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            610
                     /site_type="other"
                     /note="Critical for interaction with target DNA.
                     /evidence=ECO:0000269|PubMed:27465258; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     Site            635
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q6MZP7.3)"
     CDS             1..749
                     /gene="LIN54"
                     /gene_synonym="CXCDC1; JC8.6; MIP120; TCX1"
                     /coded_by="NM_194282.4:373..2622"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS3599.1"
                     /db_xref="GeneID:132660"
                     /db_xref="HGNC:HGNC:25397"
                     /db_xref="MIM:613367"
ORIGIN      
        1 mevvpaevns llpeeimdtg itlvdddsie avivsspipm eteleeivni nstgdstatp
       61 istepitvys nhtnqvavnt titkadsntt vkpafpsglq klgaqtpvti sanqiilnkv
      121 sqtsdlklgn qtlkpdgqkl ilttlgksgs pivlalphsq lpqaqkvttq aqsgdaklpp
      181 qqikvvtigg rpevkpvigv saltpgsqli ntttqpsvlq tqqlktvqia kkprtptsgp
      241 vitklifakp inskavtgqt tqvsppviag rvlsqstpgt psktitises gvigstlnst
      301 tqtpnkiais plkspnkavk stvqtitvgg vstsqfktii platapnvqq iqvpgskfhy
      361 vrlvtatsas sstqpvsqnp stntqplqqa kpvvvnttpv rmsvpivsaq avkqvvpkpi
      421 nptsqivtts qpqqrlimpa tplpqiqpnl tnlppgtvla papgtgnvgy avlpaqyvtq
      481 lqqssyvsia snstftgtsg iqtqarlpfn giipsesasr prkpcnctks lclklycdcf
      541 angefcnncn ctncynnleh enerqkaika cldrnpeafk pkigkgkege sdrrhskgcn
      601 ckrsgclkny cecyeakimc ssickcigck nfeesperkt lmhladaaev rvqqqtaakt
      661 klssqisdll trptpalnsg ggklpftfvt kevaeatcnc llaqaeqadk kgkskaaaer
      721 mileefgrcl msvinsagka ksdpcamnc
//
