LOCUS       NM_001024674            2874 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens lin-52 DREAM MuvB core complex component (LIN52),
            transcript variant 1, mRNA.
ACCESSION   NM_001024674 XM_370767
VERSION     NM_001024674.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2874)
  AUTHORS   Litovchick,L., Florens,L.A., Swanson,S.K., Washburn,M.P. and
            DeCaprio,J.A.
  TITLE     DYRK1A protein kinase promotes quiescence and senescence through
            DREAM complex assembly
  JOURNAL   Genes Dev 25 (8), 801-813 (2011)
   PUBMED   21498570
REFERENCE   3  (bases 1 to 2874)
  AUTHORS   Eriksson,N., Macpherson,J.M., Tung,J.Y., Hon,L.S., Naughton,B.,
            Saxonov,S., Avey,L., Wojcicki,A., Pe'er,I. and Mountain,J.
  TITLE     Web-based, participant-driven studies yield novel genetic
            associations for common traits
  JOURNAL   PLoS Genet 6 (6), e1000993 (2010)
   PUBMED   20585627
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2874)
  AUTHORS   Litovchick,L., Sadasivam,S., Florens,L., Zhu,X., Swanson,S.K.,
            Velmurugan,S., Chen,R., Washburn,M.P., Liu,X.S. and DeCaprio,J.A.
  TITLE     Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein
            complex represses human cell cycle-dependent genes in quiescence
  JOURNAL   Mol Cell 26 (4), 539-551 (2007)
   PUBMED   17531812
REFERENCE   5  (bases 1 to 2874)
  AUTHORS   Harrison,M.M., Ceol,C.J., Lu,X. and Horvitz,H.R.
  TITLE     Some C. elegans class B synthetic multivulva proteins encode a
            conserved LIN-35 Rb-containing complex distinct from a NuRD-like
            complex
  JOURNAL   Proc Natl Acad Sci U S A 103 (45), 16782-16787 (2006)
   PUBMED   17075059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC094003.1, AC006349.3 and AK023979.1.
            
            On Aug 1, 2019 this sequence version replaced NM_001024674.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307062.1, SRR11853559.10263.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000555028.7/
                                                ENSP00000451812.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               BC094003.1         161-568
            409-1785            AC006349.3         52423-53799         c
            1786-1795           AK023979.1         1777-1786
            1796-2874           AC006349.3         51334-52412         c
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2874
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /note="lin-52 DREAM MuvB core complex component"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
     exon            1..38
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..358
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein lin-52 homolog"
                     /codon_start=1
                     /product="protein lin-52 homolog isoform 1"
                     /protein_id="NP_001019845.2"
                     /db_xref="CCDS:CCDS32120.2"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
                     /translation="MASPTDGTDLEASLLSFEKLDRASPDLWPEQLPGVAEFAASFKS
                     PITSSPPKWMAEIERDDIDMLKELGSLTTANLMEKVRGLQNLAYQLGLDESREMTRGK
                     FLNILEKPKK"
     exon            39..113
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /inference="alignment:Splign:2.1.0"
     exon            114..151
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /inference="alignment:Splign:2.1.0"
     exon            152..218
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /inference="alignment:Splign:2.1.0"
     exon            219..302
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /inference="alignment:Splign:2.1.0"
     exon            303..2874
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2596..2601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /note="hexamer: AATAAA"
     polyA_site      2614
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /note="major polyA site"
     regulatory      2847..2852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /note="hexamer: AATAAA"
     polyA_site      2874
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
ORIGIN      
        1 acgtgacatg ggttggaaga tggcgtctcc cacagacggg acagatctgg aagcatcttt
       61 gctaagtttt gaaaaacttg accgtgcctc accagatctt tggccagaac aattaccagg
      121 tgttgctgaa tttgcagctt ccttcaaaag tcctattact agttctccac ccaaatggat
      181 ggctgagata gaacgtgatg acatcgacat gttgaaagaa ctggggagtc tcaccacggc
      241 taatttgatg gagaaggttc gaggcctaca gaacctagcc tatcagctgg ggctggatga
      301 gtccagagag atgacacggg ggaaattcct caatattcta gagaagccca agaagtagca
      361 gctgcttgcg gacaggatgt cctggggtcc gaaaccaagc tcccttcccg gtgcacctct
      421 aacaatgcac acctcactgc ttgcttggga gaggccagag ggtgtacctc caggactgcc
      481 ctctcccctg ctcctggcac tctacacgtc tgaggacatt cagcagcaag agaagaatct
      541 gctctaccca aggatcattg cagttactca atcaactttc agacttgaac cttcttagcc
      601 tcggatattg gtaacagctg agggcatatc attcttaaag gtcgaagtcc tgctttctca
      661 tttctggaag tgattcagga gccccaggat cttacggttg atttgactca gtcatggcag
      721 tcagttgtga catgttgatt ggatgggttc ttttgaattg ttcttgatct cttagaaagt
      781 gtttacgatg tgaggagacc agagaccaag tagattctgg accagaccat gcagcctgac
      841 ctgtgaactc tccagtatat actaagttcc cagaatcccc agctgaagaa accagaatct
      901 tctcgaaatg tatatctgtt ttttaaaact tctatacctc ttatgatagt cccatttgct
      961 tttcattcct tacttcccag ccccaccttc tagttctgac ttcgggcaga gggatccctg
     1021 agtccctcct ggaattagct tgtatagtga aaggcccatc caaggttgtc taaagaccaa
     1081 tgtgaaggtg acagaaagga cttttgagtt ctaattaatc tgttacagct tcaagcaaga
     1141 aagtcagtat agcctgaaag acaagagaaa cgggatggtt tataggagtt cccatttggt
     1201 tgaaagctag aagccctaat tgaccttaaa gtaacatgct atgggatggt gggattgtcc
     1261 cctctgacag cacatatgaa atagttcatc tatataatag aaacgcacac acacgaaaaa
     1321 gaatcttctg acttaaatac aactttcatg gagttcttca ccacttatct gtctctgtta
     1381 aaatctgaaa atctagccca tggctaaaat ctattatatg tgttctccat atttcttgta
     1441 taagccagtc cccagcatct gatgttttga gaagtgcatg gagtttccta aactttgcac
     1501 aaaagaatat cctggggccg ggcatggtgg ctcacgcctg taatcccagc actttgggag
     1561 gccgaggcag gtggatcata ggtcaaaaga tcgagaccat cctggccaat atggtgaaac
     1621 cctgtctcta ctaaaataca aaaattagct gggcatgatg gtgcatgcct atagtcccag
     1681 ctacttgggg gcctgaggca cgagaatcgc ttgaattcgg gaggtggagg ttgcagtgag
     1741 ccgaaattat gccactgcac tccagcctgg gcaacagagt gagactctgt ctcagaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaagaatat ccctgtggca atagtctgat ggtgtttgga
     1861 cacaagaaaa gttatggttt tgagtcgtga gtgtttgcta gggcatggca ctcttcagtt
     1921 taacagctga tccattaaac cttttctgac atttgtgcct tgttctcatg ctagaattaa
     1981 tgctggattt ttctctcatt tgaccatcaa tgtagtttta cttattgaaa ggaaaaaaga
     2041 cttaacacaa gataggaaag atgagtatga gaagtaaaac attctgctgg ggtgctacat
     2101 agaaggttag gttgtagggg ctttgatttt aatttaaact tattatcgat tgatatttct
     2161 gtatctcact aaatgcggtt gaagagtgtg tgtgtgtgtg tgcgcgcgcg catgtggcca
     2221 aaaaatagtg ccataatgtc aaattcttcc tttgctctgt ttttgagagt tgatgacatc
     2281 aggcactttt cagtgtttgg ggaaattgat tgggatacct cccccaaacc aactcaagtc
     2341 tgtaactgga agccaggtgg ttggttttct ggtccgcttt gtcctctttc ttttaccgtc
     2401 atcctattca ccagcactta atgtaagtag atgttttaga attgcaatat ttattggttt
     2461 agtatttgtc atccttagaa atgttaatga tgtattttta tattgataat ataaatttat
     2521 gtacagtatg tgtgtatatg tatttcagga tgttatagta ttgtactttg tatgtgatgg
     2581 tttttgtgtc ttcataataa atatgtccct tttacaggag ggtgagtttt tcctcagagg
     2641 gccgagttgg atatttaaag cacagacctc cccagaaagt acaactgtaa tgataaataa
     2701 tctactgttt tcccccttaa tatacttaat ggatagttgg gggctttaca gtcatctact
     2761 tggtctcctg ccttccattc tatcctacca ctgcccaaca cccgaaagta gtatttagaa
     2821 acccttaata ccttcccgtg tctactaata aagtctcaat ctcttgaccc ggca
//
