LOCUS       NM_001080978            2863 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor B2 (LILRB2),
            transcript variant 2, mRNA.
ACCESSION   NM_001080978
VERSION     NM_001080978.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Jiang,L., Huang,L., Dai,C., Zheng,R., Miyake,M., Mori,Y.,
            Nakao,S.Y., Morino,K., Ymashiro,K., Miao,Y.B., Li,Q., Ren,W.,
            Ye,Z., Li,H., Yang,Z. and Shi,Y.
  TITLE     Genome-Wide Association Analysis Identifies LILRB2 Gene for
            Pathological Myopia
  JOURNAL   Adv Sci (Weinh) 11 (40), e2308968 (2024)
   PUBMED   39207058
  REMARK    GeneRIF: Genome-Wide Association Analysis Identifies LILRB2 Gene
            for Pathological Myopia.
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Tian,J., Ashique,A.M., Weeks,S., Lan,T., Yang,H., Chen,H.H.,
            Song,C., Koyano,K., Mondal,K., Tsai,D., Cheung,I., Moshrefi,M.,
            Kekatpure,A., Fan,B., Li,B., Qurashi,S., Rocha,L., Aguayo,J.,
            Rodgers,C., Meza,M., Heeke,D., Medfisch,S.M., Chu,C., Starck,S.,
            Basak,N.P., Sankaran,S., Malhotra,M., Crawley,S., Tran,T.T.,
            Duey,D.Y., Ho,C., Mikaelian,I., Liu,W., Rivera,L.B., Huang,J.,
            Paavola,K.J., O'Hollaren,K., Blum,L.K., Lin,V.Y., Chen,P., Iyer,A.,
            He,S., Roda,J.M., Wang,Y., Sissons,J., Kutach,A.K., Kaplan,D.D. and
            Stone,G.W.
  TITLE     ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and
            Distinct Mechanisms
  JOURNAL   Cancer Immunol Res 12 (5), 592-613 (2024)
   PUBMED   38393969
  REMARK    GeneRIF: ILT2 and ILT4 Drive Myeloid Suppression via Both
            Overlapping and Distinct Mechanisms.
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Zhang,H., Gao,A., Liu,Q., Zhang,F., Wang,S., Chen,X., Shi,W.,
            Zhang,Y., Liu,Q., Zheng,Y. and Sun,Y.
  TITLE     ILT4 reprograms glucose metabolism to promote tumor progression in
            triple-negative breast cancer
  JOURNAL   J Cell Sci 136 (18) (2023)
   PUBMED   37622462
  REMARK    GeneRIF: ILT4 reprograms glucose metabolism to promote tumor
            progression in triple-negative breast cancer.
REFERENCE   4  (bases 1 to 2863)
  AUTHORS   Li,D.P., Huang,L., Kan,R.R., Meng,X.Y., Wang,S.Y., Zou,H.J.,
            Guo,Y.M., Luo,P.Q., Pan,L.M., Xiang,Y.X., Mao,B.B., Xie,Y.Y.,
            Wang,Z.H., Yang,M., He,R., Yang,Y., Liu,Z.L., Xie,J.H., Ma,D.L.,
            Zhang,B.P., Shao,S.Y., Chen,X., Xu,S.M., He,W.T., Li,W.J., Chen,Y.
            and Yu,X.F.
  TITLE     LILRB2/PirB mediates macrophage recruitment in fibrogenesis of
            nonalcoholic steatohepatitis
  JOURNAL   Nat Commun 14 (1), 4436 (2023)
   PUBMED   37481670
  REMARK    GeneRIF: LILRB2/PirB mediates macrophage recruitment in
            fibrogenesis of nonalcoholic steatohepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2863)
  AUTHORS   Dechavanne,C., Nouatin,O., Adamou,R., Edslev,S., Hansen,A.,
            Meurisse,F., Sadissou,I., Gbaguidi,E., Milet,J., Cottrell,G.,
            Gineau,L., Sabbagh,A., Massougbodji,A., Moutairou,K., Donadi,E.A.,
            Carosella,E.D., Moreau,P., Remarque,E., Theisen,M.,
            Rouas-Freiss,N., Garcia,A., Favier,B. and Courtin,D.
  TITLE     Placental Malaria is Associated with Higher LILRB2 Expression in
            Monocyte Subsets and Lower Anti-Malarial IgG Antibodies During
            Infancy
  JOURNAL   Front Immunol 13, 909831 (2022)
   PUBMED   35911674
  REMARK    GeneRIF: Placental Malaria is Associated with Higher LILRB2
            Expression in Monocyte Subsets and Lower Anti-Malarial IgG
            Antibodies During Infancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2863)
  AUTHORS   Nakajima,H., Asai,A., Okada,A., Ping,L., Hamajima,F., Sata,T. and
            Isobe,K.
  TITLE     Transcriptional regulation of ILT family receptors
  JOURNAL   J Immunol 171 (12), 6611-6620 (2003)
   PUBMED   14662864
REFERENCE   7  (bases 1 to 2863)
  AUTHORS   Colonna,M., Navarro,F., Bellon,T., Llano,M., Garcia,P.,
            Samaridis,J., Angman,L., Cella,M. and Lopez-Botet,M.
  TITLE     A common inhibitory receptor for major histocompatibility complex
            class I molecules on human lymphoid and myelomonocytic cells
  JOURNAL   J Exp Med 186 (11), 1809-1818 (1997)
   PUBMED   9382880
REFERENCE   8  (bases 1 to 2863)
  AUTHORS   Wagtmann,N., Rojo,S., Eichler,E., Mohrenweiser,H. and Long,E.O.
  TITLE     A new human gene complex encoding the killer cell inhibitory
            receptors and related monocyte/macrophage receptors
  JOURNAL   Curr Biol 7 (8), 615-618 (1997)
   PUBMED   9259559
REFERENCE   9  (bases 1 to 2863)
  AUTHORS   Cella,M., Dohring,C., Samaridis,J., Dessing,M., Brockhaus,M.,
            Lanzavecchia,A. and Colonna,M.
  TITLE     A novel inhibitory receptor (ILT3) expressed on monocytes,
            macrophages, and dendritic cells involved in antigen processing
  JOURNAL   J Exp Med 185 (10), 1743-1751 (1997)
   PUBMED   9151699
REFERENCE   10 (bases 1 to 2863)
  AUTHORS   Samaridis,J. and Colonna,M.
  TITLE     Cloning of novel immunoglobulin superfamily receptors expressed on
            human myeloid and lymphoid cells: structural evidence for new
            stimulatory and inhibitory pathways
  JOURNAL   Eur J Immunol 27 (3), 660-665 (1997)
   PUBMED   9079806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC429053.1, AK226015.1,
            AF004231.2 and AC245052.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001080978.3.
            
            Summary: This gene is a member of the leukocyte immunoglobulin-like
            receptor (LIR) family, which is found in a gene cluster at
            chromosomal region 19q13.4. The encoded protein belongs to the
            subfamily B class of LIR receptors which contain two or four
            extracellular immunoglobulin domains, a transmembrane domain, and
            two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
            motifs (ITIMs). The receptor is expressed on immune cells where it
            binds to MHC class I molecules on antigen-presenting cells and
            transduces a negative signal that inhibits stimulation of an immune
            response. It is thought to control inflammatory responses and
            cytotoxicity to help focus the immune response and limit
            autoreactivity. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 1. Both
            variants 2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF283986.1, AK226015.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000314446.10/
                                                ENSP00000319960.5
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DC429053.1         69-114
            47-256              AK226015.1         88-297
            257-2854            AF004231.2         187-2784
            2855-2863           AC245052.3         202352-202360       c
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2863
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /note="leukocyte immunoglobulin like receptor B2"
                     /db_xref="GeneID:10288"
                     /db_xref="HGNC:HGNC:6606"
                     /db_xref="MIM:604815"
     exon            1..150
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            151..232
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1992
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Ig-like transcript 4; monocyte/macrophage
                     immunoglobulin-like receptor 10; CD85 antigen-like family
                     member D; leukocyte immunoglobulin-like receptor,
                     subfamily B (with TM and ITIM domains), member 2; myeloid
                     inhibitory receptor 10; leucocyte Ig-like receptor B2;
                     leukocyte immunoglobulin-like receptor subfamily B member
                     2"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     B member 2 isoform 2 precursor"
                     /protein_id="NP_001074447.2"
                     /db_xref="CCDS:CCDS42612.1"
                     /db_xref="GeneID:10288"
                     /db_xref="HGNC:HGNC:6606"
                     /db_xref="MIM:604815"
                     /translation="MTPIVTVLICLGLSLGPRTRVQTGTIPKPTLWAEPDSVITQGSP
                     VTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYS
                     RARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGE
                     DEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLV
                     PGVSKKPSLSVQPGPVMAPGESLTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGL
                     SQANFTLGPVSRSYGGQYRCYGAHNLSSECSAPSDPLDILITGQIRGTPFISVQPGPT
                     VASGENVTLLCQSWRQFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAG
                     TYRCYGSLNSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPGPEDQPLTPTGSDP
                     QSGLGRHLGVVIGILVAVVLLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVG
                     PEPTDRGLQWRSSPAADAQEENLYAAVKDTQPEDGVEMDTRAAASEAPQDVTYAQLHS
                     LTLRRKATEPPPSQEREPPAEPSIYATLAIH"
     exon            233..268
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            269..553
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            554..856
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1153
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1456
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1507
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1555
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1678
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1754
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1792
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1845
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2863
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /note="hexamer: AATAAA"
     polyA_site      2863
                     /gene="LILRB2"
                     /gene_synonym="CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10;
                     MIR10"
                     /note="major polyA site"
ORIGIN      
        1 gcatttctcc tctgtgctca ctgccacaca cagctcaacc tggacagcac agccagaggc
       61 gagatgcttc tctgctgatc tgagtctgcc tgcagcatgg acctgggtct tccctgaagc
      121 atctccaggg ctggagggac gactgccatg caccgagggc tcatccatcc gcagagcagg
      181 gcagtgggag gagacgccat gacccccatc gtcacagtcc tgatctgtct cgggctgagt
      241 ctgggcccca ggacccgcgt gcagacaggg accatcccca agcccaccct gtgggctgag
      301 ccagactctg tgatcaccca ggggagtccc gtcaccctca gttgtcaggg gagccttgaa
      361 gcccaggagt accgtctata tagggagaaa aaatcagcat cttggattac acggatacga
      421 ccagagcttg tgaagaacgg ccagttccac atcccatcca tcacctggga acacacaggg
      481 cgatatggct gtcagtatta cagccgcgct cggtggtctg agctcagtga ccccctggtg
      541 ctggtgatga caggagccta cccaaaaccc accctctcag cccagcccag ccctgtggtg
      601 acctcaggag gaagggtgac cctccagtgt gagtcacagg tggcatttgg cggcttcatt
      661 ctgtgtaagg aaggagaaga tgaacaccca caatgcctga actcccagcc ccatgcccgt
      721 gggtcgtccc gcgccatctt ctccgtgggc cccgtgagcc cgaatcgcag gtggtcgcac
      781 aggtgctatg gttatgactt gaactctccc tatgtgtggt cttcacccag tgatctcctg
      841 gagctcctgg tcccaggtgt ttctaagaag ccatcactct cagtgcagcc gggtcctgtc
      901 atggcccctg gggaaagcct gaccctccag tgtgtctctg atgtcggcta tgacagattt
      961 gttctgtaca aggaggggga acgtgacctt cgccagctcc ctggccggca gccccaggct
     1021 gggctctccc aggccaactt caccctgggc cctgtgagcc gctcctacgg gggccagtac
     1081 agatgctacg gtgcacacaa cctctcctct gagtgctcgg cccccagcga ccccctggac
     1141 atcctgatca caggacagat ccgtggcaca cccttcatct cagtgcagcc aggccccaca
     1201 gtggcctcag gagagaacgt gaccctgctg tgtcagtcat ggcggcagtt ccacactttc
     1261 cttctgacca aggcgggagc agctgatgcc ccactccgtc taagatcaat acacgaatat
     1321 cctaagtacc aggctgaatt ccccatgagt cctgtgacct cagcccacgc ggggacctac
     1381 aggtgctacg gctcactcaa ctccgacccc tacctgctgt ctcaccccag tgagcccctg
     1441 gagctcgtgg tctcaggacc ctccatgggt tccagccccc cacccaccgg tcccatctcc
     1501 acacctggcc ctgaggacca gcccctcacc cccactgggt cggatcccca aagtggtctg
     1561 ggaaggcacc tgggggttgt gatcggcatc ttggtggccg tcgtcctact gctcctcctc
     1621 ctcctcctcc tcttcctcat cctccgacat cgacgtcagg gcaaacactg gacatcgacc
     1681 cagagaaagg ctgatttcca acatcctgca ggggctgtgg ggccagagcc cacagacaga
     1741 ggcctgcagt ggaggtccag cccagctgcc gacgcccagg aagaaaacct ctatgctgcc
     1801 gtgaaggaca cacagcctga agatggggtg gagatggaca ctcgggctgc tgcatctgaa
     1861 gccccccagg atgtgaccta cgcccagctg cacagcttga ccctcagacg gaaggcaact
     1921 gagcctcctc catcccagga aagggaacct ccagctgagc ccagcatcta cgccaccctg
     1981 gccatccact agcccggagg gtacgcagac tccacactca gtagaaggag actcaggact
     2041 gctgaaggca cgggagctgc ccccagtgga caccaatgaa ccccagtcag cctggacccc
     2101 taacaaagac catgaggaga tgctgggaac tttgggactc acttgattct gcagtcgaaa
     2161 taactaatat ccctacattt tttaattaaa gcaacagact tctcaataat caatgagtta
     2221 accgagaaaa ctaaaatcag aagtaagaat gtgctttaaa ctgaatcaca atataaatat
     2281 tacacatcac acaatgaaat tgaaaaagta caaaccacaa atgaaaaaag tagaaacgaa
     2341 aaaaaaaaac taggaaatga atgacgttgg ctttcgtata aggaatttag aaaaagaata
     2401 accaattatt ccaaatgaag gtgtaagaaa gggaataaga agaagaagag ttgctcatga
     2461 ggaaaaacca aaacttgaaa attcaacaaa gccaatgaag ctcattcttg aaaatattaa
     2521 ttacagtcat aaatcctaac tacattgagc aagagaaaga aagagcaggc acgcatttcc
     2581 atatgggagt gagccagcag acagcccagc agatcctaca cacattttca caaactaacc
     2641 ccagaacagg ctgcaaacct ataccaatat actagaaaat gcagattaaa tggatgaaat
     2701 attcaaaact ggagtttaca taatgaacgt aagagtaatc agagaatctg actcatttta
     2761 aatgtgtgtg tatgtgtgtg tatatatatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgaa
     2821 aaacattgac tgtaataaaa atgttcccat cgtatcaact cca
//
