LOCUS       NM_006864               2742 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor B3 (LILRB3),
            transcript variant 2, mRNA.
ACCESSION   NM_006864 XM_003960767 XM_003960768 XM_003960769 XM_003960770
            XM_003960771 XM_003960772 XM_003960773 XM_003960774 XM_003960775
            XM_005277227 XM_005277287 XM_011548671
VERSION     NM_006864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Hirayasu,K., Khor,S.S., Kawai,Y., Shimada,M., Omae,Y., Hasegawa,G.,
            Hashikawa,Y., Tanimoto,H., Ohashi,J., Hosomichi,K., Tajima,A.,
            Nakamura,H., Nakamura,M., Tokunaga,K., Hanayama,R. and Nagasaki,M.
  TITLE     Identification of the hybrid gene LILRB5-3 by long-read sequencing
            and implication of its novel signaling function
  JOURNAL   Front Immunol 15, 1398935 (2024)
   PUBMED   38807600
  REMARK    GeneRIF: Identification of the hybrid gene LILRB5-3 by long-read
            sequencing and implication of its novel signaling function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Bashirova,A.A., Kasprzak,W., O'hUigin,C. and Carrington,M.
  TITLE     Distinct frequency patterns of LILRB3 and LILRA6 allelic variants
            in Europeans
  JOURNAL   Immunogenetics 75 (3), 263-267 (2023)
   PUBMED   36449053
  REMARK    GeneRIF: Distinct frequency patterns of LILRB3 and LILRA6 allelic
            variants in Europeans.
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Zhou,J., Wang,Y., Huang,G., Yang,M., Zhu,Y., Jin,C., Jing,D., Ji,K.
            and Shi,Y.
  TITLE     LilrB3 is a putative cell surface receptor of APOE4
  JOURNAL   Cell Res 33 (2), 116-130 (2023)
   PUBMED   36588123
  REMARK    GeneRIF: LilrB3 is a putative cell surface receptor of APOE4.
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Wu,G., Xu,Y., Schultz,R.D., Chen,H., Xie,J., Deng,M., Liu,X.,
            Gui,X., John,S., Lu,Z., Arase,H., Zhang,N., An,Z. and Zhang,C.C.
  TITLE     LILRB3 supports acute myeloid leukemia development and regulates
            T-cell antitumor immune responses through the TRAF2-cFLIP-NF-kappaB
            signaling axis
  JOURNAL   Nat Cancer 2 (11), 1170-1184 (2021)
   PUBMED   35122056
  REMARK    GeneRIF: LILRB3 supports acute myeloid leukemia development and
            regulates T-cell antitumor immune responses through the
            TRAF2-cFLIP-NF-kappaB signaling axis.
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Ayukawa,S., Kamoshita,N., Nakayama,J., Teramoto,R., Pishesha,N.,
            Ohba,K., Sato,N., Kozawa,K., Abe,H., Semba,K., Goda,N., Fujita,Y.
            and Maruyama,T.
  TITLE     Epithelial cells remove precancerous cells by cell competition via
            MHC class I-LILRB3 interaction
  JOURNAL   Nat Immunol 22 (11), 1391-1402 (2021)
   PUBMED   34686865
  REMARK    GeneRIF: Epithelial cells remove precancerous cells by cell
            competition via MHC class I-LILRB3 interaction.
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Bashirova,A.A., Apps,R., Vince,N., Mochalova,Y., Yu,X.G. and
            Carrington,M.
  TITLE     Diversity of the human LILRB3/A6 locus encoding a myeloid
            inhibitory and activating receptor pair
  JOURNAL   Immunogenetics 66 (1), 1-8 (2014)
   PUBMED   24096970
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Colonna,M., Navarro,F., Bellon,T., Llano,M., Garcia,P.,
            Samaridis,J., Angman,L., Cella,M. and Lopez-Botet,M.
  TITLE     A common inhibitory receptor for major histocompatibility complex
            class I molecules on human lymphoid and myelomonocytic cells
  JOURNAL   J Exp Med 186 (11), 1809-1818 (1997)
   PUBMED   9382880
REFERENCE   8  (bases 1 to 2742)
  AUTHORS   Arm,J.P., Nwankwo,C. and Austen,K.F.
  TITLE     Molecular identification of a novel family of human Ig superfamily
            members that possess immunoreceptor tyrosine-based inhibition
            motifs and homology to the mouse gp49B1 inhibitory receptor
  JOURNAL   J Immunol 159 (5), 2342-2349 (1997)
   PUBMED   9278324
REFERENCE   9  (bases 1 to 2742)
  AUTHORS   Cella,M., Dohring,C., Samaridis,J., Dessing,M., Brockhaus,M.,
            Lanzavecchia,A. and Colonna,M.
  TITLE     A novel inhibitory receptor (ILT3) expressed on monocytes,
            macrophages, and dendritic cells involved in antigen processing
  JOURNAL   J Exp Med 185 (10), 1743-1751 (1997)
   PUBMED   9151699
REFERENCE   10 (bases 1 to 2742)
  AUTHORS   Samaridis,J. and Colonna,M.
  TITLE     Cloning of novel immunoglobulin superfamily receptors expressed on
            human myeloid and lymphoid cells: structural evidence for new
            stimulatory and inhibitory pathways
  JOURNAL   Eur J Immunol 27 (3), 660-665 (1997)
   PUBMED   9079806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA620532.1, AF009633.1,
            BC028153.1 and CA434108.1.
            
            On Jun 2, 2019 this sequence version replaced NM_006864.3.
            
            Summary: This gene is a member of the leukocyte immunoglobulin-like
            receptor (LIR) family, which is found in a gene cluster at
            chromosomal region 19q13.4. The encoded protein belongs to the
            subfamily B class of LIR receptors which contain two or four
            extracellular immunoglobulin domains, a transmembrane domain, and
            two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
            motifs (ITIMs). The receptor is expressed on immune cells where it
            binds to MHC class I molecules on antigen-presenting cells and
            transduces a negative signal that inhibits stimulation of an immune
            response. It is thought to control inflammatory responses and
            cytotoxicity to help focus the immune response and limit
            autoreactivity. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF009633.1, AK223265.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445347.2/ ENSP00000388199.2
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA620532.1         81-109
            30-2092             AF009633.1         1-2063
            2093-2346           BC028153.1         2147-2400
            2347-2742           CA434108.1         19-414              c
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2742
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /note="leukocyte immunoglobulin like receptor B3"
                     /db_xref="GeneID:11025"
                     /db_xref="HGNC:HGNC:6607"
                     /db_xref="MIM:604820"
     exon            1..65
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1927
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; monocyte inhibitory receptor HL9;
                     immunoglobulin-like transcript 5; CD85 antigen-like family
                     member A; leukocyte immunoglobulin-like receptor,
                     subfamily A (with TM domain), member 6; leukocyte
                     immunoglobulin-like receptor, subfamily B (with TM and
                     ITIM domains), member 3; leucocyte Ig-like receptor B3"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     B member 3 isoform 2 precursor"
                     /protein_id="NP_006855.3"
                     /db_xref="CCDS:CCDS33105.1"
                     /db_xref="GeneID:11025"
                     /db_xref="HGNC:HGNC:6607"
                     /db_xref="MIM:604820"
                     /translation="MTPALTALLCLGLSLGPRTRMQAGPFPKPTLWAEPGSVISWGSP
                     VTIWCQGSLEAQEYQLDKEGSPEPWDRNNPLEPKNKARFSIPSMTQHHAGRYRCHYYS
                     SAGWSEPSDPLELVMTGFYNKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGE
                     HQLPRTLDSQQLHSGGFQALFPVGPVTPSHRWRFTCYYYYTNTPWVWSHPSDPLEILP
                     SGVSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYDRFVLYKEGERDFLQRPGQQPQAGL
                     SQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILITGQIYDTVSLSAQPGPT
                     VASGENMTLLCQSRGYFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAG
                     TYRCYGSRSSNPHLLSFPSEPLELMVSGHSGGSSLPPTGPPSTPGLGRYLEVLIGVSV
                     AFVLLLFLLLFLLLLRQRHSKHRTSDQRKTDFQRPAGAAETEPKDRGLLRRSSPAADV
                     QEENLYAAVKDTQSEDRVELDSQSPHDEDPQAVTYAPVKHSSPRREMASPPSSLSGEF
                     LDTKDRQVEEDRQMDTEAAASEASQDVTYAQLHSLTLRRKATEPPPSQEGEPPAEPSI
                     YATLAIH"
     exon            66..101
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            102..386
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            387..689
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            690..986
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1289
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1340
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1457
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1533
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1571
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1624
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1780
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2742
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /note="hexamer: AATAAA"
     polyA_site      2139
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /note="major polyA site"
     polyA_site      2351
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="LILRB3"
                     /gene_synonym="CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3;
                     LIR3; PIR-B; PIRB"
ORIGIN      
        1 gcagagcgcg gggtcaccgg gaggagacgc catgacgccc gccctcacag ccctgctctg
       61 ccttgggctg agtctgggcc ccaggacccg catgcaggca gggcccttcc ccaaacccac
      121 cctctgggct gagccaggct ctgtgatcag ctgggggagc cccgtgacca tctggtgtca
      181 ggggagcctg gaggcccagg agtaccaact ggataaagag ggaagcccag agccctggga
      241 cagaaataac ccactggaac ccaagaacaa ggccagattc tccatcccat ccatgacaca
      301 gcaccatgca gggagatacc gctgccacta ttacagctct gcaggctggt cagagcccag
      361 cgaccccctg gagctggtga tgacaggatt ctacaacaaa cccaccctct cagccctgcc
      421 cagccctgtg gtggcctcag gggggaatat gaccctccga tgtggctcac agaagggata
      481 tcaccatttt gttctgatga aggaaggaga acaccagctc ccccggaccc tggactcaca
      541 gcagctccac agtggggggt tccaggccct gttccctgtg ggccccgtga cccccagcca
      601 caggtggagg ttcacatgct attactatta tacaaacacc ccctgggtgt ggtcccaccc
      661 cagtgacccc ctggagattc tgccctcagg cgtgtctagg aagccctccc tcctgaccct
      721 gcagggccct gtcctggccc ctgggcagag cctgaccctc cagtgtggct ctgatgtcgg
      781 ctacgacaga tttgttctgt ataaggaggg ggaacgtgac ttcctccagc gccctggcca
      841 gcagccccag gctgggctct cccaggccaa cttcaccctg ggccctgtga gccgctccta
      901 cgggggccag tacaggtgct atggtgcaca caacctctcc tccgagtggt cggcccccag
      961 tgaccccctg gacatcctga tcacaggaca gatctatgac accgtctccc tgtcagcaca
     1021 gccgggcccc acagtggcct caggagagaa catgaccctg ctgtgtcagt cacgggggta
     1081 ttttgacact ttccttctga ccaaagaagg ggcagcccat cccccactgc gtctgagatc
     1141 aatgtacgga gctcataagt accaggctga attccccatg agtcctgtga cctcagccca
     1201 cgcggggacc tacaggtgct acggctcacg cagctccaac ccccacctgc tgtctttccc
     1261 cagtgagccc ctggaactca tggtctcagg acactctgga ggctccagcc tcccacccac
     1321 agggccgccc tccacacctg gtctgggaag atacctggag gttttgattg gggtctcggt
     1381 ggccttcgtc ctgctgctct tcctcctcct cttcctcctc ctcctccgtc agcgtcacag
     1441 caaacacagg acatctgacc agagaaagac tgatttccag cgtcctgcag gggctgcgga
     1501 gacagagccc aaggacaggg gcctgctgag gaggtccagc ccagctgctg acgtccagga
     1561 agaaaacctc tatgctgctg tgaaggacac acagtctgag gacagggtgg agctggacag
     1621 tcagagccca cacgatgaag acccccaggc agtgacgtat gccccggtga aacactccag
     1681 tcctaggaga gaaatggcct ctcctccctc ctcactgtct ggggaattcc tggacacaaa
     1741 ggacagacag gtggaagagg acaggcagat ggacactgag gctgctgcat ctgaagcctc
     1801 ccaggatgtg acctacgccc agctgcacag cttgaccctt agacggaagg caactgagcc
     1861 tcctccatcc caggaagggg aacctccagc tgagcccagc atctacgcca ctctggccat
     1921 ccactagccc ggggggtacg cagaccccac actcagcaga aggagactca ggactgctga
     1981 aggcacggga gctgccccca gtggacacca gtgaacccca gtcagcctgg acccctaaca
     2041 cagaccatga ggagacgctg ggaacttgtg ggactcacct gactcaaaga tgactaatat
     2101 cgtcccattt tggaaataaa gcaacagact tctcaacaat caatgagtta ataacaaaaa
     2161 aacaaaaaac aaaaacagac gtaaaggccg ggtgtggtac tcaggaggct gagtggggag
     2221 gattccttga acacaagaag ttaaggctgc tgaggctgca gtgagctatg actgtgccac
     2281 tgcactccag cctgtgtgac agagcgagac cttgtctcta aaaaaaaaaa cagtgaatgt
     2341 tttaaactga atgataatgt aaatattata catcgaactt atgacatggg aaaattaaga
     2401 agcataaata ggccgggcgc ggtggctcac gcctataatc tcagcacttt gggaggctga
     2461 tgcgggcgga tcatgaggtc aggagatcga gaccatcctg gctaacacgg tgaaaccccg
     2521 tctctactaa aaatacaaaa aaattagccg ggcgtggtgg cgagtgccta tagtcccagc
     2581 tactcaggag gctgaggcag gagaatggca tgagcccggg aggcagagct tgcagtgagc
     2641 tgagatcgca ccactgcact ccagcctggg cgacagagtg agattccgtc tcgaaaaaaa
     2701 aaaaaaaaga aagaaaaaaa ataaaaaaga agcataacca gg
//
