LOCUS       NM_001394901            2094 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens LIM zinc finger domain containing 3 (LIMS3),
            transcript variant 3, mRNA.
ACCESSION   NM_001394901
VERSION     NM_001394901.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   Liu,Y., Liu,J., Chen,J., Cheng,L., Cao,Q., Zhu,L., Sun,Y., Liu,Q.
            and Li,J.
  TITLE     Molecular cloning and characterization of a novel splice variant of
            the LIM domain family gene, PINCH 2, in human testis
  JOURNAL   Mol Biotechnol 35 (2), 109-118 (2007)
   PUBMED   17435276
  REMARK    GeneRIF: The full length of its cDNA was 963 bp, with a 354-bp open
            reading frame (ORF), encoding a 117-amino acid protein. PINCH 2 was
            a splicing isoform of PINCH.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013271.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000480744.3/ ENSP00000488486.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC013271.4         38869-39091         c
            224-383             AC013271.4         34367-34526         c
            384-450             AC013271.4         23302-23368         c
            451-571             AC013271.4         21707-21827         c
            572-721             AC013271.4         21123-21272         c
            722-872             AC013271.4         18136-18286         c
            873-965             AC013271.4         17433-17525         c
            966-1014            AC013271.4         16091-16139         c
            1015-1090           AC013271.4         13356-13431         c
            1091-2094           AC013271.4         12154-13157         c
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..2094
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /note="LIM zinc finger domain containing 3"
                     /db_xref="GeneID:96626"
                     /db_xref="HGNC:HGNC:30047"
     exon            1..223
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1238
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /note="isoform b is encoded by transcript variant 3; pinch
                     2; LIM and senescent cell antigen-like-containing domain
                     protein 3; particularly interesting new Cys-His protein 3;
                     LIM and senescent cell antigen-like domains 3; LIM-type
                     zinc finger domains 3; LIM and senescent cell
                     antigen-like-containing domain protein 4; LIM and
                     senescent cell antigen-like-containing domain protein
                     3-like"
                     /codon_start=1
                     /product="LIM and senescent cell antigen-like-containing
                     domain protein 3 isoform b"
                     /protein_id="NP_001381830.1"
                     /db_xref="CCDS:CCDS92835.1"
                     /db_xref="GeneID:96626"
                     /db_xref="HGNC:HGNC:30047"
                     /translation="MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRR
                     HSDVKVYKEFCDFYAKFNMANALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQ
                     CFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCD
                     LCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHP
                     DHFNCANCGKDLTADAQELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHV
                     EHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWC
                     VNCFACSTCNTKLTLKDKFVEIDLKPVCKHCYEKMPEEFKRRLAKREREAKDKDKQKK
                     KKPVCL"
     exon            224..383
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            384..450
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..571
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..721
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..872
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            873..965
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1014
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1090
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..2094
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2067..2072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /note="hexamer: AATAAA"
     polyA_site      2094
                     /gene="LIMS3"
                     /gene_synonym="LIMS3L; LIMS4; PINCH-3"
                     /note="major polyA site"
ORIGIN      
        1 gccattctca tccctgtgct cagagctctc aagcacccac gatggccttc tcaggccgag
       61 cgcgcccctg cattatccca gagaacgaag aaatcccccg agcagccctt aacactgtcc
      121 acgaggccaa tgggaccgag gacgagaggg ctgtttccaa actgcagcgc aggcacagtg
      181 acgtgaaagt ctacaaggag ttctgtgact tttatgcgaa attcaacatg gccaacgccc
      241 tggccagcgc cacttgcgag cgctgcaagg gcggctttgc gcccgctgag acgatcgtga
      301 acagtaatgg ggagctgtac catgagcagt gtttcgtgtg cgctcagtgc ttccagcagt
      361 tcccagaagg actcttctat gagtttgaag gaagaaagta ctgtgaacat gactttcaga
      421 tgctctttgc cccttgctgt catcagtgtg gtgaattcat cattggccga gttatcaaag
      481 ccatgaataa cagctggcat ccggagtgct tccgctgtga cctctgccag gaagttctgg
      541 cagatatcgg gtttgtcaag aatgctggga gacacctgtg tcgcccctgt cataatcgtg
      601 agaaagccag aggccttggg aaatacatct gccagaaatg ccatgctatc atcgatgagc
      661 agcctctgat attcaagaac gacccctacc atccagacca tttcaactgc gccaactgcg
      721 ggaaggatct gactgccgat gcacaggagc tgaaagggga gctatactgc ctgccatgcc
      781 atgataaaat gggggtcccc atctgtggcg cttgccgacg gcccatcgaa gggcgtgtgg
      841 tgaacgccat gggcaagcag tggcatgtgg agcattttgt ttgtgccaag tgtgagaaac
      901 cctttcttgg acatcgccat tatgagagga aaggcctggc gtattgtgaa actcactata
      961 accagctatt tggtgatgtt tgcttccact gcaatcgtgt tatagaaggt gatgtggtct
     1021 ctgctcttaa taaggcctgg tgcgtgaact gctttgcctg ttctacctgc aacactaaat
     1081 taacactcaa ggataagttt gttgaaattg acctaaagcc agtctgcaaa cactgttatg
     1141 agaaaatgcc agaagaattt aagaggcgac ttgccaaacg ggagagagaa gcaaaggata
     1201 aggacaagca gaaaaagaaa aagccagtct gtttgtaaac ttttctatcc ctgtgtcatc
     1261 attttcacta ctttctcctt tggttagtcc tttggaatat gtttttgttc tgtttctgtc
     1321 ttttgctttc ttccccccct gcaacttttg ggcgtgtatt tgtagtcatc agaaatttgg
     1381 gccaagggga gcggatcacg aggtcaggag atcgagacta tcctggctaa cacggtgaaa
     1441 ccccatctct actaaaaata caaaaaaaac attagccagg cgtggtggcg gtcgcctgta
     1501 gtcccagctc ctcaggaggc tgaggcagga gaatggcttg aacccaggag gcggagcttg
     1561 cagtgagccg agaccgcgcc gctgcactcc agcctgggtg acagagcaag actctgtctc
     1621 aaaaaaaaaa aaaaaaaagt gtaagtggat taaaagagaa acttggtcta gttcataata
     1681 tttttaatag ggctttccct ggctgctgga aaacttaggc cagtaagcat ctctttgttt
     1741 aaagtcctac aagacaattt gaaataattc attgttcatg ccaaaattct aagtactgtt
     1801 tttcttagca agtgtaacat aatcaggaac aatgggtacg agtaaaacat tctttggatg
     1861 atattcagag ccttattagc actgcatctg aataataggt cattttgcct cactcatttg
     1921 ccaaagtagc catttctaag ttaaggaagt ttttagatag gctcatagcc ttgtatttcg
     1981 ttttagattg taagctcaat ggtagggata ctatattggt aattatgttt tcatatagca
     2041 accaccacag tatattcttg gtgcttaata aatgtttata attgttaaca ataa
//
