LOCUS       NM_024674               3975 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens lin-28 homolog A (LIN28A), mRNA.
ACCESSION   NM_024674
VERSION     NM_024674.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3975)
  AUTHORS   Zhou,S., Guo,L., Cui,X., Zhang,X., Yang,Y., Zhang,M. and Zhang,P.
  TITLE     Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin
            damage repair after burn injury
  JOURNAL   Cell Signal 120, 111217 (2024)
   PUBMED   38729326
  REMARK    GeneRIF: Inhibition of Let-7b-5p maturation by LIN28A promotes
            thermal skin damage repair after burn injury.
REFERENCE   2  (bases 1 to 3975)
  AUTHORS   Xu,M., Pang,M., Wang,C., An,N., Chen,R., Bai,Y., He,J., Wang,C. and
            Qi,Y.
  TITLE     MiR-92a-3p Knockdown Attenuates Transforming Growth
            Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting
            LIN28A-mediated EMT Pathway
  JOURNAL   J Physiol Investig 67 (4), 198-206 (2024)
   PUBMED   39148295
  REMARK    GeneRIF: MiR-92a-3p Knockdown Attenuates Transforming Growth
            Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting
            LIN28A-mediated EMT Pathway.
REFERENCE   3  (bases 1 to 3975)
  AUTHORS   Guo,L., Sun,H. and Pu,J.
  TITLE     GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced
            inflammation and osteogenic differentiation in periodontal stem
            cells by mediating the NF-kappaB/NLRP3 inflammasome pathway
  JOURNAL   Arch Oral Biol 163, 105974 (2024)
   PUBMED   38636252
  REMARK    GeneRIF: GNAI3 mediated by Lin28A regulates
            lipopolysaccharide-induced inflammation and osteogenic
            differentiation in periodontal stem cells by mediating the
            NF-kappaB/NLRP3 inflammasome pathway.
REFERENCE   4  (bases 1 to 3975)
  AUTHORS   Zhang,X.Y., Zhu,B.C., He,M. and Dong,S.S.
  TITLE     Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian
            cancer cells by downregulating lncRNA NKILA and modulating cancer
            stemness and LIN28A-let7 axis
  JOURNAL   J Ovarian Res 17 (1), 102 (2024)
   PUBMED   38745302
  REMARK    GeneRIF: Proto-oncogene c-Myb potentiates cisplatin resistance of
            ovarian cancer cells by downregulating lncRNA NKILA and modulating
            cancer stemness and LIN28A-let7 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3975)
  AUTHORS   Viswanathan,S.R., Powers,J.T., Einhorn,W., Hoshida,Y., Ng,T.L.,
            Toffanin,S., O'Sullivan,M., Lu,J., Phillips,L.A., Lockhart,V.L.,
            Shah,S.P., Tanwar,P.S., Mermel,C.H., Beroukhim,R., Azam,M.,
            Teixeira,J., Meyerson,M., Hughes,T.P., Llovet,J.M., Radich,J.,
            Mullighan,C.G., Golub,T.R., Sorensen,P.H. and Daley,G.Q.
  TITLE     Lin28 promotes transformation and is associated with advanced human
            malignancies
  JOURNAL   Nat Genet 41 (7), 843-848 (2009)
   PUBMED   19483683
  REMARK    GeneRIF: Study shows that LIN28 and LIN28B are overexpressed in
            primary human tumors and human cancer cell lines (overall frequency
            approximately 15%), and that overexpression is linked to repression
            of let-7 family miRNAs and derepression of let-7 targets.
REFERENCE   6  (bases 1 to 3975)
  AUTHORS   Rybak,A., Fuchs,H., Smirnova,L., Brandt,C., Pohl,E.E., Nitsch,R.
            and Wulczyn,F.G.
  TITLE     A feedback loop comprising lin-28 and let-7 controls pre-let-7
            maturation during neural stem-cell commitment
  JOURNAL   Nat Cell Biol 10 (8), 987-993 (2008)
   PUBMED   18604195
REFERENCE   7  (bases 1 to 3975)
  AUTHORS   Lee,Y.S., Kim,H.K., Chung,S., Kim,K.S. and Dutta,A.
  TITLE     Depletion of human micro-RNA miR-125b reveals that it is critical
            for the proliferation of differentiated cells but not for the
            down-regulation of putative targets during differentiation
  JOURNAL   J Biol Chem 280 (17), 16635-16641 (2005)
   PUBMED   15722555
REFERENCE   8  (bases 1 to 3975)
  AUTHORS   Gerecht-Nir,S., Dazard,J.E., Golan-Mashiach,M., Osenberg,S.,
            Botvinnik,A., Amariglio,N., Domany,E., Rechavi,G., Givol,D. and
            Itskovitz-Eldor,J.
  TITLE     Vascular gene expression and phenotypic correlation during
            differentiation of human embryonic stem cells
  JOURNAL   Dev Dyn 232 (2), 487-497 (2005)
   PUBMED   15614775
REFERENCE   9  (bases 1 to 3975)
  AUTHORS   Sempere,L.F., Freemantle,S., Pitha-Rowe,I., Moss,E., Dmitrovsky,E.
            and Ambros,V.
  TITLE     Expression profiling of mammalian microRNAs uncovers a subset of
            brain-expressed microRNAs with possible roles in murine and human
            neuronal differentiation
  JOURNAL   Genome Biol 5 (3), R13 (2004)
   PUBMED   15003116
REFERENCE   10 (bases 1 to 3975)
  AUTHORS   Moss,E.G. and Tang,L.
  TITLE     Conservation of the heterochronic regulator Lin-28, its
            developmental expression and microRNA complementary sites
  JOURNAL   Dev Biol 258 (2), 432-442 (2003)
   PUBMED   12798299
  REMARK    GeneRIF: microRNA regulation is a conserved feature of the Lin-28
            gene in diverse animals.
            Erratum:[Dev Biol. 2003 Oct 15;262(2):361]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028566.2 and AL513365.27.
            
            On Nov 23, 2018 this sequence version replaced NM_024674.5.
            
            Summary: This gene encodes a LIN-28 family RNA-binding protein that
            acts as a posttranscriptional regulator of genes involved in
            developmental timing and self-renewal in embryonic stem cells. The
            encoded protein functions through direct interaction with target
            mRNAs and by disrupting the maturation of certain miRNAs involved
            in embryonic development. This protein prevents the terminal
            processing of the LET7 family of microRNAs which are major
            regulators of cellular growth and differentiation. Aberrant
            expression of this gene is associated with cancer progression in
            multiple tissues. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA738314.1, BC028566.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326279.11/ ENSP00000363314.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-747               BC028566.2         40-786
            748-3975            AL513365.27        84616-87843         c
FEATURES             Location/Qualifiers
     source          1..3975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..3975
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /note="lin-28 homolog A"
                     /db_xref="GeneID:79727"
                     /db_xref="HGNC:HGNC:15986"
                     /db_xref="MIM:611043"
     exon            1..106
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..705
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /note="zinc finger, CCHC domain containing 1; RNA-binding
                     protein LIN-28; zinc finger CCHC domain-containing protein
                     1"
                     /codon_start=1
                     /product="protein lin-28 homolog A"
                     /protein_id="NP_078950.1"
                     /db_xref="CCDS:CCDS280.1"
                     /db_xref="GeneID:79727"
                     /db_xref="HGNC:HGNC:15986"
                     /db_xref="MIM:611043"
                     /translation="MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGIC
                     KWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAK
                     GLESIRVTGPGGVFCIGSERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKK
                     CHFCQSISHMVASCPLKAQQGPSAQGKPTYFREEEEEIHSPTLLPEAQN"
     exon            107..303
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..488
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..3975
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3946..3951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /note="hexamer: AATAAA"
     polyA_site      3975
                     /gene="LIN28A"
                     /gene_synonym="CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1"
                     /note="major polyA site"
ORIGIN      
        1 cctttgcctt cggacttctc cggggccagc agccgcccga ccaggggccc ggggccacgg
       61 gctcagccga cgaccatggg ctccgtgtcc aaccagcagt ttgcaggtgg ctgcgccaag
      121 gcggcagaag aggcgcccga ggaggcgccg gaggacgcgg cccgggcggc ggacgagcct
      181 cagctgctgc acggtgcggg catctgtaag tggttcaacg tgcgcatggg gttcggcttc
      241 ctgtccatga ccgcccgcgc cggggtcgcg ctcgaccccc cagtggatgt ctttgtgcac
      301 cagagtaagc tgcacatgga agggttccgg agcttgaagg agggtgaggc agtggagttc
      361 acctttaaga agtcagccaa gggtctggaa tccatccgtg tcaccggacc tggtggagta
      421 ttctgtattg ggagtgagag gcggccaaaa ggaaagagca tgcagaagcg cagatcaaaa
      481 ggagacaggt gctacaactg tggaggtcta gatcatcatg ccaaggaatg caagctgcca
      541 ccccagccca agaagtgcca cttctgccag agcatcagcc atatggtagc ctcatgtccg
      601 ctgaaggccc agcagggccc tagtgcacag ggaaagccaa cctactttcg agaggaagaa
      661 gaagaaatcc acagccctac cctgctcccg gaggcacaga attgagccac aatgggtggg
      721 ggctattctt ttgctatcag gaagttttga ggagcaggca gagtggagaa agtgggaata
      781 gggtgcattg gggctagttg gcactgccat gtatctcagg cttgggttca caccatcacc
      841 ctttcttccc tctaggtggg gggaaagggt gagtcaaagg aactccaacc atgctctgtc
      901 caaatgcaag tgagggttct gggggcaacc aggagggggg aatcacccta caacctgcat
      961 actttgagtc tccatcccca gaatttccag cttttgaaag tggcctggat agggaagttg
     1021 ttttcctttt aaagaaggat atataataat tcccatgcca gagtgaaatg attaagtata
     1081 agaccagatt catggagcca agccactaca ttctgtggaa ggagatctct caggagtaag
     1141 cattgttttt ttttcacatc ttgtatcctc atacccactt ttgggatagg gtgctggcag
     1201 ctgtcccaag caatgggtaa tgatgatggc aaaaagggtg tttgggggaa cagctgcaga
     1261 cctgctgctc tatgctcacc cccgccccat tctgggccaa tgtgatttta tttatttgct
     1321 cccttggata ctgcaccttg ggtcccactt tctccaggat gccaactgca ctagctgtgt
     1381 gcgaatgacg tatcttgtgc attttaactt tttttcctta atataaatat tctggttttg
     1441 tatttttgta tattttaatc taaggccctc atttcctgca ctgtgttctc aggtacatga
     1501 gcaatctcag ggatagccag cagcagctcc aggtctgcgc agcaggaatt actttttgtt
     1561 gtttttgcca ccgtggagag caactatttg gagtgcacag cctattgaac tacctcattt
     1621 ttgccaataa gagctggctt ttctgccata gtgtcctctt gaaaccccct ctgccttgaa
     1681 aatgttttat gggagactag gttttaactg ggtggcccca tgacttgatt gccttctact
     1741 ggaagattgg gaattagtct aaacaggaaa tggtggtaca cagaggctag gagaggctgg
     1801 gcccggtgaa aaggccagag agcaagccaa gattaggtga gggttgtcta atcctatggc
     1861 acaggacgtg ctttacatct ccagatctgt tcttcaccag attaggttag gcctaccatg
     1921 tgccacaggg tgtgtgtgtg tttgtaaaac tagagttgct aaggataagt ttaaagacca
     1981 atacccctgt acttaatcct gtgctgtcga gggatggata tatgaagtaa ggtgagatcc
     2041 ttaacctttc aaaattttcg ggttccaggg agacacacaa gcgagggttt tgtggtgcct
     2101 ggagcctgtg tcctgccctg ctacagtagt gattaatagt gtcatggtag ctaaaggaga
     2161 aaaagggggt ttcgtttaca cgctgtgaga tcaccgcaaa cctaccttac tgtgttgaaa
     2221 cgggacaaat gcaatagaac gcattgggtg gtgtgtgtct gatcctgggt tcttgtctcc
     2281 cctaaatgct gccccccaag ttactgtatt tgtctgggct ttgtaggact tcactacgtt
     2341 gattgctagg tggcctagtt tgtgtaaata taatgtattg gtctttctcc gtgttctttg
     2401 ggggttttgt ttacaaactt ctttttgtat tgagagaaaa atagccaaag catctttgac
     2461 agaaggttct gcaccaggca aaaagatctg aaacattagt ttggggggcc ctcttcttaa
     2521 agtggggatc ttgaaccatc ctttcttttg tattcccctt cccctattac ctattagacc
     2581 agatcttctg tcctaaaaac ttgtcttcta ccctgccctc ttttctgttc acccccaaaa
     2641 gaaaacttac acacccacac acatacacat ttcatgcttg gagtgtctcc acaactctta
     2701 aatgatgtat gcaaaaatac tgaagctagg aaaaccctcc atcccttgtt cccaacctcc
     2761 taagtcaaga ccattaccat ttctttcttt cttttttttt tttttttaaa atggagtctc
     2821 actgtgtcac ccaggctgga gtgcagtggc atgatcggct cactgcagcc tctgcctctt
     2881 gggttcaagt gattctcctg cctcagcctc ctgagtagct gggatttcag gcacccgcca
     2941 cactcagcta atttttgtat ttttagtaga gacggggttt caccatgttg tccaggctgg
     3001 tctggaactc ctgacctcag gtgatctgcc caccttggct tcccaaagtg ctgggattac
     3061 aggcatgagc caccatgctg ggccaaccat ttcttggtgt attcatgcca aacacttaag
     3121 acactgctgt agcccaggcg cggtggctca cacctgtaat cccagcactt tggaaggctg
     3181 aggcgggcgg atcacaaggt cacgagttca aaactatcct ggccaacaca gtgaaacccc
     3241 gtctctacta aaatacaaaa aaattagccg ggtgtggtgg tgcatgcctt tagtcctagc
     3301 tattcaggag gctgaggcag gggaatcgct tgaacccgag aggcagaggt tgcagtgagc
     3361 tgagatcgca ccactgcact ccagcctggt tacagagcaa gactctgtct caaacaaaac
     3421 aaaacaaaac aaaaacacac tactgtattt tggatggatc aaacctcctt aattttaatt
     3481 tctaatccta aagtaaagag atgcaattgg gggccttcca tgtagaaagt ggggtcagga
     3541 ggccaagaaa gggaatatga atgtatatcc aagtcactca ggaactttta tgcaggtgct
     3601 agaaacttta tgtcaaagtg gccacaagat tgtttaatag gagacgaacg aatgtaactc
     3661 catgtttact gctaaaaacc aaagctttgt gtaaaatctt gaatttatgg ggcgggaggg
     3721 taggaaagcc tgtacctgtc tgtttttttc ctgatccttt tccctcattc ctgaactgca
     3781 ggagactgag cccctttggg ctttggtgac cccatcactg gggtgtgttt atttgatggt
     3841 tgattttgct gtactgggta cttcctttcc cattttctaa tcatttttta acacaagctg
     3901 actcttccct tcccttctcc tttccctggg aaaatacaat gaataaataa agacttattg
     3961 gtacgcaaac tgtca
//
