LOCUS       NM_001278426            2095 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor B4 (LILRB4),
            transcript variant 1, mRNA.
ACCESSION   NM_001278426
VERSION     NM_001278426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   Xie,L., Chen,C., Zhang,T., Yang,W., Zheng,D., Cao,L., Yuan,J.,
            Xu,Y., Zhang,Y., Liu,L., Liang,A., Yu,Z. and Zheng,J.
  TITLE     LILRB4 regulates multiple myeloma development through STAT3-PFKFB1
            pathway
  JOURNAL   Cell Death Dis 15 (7), 515 (2024)
   PUBMED   39025844
  REMARK    GeneRIF: LILRB4 regulates multiple myeloma development through
            STAT3-PFKFB1 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Wang,H., Wang,L., Luan,H., Xiao,J., Zhao,Z., Yu,P., Deng,M.,
            Liu,Y., Ji,S., Ma,J., Zhou,Y., Zhang,J., Meng,X., Zhang,J.,
            Zhao,X., Li,C., Li,F., Wang,D., Wei,S., Hui,L., Nie,S., Jin,C.,
            An,Z., Zhang,N., Wang,Y., Zhang,C.C. and Li,Z.
  TITLE     LILRB4 on multiple myeloma cells promotes bone lesion by
            p-SHP2/NF-kappaB/RELT signal pathway
  JOURNAL   J Exp Clin Cancer Res 43 (1), 183 (2024)
   PUBMED   38951916
  REMARK    GeneRIF: LILRB4 on multiple myeloma cells promotes bone lesion by
            p-SHP2/NF-kappaB/RELT signal pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2095)
  AUTHORS   Xiong,J., Wang,L., Xiong,X. and Deng,Y.
  TITLE     Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell
            Contractile Phenotypic Switch and Apoptosis in Aortic Dissection
  JOURNAL   Cardiovasc Toxicol 24 (3), 225-239 (2024)
   PUBMED   38324114
  REMARK    GeneRIF: Downregulation of LILRB4 Promotes Human Aortic Smooth
            Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic
            Dissection.
REFERENCE   4  (bases 1 to 2095)
  AUTHORS   Xiang,Z., Yin,X., Wei,L., Peng,M., Zhu,Q., Lu,X., Guo,J., Zhang,J.,
            Li,X. and Zou,Y.
  TITLE     LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and
            Disease Targets
  JOURNAL   Biomolecules 14 (2), 187 (2024)
   PUBMED   38397424
  REMARK    GeneRIF: LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism
            and Disease Targets.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2095)
  AUTHORS   Li,Y., Guo,J., Zhang,H., Li,Z., Ren,Y., Jiang,Y., Liu,X. and Hu,X.
  TITLE     LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6
            pathway during Toxoplasma gondii infection
  JOURNAL   Parasit Vectors 16 (1), 237 (2023)
   PUBMED   37461040
  REMARK    GeneRIF: LILRB4 regulates the function of decidual MDSCs via the
            SHP-2/STAT6 pathway during Toxoplasma gondii infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2095)
  AUTHORS   Jones,D.C., Roghanian,A., Brown,D.P., Chang,C., Allen,R.L.,
            Trowsdale,J. and Young,N.T.
  TITLE     Alternative mRNA splicing creates transcripts encoding soluble
            proteins from most LILR genes
  JOURNAL   Eur J Immunol 39 (11), 3195-3206 (2009)
   PUBMED   19658091
REFERENCE   7  (bases 1 to 2095)
  AUTHORS   Borges,L., Hsu,M.L., Fanger,N., Kubin,M. and Cosman,D.
  TITLE     A family of human lymphoid and myeloid Ig-like receptors, some of
            which bind to MHC class I molecules
  JOURNAL   J Immunol 159 (11), 5192-5196 (1997)
   PUBMED   9548455
REFERENCE   8  (bases 1 to 2095)
  AUTHORS   Arm,J.P., Nwankwo,C. and Austen,K.F.
  TITLE     Molecular identification of a novel family of human Ig superfamily
            members that possess immunoreceptor tyrosine-based inhibition
            motifs and homology to the mouse gp49B1 inhibitory receptor
  JOURNAL   J Immunol 159 (5), 2342-2349 (1997)
   PUBMED   9278324
REFERENCE   9  (bases 1 to 2095)
  AUTHORS   Cella,M., Dohring,C., Samaridis,J., Dessing,M., Brockhaus,M.,
            Lanzavecchia,A. and Colonna,M.
  TITLE     A novel inhibitory receptor (ILT3) expressed on monocytes,
            macrophages, and dendritic cells involved in antigen processing
  JOURNAL   J Exp Med 185 (10), 1743-1751 (1997)
   PUBMED   9151699
REFERENCE   10 (bases 1 to 2095)
  AUTHORS   Samaridis,J. and Colonna,M.
  TITLE     Cloning of novel immunoglobulin superfamily receptors expressed on
            human myeloid and lymphoid cells: structural evidence for new
            stimulatory and inhibitory pathways
  JOURNAL   Eur J Immunol 27 (3), 660-665 (1997)
   PUBMED   9079806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243962.3.
            
            On May 12, 2021 this sequence version replaced NM_001278426.3.
            
            Summary: This gene is a member of the leukocyte immunoglobulin-like
            receptor (LIR) family, which is found in a gene cluster at
            chromosomal region 19q13.4. The encoded protein belongs to the
            subfamily B class of LIR receptors which contain two or four
            extracellular immunoglobulin domains, a transmembrane domain, and
            two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
            motifs (ITIMs). The receptor is expressed on immune cells where it
            binds to MHC class I molecules on antigen-presenting cells and
            transduces a negative signal that inhibits stimulation of an immune
            response. The receptor can also function in antigen capture and
            presentation. It is thought to control inflammatory responses and
            cytotoxicity to help focus the immune response and limit
            autoreactivity. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026309.1, AF025532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695418.1/ ENSP00000511897.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC243962.3         41432-41514
            84-119              AC243962.3         41979-42014
            120-404             AC243962.3         42201-42485
            405-704             AC243962.3         42633-42932
            705-755             AC243962.3         43246-43296
            756-806             AC243962.3         43577-43627
            807-923             AC243962.3         44262-44378
            924-999             AC243962.3         44687-44762
            1000-1037           AC243962.3         44846-44883
            1038-1090           AC243962.3         45144-45196
            1091-1249           AC243962.3         46082-46240
            1250-2095           AC243962.3         46320-47165
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2095
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /note="leukocyte immunoglobulin like receptor B4"
                     /db_xref="GeneID:11006"
                     /db_xref="HGNC:HGNC:6608"
                     /db_xref="MIM:604821"
     exon            1..83
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1396
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte immunoglobulin-like receptor 5;
                     monocyte inhibitory receptor HM18; immunoglobulin-like
                     transcript 3; CD85 antigen-like family member K; leukocyte
                     immunoglobulin-like receptor, subfamily B (with TM and
                     ITIM domains), member 4; leucocyte Ig-like receptor B4"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     B member 4 isoform 1 precursor"
                     /protein_id="NP_001265355.2"
                     /db_xref="CCDS:CCDS12902.1"
                     /db_xref="GeneID:11006"
                     /db_xref="HGNC:HGNC:6608"
                     /db_xref="MIM:604821"
                     /translation="MIPTFTALLCLGLSLGPRTHMQAGPLPKPTLWAEPGSVISWGNS
                     VTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRS
                     PVGWSQPSDPLELVMTGAYSKPTLSALPSPLVTSGKSVTLLCQSRSPMDTFLLIKERA
                     AHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHGFSHYLLSHPSDPLELIVS
                     GSLEGPRPSPTRSVSTAAGPEDQPLMPTGSVPHSGLRRHWEVLIGVLVVSILLLSLLL
                     FLLLQHWRQGKHRTLAQRQADFQRPPGAAEPEPKDGGLQRRSSPAADVQGENFCAAVK
                     NTQPEDGVEMDTRQSPHDEDPQAVTYAKVKHSRPRREMASPPSPLSGEFLDTKDRQAE
                     EDRQMDTEAAASEAPQDVTYARLHSFTLRQKATEPPPSQEGASPAEPSVYATLAIH"
     exon            84..119
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            120..404
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            405..704
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..755
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            756..806
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            807..923
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            924..999
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1037
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1090
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1249
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..2095
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1582..1587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /note="hexamer: AATAAA"
     polyA_site      1607
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /note="major polyA site"
     polyA_site      1632
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /note="hexamer: AATAAA"
     polyA_site      1774
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
     regulatory      1811..1816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /note="hexamer: AATAAA"
     polyA_site      1828
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
                     /note="hexamer: AGTAAA"
     polyA_site      2095
                     /gene="LILRB4"
                     /gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
ORIGIN      
        1 actgaggact catccatctg cacagctggg gcccctggga ggagacgcca tgatccccac
       61 cttcacggct ctgctctgcc tcgggctgag tctgggcccc aggacccaca tgcaggcagg
      121 gcccctcccc aaacccaccc tctgggctga gccaggctct gtgatcagct gggggaactc
      181 tgtgaccatc tggtgtcagg ggaccctgga ggctcgggag taccgtctgg ataaagagga
      241 aagcccagca ccctgggaca gacagaaccc actggagccc aagaacaagg ccagattctc
      301 catcccatcc atgacagagg actatgcagg gagataccgc tgttactatc gcagccctgt
      361 aggctggtca cagcccagtg accccctgga gctggtgatg acaggagcct acagtaaacc
      421 caccctttca gccctgccga gtcctcttgt gacctcagga aagagcgtga ccctgctgtg
      481 tcagtcacgg agcccaatgg acacttttct tctgatcaag gagcgggcag cccatcccct
      541 actgcatctg agatcagagc acggagctca gcagcaccag gctgaattcc ccatgagtcc
      601 tgtgacctca gtgcacgggg ggacctacag gtgcttcagc tcacacggct tctcccacta
      661 cctgctgtca caccccagtg accccctgga gctcatagtc tcaggatcct tggagggtcc
      721 caggccctca cccacaaggt ccgtctcaac agctgcaggc cctgaggacc agcccctcat
      781 gcctacaggg tcagtccccc acagtggtct gagaaggcac tgggaggtac tgatcggggt
      841 cttggtggtc tccatcctgc ttctctccct cctcctcttc ctcctcctcc aacactggcg
      901 tcagggaaaa cacaggacat tggcccagag acaggctgat ttccaacgtc ctccaggggc
      961 tgccgagcca gagcccaagg acgggggcct acagaggagg tccagcccag ctgctgacgt
     1021 ccagggagaa aacttctgtg ctgccgtgaa gaacacacag cctgaggacg gggtggaaat
     1081 ggacactcgg cagagcccac acgatgaaga cccccaggca gtgacgtatg ccaaggtgaa
     1141 acactccaga cctaggagag aaatggcctc tcctccctcc ccactgtctg gggaattcct
     1201 ggacacaaag gacagacagg cagaagagga cagacagatg gacactgagg ctgctgcatc
     1261 tgaagccccc caggatgtga cctacgcccg gctgcacagc tttaccctca gacagaaggc
     1321 aactgagcct cctccatccc aggaaggggc ctctccagct gagcccagtg tctatgccac
     1381 tctggccatc cactaatcca ggggggaccc agaccccaca agccatggag actcaggacc
     1441 ccagaaggca tggaagctgc ctccagtaga catcactgaa ccccagccag cccagacccc
     1501 tgacacagac cactagaaga ttccgggaac gttgggagtc acctgattct gcaaagataa
     1561 ataatatccc tgcattatca aaataaagta gcagacctct caattcacaa tgagttaact
     1621 gataaaacaa aacagaagtc agacaatgtt ttaaattgaa tgatcatgta aatattacac
     1681 atcaaaccaa tgacatggga aaatgggagc ttctaatgag gacaaacaaa aaatagagaa
     1741 aaattaataa agtcaaaatg tttattcttg aaaacattaa tgatacatga atcttggcca
     1801 caatgagaaa aataaaaatg aaaaaagagc aggcatccat ttccatacag gaacaaaata
     1861 ggaggcagca ctacagaccc tacacacagc tttacagagg tgaaagaaaa ctgtcagcaa
     1921 ttctatgctg acataacaga aaatgtagat gagatagatg aaatacgaaa aattacagtt
     1981 tacttaatga acataaggat aaatagaaaa actgaatcat catacataaa catatataaa
     2041 atgcattgat cctgtaatca aaaatgttcc cacaaagtaa atgccacttc agcaa
//
