LOCUS       NM_014240              11442 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens LIM domain containing 1 (LIMD1), mRNA.
ACCESSION   NM_014240
VERSION     NM_014240.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11442)
  AUTHORS   Mukhopadhyay,D., Chakraborty,B., Sarkar,S., Alam,N. and Panda,C.K.
  TITLE     Clinical implications of activation of the LIMD1-VHL-HIF1alpha
            pathway during head-&-neck squamous cell carcinoma development
  JOURNAL   Indian J Med Res 159 (5), 479-493 (2024)
   PUBMED   39382421
  REMARK    GeneRIF: Clinical implications of activation of the
            LIMD1-VHL-HIF1alpha pathway during head-&-neck squamous cell
            carcinoma development.
REFERENCE   2  (bases 1 to 11442)
  AUTHORS   Basu,M., Chatterjee,A., Chakraborty,B., Chatterjee,E., Ghosh,S.,
            Samadder,S., Pal,D.K., Roy,A., Chakrabarti,J., Ghosh,A. and
            Panda,C.K.
  TITLE     High nuclear expression of HIF1alpha, synergizing with inactivation
            of LIMD1 and VHL, portray worst prognosis among the bladder cancer
            patients: association with arsenic prevalence
  JOURNAL   J Cancer Res Clin Oncol 147 (8), 2309-2322 (2021)
   PUBMED   34080067
  REMARK    GeneRIF: High nuclear expression of HIF1alpha, synergizing with
            inactivation of LIMD1 and VHL, portray worst prognosis among the
            bladder cancer patients: association with arsenic prevalence.
REFERENCE   3  (bases 1 to 11442)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 11442)
  AUTHORS   Wang,Y., Zhang,C., Yang,W., Shao,S., Xu,X., Sun,Y., Li,P., Liang,L.
            and Wu,C.
  TITLE     LIMD1 phase separation contributes to cellular mechanics and
            durotaxis by regulating focal adhesion dynamics in response to
            force
  JOURNAL   Dev Cell 56 (9), 1313-1325 (2021)
   PUBMED   33891898
  REMARK    GeneRIF: LIMD1 phase separation contributes to cellular mechanics
            and durotaxis by regulating focal adhesion dynamics in response to
            force.
REFERENCE   5  (bases 1 to 11442)
  AUTHORS   Zhou,J., Zhang,L., Zhou,W., Chen,Y., Cheng,Y. and Dong,J.
  TITLE     LIMD1 phosphorylation in mitosis is required for mitotic
            progression and its tumor-suppressing activity
  JOURNAL   FEBS J 286 (5), 963-974 (2019)
   PUBMED   30600590
  REMARK    GeneRIF: findings suggest that LIMD1 is a key regulator of mitotic
            progression, and that dysregulation of LIMD1 contributes to
            tumorigenesis
REFERENCE   6  (bases 1 to 11442)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 11442)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   8  (bases 1 to 11442)
  AUTHORS   Kiss,H., Kedra,D., Kiss,C., Kost-Alimova,M., Yang,Y., Klein,G.,
            Imreh,S. and Dumanski,J.P.
  TITLE     The LZTFL1 gene is a part of a transcriptional map covering 250 kb
            within the common eliminated region 1 (C3CER1) in 3p21.3
  JOURNAL   Genomics 73 (1), 10-19 (2001)
   PUBMED   11352561
REFERENCE   9  (bases 1 to 11442)
  AUTHORS   Jiang,T. and Altman,S.
  TITLE     Protein-protein interactions with subunits of human nuclear RNase P
  JOURNAL   Proc Natl Acad Sci U S A 98 (3), 920-925 (2001)
   PUBMED   11158571
REFERENCE   10 (bases 1 to 11442)
  AUTHORS   Kiss,H., Kedra,D., Yang,Y., Kost-Alimova,M., Kiss,C., O'Brien,K.P.,
            Fransson,I., Klein,G., Imreh,S. and Dumanski,J.P.
  TITLE     A novel gene containing LIM domains (LIMD1) is located within the
            common eliminated region 1 (C3CER1) in 3p21.3
  JOURNAL   Hum Genet 105 (6), 552-559 (1999)
   PUBMED   10647888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099539.2, BC117236.1, BU428864.1, AJ132408.1 and AC098476.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014240.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.205164.1, AJ132408.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273317.5/ ENSP00000273317.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC099539.2         23734-23813         c
            81-1010             BC117236.1         1-930
            1011-1011           AC099539.2         22803-22803         c
            1012-1196           BC117236.1         932-1116
            1197-1502           BU428864.1         8-313               c
            1503-3084           BC117236.1         1423-3004
            3085-3444           AJ132408.1         2977-3336
            3445-6364           AC098476.2         29017-31936
            6365-11442          AC098476.2         31937-37014
FEATURES             Location/Qualifiers
     source          1..11442
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..11442
                     /gene="LIMD1"
                     /note="LIM domain containing 1"
                     /db_xref="GeneID:8994"
                     /db_xref="HGNC:HGNC:6612"
                     /db_xref="MIM:604543"
     exon            1..1537
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2160
                     /gene="LIMD1"
                     /note="LIM domains containing 1"
                     /codon_start=1
                     /product="LIM domain-containing protein 1"
                     /protein_id="NP_055055.1"
                     /db_xref="CCDS:CCDS2729.1"
                     /db_xref="GeneID:8994"
                     /db_xref="HGNC:HGNC:6612"
                     /db_xref="MIM:604543"
                     /translation="MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEET
                     RRVFATKMAKIHLQQQQQQLLQEETLPRGSRGPVNGGGRLGPQARWEVVGSKLTVDGA
                     AKPPLAASTGAPGAVTTLAAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSEMS
                     AFHQPGPCEDPSCLTHGDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPL
                     PKPCGDHPLNHRQLSLSSSRSSEGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLP
                     SPNLENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQ
                     PWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPV
                     MSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAELKLE
                     ALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLR
                     GKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVIC
                     NECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYH
                     VECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRLEKRPSSTALHQHHF"
     exon            1538..1639
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1707
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1770
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1901
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1953
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2022
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..11442
                     /gene="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6342..6347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMD1"
                     /note="hexamer: ATTAAA"
     polyA_site      6364
                     /gene="LIMD1"
                     /note="major polyA site"
     regulatory      11416..11421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIMD1"
                     /note="hexamer: AATAAA"
     polyA_site      11442
                     /gene="LIMD1"
ORIGIN      
        1 cttcgccagc atctccccgc tgccctcaac acacacacac acacacacac acacacacac
       61 acacacacac acacacacac acacacacac acacggcacc tgggctaggc ccggacacct
      121 gtctgcagca tggataagta tgacgacctg ggcctggagg ccagtaaatt catcgaggac
      181 ctgaacatgt atgaggcctc taaggatggg ctcttccgag tggacaaggg tgcaggcaac
      241 aaccccgagt ttgaggaaac tcgcagggtg ttcgccacca agatggccaa aatccacctc
      301 cagcagcagc agcagcagct cctgcaggag gagactctgc ccagggggag tagaggccct
      361 gtcaatggag ggggccgcct gggcccacag gcccgttggg aagttgtggg cagcaagctg
      421 actgtggatg gtgctgccaa gcctcctctt gctgcctcga caggggcacc tggggcagtc
      481 accaccctcg ctgctgggca gcccccgtac ccaccgcagg agcagagatc caggccatac
      541 ctgcatggca cgaggcatgg cagccaggac tgtggttcca gggagagcct ggcgacttct
      601 gagatgtctg ctttccacca gccaggcccc tgtgaggatc cttcctgcct cactcatgga
      661 gactattatg acaacctctc cttggcaagc ccaaagtggg gtgacaaacc aggagtgtcc
      721 cccagcatcg gcctgagtgt agggagtggg tggcctagct ccccggggag tgacccacca
      781 ctgcccaaac cctgcgggga ccatccccta aatcaccgac agctctccct gagctccagc
      841 aggtcttctg agggtagcct cggtggtcag aatagtggca ttggtggccg cagcagcgag
      901 aagccaacag gcctttggtc cactgcctcc tcccagcggg tgagccctgg cctgccttcc
      961 ccaaacttgg agaacggagc accagctgtg gggcctgttc agcccaggac cccttctgtg
     1021 tcagcaccct tggccctgag ctgccccagg caaggaggtc ttccaagatc aaactcgggg
     1081 ctggggggtg aggtttcagg tgtgatgtcc aaacccaatg tggaccccca accctggttc
     1141 caggatgggc ccaaatctta cctttccagt tctgccccgt catcctcgcc agctggtctg
     1201 gacggttcac agcagggtgc ggtccctggg ctggggccga agcctggctg cacagacctt
     1261 ggcactggtc ccaagctcag ccccaccagt cttgtccatc cagtgatgtc caccctgcct
     1321 gagttatctt gtaaagaggg tcccctgggc tggtcttctg atggtagcct gggatctgtg
     1381 ctcctggaca gccccagctc ccctagggta aggctgccct gccagcccct cgtcccaggt
     1441 cctgagctga gaccctctgc tgctgagttg aaattagaag ccctcaccca acgtctggag
     1501 cgagagatgg atgctcaccc gaaggctgat tactttggag cctgtgtgaa atgcagcaaa
     1561 ggggtgtttg gggctggcca ggcctgtcag gccatgggga acctctacca tgacacatgc
     1621 ttcacctgtg cagcttgcag ccggaagctg agaggaaaag ccttttattt tgtcaacggc
     1681 aaagtgtttt gtgaagaaga cttcctgtac tctggtttcc agcagtcggc tgacaggtgt
     1741 tttctttgtg gacatctgat catggacatg atcctgcaag ccctggggaa gtcctaccac
     1801 cccggctgtt tccgctgtgt catctgtaat gagtgtttgg atggggtgcc cttcaccgtg
     1861 gactcagaga acaagatcta ctgtgtccga gattaccaca aggtgctggc ccccaagtgt
     1921 gcagcctgtg ggcttcccat ccttccacct gagggctcag atgagaccat ccgtgtcgtg
     1981 tccatggaca gagactacca cgtggagtgt taccactgcg aggactgtgg tctggagctc
     2041 aatgatgaag atggccaccg ctgttatccg ctggaggacc acctgttctg tcactcctgc
     2101 cacgtgaaga ggctggagaa gagaccctca tctacagccc ttcaccagca ccacttctag
     2161 ccagagccac ttgcagacat cacggcaggg gatgaggagc cggggttgct gctgctgctt
     2221 ccggtggccc ctggggtgga agtggggtag gggaagagga ggggcaggag ggagagttcc
     2281 tgtgagcatg tggggggtgc ctttccttta accagggagg tgaacactac ctgcctcctg
     2341 cgtgtatttt ccaagtgctt ttctctgttg ccacattttc ctcaggttac tcaggaaaat
     2401 gctccagcat gtgcgagcac atgacctgag gttgcatcat agcaccaaag gaatcctcct
     2461 gtcccctctg ggaacatttc atgcttcaga gggagaggtt tttattgagc ttgtttcaca
     2521 atatcccctt gaagggacag ctcagctgcc aatacattca accctttctc ttccttcagg
     2581 aaaataccta tacccaaatg ttccctcccc cgacatatat catggcatga tttaaggctt
     2641 cttttcacct gagagcttca gttcttctgc agaatggctg caaatttaat tgcattaagg
     2701 caagaaggaa gctctaatgt gtgctttgta tcctaagata aatttgctta gaaaaccaga
     2761 gtcaagattt gaaataggtg aggcagggtt tcctccttag acactgacag cattctctgt
     2821 accccttcaa atccttactc tcctaaaggc agctgagtcc gcgacagaaa tttgccctat
     2881 gtgagtaaaa catactttgg gagaagaact tggtgcaggc accaggattt ttttttttgc
     2941 ccacgtgttt gcgctgtttt tctctggagt tctcaagagt tggtgacttg gaaggccgct
     3001 tctgcaaggc aagtctcagg aacccatgca ggtacatcgc ttgcacctgt ttttagctta
     3061 tttaatgacg ggcttttggg aagagctgcc cgcatactga gagacagctt cttataaaca
     3121 aggagagttt ttgtgtgtgc gagatctcta agccagcgtg ggagggagcg cctcaggata
     3181 agttattata ttcatttcgt tggtttctct cctgcccaat tcttggcaca ggcattatgt
     3241 ttgaagaaac caggataagg tacactgctt ttgtctgttt aattttttta gttgtttccc
     3301 ttcactttca gtcttccaca cacaaaaaat acctcacaga gcttcaccaa atcacagatt
     3361 caggaggaat ttggctttca cactggactc agataccttc ttcagtgtgt tggaaatcac
     3421 tggcttcaca caggcccaac tccagctggt cagggcagag tgatcgtaac taaaggtcag
     3481 tggggaatag atccgattca gtgcttttgc cttatgcatt tcagcatcct ggctccccag
     3541 ggtggcagga gctgagggag ggccacacac tggcaagatt tcaagaccac tctctgcact
     3601 gaagaggtaa aatttgcact gcaagtcaca tccctgaggc cagaggtcag taccctttgg
     3661 tatttcgatt agaagaagct gcaaaagaaa ggcagcccat tttaccattg ccagccaggc
     3721 cggggacaca ggagccggtg tgtgcactct gcctcctcac cttgcaccca gagcaagagg
     3781 actgggtgct gggctgcaga ggccggtcag tggagcccct agcacgtgtg aactcaggct
     3841 tttcattggg cccggctcca cttctaggcc atgttttgac tcatttggta accattgcct
     3901 gtaagcagca cagaattggt gccatggatt atcttttcca tgttgatgga attcattctg
     3961 ttggaatcct ttggccagat gtcacttcag ccagggtgtg catcatcatt ggttcttttt
     4021 cacaggctga gcctcctgaa aacccatgaa cgctggggct ggggaagtga accctgaggt
     4081 ggggaccctc tcttcccatc aaatcatcca gctcagtgtg gggcgtggca ggggggtaaa
     4141 tgaagccagc caatgtgtta acctgtctct gtcaacctaa gaatgttggc cttactgaca
     4201 cacctttgct ccatgttcaa gaccagaagt agctgggatt tgtttgcaaa ttgggtaatt
     4261 agtttaaaaa tctgtgatta catttttaaa tgaaattttc aaagtggcct agattgaggt
     4321 gattcagata ggtttgcgaa tataccattt tatattgttg agaaagaaca aaaagggaat
     4381 ttccagatgt cctagaaatc ctagcaacag atttctctgg ttgtcagttt ccctggagaa
     4441 ggcgccagat aggaatctcc aatcagttgt ttttctcttc gcttcaggcc cttacacaaa
     4501 agccatgaag agatgttcac ctacccggta ttttaaatgt tctgtaaatt attagccaaa
     4561 tagaactgta atggggttgt atttatgggc gcctagaaag aaaacacaag gacttggtag
     4621 gccaggaaga aaagatttta aaatttagaa tgaatagccc ttctgggttt tctttttgac
     4681 aattcttgga cttgaggtaa aacaaggagg attgtggccg gatttcagat cccaaagcca
     4741 gcctccatct taggcctttg cctcattgtg ccttttaggt tttcttaccc accgtctcct
     4801 gttttgtctt ttttttcttt tctcctaccc ctatcttggg acattcagaa actgcctggg
     4861 tggtttgaga agagacaacc cagtttgatc tgcaatacaa ggatccattc gtaatctctc
     4921 tctcactgat gttattcccc catctgccgt cttggttcat ctcaccacag aagggcattt
     4981 agtcctaccc agccatcggc tgcgtatgac agcaggatgg cacttcccat ttctctgtgg
     5041 ttagtgctcg agtgaaaacc tctttcagct gagtcctctg aggttctgct gttgagtcct
     5101 gggtggctga tggaatgatt gaggaggtct ggtcaccctc aagcgccgtc atcgccttgt
     5161 ttccatgggc ttctgtcaca caaaatgaag aacagaaatg ttaggactta agagaatgtt
     5221 tggaattcac acctctttgc agtcctttca aggctgctgc tctgtgctgt gtcccatgca
     5281 tgtgaaagta gagctgtgat ggctgctggg acgcttgcaa agatcatgtg tgagaattga
     5341 gcacaagacc acaaattatt actgcttgat gcgcttgtta aaactctatc tgccaggaaa
     5401 ccaaattttc ttttcttttc tttttttttt tgagacaggg cctcactctg ttgcccaggc
     5461 tggagtgcag tggcgcgatc tcagctcact gcagcctcca cctactgggc tcaagtgatc
     5521 ctcccacctc agcctcccga gtagccggga ccacaggcgt gtatgactgg ctacgcctgg
     5581 ctaatttttg tatttttaat agagacgagt ttcaccatgt tgcccaggat ggtctggaac
     5641 tcctgggctc aagtgatctg cccacttccg cctcccaaag tgttgggatt atggccatta
     5701 gccactgtac ctggcacaat ttttttttgt accctccttt atgccaagaa tcagtcctaa
     5761 tttctttact atgtgaagta acttttaaag gtaatagaaa aggccaggca cagtggctca
     5821 tgcctgtaat cccaggcgcc gtggctcacg cctgtaatcc cagcactttg agaggctgag
     5881 gcgggtggat cacttaaggt caggagttag agaccagcct gaccaacatg gtgaaacact
     5941 gtctctacta aaaatacaaa attagctggg tttggtggcg cacgcctgta atcccagcta
     6001 cctgagaggt tgaggcagga gaatcgcttg aacctgggag gcagaggttg cagtgagccg
     6061 agatggtgcc attgcactcc gacctgggca acagagcgaa acactgtctc aaaaaaaaaa
     6121 aaaaaagtaa cagaaaaaag agtgaaatat attagctatc ttttattctg agccaaaact
     6181 tgacagatgt gggaaatctt catatagtgt atgaaaattt cattgtacag ggaaattatt
     6241 ttcctctgtg tcttttcttt tactataaag tgattcagaa ttttactgtt actataaaat
     6301 tatgcaaagt attgtgacaa aactgcatca atttgttgac tattaaagtg ctccttgaac
     6361 attatatttc ctgggtcttt tctgtgtgtg gagtcagcaa actgtttttt gctacctgga
     6421 ctttgtcttc ttttacagct ctggattctt aaaagtacca cataggtagc aaacctgtga
     6481 agggtatgag attttaccct acttgcaggc taataaagtg agcacaccac atgggttcat
     6541 ggatcctggc agaagttatg agactcatag gtcagagaca aaggacagtt tattatagca
     6601 atagcagtgg ccagattatc agcatttaca ctggttccct gagccccagg ccccaagaag
     6661 agggccaggt gagacctgca cacgcagtgg gctgcattac aagaggaacc cccatgctta
     6721 ggggaccctg gtatttgata atgggcagta agcctgcctg acttttgctc cagagacaga
     6781 cactatctct gtcatccaag actgttcact agataaacat ccttgaaaat ataagtctgg
     6841 aacctggcaa ttggtgtcta ttcttaccag atgtataaaa atgtgagagg ccttggagaa
     6901 tcatatccca agaatcagca gtttctttta ctggaccttt aagattgaga cttgtaaggt
     6961 cctgatgcag tgacttgtaa ggtcactttg tctctcttgt gaatgttact gttttttctc
     7021 ttctgaggtt atgaccaaag aatcctcaag gcgagtgatc cttcaggttt gagacagcca
     7081 catgcaggaa gacaggactt gtagagtgtt ggggccaagt gtgtggttag aatccttggg
     7141 gtggggaaag agtttgttct agactccagt gtagtccttg tggctaccag gtctgacgtg
     7201 ccaaggacac gggaaagctg ggagtgagga tactcatagt catagcacct tacaccagaa
     7261 taaaagtttt ttttttcttt ttaagtgatg agagaatggc tagtctgatt ttgccaacat
     7321 gggctgctat ttgcttaaga ccttgatggt ataaggagtg aagatgcaat cagggtaaaa
     7381 ggcggtctgg agttgtggtg tgctggcaaa ccagccctct ggggcaaaaa attaaaaagc
     7441 cttgatatgg agtgtttgct gatacctatg atgtaaatat tcccgccatg gccactttcc
     7501 agctaccagc aaggcatcct ggcaccaggg attgggagga gatggcatag tcctaagagt
     7561 cagccttggg cattgggcca tgtgggactg ggcagtgggg tatctggtct ggttctaagt
     7621 gctgtgatga agcagtagca gctgtaatag ctggcatttc ccgtgtgctc atcacatagc
     7681 agatgttatt ccaaggactg tatgttcttt atcatccctc atttgataga caagacaact
     7741 gagacacaaa agggtgaaat aaacagtaag tactccatcc caggccatct catccagagg
     7801 gtgctgtctt gaccactcta ctactctggt tgatgggagg cagtaaattg tccatcagta
     7861 tacttcttca tcaaagctac atagtcaaaa agccacagga ggctgtgagg agaagctcac
     7921 tgctgctctg ttgaagtctg tattggtttc ctatggccac tcttaacaaa ttaccacaac
     7981 ctcagtggct taaaacaaca caaatatatc attctgtcat cctggacacg agccaaaggt
     8041 tgtcggcaga agcgaattgc ttccagaggt gctatagggt gctgcccatt ccttgcccct
     8101 tttccgcttc tagaggctgc ccattttcct tggcttgtgg ctgcatcatt ctggctgctt
     8161 ctattgtcac acctcctctc tgaccctccc tgcctccttg taaggacact tgggattacg
     8221 cccatccaga taatctagaa taatctccca ttttgtgatt cttaataaca tctgcaaagc
     8281 ctcttttacc ttgcagaata agatattcac aggttctggt gaggaggaca gggacatctc
     8341 tgaaggggag ggaagcagga gatagggtct ggaggcatgg aattggcttc ctaaggccaa
     8401 ttcaggctga cttcctagaa ctaagtcaaa aggaaaaccc caactttcca cgctcaagta
     8461 acaaaaggac cagaggctac tccctttgca acctccccac ccccagcccc ttttctgcat
     8521 ggcaggtgaa aaattgaaag tatcgctaat tgatcccctc ccacaaccaa tcagactggt
     8581 cttaggccaa gtcttcattt gcctaggagt ataactttgt aacttcagcc tctgattggg
     8641 cgttttacac aaccagtcag atgtttgtat agggtggtgt aactttgtaa ctttgcttca
     8701 gcctctgatt ggtcccctcc cacaaccaat caaactgatc atggacctct gcttcattta
     8761 catagggtgt acaccaagta accaatggga aacctctaga gggtatttaa atcccagaaa
     8821 attctgtaac cgggttcttg agctgcttgg gctgctccca ccctgtggag cgtactttcg
     8881 tttttcaata aatctctttt gttgcttcat tctttacttg ctttgtgcgt tttgtccatt
     8941 tctttatcaa gacgccaaga acctggacac cctccaccgg taacaggagg agcattagtc
     9001 agcctaccac agactccaac gaacgttttt tgagaggaaa tgaaagaata ttcctaagtt
     9061 attgggtgcc ttttcttcag gaatccctga aagtgggggt ttgcaatttt ccctggattg
     9121 aaaacagaaa tgcttcctac acaaacatga ttgagacctt gtactctagg tgtaaaaaaa
     9181 cagagtaggt catactctgt gggttatggt cagagagatc tggttagaag ttcccaggta
     9241 ggcgacagcc ctagatgtgt gacacttcta ggagaatctc tggctatgtg gatacgtcca
     9301 ggtgtgtaag gcagcctcag ggactgccac cacttggtca catacatgtc cctccaacta
     9361 atcctagctc tcaaggacag gtggttctgg gccctgtgtt gcccatgaga cttggtccac
     9421 ggcaagcctg tgacggagtg aaagtgaggg gacacccaat ttgaaaactc ggcaggaagc
     9481 cagactccat gacatacaaa tagatcaaag tgaatcggct ccgttgtttg gggaaatacc
     9541 tgaggtttgt tgtttcgtgc caagaagatt aacaacacgg acacacgtgg gtgggttaag
     9601 gagcagaaag tttaacaggc agaaaaaaga gaacagctcc cccatgcaga gggaggagga
     9661 ctccgaatgg atctccccat tcctggcggg aagcagactg atatatagag gagggggttt
     9721 gaagaggtgg tatttgattt acatagagcc caagggattg gtttgaccag gtgtgccatt
     9781 tacatagccc tcgaagaaac tggccattcc accttgatct tttattatgc agatagggtt
     9841 ttttacttgg ccagagcctt gacacctgca cacatggcaa caaacagaag ggaggcgaaa
     9901 tcttccatat tggatgcacc tgtcttccag gtgcagctgc cggcatttat ctgtgcaagc
     9961 ttctagcttg cttatttatg cttgcagctt gacttttcag gctgctttct gttggaaaag
    10021 aaatggtttt gggggctgct ttttattaaa agaaaagcct taccaaggac tcctgtaccc
    10081 tatctgccta aatttttttt aactactata ttaaaaggtc tgtaagtggg agctggccct
    10141 aaaagtaggt tgtagagatt atttggatgt gccaacaagc ttcatctgca gcttggactg
    10201 tctccattgg aaggcctctg gcagattttg taaaaagtta tataacaatt ttactatagg
    10261 aaaaacttgg ctacagatat gaatttatat tacccatcat tggctggttc cttatcctga
    10321 acattggttt ccttggaatc tgattttggc ttgtttggcc tttaaaaacc ccagaagaat
    10381 ggggtttctg ccagattatt ttctggtttt cagtctcact gaatgtcaca aaggccttgg
    10441 tttatggttc ccaactggta aagaaacgtc aaactttgcc tctcttagtt ccttctacat
    10501 gacaatgggt ggcagttgct catatggaag catttctttt ccccctaaag cctatgagac
    10561 aggctgcaac ttaaacccct attttattaa aggagaggaa atgtccaaga gcccagagat
    10621 agtgggtaaa agcatcataa ggactagaaa tggggtcttc ttgttgctaa ttagtagggg
    10681 tgaggggtaa gtggcagatg tgactgccgt ccatgcccag acagggaatt gtccttgaac
    10741 ctactcatgc ggtgtcttct ggggtacagt gagtccacag ggcaggacgg ccttggagtc
    10801 aagagcccag actcacattc tatctcaggc ttcataactc aattgctcca tgaccttaag
    10861 ccaatttagt tccctcatct gtaaaaatgg ggataacaac tgaatttacc tcatgggatt
    10921 gtgtaatgcc caaccttgtt tttactaacc ctgtttttag actctccctc ttcctttaat
    10981 cacctagcct tgtttccacc tgaattgact ctcccttagc taagacagcc agacagactc
    11041 catcttggct ctttcactgg caccccttcc tcaaggactt aacttgtgca agctgactcc
    11101 cagcacatcc aagaatgcaa ttaactgata agatactgtg gcaagctata tccgcaattc
    11161 ccaggaattc gtctgattga taacgcccaa agccccgggt ctatcacctt gtaatagtct
    11221 taaagcccct gcacctggaa ctgtttactt tcctgtaacc atttatcctt ttaacttttt
    11281 gcctacttta tttctgtaaa attgttttaa ctagaccccc ccctcccctt tctaaaccaa
    11341 agtataaaag aaaatctagc cctttcctca gggctgagaa aattttgagt gttagccgtc
    11401 tctcggtcgc tggctaataa aggactctta attcgtctta aa
//
