LOCUS       NM_001004317            5446 bp    mRNA    linear   PRI 04-MAR-2025
DEFINITION  Homo sapiens lin-28 homolog B (LIN28B), transcript variant 1, mRNA.
ACCESSION   NM_001004317 XM_371842
VERSION     NM_001004317.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5446)
  AUTHORS   Pastori,V., Zambanini,G., Citterio,E., Weiss,T., Nakamura,Y.,
            Cantu,C. and Ronchi,A.E.
  TITLE     Transcriptional repression of the oncofetal LIN28B gene by the
            transcription factor SOX6
  JOURNAL   Sci Rep 14 (1), 10287 (2024)
   PUBMED   38704454
  REMARK    GeneRIF: Transcriptional repression of the oncofetal LIN28B gene by
            the transcription factor SOX6.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5446)
  AUTHORS   Oyejobi,G.K., Yan,X., Sliz,P. and Wang,L.
  TITLE     Regulating Protein-RNA Interactions: Advances in Targeting the
            LIN28/Let-7 Pathway
  JOURNAL   Int J Mol Sci 25 (7), 3585 (2024)
   PUBMED   38612395
  REMARK    GeneRIF: Regulating Protein-RNA Interactions: Advances in Targeting
            the LIN28/Let-7 Pathway.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5446)
  AUTHORS   Li,Y., Mendoza-Castrejon,J., Patel,R.M., Casey,E.B., Denby,E.,
            Bryder,D. and Magee,J.A.
  TITLE     LIN28B promotes differentiation of fully transformed AML cells but
            is dispensable for fetal leukemia suppression
  JOURNAL   Leukemia 38 (3), 648-651 (2024)
   PUBMED   38321106
  REMARK    GeneRIF: LIN28B promotes differentiation of fully transformed AML
            cells but is dispensable for fetal leukemia suppression.
REFERENCE   4  (bases 1 to 5446)
  AUTHORS   Stocchero,M., Corallo,D., Bresolin,S., Pantile,M., Pirillo,P.,
            Bortolozzi,R., Menegazzo,S., Boso,D., Viola,G., Baraldi,E.,
            Biffi,A., Giordano,G. and Aveic,S.
  TITLE     A Multi-Omics Approach Reveals Enrichment in Metabolites Involved
            in the Regulation of the Glutathione Pathway in LIN28B-Dependent
            Cancer Cells
  JOURNAL   Int J Mol Sci 25 (3), 1602 (2024)
   PUBMED   38338881
  REMARK    GeneRIF: A Multi-Omics Approach Reveals Enrichment in Metabolites
            Involved in the Regulation of the Glutathione Pathway in
            LIN28B-Dependent Cancer Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5446)
  AUTHORS   Zuo,X., Shao,Y., Liang,Y., Huo,C. and Wang,S.
  TITLE     MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and
            Proliferation of Hepatocellular Carcinoma Cells
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (3), 17-26 (2024)
   PUBMED   38305285
  REMARK    GeneRIF: MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage
            Polarization and Proliferation of Hepatocellular Carcinoma Cells.
REFERENCE   6  (bases 1 to 5446)
  AUTHORS   Chang,T.C., Zeitels,L.R., Hwang,H.W., Chivukula,R.R., Wentzel,E.A.,
            Dews,M., Jung,J., Gao,P., Dang,C.V., Beer,M.A.,
            Thomas-Tikhonenko,A. and Mendell,J.T.
  TITLE     Lin-28B transactivation is necessary for Myc-mediated let-7
            repression and proliferation
  JOURNAL   Proc Natl Acad Sci U S A 106 (9), 3384-3389 (2009)
   PUBMED   19211792
  REMARK    GeneRIF: highlight an important role for Lin-28B in Myc-driven
            cellular phenotypes
REFERENCE   7  (bases 1 to 5446)
  AUTHORS   Heo,I., Joo,C., Cho,J., Ha,M., Han,J. and Kim,V.N.
  TITLE     Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA
  JOURNAL   Mol Cell 32 (2), 276-284 (2008)
   PUBMED   18951094
REFERENCE   8  (bases 1 to 5446)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   9  (bases 1 to 5446)
  AUTHORS   Lettre,G., Jackson,A.U., Gieger,C., Schumacher,F.R., Berndt,S.I.,
            Sanna,S., Eyheramendy,S., Voight,B.F., Butler,J.L., Guiducci,C.,
            Illig,T., Hackett,R., Heid,I.M., Jacobs,K.B., Lyssenko,V., Uda,M.,
            Boehnke,M., Chanock,S.J., Groop,L.C., Hu,F.B., Isomaa,B., Kraft,P.,
            Peltonen,L., Salomaa,V., Schlessinger,D., Hunter,D.J., Hayes,R.B.,
            Abecasis,G.R., Wichmann,H.E., Mohlke,K.L. and Hirschhorn,J.N.
  CONSRTM   Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung
            Colorectal and Ovarian Cancer Screening Trial; Nurses' Health
            Study; SardiNIA
  TITLE     Identification of ten loci associated with height highlights new
            biological pathways in human growth
  JOURNAL   Nat Genet 40 (5), 584-591 (2008)
   PUBMED   18391950
REFERENCE   10 (bases 1 to 5446)
  AUTHORS   Guo,Y., Chen,Y., Ito,H., Watanabe,A., Ge,X., Kodama,T. and
            Aburatani,H.
  TITLE     Identification and characterization of lin-28 homolog B (LIN28B) in
            human hepatocellular carcinoma
  JOURNAL   Gene 384, 51-61 (2006)
   PUBMED   16971064
  REMARK    GeneRIF: These findings strongly implicate a critical role of
            LIN28B during development and tumorigenesis and suggest a possible
            novel mechanism.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ127228.1 and AW674597.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001004317.3.
            
            Summary: The protein encoded by this gene belongs to the lin-28
            family, which is characterized by the presence of a cold-shock
            domain and a pair of CCHC zinc finger domains. This gene is highly
            expressed in testis, fetal liver, placenta, and in primary human
            tumors and cancer cell lines. It is negatively regulated by
            microRNAs that target sites in the 3' UTR, and overexpression of
            this gene in primary tumors is linked to the repression of let-7
            family of microRNAs and derepression of let-7 targets, which
            facilitates cellular transformation. [provided by RefSeq, Jun
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ127228.1, BC137526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345080.5/ ENSP00000344401.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5445              DQ127228.1         60-5504
            5446-5446           AW674597.1         13-13               c
FEATURES             Location/Qualifiers
     source          1..5446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.3-q21"
     gene            1..5446
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /note="lin-28 homolog B"
                     /db_xref="GeneID:389421"
                     /db_xref="HGNC:HGNC:32207"
                     /db_xref="MIM:611044"
     exon            1..154
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..897
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein lin-28 homolog B; Lin-28.2; lin-28B"
                     /codon_start=1
                     /product="protein lin-28 homolog B isoform 1"
                     /protein_id="NP_001004317.1"
                     /db_xref="CCDS:CCDS34504.1"
                     /db_xref="GeneID:389421"
                     /db_xref="HGNC:HGNC:32207"
                     /db_xref="MIM:611044"
                     /translation="MAEGGASKGGGEEPGKLPEPAEEESQVLRGTGHCKWFNVRMGFG
                     FISMINREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGP
                     GGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHM
                     VANCPHKNVAQPPASSQGRQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERS
                     GRSPQEASSTKSSIAPEEQSKKGPSVQKRKKT"
     exon            155..342
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..527
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..5446
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5421..5426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /note="hexamer: AATAAA"
     polyA_site      5446
                     /gene="LIN28B"
                     /gene_synonym="CSDD2"
                     /note="major polyA site"
ORIGIN      
        1 caaaagaagg aaagcacatt agaccatgcg agctaaattt gtgatcgcac aaaatcaaga
       61 tgttagattg atgcagaaga tcactccgtt ccaaagggaa agttttcatc tcacgagttt
      121 ggagctgagg gcccgtgggg caacatggcc gaaggcgggg ctagcaaagg tggtggagaa
      181 gagcccggga agctgccgga gccggcagag gaggaatccc aggttttgcg cggaactggc
      241 cactgtaagt ggttcaatgt gcgcatggga tttggattca tctccatgat aaaccgagag
      301 ggaagcccct tggatattcc agtcgatgta tttgtacacc aaagcaaact attcatggaa
      361 ggatttagaa gcctaaaaga aggagaacca gtggaattca catttaaaaa atcttccaaa
      421 ggccttgagt caatacgggt aacaggacct ggtgggagcc cctgtttagg aagtgaaaga
      481 agacccaaag ggaagacact acagaaaaga aaaccaaagg gagatagatg ctacaactgt
      541 ggtggccttg atcatcatgc taaggaatgt agtctacctc ctcagccaaa gaagtgccat
      601 tactgtcaga gcatcatgca catggtggca aactgcccac ataaaaatgt tgcacagcca
      661 cccgcgagtt ctcagggaag acaggaagca gaatcccagc catgcacttc aactctccct
      721 cgagaagtgg gaggcgggca tggctgtaca tcaccaccgt ttcctcagga ggctagggca
      781 gagatctcag aacggtcagg caggtcacct caagaagctt cctccacgaa gtcatctata
      841 gcaccagaag agcaaagcaa aaaggggcct tcagttcaaa aaaggaaaaa gacataacag
      901 gtcttcttca tatgttcttt cctttacccg gttgcaaagt ctacctcatg caagtatagg
      961 ggaacagtat ttcacaagca gtagctgacc tgggatttta actactattg gggaactgtg
     1021 aattttttaa acagacaaat cactctaagc aaattacatt tgagcagggt gtcatgtttt
     1081 atgttaattc agagaataag atactatgtc tgtcaatatg tgcatgtgtg agagggagag
     1141 agcctgagtc tgtgtgtgta catgaggatt tttatatagg aatgtagaca catatataaa
     1201 gaggctttgt ctttatatat ttgtgtatag atcaaagcac acaccctctc tcatataatt
     1261 ggatatttcc aagaattgaa aacccatgtg aagcattata gatagtttta aatttaaccc
     1321 actggagttt tcttgaaata ccacttcttt tatattatat aaaactaaaa acacgactgt
     1381 taccttttgt gtgaaccaaa ggatacttca gatctcagag ctgccaatta tggggtacta
     1441 aaggttttta agacatccag ttctcccgaa tttgggattg cctctttttc ttgaaatctc
     1501 tggagtagta atttttttcc cccttttttg aaggcagtac cttaacttca tatgcctctg
     1561 actgccataa gcttttttga ttctgggata acataactcc agaaaagaca atgaatgtgt
     1621 aatttgggcc gatatttcac tgttttaaat tctgtgttta attgtaaaat tagatgccta
     1681 ttaagagaaa tgaaggggag gatcatctta gtggcttgtt ttcagtagta ttttaatatc
     1741 agcttcttgt aaccttttcc atgttgtgag ggttgtaagg gattgtgtgg caacagcagc
     1801 ttcccttggc taactcaatc ttctacccat tgcttagagc agggagccct ccttatttac
     1861 tactgaagac cttagagaac tccaattgtt tggcatatat ttttggtggt ggtttttatt
     1921 cctcctggag agttatctaa tttgtttcta aaacaaacaa gcagcaaaga aatgaattaa
     1981 atactggggt tgagaattaa aattaagtgg atgttcacag ttgcccaata tatatgacct
     2041 gcaaatgata cgaaaaagtg cagcatttag tggcagttaa caagagtgac aagcctgggg
     2101 cagaggtacc aaacctctcc caccagagag ctagaagtat tttatacagt aactttgatc
     2161 ttatggaagt gaccttcaat gcttattctg aagtaaccta tatggtggat acaggatgaa
     2221 cattcagtgc cagggagaat cttctcaggt tggttctcgt tagagtgata aactggctag
     2281 gggccatagt attggtcctg ttaggtttcg gtcatggaaa aaaaaattat tttggggtca
     2341 tcctggctct agatgttatg ggcaaatttc tgaaacatct gcaagaaggt accagttaat
     2401 tatagtgctt aatattggga ataagattaa gcattataat tataatgtat gggcctgttg
     2461 gtgtaagctc agataattaa ataaaaatag catgactcaa atgagacata ttctgctgaa
     2521 cagtttctac ttcctctccc gcctgtcctg tcatgggaga cgtgtatagt tgctgctgtt
     2581 tcagcaaacc accataagac gaaaatgcct caggttgggt tgccagtcct ttacaactca
     2641 gcttgaattt cacaacagtg attgtgagaa tctgcgtggt atacactgaa atatcggtgt
     2701 gctgtgatgc aaagcttacc tttgacgata ttgaatgtga tatagctgta gagaagtact
     2761 tccttgcctt atgtgaggat ttcaaactta tttaaattat gtagacaaat caaagtggca
     2821 ttgcttaatt tttagcaggc ataataagca agttaacagt aaaatgcaaa acatgataag
     2881 cgttgctcaa tttttagcag gtataataag caggttaaca gtaaaaatgc aaaacatgat
     2941 agataagtca ctttgaaaat tcaaaccaaa gttccttcac cttatggaaa taggaaatta
     3001 tggacttcaa aattggacac ttcctgttta caaaaagaaa ttcagagcta aaatcatggt
     3061 aaaaaaaaat agaaacactt gagaactatg gtctttatgg gtgcaatttg aaatcctttt
     3121 catcatctta ccagactaaa ctaagagcac ataccaaacc tatcttatgg ttgaaagttg
     3181 gggtttattt tttatatgag aatattatca ctattacata acatactcag gacaaagaac
     3241 tttgctcagg gaacatacca tgtaatattt ttgttgtttc tttacagact agtctacagt
     3301 cctgcttact caaaacaaac caaataactt atacctttat ataagtatta tgtactgatg
     3361 atagtaacta cctctgagtt tgacacagat caaaattttt gaatatcaga tatcagttat
     3421 cctattttta tttcatgtga aaactcctct aaagcagatt ccctcaactc tgtgcatatg
     3481 tgaatatcac tgatgtgaac acattgttca tttacatagg taaaatatta ctctgtttac
     3541 agcaaaaggc tacctcatag ttgatacata gcacacctgt atgtatgctg ttccagcctt
     3601 acaggtggct gataattctc tggtacagaa cctttttatc tgtattataa atagcaattc
     3661 acaactgcat gtttctgaca aacacttgtg aataatgaag catctcgttt tagttagcaa
     3721 agtctccaaa catttcctta aaataatcat gtatttagtt taaagaatta tgggcactgt
     3781 tcaacttaag caaaacagaa cacggaagca gtcttagaag caccactttg cccagaggtg
     3841 gaggttggaa ggggtagcag ggagaggggt tggtgtatgc aggtattcat gctaggcaaa
     3901 gagtttaaaa gacgccaatg tccttcattt actgtctgtg ctgccctgaa gccaagcgta
     3961 ttgcagcatt atagccccag gcacataact aactagcact ggcttgccaa ggaatgaaca
     4021 tgcaatgcca ttactagcta ttgagggaaa agggtctgtg tgaagcatca ctttgcaggg
     4081 attactaatg gtggggcagc aggtctgtga attaagttat ctcttgacct caccctcatg
     4141 tcaacacaaa tgtaattcct aaacaagatg cattgccagt ctcttagccc tgtaagctga
     4201 tcttttgcta catggcagac tataatgaaa acatttttat acttgggttt ctagtcttca
     4261 ctagaaggcc ttggatgtat ttttgcagtt gaaagattta gaaagatttt tacctgctta
     4321 taacttggaa gtttagagtg caatgtaaga aaaaagatca agaaatgtca tgttattagc
     4381 atcagtccac ctccaatatt gccgatactt tttttattct ggctcagttt tattttgcac
     4441 cagtgcggcc ccaagttact gctggttgta tttagtttgt gaataggagc ccataagtgt
     4501 taatagactt tgtaacattc actataagat gaattataca ggacatggga aatctcatta
     4561 agtcttaaag ttaatttaaa ttaatttatc tgttttctct aagaaatgtt tatcataaaa
     4621 tatatatgtg tatttcccct ttggttataa aatttgggaa agtatgtaca agtgcagctg
     4681 cactgacttt aattttctag atgtcttaat gagatttatt tgttttagag aagaacatct
     4741 tgttaaaagc atcaaactct gtcttacata gctgtcaaca gcctctttaa gatgtggtgg
     4801 ttgtatgatc tgtgtcttaa ttgttcagtt agagtgagaa gttgacctat gattcatttt
     4861 taaattttat atttggaaca aagctgcaag ttatggtaaa gtactgtact gtgagaagta
     4921 ttatgatatt taatgcatct gtggcttaac acttgtgaga gttaccagct tgaaaatgat
     4981 ggtgttgact acctcttgaa tcacatctat caaccactgg cacctaccac caagctggct
     5041 tcaattagta tgtgttgctt tttggtatta acaactaacc gtactagaga ccaaagtgaa
     5101 ccctgatttt tatatgtctt taataatggt gttttatcta gtgtttttaa attatcctgt
     5161 gtagtattta gattacctca ttgtccattt tgactcatgt tgtttacaag tgaaaataaa
     5221 aacacttgaa ctgtatgttt ttaaaagaca aaaaaggggt agatgtttgg aatgcgtttc
     5281 actcgcatgc agtcatctgg agggactgaa gcactgtttg cctttctgta cactctgggt
     5341 tttatattct catttcatgc ctaatgtctt attctgtcaa ttatggatat gttgaggttt
     5401 aaaaaaatta cttgattaaa aataaaacat ataacgttgg cattta
//
