LOCUS       NM_001161403            2387 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LIM zinc finger domain containing 2 (LIMS2),
            transcript variant 3, mRNA.
ACCESSION   NM_001161403
VERSION     NM_001161403.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2387)
  AUTHORS   Wang,J. and Zhang,S.
  TITLE     Fluid shear stress modulates endothelial inflammation by targeting
            LIMS2
  JOURNAL   Exp Biol Med (Maywood) 245 (18), 1656-1663 (2020)
   PUBMED   32752897
  REMARK    GeneRIF: Fluid shear stress modulates endothelial inflammation by
            targeting LIMS2.
REFERENCE   2  (bases 1 to 2387)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2387)
  AUTHORS   Xu,H., Cao,H. and Xiao,G.
  TITLE     Signaling via PINCH: Functions, binding partners and implications
            in human diseases
  JOURNAL   Gene 594 (1), 10-15 (2016)
   PUBMED   27590440
  REMARK    GeneRIF: Mammalian cells have two functional PINCH proteins, PINCH1
            and PINCH2. PINCH not only binds to Nck2 and engages in the
            signaling of growth factor receptors, but also forms a ternary
            complex with ILK and parvin (IPP complex).
            Review article
REFERENCE   4  (bases 1 to 2387)
  AUTHORS   Chardon,J.W., Smith,A.C., Woulfe,J., Pena,E., Rakhra,K., Dennie,C.,
            Beaulieu,C., Huang,L., Schwartzentruber,J., Hawkins,C., Harms,M.B.,
            Dojeiji,S., Zhang,M., Majewski,J., Bulman,D.E., Boycott,K.M. and
            Dyment,D.A.
  CONSRTM   FORGE Canada Consortium
  TITLE     LIMS2 mutations are associated with a novel muscular dystrophy,
            severe cardiomyopathy and triangular tongues
  JOURNAL   Clin Genet 88 (6), 558-564 (2015)
   PUBMED   25589244
  REMARK    GeneRIF: Data indicate compound heterozygous missense mutations
            that are predicted to be pathogenic in LIM and senescent cell
            antigen-like domains 2 protein (LIMS2).
REFERENCE   5  (bases 1 to 2387)
  AUTHORS   Park,C.H., Rha,S.Y., Ahn,J.B., Shin,S.J., Kwon,W.S., Kim,T.S.,
            An,S., Kim,N.K., Yang,W.I. and Chung,H.C.
  TITLE     PINCH-2 presents functional copy number variation and suppresses
            migration of colon cancer cells by paracrine activity
  JOURNAL   Int J Cancer 136 (10), 2273-2283 (2015)
   PUBMED   25346044
  REMARK    GeneRIF: Results defined the functional role of copy number
            variations involving PINCH-2 in cancer progression based on the
            field cancerization effect; cell migration and invasion through
            autocrine and paracrine function as part of the field cancerization
            effect.
REFERENCE   6  (bases 1 to 2387)
  AUTHORS   Shi,X., Qu,H., Kretzler,M. and Wu,C.
  TITLE     Roles of PINCH-2 in regulation of glomerular cell shape change and
            fibronectin matrix deposition
  JOURNAL   Am J Physiol Renal Physiol 295 (1), F253-F263 (2008)
   PUBMED   18480182
REFERENCE   7  (bases 1 to 2387)
  AUTHORS   Liu,Y., Liu,J., Chen,J., Cheng,L., Cao,Q., Zhu,L., Sun,Y., Liu,Q.
            and Li,J.
  TITLE     Molecular cloning and characterization of a novel splice variant of
            the LIM domain family gene, PINCH 2, in human testis
  JOURNAL   Mol Biotechnol 35 (2), 109-118 (2007)
   PUBMED   17435276
REFERENCE   8  (bases 1 to 2387)
  AUTHORS   Kim,S.K., Jang,H.R., Kim,J.H., Noh,S.M., Song,K.S., Kim,M.R.,
            Kim,S.Y., Yeom,Y.I., Kim,N.S., Yoo,H.S. and Kim,Y.S.
  TITLE     The epigenetic silencing of LIMS2 in gastric cancer and its
            inhibitory effect on cell migration
  JOURNAL   Biochem Biophys Res Commun 349 (3), 1032-1040 (2006)
   PUBMED   16959213
  REMARK    GeneRIF: LIMS2 may be useful as a molecular biomarker and a
            therapeutic target by increasing its expression and activity in
            gastric cancer
REFERENCE   9  (bases 1 to 2387)
  AUTHORS   Zhang,Y., Chen,K., Guo,L. and Wu,C.
  TITLE     Characterization of PINCH-2, a new focal adhesion protein that
            regulates the PINCH-1-ILK interaction, cell spreading, and
            migration
  JOURNAL   J Biol Chem 277 (41), 38328-38338 (2002)
   PUBMED   12167643
  REMARK    GeneRIF: These results identify a novel nuclear and focal adhesion
            protein that associates with ILK and reveals an important role of
            PINCH-2 in the regulation of the PINCH-1-ILK interaction, cell
            shape change, and migration.
REFERENCE   10 (bases 1 to 2387)
  AUTHORS   Tu,Y., Huang,Y., Zhang,Y., Hua,Y. and Wu,C.
  TITLE     A new focal adhesion protein that interacts with integrin-linked
            kinase and regulates cell adhesion and spreading
  JOURNAL   J Cell Biol 153 (3), 585-598 (2001)
   PUBMED   11331308
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074114.6, DR006887.1,
            BC065816.1 and AC010976.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_001161403.2.
            
            Summary: This gene encodes a member of a small family of focal
            adhesion proteins which interacts with ILK (integrin-linked
            kinase), a protein which effects protein-protein interactions with
            the extraceullar matrix. The encoded protein has five LIM domains,
            each domain forming two zinc fingers, which permit interactions
            which regulate cell shape and migration. A pseudogene of this gene
            is located on chromosome 4. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            5' coding region compared to variant 1. The encoded isoform (3) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF527765.1, BC065816.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355119.9/ ENSP00000347240.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AC074114.6         23715-24054         c
            341-422             DR006887.1         7-88
            423-904             BC065816.1         1-482
            905-905             AC010976.6         193701-193701       c
            906-2387            BC065816.1         484-1965
FEATURES             Location/Qualifiers
     source          1..2387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..2387
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /note="LIM zinc finger domain containing 2"
                     /db_xref="GeneID:55679"
                     /db_xref="HGNC:HGNC:16084"
                     /db_xref="MIM:607908"
     exon            1..517
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..1532
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /note="isoform 3 is encoded by transcript variant 3; LIM
                     and senescent cell antigen-like-containing domain protein
                     2; LIM and senescent cell antigen-like domains 2; LIM-type
                     zinc finger domains 2; ILK-binding protein; particularly
                     interesting new Cys-His protein 2"
                     /codon_start=1
                     /product="LIM and senescent cell antigen-like-containing
                     domain protein 2 isoform 3"
                     /protein_id="NP_001154875.1"
                     /db_xref="CCDS:CCDS54395.1"
                     /db_xref="GeneID:55679"
                     /db_xref="HGNC:HGNC:16084"
                     /db_xref="MIM:607908"
                     /translation="MTGSNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCA
                     QCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRC
                     ELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYH
                     PDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQWH
                     VEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAW
                     CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPK
                     ATDLNSA"
     exon            518..677
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..744
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..865
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1015
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1166
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1259
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1308
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1384
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..2387
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /note="hexamer: AATGAA"
     polyA_site      2387
                     /gene="LIMS2"
                     /gene_synonym="LGMD2W; MDRCMTT; PINCH-2; PINCH2"
                     /note="major polyA site"
ORIGIN      
        1 gaggtggcga gcagagcccg ggttgggaag gacttgaccc gcgcccgccg ctggccgcgc
       61 tccgtgtccc tggagctggg gctgtgcggg agcggggccc accctctacc tttaccccta
      121 cttttacccc cactcccacc cccgcctcac tctcacccct ccaaccccac cgtcagcccc
      181 acctttaacc cccacccctc caaccctacc cgccgccacc cccacctgcc acccccaccc
      241 ccacctatac tcccgcaacc tcccaccgtc acctccccaa cacccccacc accctcagcc
      301 ttgacctccc catcccaccc cgccccgcgg gccccaccct gccacccccg cccacccctc
      361 tcgcgggcgg agcggctctt ggcctttttt gggcgtctcc ctgctccgcg gcccgggctg
      421 gcgggcgggc gctcggctgg cggctgcagc agcagaggga gacccgcggc aaccccggca
      481 acccagggct cggcgtcgct gccaccatga cgggaagcaa tatgtcggac gccttggcca
      541 acgccgtgtg ccagcgctgc caggcccgct tctcccccgc cgagcgcatt gtcaacagca
      601 atggggagct gtaccatgag cactgcttcg tgtgtgccca gtgcttccgg cccttccccg
      661 aggggctctt ctatgagttt gaaggccgga agtactgcga acacgacttc caaatgctgt
      721 ttgctccgtg ctgtggatcc tgcggtgagt tcatcattgg ccgcgtcatc aaggccatga
      781 acaacaactg gcacccgggc tgcttccgct gcgagctgtg tgatgtggag ctggctgacc
      841 tgggctttgt gaagaatgcc ggcaggcatc tctgccggcc ttgccacaac cgtgagaagg
      901 ccaagggcct gggcaagtac atctgccagc ggtgccacct ggtcatcgac gagcagcccc
      961 tcatgttcag gagcgacgcc taccaccctg accacttcaa ctgcacccac tgtgggaagg
     1021 agctgacagc cgaggcccgc gagctgaagg gtgagctcta ctgcctgccc tgccatgaca
     1081 agatgggcgt ccccatctgc ggggcctgcc gccggcccat cgagggccga gtggtcaacg
     1141 cgctgggcaa gcagtggcac gtggagcact ttgtctgtgc caagtgtgag aagccattcc
     1201 tggggcaccg gcactatgag aagaagggcc tggcctactg cgagactcac tacaaccagc
     1261 tcttcgggga cgtctgctac aactgcagcc atgtgattga aggcgatgtg gtgtcggccc
     1321 tcaacaaggc ctggtgtgtg agctgcttct cctgctccac ctgcaacagc aagctcaccc
     1381 tgaagaacaa gtttgtggag ttcgacatga agcccgtgtg taagaggtgc tacgagaagt
     1441 tcccgctgga gctgaagaag cggctgaaga agctgtcgga gctgacctcc cgcaaggccc
     1501 agcccaaggc cacagacctc aactctgcct gaaggccctc ttgcgcagct gcctctcggc
     1561 ccctccgcct tctcccctcc tgctgtccat gcttggcccc ctcgtcccca tccacctgtg
     1621 ccctccgcat cttaccctcc ctttctcttt cctcattgcc ttctcccttc ctgttccctc
     1681 atctctgcct tccccatgtc tctcctctcc ttggccgtgg cttctgtctg tgaggaggca
     1741 ggagctgggg agtgggagcc tatgacccca cgtctgacag ccatgtccac ctgtgcccac
     1801 agcttccgcc cacagacctc cagggacagg agcaaattgc accacagctc cccgcctggc
     1861 ctggccctcc ccaggcggct cagtggctca tgctgtcctg tgagagcccc tgccccagag
     1921 cggccccact aagcgcatgt ggctcctggg ctacccacag ccagggcagc ctgctggagc
     1981 cacagggcca gggccatgca gatggaggcc tctgggagcc acctccaatc cctcaccact
     2041 cactcaacca gtggcacagt gtccttgtgc ccacactgag ccagcaagtc ctgctgtcca
     2101 cacccacaag ctacctggag ggacaggacc cacctccatc cttcggaagg ccttcctgga
     2161 atcccacctt ggcctccgcc ctcggttccg ccccgcccct ctccccccga ccttggggct
     2221 tgtgtcgagc ccttgggtgg ggccaggagg aggtgatggc gtcagaggag gtgtggtcag
     2281 aggtgacttg ttcccacctc cagggaggac gcttcgtctt cggccagcgc agacctggtg
     2341 tttgtttgtt gggctcacgc ttgcacaatg aaggcttgtt cacacaa
//
