LOCUS       NM_001371340            2091 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens LIM zinc finger domain containing 4 (LIMS4),
            transcript variant 3, mRNA.
ACCESSION   NM_001371340 XM_005263563
VERSION     NM_001371340.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108938.3 and AC112229.4.
            
            On Feb 11, 2020 this sequence version replaced NM_001371340.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000632897.2/ ENSP00000488340.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC108938.3         100398-100617       c
            221-380             AC108938.3         95896-96055         c
            381-447             AC112229.4         3720-3786
            448-568             AC112229.4         5261-5381
            569-718             AC112229.4         5816-5965
            719-869             AC112229.4         8802-8952
            870-962             AC112229.4         9563-9655
            963-1011            AC112229.4         10949-10997
            1012-1087           AC112229.4         13656-13731
            1088-2091           AC112229.4         13930-14933
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..2091
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /note="LIM zinc finger domain containing 4"
                     /db_xref="GeneID:100288695"
                     /db_xref="HGNC:HGNC:39941"
     exon            1..220
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1235
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /note="isoform 2 is encoded by transcript variant 3;
                     particularly interesting new Cys-His protein 3; LIM and
                     senescent cell antigen-like domains 3-like; LIM-type zinc
                     finger domains 4; LIM and senescent cell
                     antigen-like-containing domain protein 4; LIM and
                     senescent cell antigen-like-containing domain protein
                     3-like"
                     /codon_start=1
                     /product="LIM and senescent cell antigen-like-containing
                     domain protein 4 isoform 2"
                     /protein_id="NP_001358269.1"
                     /db_xref="CCDS:CCDS92838.1"
                     /db_xref="GeneID:100288695"
                     /db_xref="HGNC:HGNC:39941"
                     /translation="MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRR
                     HSDVKVYKEFCDFYAKFNMANALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQ
                     CFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCD
                     LCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHP
                     DHFNCANCGKDLTADAQELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHV
                     EHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWC
                     VNCFACSTCNTKLTLKDKFVEIDLKPVCKHCYEKMPEEFKRRLAKREREAKDKDKQKK
                     KKPVCL"
     exon            221..380
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            381..447
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            448..568
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            569..718
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            719..869
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            870..962
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1011
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1087
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..2091
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2064..2069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /note="hexamer: AATAAA"
     polyA_site      2091
                     /gene="LIMS4"
                     /gene_synonym="LIMS3L"
                     /note="major polyA site"
ORIGIN      
        1 attctcatcc ctgtgctcag agctctcaag cacccacgat ggccttctca ggccgagcgc
       61 gcccctgcat tatcccagag aacgaagaaa tcccccgagc agcccttaac actgtccacg
      121 aggccaatgg gaccgaggac gagagggctg tttccaaact gcagcgcagg cacagtgacg
      181 tgaaagtcta caaggagttc tgtgactttt atgcgaaatt caacatggcc aacgccctgg
      241 ccagcgccac ttgcgagcgc tgcaagggcg gctttgcgcc cgctgagacg atcgtgaaca
      301 gtaatgggga gctgtaccat gagcagtgtt tcgtgtgcgc tcagtgcttc cagcagttcc
      361 cagaaggact cttctatgag tttgaaggaa gaaagtactg tgaacatgac tttcagatgc
      421 tctttgcccc ttgctgtcat cagtgtggtg aattcatcat tggccgagtt atcaaagcca
      481 tgaataacag ctggcatccg gagtgcttcc gctgtgacct ctgccaggaa gttctggcag
      541 atatcgggtt tgtcaagaat gctgggagac acctgtgtcg cccctgtcat aatcgtgaga
      601 aagccagagg ccttgggaaa tacatctgcc agaaatgcca tgctatcatc gatgagcagc
      661 ctctgatatt caagaacgac ccctaccatc cagaccattt caactgcgcc aactgcggga
      721 aggatctgac tgccgatgca caggagctga aaggggagct atactgcctg ccatgccatg
      781 ataaaatggg ggtccccatc tgtggcgctt gccgacggcc catcgaaggg cgtgtggtga
      841 acgccatggg caagcagtgg catgtggagc attttgtttg tgccaagtgt gagaaaccct
      901 ttcttggaca tcgccattat gagaggaaag gcctggcgta ttgtgaaact cactataacc
      961 agctatttgg tgatgtttgc ttccactgca atcgtgttat agaaggtgat gtggtctctg
     1021 ctcttaataa ggcctggtgc gtgaactgct ttgcctgttc tacctgcaac actaaattaa
     1081 cactcaagga taagtttgtt gaaattgacc taaagccagt ctgcaaacac tgttatgaga
     1141 aaatgccaga agaatttaag aggcgacttg ccaaacggga gagagaagca aaggataagg
     1201 acaagcagaa aaagaaaaag ccagtctgtt tgtaaacttt tctatccctg tgtcatcatt
     1261 ttcactactt tctcctttgg ttagtccttt ggaatatgtt tttgttctgt ttctgtcttt
     1321 tgctttcttc cccccctgca acttttgggc gtgtatttgt agtcatcaga aatttgggcc
     1381 aaggggagcg gatcacgagg tcaggagatc gagactatcc tggctaacac ggtgaaaccc
     1441 catctctact aaaaatacaa aaaaaacatt agccaggcgt ggtggcggtc gcctgtagtc
     1501 ccagctcctc aggaggctga ggcaggagaa tggcttgaac ccaggaggcg gagcttgcag
     1561 tgagccgaga ccgcgccgct gcactccagc ctgggtgaca gagcaagact ctgtctcaaa
     1621 aaaaaaaaaa aaaaagtgta agtggattaa aagagaaact tggtctagtt cataatattt
     1681 ttaatagggc tttccctggc tgctggaaaa cttaggccag taagcatctc tttgtttaaa
     1741 gtcctacaag acaatttgaa ataattcatt gttcatgcca aaattctaag tactgttttt
     1801 cttagcaagt gtaacataat caggaacaat gggtacgagt aaaacattct ttggatgata
     1861 ttcagagcct tattagcact gcatctgaat aataggtcat tttgcctcac tcatttgcca
     1921 aagtagccat ttctaagtta aggaagtttt tagataggct catagccttg tatttcgttt
     1981 tagattgtaa gctcaatggt agggatacta tattggtaat tatgttttca tatagcaacc
     2041 accacagtat attcttggtg cttaataaat gtttataatt gttaacaata a
//
