LOCUS       NM_019104                935 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lin-37 DREAM MuvB core complex component (LIN37),
            transcript variant 1, mRNA.
ACCESSION   NM_019104
VERSION     NM_019104.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 935)
  AUTHORS   Uxa,S., Bernhart,S.H., Mages,C.F.S., Fischer,M., Kohler,R.,
            Hoffmann,S., Stadler,P.F., Engeland,K. and Muller,G.A.
  TITLE     DREAM and RB cooperate to induce gene repression and cell-cycle
            arrest in response to p53 activation
  JOURNAL   Nucleic Acids Res 47 (17), 9087-9103 (2019)
   PUBMED   31400114
  REMARK    GeneRIF: Abrogation of DREAM function by knockout of the DREAM
            component LIN37 results in a reduced repression of cell-cycle
            genes.
REFERENCE   3  (bases 1 to 935)
  AUTHORS   Litovchick,L., Florens,L.A., Swanson,S.K., Washburn,M.P. and
            DeCaprio,J.A.
  TITLE     DYRK1A protein kinase promotes quiescence and senescence through
            DREAM complex assembly
  JOURNAL   Genes Dev 25 (8), 801-813 (2011)
   PUBMED   21498570
REFERENCE   4  (bases 1 to 935)
  AUTHORS   Litovchick,L., Sadasivam,S., Florens,L., Zhu,X., Swanson,S.K.,
            Velmurugan,S., Chen,R., Washburn,M.P., Liu,X.S. and DeCaprio,J.A.
  TITLE     Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein
            complex represses human cell cycle-dependent genes in quiescence
  JOURNAL   Mol Cell 26 (4), 539-551 (2007)
   PUBMED   17531812
REFERENCE   5  (bases 1 to 935)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 935)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC396639.1, CB152701.1 and BC009071.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019104.2.
            
            Summary: This gene encodes a protein expressed in the eye.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.24306.1,
                                           SRR5189667.57993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301159.14/ ENSP00000301159.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DC396639.1         216-222
            8-66                CB152701.1         25-83
            67-935              BC009071.1         1-869
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..935
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /note="lin-37 DREAM MuvB core complex component"
                     /db_xref="GeneID:55957"
                     /db_xref="HGNC:HGNC:33234"
     exon            1..183
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..890
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein F25965; protein lin-37 homolog; antolefinin"
                     /codon_start=1
                     /product="protein lin-37 homolog isoform 1"
                     /protein_id="NP_061977.1"
                     /db_xref="CCDS:CCDS62642.1"
                     /db_xref="GeneID:55957"
                     /db_xref="HGNC:HGNC:33234"
                     /translation="MFPVKVKVEKSELEMAKARNQLDAVLQCLLEKSHMDRERLDEEA
                     GKTPSDTHNKDCSIAATGKRPSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDR
                     SVDLAQFSENTPLYPICRAWMRNSPSVRERECSPSSPLPPLPEDEEGSEVTNSKSRDV
                     YKLPPPTPPGPPGDACRSRIPSPLQPEMQGTPDDEPSEPEPSPSTLIYRNMQRWKRIR
                     QRWKEASHRNQLRYSESMKILREMYERQ"
     exon            184..259
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     exon            260..310
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     exon            311..340
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..426
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     exon            427..593
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     exon            594..734
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     exon            735..808
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..935
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      913..918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /note="hexamer: AGTAAA"
     polyA_site      935
                     /gene="LIN37"
                     /gene_synonym="F25965; lin-37; ZK418.4"
                     /note="major polyA site"
ORIGIN      
        1 acggtccagg ctggacacaa ccaaaggcgg aggacccgtg gcccacgaag ctcatctttg
       61 aactgtcccc gccttctccc gccttgactt gtgaccctag gccctttggg gcgcctctga
      121 cccagctagc cagatcccgg acccaaacca tgttccctgt gaaggtgaaa gtggagaaat
      181 cagagctgga gatggccaaa gcccggaacc aactggatgc tgtcttgcag tgtctgctgg
      241 agaagagtca catggacagg gagcgtctgg atgaggaagc tgggaaaaca ccctcagaca
      301 cccacaataa ggactgctcc atcgcagcca ctggcaaaag gccatctgcc cgcttccccc
      361 accagcggag gaagaagagg agggagatgg atgatgggct ggctgaggga gggccgcagc
      421 gatccaacac atatgtgatc aagctgttcg accggagcgt ggacttggcc cagttcagcg
      481 agaacacgcc actgtaccca atctgccgcg cctggatgcg caacagcccc tctgtgcgcg
      541 agcgtgaatg ctctcccagc tcacccctgc ccccgctgcc tgaggatgag gagggctcag
      601 aggtaaccaa cagcaagagt cgtgatgtgt acaagctgcc gccacccaca cccccggggc
      661 cacccggaga tgcctgcaga tcccgcatcc catctccact gcagcctgag atgcagggca
      721 cccctgacga tgagccctct gagcccgagc cctcaccctc cacactcatc tatcgcaaca
      781 tgcagcgctg gaaacgcatc cgccagaggt ggaaggaggc ctctcatcgg aaccagcttc
      841 gttactcaga aagcatgaag atcctacgag agatgtacga acgacagtga tgttcccagg
      901 tccccccaca ccagtaaaca tcccccagct ccaca
//
