LOCUS       NM_030576               3192 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens LIM domain containing 2 (LIMD2), mRNA.
ACCESSION   NM_030576
VERSION     NM_030576.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3192)
  AUTHORS   Tao,P., Chen,X., Xu,L., Chen,J., Nie,Q., Xu,M. and Feng,J.
  TITLE     LIMD2 is the Signature of Cell Aging-immune/Inflammation in Acute
            Myocardial Infarction
  JOURNAL   Curr Med Chem 31 (17), 2400-2413 (2024)
   PUBMED   37936458
  REMARK    GeneRIF: LIMD2 is the Signature of Cell Aging-immune/Inflammation
            in Acute Myocardial Infarction.
REFERENCE   2  (bases 1 to 3192)
  AUTHORS   Chen,L., Qian,J., You,Q. and Ma,J.
  TITLE     LIM domain-containing 2 (LIMD2) promotes the progress of ovarian
            cancer via the focal adhesion signaling pathway
  JOURNAL   Bioengineered 12 (2), 10089-10100 (2021)
   PUBMED   34724866
  REMARK    GeneRIF: LIM domain-containing 2 (LIMD2) promotes the progress of
            ovarian cancer via the focal adhesion signaling pathway.
REFERENCE   3  (bases 1 to 3192)
  AUTHORS   Wang,F., Li,Z., Xu,L., Li,Y., Li,Y., Zhang,X., Wang,Y. and Liu,D.
  TITLE     LIMD2 targeted by miR-34a promotes the proliferation and invasion
            of non-small cell lung cancer cells
  JOURNAL   Mol Med Rep 18 (5), 4760-4766 (2018)
   PUBMED   30221696
  REMARK    GeneRIF: the results of the present study revealed that LIMD2
            promoted nonsmall cell lung cancer (NSCLC)progression and was
            regulated by miR34a.
REFERENCE   4  (bases 1 to 3192)
  AUTHORS   Pinheiro Dos Santos,M.J.C., Bastos,A.U., da Costa,V.R., Delcelo,R.,
            Lindsey,S.C., Colozza-Gama,G.A., Peng,H., Rauscher,F.J. 3rd,
            Oler,G. and Cerutti,J.M.
  TITLE     LIMD2 Is Overexpressed in BRAF V600E-Positive Papillary Thyroid
            Carcinomas and Matched Lymph Node Metastases
  JOURNAL   Endocr Pathol 29 (3), 222-230 (2018)
   PUBMED   29560564
  REMARK    GeneRIF: Our data suggest that LIMD2 may play an important role in
            the metastatic process of papillary thyroid carcinoma
REFERENCE   5  (bases 1 to 3192)
  AUTHORS   Peng,H., Talebzadeh-Farrooji,M., Osborne,M.J., Prokop,J.W.,
            McDonald,P.C., Karar,J., Hou,Z., He,M., Kebebew,E., Orntoft,T.,
            Herlyn,M., Caton,A.J., Fredericks,W., Malkowicz,B., Paterno,C.S.,
            Carolin,A.S., Speicher,D.W., Skordalakes,E., Huang,Q., Dedhar,S.,
            Borden,K.L.B. and Rauscher,F.J. 3rd.
  TITLE     LIMD2 is a small LIM-only protein overexpressed in metastatic
            lesions that regulates cell motility and tumor progression by
            directly binding to and activating the integrin-linked kinase
  JOURNAL   Cancer Res 74 (5), 1390-1403 (2014)
   PUBMED   24590809
REFERENCE   6  (bases 1 to 3192)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 3192)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 3192)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092301.1, CD632650.1, AA251318.1 and AC046185.14.
            
            On Nov 22, 2018 this sequence version replaced NM_030576.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092301.1, BC004400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259006.8/ ENSP00000259006.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2422              AK092301.1         1-2422
            2423-2423           CD632650.1         143-143             c
            2424-3178           AK092301.1         2424-3178
            3179-3191           AA251318.1         8-20                c
            3192-3192           AC046185.14        33735-33735
FEATURES             Location/Qualifiers
     source          1..3192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..3192
                     /gene="LIMD2"
                     /note="LIM domain containing 2"
                     /db_xref="GeneID:80774"
                     /db_xref="HGNC:HGNC:28142"
     exon            1..94
                     /gene="LIMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            95..186
                     /gene="LIMD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..528
                     /gene="LIMD2"
                     /note="testicular tissue protein Li 106"
                     /codon_start=1
                     /product="LIM domain-containing protein 2"
                     /protein_id="NP_085053.1"
                     /db_xref="CCDS:CCDS11641.1"
                     /db_xref="GeneID:80774"
                     /db_xref="HGNC:HGNC:28142"
                     /translation="MFQAAGAAQATPSHDAKGGGSSTVQRSKSFSLRAQVKETCAACQ
                     KTVYPMERLVADKLIFHNSCFCCKHCHTKLSLGSYAALHGEFYCKPHFQQLFKSKGNY
                     DEGFGRKQHKELWAHKEVDPGTKTA"
     exon            187..228
                     /gene="LIMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..368
                     /gene="LIMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..3192
                     /gene="LIMD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1255..1260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMD2"
                     /note="hexamer: AATAGA"
     polyA_site      1273
                     /gene="LIMD2"
                     /note="major polyA site"
     regulatory      3154..3159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMD2"
                     /note="hexamer: ATTAAA"
     regulatory      3164..3169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMD2"
                     /note="hexamer: AATAAA"
     polyA_site      3177
                     /gene="LIMD2"
     polyA_site      3192
                     /gene="LIMD2"
ORIGIN      
        1 gaccactggt agcggcagca gctcgcgccc gcgccctcct cgtacccgtg cgcccccgga
       61 gaccgatccc gccccgcggc ccaggccggg cctgaaccca gcgggtgccg cttctccacc
      121 cgaggcttcc acctccaacg agccatgttc caggctgcag gagccgccca ggccaccccc
      181 tctcatgacg ccaaaggcgg cggcagcagc acggtgcagc gctccaagtc cttcagcctg
      241 cgggcccagg tgaaggagac ctgcgccgcc tgccagaaga ccgtgtaccc catggagcgg
      301 ctggtggccg acaagctcat tttccacaac tcttgcttct gctgcaagca ctgtcacacc
      361 aagctcagcc tgggcagcta cgccgcgctg cacggggagt tctactgcaa accccacttc
      421 cagcagctgt ttaagagcaa aggcaactac gacgaggggt ttggccgcaa gcagcacaag
      481 gagctctggg cccacaagga ggtggacccc ggcaccaaga cggcctgagg cctctgtaac
      541 cttccacccc ctctgcggaa ggcctggagc cggcaggggg aaggtgggaa ggaggtcgag
      601 ctgggcttgc gtgggggcca ggtgggaagg ggatgaggct tgctcaggcg taggggacca
      661 gggcagggct ctgctccagg actccttcct tcttccttct cccgcagccg gtgagggttt
      721 ggaaaccagg attggggtct gcccaccacc ctgcttcctg cttcgttcag cctccctccc
      781 cacctcaccc caggaccccc tgggaggccc ccaagcccag ctcccctatc taggtgcctt
      841 ttctccagca aggagtcagc atgcccccct cagggtccca agctccctca ctgccaccgg
      901 agactgtgtg gcccccacgt ctccccatct acctctaccc ttaacctgtt tctgagccac
      961 ggagacaggg aggaaggagc gcgacagtgc cacctgttgg gcatcataaa tgcccctgca
     1021 gcccatgggg gaggagatgg ggaagtggag ccaccctgcc tctgcagggc aaggcagggc
     1081 ctgccccagt ggggcttggg accatctcga accaccagcg tggagaagca gaagcaaaag
     1141 cactcgccag gctgcagcct caggcactgg caggggctgg tgcggcccca ctcccctccc
     1201 ccgctcccat ttgtgcccat cctgttgtga ccaaccccgt tttaaacatg tttcaataga
     1261 tccagattct ctattgtgtg gcctgctggg ggatctgtca caggaagggt gcagactcac
     1321 catggggcgg gcatgggggg acagggccag ccccgactac ctcggccctg atgggggcag
     1381 ggagctagaa gtgggtgtca gttccctgac acaccattga gaaatgggag ggctcctctt
     1441 cacagcgagg gcttcatgct gtcacaccca cagtggtttt ggaactgaaa ctccacctca
     1501 cccctcagtt ctgggttggt tcagacccac caacttacca tatgcacccc attgtgaaga
     1561 ggcctgagag cgggagggcc aggctgccag tgggtgatgg cgcctgtcct cgctgcactt
     1621 cagtgcctgg ggtgcaagct gccgcgttcc ctggctggtt ccagctgtct agctccctcc
     1681 cttcttccca gccctttgac ctggaagtaa gttagcgaag aatggcggta accagcagac
     1741 ccagcaagtg ctgcccaagg ttttagtgac ccctggattg tcccccctca tcattacccc
     1801 tcgctgctgt catcatcccc ttgccttttc aagctctgcg gaggtgcagt cacagctact
     1861 gtctcaggaa atccaaagag aaactacctc tgcttctctg aaaacccagg gacaatgagg
     1921 gatgagttca cagcagagca aaccaggcaa gttgggagga cctgagggcg ccccggtggg
     1981 acacaggcag aagtctgggt tgtcctgctc cagattcaac ttcctgatgt ctccagacat
     2041 gggatcgatg agaacagaga ctcctggagg gtttgctgcc accacaccat acaactgcct
     2101 gagttcctaa gtggcctccc cgtggaacag ggcagggagc tgggccacag gctccagtgt
     2161 cacataagtc actatgctga ggcaggcact gctcctcgag ggagcagagc gaatactcag
     2221 cagagatggt gccccggcct ggatcctccc aagtgtgaag tgagcgcctc agagcctctc
     2281 agggcaggcc aacttcctgc accagaggtc tcagatggca aggatcatct tggttcggtt
     2341 aagcaacagt agcagatgac cacaaggggg tactggagag gtggctcttg gagacacctg
     2401 acccctgccc tgcaaagatg ggactgaagg aagtcctctg ggccaggaag accctaccaa
     2461 atatcatgaa agctccggga actcagccac tggtgacgtt caggttgtga gggccagcag
     2521 tgccaccctg gtaaatcagc cctgttggga ccaccccagt ggagctcctg gaggggcaac
     2581 tggaggaaag gggcagacac ctctggactg acaatggtat cagccagatc accccaggac
     2641 ccctctactt ggagtcaagt tctcttctgc ttgaaaggcc caggctcgtt gccaggcacc
     2701 atacctggcc cctgctaagc aaaaacctac ctccaccccc cacaactgaa agcactgcca
     2761 caggacccct ctgatataaa tgatcccttt tattgtaagt aatgcgcaac actggcctgg
     2821 ctttgcactg caagccctcg gtcaagatat agtcaaataa ctatggctgc aggttccaca
     2881 gttccacaat aaccatggct gcacgatcca caattcagac acagacatag agctggggtg
     2941 ggtggaaggg gcaggagggt ggcagagtgc ggactgtccc cagccctggc ctctccatgc
     3001 agagttggcc caggcagaca caccccatgg aatgatgaga aagtgacggc acggcccctt
     3061 cccacagcaa gcctggggct gccaggaact gcccttcaga acctttgggc ccaggtcacc
     3121 ctgaagcccc acaacttttt atctggatta gttattaaaa aacaataaat taagcaacaa
     3181 cttggtcctg ag
//
