LOCUS       NM_001081442            3221 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor B5 (LILRB5),
            transcript variant 1, mRNA.
ACCESSION   NM_001081442
VERSION     NM_001081442.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3221)
  AUTHORS   Hirayasu,K., Khor,S.S., Kawai,Y., Shimada,M., Omae,Y., Hasegawa,G.,
            Hashikawa,Y., Tanimoto,H., Ohashi,J., Hosomichi,K., Tajima,A.,
            Nakamura,H., Nakamura,M., Tokunaga,K., Hanayama,R. and Nagasaki,M.
  TITLE     Identification of the hybrid gene LILRB5-3 by long-read sequencing
            and implication of its novel signaling function
  JOURNAL   Front Immunol 15, 1398935 (2024)
   PUBMED   38807600
  REMARK    GeneRIF: Identification of the hybrid gene LILRB5-3 by long-read
            sequencing and implication of its novel signaling function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3221)
  AUTHORS   Hogan,L.E., Jones,D.C. and Allen,R.L.
  TITLE     Expression of the innate immune receptor LILRB5 on monocytes is
            associated with mycobacteria exposure
  JOURNAL   Sci Rep 6, 21780 (2016)
   PUBMED   26908331
  REMARK    GeneRIF: The transcriptional profile of the orphan receptor LILRB5
            is significantly up-regulated following exposure to mycobacteria.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3221)
  AUTHORS   Zhang,Z., Hatano,H., Shaw,J., Olde Nordkamp,M., Jiang,G., Li,D. and
            Kollnberger,S.
  TITLE     The Leukocyte Immunoglobulin-Like Receptor Family Member LILRB5
            Binds to HLA-Class I Heavy Chains
  JOURNAL   PLoS One 10 (6), e0129063 (2015)
   PUBMED   26098415
  REMARK    GeneRIF: LILRB5 binding to intracellular HLA-class I heavy chains
            suggests a chaperone function
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3221)
  AUTHORS   Dube,M.P., Zetler,R., Barhdadi,A., Brown,A.M., Mongrain,I.,
            Normand,V., Laplante,N., Asselin,G., Zada,Y.F., Provost,S.,
            Bergeron,J., Kouz,S., Dufour,R., Diaz,A., de Denus,S., Turgeon,J.,
            Rheaume,E., Phillips,M.S. and Tardif,J.C.
  TITLE     CKM and LILRB5 are associated with serum levels of creatine kinase
  JOURNAL   Circ Cardiovasc Genet 7 (6), 880-886 (2014)
   PUBMED   25214527
  REMARK    GeneRIF: The rs12975366 in the LILRB5 gene was significantly
            associated with CK levels of statin users.
REFERENCE   5  (bases 1 to 3221)
  AUTHORS   Tedla,N., Lee,C.W., Borges,L., Geczy,C.L. and Arm,J.P.
  TITLE     Differential expression of leukocyte immunoglobulin-like receptors
            on cord-blood-derived human mast cell progenitors and mature mast
            cells
  JOURNAL   J Leukoc Biol 83 (2), 334-343 (2008)
   PUBMED   17998301
  REMARK    GeneRIF: Mature cord-blood-derived mast cells expressed LILRB5 in
            cytoplasmic granules and upon cross-linking of the high-affinity
            IgE receptor, released LILRB5 into the culture medium.
REFERENCE   6  (bases 1 to 3221)
  AUTHORS   Borges,L., Hsu,M.L., Fanger,N., Kubin,M. and Cosman,D.
  TITLE     A family of human lymphoid and myeloid Ig-like receptors, some of
            which bind to MHC class I molecules
  JOURNAL   J Immunol 159 (11), 5192-5196 (1997)
   PUBMED   9548455
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245052.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001081442.2.
            
            Summary: This gene is a member of the leukocyte immunoglobulin-like
            receptor (LIR) family, which is found in a gene cluster at
            chromosomal region 19q13.4. The encoded protein belongs to the
            subfamily B class of LIR receptors which contain two or four
            extracellular immunoglobulin domains, a transmembrane domain, and
            two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
            motifs (ITIMs). Several other LIR subfamily B receptors are
            expressed on immune cells where they bind to MHC class I molecules
            on antigen-presenting cells and inhibit stimulation of an immune
            response. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223296.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449561.3/ ENSP00000406478.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC245052.3         185700-185813       c
            115-150             AC245052.3         185501-185536       c
            151-435             AC245052.3         185029-185313       c
            436-735             AC245052.3         184583-184882       c
            736-1032            AC245052.3         183826-184122       c
            1033-1335           AC245052.3         183275-183577       c
            1336-1386           AC245052.3         182905-182955       c
            1387-1437           AC245052.3         182558-182608       c
            1438-1554           AC245052.3         181411-181527       c
            1555-1618           AC245052.3         181026-181089       c
            1619-1656           AC245052.3         180906-180943       c
            1657-1709           AC245052.3         180594-180646       c
            1710-3221           AC245052.3         177961-179472       c
FEATURES             Location/Qualifiers
     source          1..3221
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3221
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="leukocyte immunoglobulin like receptor B5"
                     /db_xref="GeneID:10990"
                     /db_xref="HGNC:HGNC:6609"
                     /db_xref="MIM:604814"
     exon            1..114
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1856
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte immunoglobulin-like receptor
                     subfamily B member 5; leukocyte immunoglobulin-like
                     receptor 8; CD85 antigen-like family member C; leukocyte
                     immunoglobulin-like receptor, subfamily B (with TM and
                     ITIM domains), member 5; leucocyte Ig-like receptor B5;
                     leukocyte immunoglobulin like receptor B5 short splicing
                     isoform; leukocyte immunoglobulin like receptor B5 long
                     splicing isoform"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     B member 5 isoform 1 precursor"
                     /protein_id="NP_001074911.2"
                     /db_xref="CCDS:CCDS46176.1"
                     /db_xref="GeneID:10990"
                     /db_xref="HGNC:HGNC:6609"
                     /db_xref="MIM:604814"
                     /translation="MTLTLSVLICLGLSVGPRTCVQAGTLPKPTLWAEPASVIARGKP
                     VTLWCQGPLETEEYRLDKEGLPWARKRQNPLEPGAKAKFHIPSTVYDSAGRYRCYYET
                     PAGWSEPSDPLELVATGFYAEPTLLALPSPVVASGGNVTLQCDTLDGLLTFVLVEEEQ
                     KLPRTLYSQKLPKGPSQALFPVGPVTPSCRWRFRCYYYYRKNPQVWSNPSDLLEILVP
                     GVSRKPSLLIPQGSVVARGGSLTLQCRSDVGYDIFVLYKEGEHDLVQGSGQQPQAGLS
                     QANFTLGPVSRSHGGQYRCYGAHNLSPRWSAPSDPLDILIAGLIPDIPALSVQPGPKV
                     ASGENVTLLCQSWHQIDTFFLTKEGAAHPPLCLKSKYQSYRHQAEFSMSPVTSAQGGT
                     YRCYSAIRSYPYLLSSPSYPQELVVSGPSGDPSLSPTGSTPTPAGPEDQPLTPTGLDP
                     QSGLGRHLGVVTGVSVAFVLLLFLLLFLLLRHRHQSKHRTSAHFYRPAGAAGPEPKDQ
                     GLQKRASPVADIQEEILNAAVKDTQPKDGVEMDAPAAASEAPQDVTYAQLHSLTLRRE
                     ATEPPPSQEREPPAEPSIYAPLAIH"
     exon            115..150
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            151..435
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            436..735
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1032
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1335
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1386
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1437
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1554
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1618
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1656
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1709
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..3221
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="hexamer: AATAAA"
     polyA_site      2099
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="major polyA site"
     regulatory      2150..2155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="hexamer: ATTAAA"
     polyA_site      2174
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="major polyA site"
     regulatory      3193..3198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="hexamer: ATTAAA"
     polyA_site      3221
                     /gene="LILRB5"
                     /gene_synonym="CD85C; LIR-8; LIR8"
                     /note="major polyA site"
ORIGIN      
        1 acactctgcg tgtttttgtg tcctgccagg caccgtggtc tcatccgcct gcacagctga
       61 gtccagtggg agctgacgcc atgaccctca ccctctcagt cctgatttgc ctcgggctga
      121 gtgtgggccc caggacctgc gtgcaggcag gcaccctccc caaacccacc ctctgggctg
      181 agccagcctc tgtgatagct cgggggaagc ccgtgaccct ctggtgtcag gggcccctgg
      241 agactgagga gtaccgtctg gataaggagg gactcccatg ggcccggaag agacagaacc
      301 cactggagcc tggagccaag gccaagttcc acattccatc cacggtgtat gacagtgcag
      361 ggcgataccg ctgctactat gagacccctg caggctggtc agagcccagt gaccccctgg
      421 agctggtggc gacaggattc tatgcagaac ccactctttt agccctgccg agtcctgtgg
      481 tggcctcagg aggaaatgtg accctccagt gtgatacact ggacggactt ctcacgtttg
      541 ttcttgttga ggaagaacag aagctcccca ggaccctgta ctcacagaag ctccccaaag
      601 ggccatccca ggccctgttc cctgtgggtc ccgtgacccc cagctgcagg tggaggttca
      661 gatgctatta ctattacagg aaaaaccctc aggtgtggtc gaaccccagt gacctcctgg
      721 agattctggt cccaggcgtg tctaggaagc cctccctcct gatcccgcag ggctctgtcg
      781 tggcccgcgg aggcagcctg accctgcagt gtcgctctga tgtcggctat gacatattcg
      841 ttctgtacaa ggagggggaa catgacctcg tccagggctc tggccagcag ccccaggctg
      901 ggctctccca ggccaacttc accctgggcc ctgtgagccg ctcccacggg ggccagtaca
      961 gatgctacgg tgcacacaac ctctccccta ggtggtcggc ccccagcgac cccctggaca
     1021 tcctgatcgc aggactgatc cctgacatac ccgccctctc ggtgcagccg ggccccaagg
     1081 tggcctcagg agagaacgtg accctgctgt gtcagtcatg gcatcagata gacactttct
     1141 ttttgaccaa ggagggggca gcccatcccc cgctgtgtct aaagtcaaag taccagtctt
     1201 atagacacca ggctgaattc tccatgagtc ctgtgacctc agcccagggt ggaacctacc
     1261 gatgctacag cgcaatcagg tcctacccct acctgctgtc cagccctagt tacccccagg
     1321 agctcgtggt ctcaggaccc tctggggatc ccagcctctc acctacaggc tccaccccca
     1381 cacctgcagg ccctgaggac cagcccctca cccccacggg gttggatccc cagagtggtc
     1441 tgggaaggca cctgggggtt gtgactgggg tctcagtggc cttcgtcctg ctgctgttcc
     1501 tcctcctctt cctcctcctc cgacatcggc atcagagcaa acacaggaca tcggcccatt
     1561 tctaccgtcc tgcaggggct gcggggccag agcccaagga ccagggcctg cagaagaggg
     1621 ccagcccagt tgctgacatc caggaggaaa ttctcaatgc tgccgtgaag gacacacagc
     1681 ccaaggacgg ggtggagatg gatgctccgg ctgctgcatc tgaagccccc caggatgtga
     1741 cctacgccca gctgcacagc ttgaccctca gacgggaggc aactgagcct cctccatccc
     1801 aggaaaggga acctccagct gaacccagca tctacgcccc cctggccatc cactagccca
     1861 cgggggaccc agatctcata ctcaacagaa ggagactcag agactccaga aggcacagga
     1921 gctgccccca gtggacacca atgaacccca gccagcctgg acccctaaca aagaccacca
     1981 ggacatcctg ggaactctgg gactcactag attctgcagt caaagatgac taatatcctt
     2041 gcatttttga aatgaagcca cagacttctc aataaatcaa tgagctgaga aaactgaaac
     2101 agaaattaga gcatggtata aatttggaat gataatgtaa atattacaca ttaaatgatg
     2161 aaatcggaaa actacaaatg agcgaatgaa ttagaaaaga ataaaaccta cgtaattaat
     2221 gaccttggca atgacagaaa gaatttagaa aaagaacaac aaattattcc aaatgaaggt
     2281 gtgaggaagg ggacaaaaat aacaagagga gttactaatg agggctacgt gaaaactcga
     2341 tgaagccaaa aaagctcatt cttgagaatg tgaattacat tcacaaatcc tagccacaat
     2401 aagcaaggaa aaaagcgggg ttcaggcaca catttccata tgggggtgaa acagcagaca
     2461 ccaccacaaa tctgacacat attgccttta tttttttcac ttttaagttc agggatacat
     2521 gtgcaggttt gttagacaga taaacttgtg tcaaggggat ttgtcttggt ttttgtgtga
     2581 gggtttttgt tttgttttgt tttgtttttt gagacggagt ctcgctctat caccaggctg
     2641 gagtacagtg gagtgatctc ggctcactgc aacctctgcc tcccgggttc aagcgattct
     2701 cctgcctcag tctcccgagt aactgggact acaggcacct gccaccacgc ccggctaatt
     2761 tttgtatttt tagtagagac agggtttctc catgttggtc aggctggtct caaactcccg
     2821 acctcaggtg atccgcccgc ctcagcctcc caaagtgctg ggcttacagg cgtgagccac
     2881 cacgtccagc ccatacattt caattttaaa gggatgcgcc ctagtcctta gttagtctct
     2941 cctcatctct ataaaatgtt cagctactca cctcttgggc tattgctaga catcgttttc
     3001 tcttccttct ttctgacgcc tacaatagat aggacattcc ccctcctcat tctattctcc
     3061 caagtacttt aaattgcaat ttataaagtt tctatgctac actctaaaaa aaattctgtt
     3121 ttgttttcta atttcataat tggtgcttca ctgtgtcttg tcctcgaagg aatgagtatt
     3181 ttgattgtgt tcattaaatc tgatttttct atgtcttcta a
//
