LOCUS       NM_001081637            3301 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor B1 (LILRB1),
            transcript variant 2, mRNA.
ACCESSION   NM_001081637
VERSION     NM_001081637.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Wang,J., Chai,Q., Lei,Z., Wang,Y., He,J., Ge,P., Lu,Z., Qiang,L.,
            Zhao,D., Yu,S., Qiu,C., Zhong,Y., Li,B.X., Zhang,L., Pang,Y.,
            Gao,G.F. and Liu,C.H.
  TITLE     LILRB1-HLA-G axis defines a checkpoint driving natural killer cell
            exhaustion in tuberculosis
  JOURNAL   EMBO Mol Med 16 (8), 1755-1790 (2024)
   PUBMED   39030302
  REMARK    GeneRIF: LILRB1-HLA-G axis defines a checkpoint driving natural
            killer cell exhaustion in tuberculosis.
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Xian,M., Wang,Q., Xiao,L., Zhong,L., Xiong,W., Ye,L., Su,P.,
            Zhang,C., Li,Y., Orlowski,R.Z., Zhan,F., Ganguly,S., Zu,Y., Qian,J.
            and Yi,Q.
  TITLE     Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human
            multiple myeloma cells from ferroptosis by maintaining cholesterol
            homeostasis
  JOURNAL   Nat Commun 15 (1), 5767 (2024)
   PUBMED   38982045
  REMARK    GeneRIF: Leukocyte immunoglobulin-like receptor B1 (LILRB1)
            protects human multiple myeloma cells from ferroptosis by
            maintaining cholesterol homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3301)
  AUTHORS   Tian,J., Ashique,A.M., Weeks,S., Lan,T., Yang,H., Chen,H.H.,
            Song,C., Koyano,K., Mondal,K., Tsai,D., Cheung,I., Moshrefi,M.,
            Kekatpure,A., Fan,B., Li,B., Qurashi,S., Rocha,L., Aguayo,J.,
            Rodgers,C., Meza,M., Heeke,D., Medfisch,S.M., Chu,C., Starck,S.,
            Basak,N.P., Sankaran,S., Malhotra,M., Crawley,S., Tran,T.T.,
            Duey,D.Y., Ho,C., Mikaelian,I., Liu,W., Rivera,L.B., Huang,J.,
            Paavola,K.J., O'Hollaren,K., Blum,L.K., Lin,V.Y., Chen,P., Iyer,A.,
            He,S., Roda,J.M., Wang,Y., Sissons,J., Kutach,A.K., Kaplan,D.D. and
            Stone,G.W.
  TITLE     ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and
            Distinct Mechanisms
  JOURNAL   Cancer Immunol Res 12 (5), 592-613 (2024)
   PUBMED   38393969
  REMARK    GeneRIF: ILT2 and ILT4 Drive Myeloid Suppression via Both
            Overlapping and Distinct Mechanisms.
REFERENCE   4  (bases 1 to 3301)
  AUTHORS   Bernit,E., Jean,E., Marlot,B., Laget,L., Izard,C., Dettori,I.,
            Beley,S., Gautier,I., Agouti,I., Frassati,C., Pedini,P., Picard,C.,
            Paganini,J., Chiaroni,J. and Di Cristofaro,J.
  TITLE     HLA-F and LILRB1 Genetic Polymorphisms Associated with
            Alloimmunisation in Sickle Cell Disease
  JOURNAL   Int J Mol Sci 24 (17), 13591 (2023)
   PUBMED   37686397
  REMARK    GeneRIF: HLA-F and LILRB1 Genetic Polymorphisms Associated with
            Alloimmunisation in Sickle Cell Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3301)
  AUTHORS   Jones,D.C., Roghanian,A., Brown,D.P., Chang,C., Allen,R.L.,
            Trowsdale,J. and Young,N.T.
  TITLE     Alternative mRNA splicing creates transcripts encoding soluble
            proteins from most LILR genes
  JOURNAL   Eur J Immunol 39 (11), 3195-3206 (2009)
   PUBMED   19658091
REFERENCE   6  (bases 1 to 3301)
  AUTHORS   Nakajima,H., Asai,A., Okada,A., Ping,L., Hamajima,F., Sata,T. and
            Isobe,K.
  TITLE     Transcriptional regulation of ILT family receptors
  JOURNAL   J Immunol 171 (12), 6611-6620 (2003)
   PUBMED   14662864
REFERENCE   7  (bases 1 to 3301)
  AUTHORS   Borges,L., Hsu,M.L., Fanger,N., Kubin,M. and Cosman,D.
  TITLE     A family of human lymphoid and myeloid Ig-like receptors, some of
            which bind to MHC class I molecules
  JOURNAL   J Immunol 159 (11), 5192-5196 (1997)
   PUBMED   9548455
REFERENCE   8  (bases 1 to 3301)
  AUTHORS   Wagtmann,N., Rojo,S., Eichler,E., Mohrenweiser,H. and Long,E.O.
  TITLE     A new human gene complex encoding the killer cell inhibitory
            receptors and related monocyte/macrophage receptors
  JOURNAL   Curr Biol 7 (8), 615-618 (1997)
   PUBMED   9259559
REFERENCE   9  (bases 1 to 3301)
  AUTHORS   Cosman,D., Fanger,N., Borges,L., Kubin,M., Chin,W., Peterson,L. and
            Hsu,M.L.
  TITLE     A novel immunoglobulin superfamily receptor for cellular and viral
            MHC class I molecules
  JOURNAL   Immunity 7 (2), 273-282 (1997)
   PUBMED   9285411
REFERENCE   10 (bases 1 to 3301)
  AUTHORS   Samaridis,J. and Colonna,M.
  TITLE     Cloning of novel immunoglobulin superfamily receptors expressed on
            human myeloid and lymphoid cells: structural evidence for new
            stimulatory and inhibitory pathways
  JOURNAL   Eur J Immunol 27 (3), 660-665 (1997)
   PUBMED   9079806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245036.3.
            
            On Oct 26, 2020 this sequence version replaced NM_001081637.2.
            
            Summary: This gene is a member of the leukocyte immunoglobulin-like
            receptor (LIR) family, which is found in a gene cluster at
            chromosomal region 19q13.4. The encoded protein belongs to the
            subfamily B class of LIR receptors which contain two or four
            extracellular immunoglobulin domains, a transmembrane domain, and
            two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
            motifs (ITIMs). The receptor is expressed on immune cells where it
            binds to MHC class I molecules on antigen-presenting cells and
            transduces a negative signal that inhibits stimulation of an immune
            response. It is thought to control inflammatory responses and
            cytotoxicity to help focus the immune response and limit
            autoreactivity. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) has a shorter 5' UTR and uses
            two alternate in-frame splice sites in the coding region, compared
            to variant 1. The resulting protein (isoform 2) is longer, compared
            to isoform 1.
            
            Sequence Note: A downstream translational start codon is selected
            for this RefSeq based on its better conservation in mammalian
            species and on the presence of a predicted signal peptide in the
            protein N-terminus. An upstream in-frame start codon is also
            present but is only conserved in primates, and use of the upstream
            start codon would result in a protein that is 17 aa longer at the
            N-terminus and lacks a predicted signal peptide. Leaky scanning by
            ribosomes may allow translation initiation at the downstream start
            codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF009221.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000324602.12/
                                                ENSP00000315997.7
            RefSeq Select criteria           :: based on manual assertion,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC245036.3         180488-180637
            151-232             AC245036.3         181030-181111
            233-268             AC245036.3         181275-181310
            269-556             AC245036.3         181504-181791
            557-859             AC245036.3         181939-182241
            860-1156            AC245036.3         182468-182764
            1157-1459           AC245036.3         183020-183322
            1460-1510           AC245036.3         183642-183692
            1511-1561           AC245036.3         183975-184025
            1562-1684           AC245036.3         184645-184767
            1685-1760           AC245036.3         185108-185183
            1761-1798           AC245036.3         185263-185300
            1799-1851           AC245036.3         185561-185613
            1852-2010           AC245036.3         186498-186656
            2011-3301           AC245036.3         186736-188026
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3301
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /note="leukocyte immunoglobulin like receptor B1"
                     /db_xref="GeneID:10859"
                     /db_xref="HGNC:HGNC:6605"
                     /db_xref="MIM:604811"
     exon            1..150
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            151..232
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2157
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Ig-like transcript 2; monocyte/macrophage
                     immunoglobulin-like receptor 7; leukocyte
                     immunoglobulin-like receptor, subfamily B (with TM and
                     ITIM domains), member 1; CD85 antigen-like family member
                     J; myeloid inhibitory receptor 7; leucocyte Ig-like
                     receptor B1; immunoglobulin heavy chain variable region;
                     leukocyte immunoglobulin-like receptor subfamily B member
                     1"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     B member 1 isoform 2 precursor"
                     /protein_id="NP_001075106.2"
                     /db_xref="CCDS:CCDS42614.1"
                     /db_xref="GeneID:10859"
                     /db_xref="HGNC:HGNC:6605"
                     /db_xref="MIM:604811"
                     /translation="MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSP
                     VTLRCQGGQETQEYRLYREKKTAPWITRIPQELVKKGQFPIPSITWEHTGRYRCYYGS
                     DTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVTLQCDSQVAFDGFILCKEG
                     EDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELL
                     VLGVSKKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAG
                     LSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGP
                     TVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTYQSQKYQAEFPMGPVTSAHA
                     GTYRCYGSQSSKPYLLTHPSDPLELVVSGPSGGPSSPTTGPTSTSAGPEDQPLTPTGS
                     DPQSGLGRHLGVVIGILVAVILLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGA
                     VGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQPEDGVEMDTRQSPHDEDPQAVTYAE
                     VKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSLTL
                     RREATEPPPSQEGPSPAVPSIYATLAIH"
     exon            233..268
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            269..556
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            557..859
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1156
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1459
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1510
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1561
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1684
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1760
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1798
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1851
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2010
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..3301
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3280..3285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /note="hexamer: AATAAA"
     polyA_site      3301
                     /gene="LILRB1"
                     /gene_synonym="CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7;
                     MIR7; PIR-B; PIRB"
                     /note="major polyA site"
ORIGIN      
        1 gcatttctct tctgtgctca ctgccacacg cagctcagcc tgggcggcac agccagatgc
       61 gagatgcgtc tctgctgatc tgagtctgcc tgcagcatgg acctgggtct tccctgaagc
      121 atctccaggg ctggagggac gactgccatg caccgagggc tcatccatcc acagagcagg
      181 gcagtgggag gagacgccat gacccccatc ctcacggtcc tgatctgtct cgggctgagt
      241 ctgggccccc ggacccacgt gcaggcaggg cacctcccca agcccaccct ctgggctgaa
      301 ccaggctctg tgatcaccca ggggagtcct gtgaccctca ggtgtcaggg gggccaggag
      361 acccaggagt accgtctata tagagaaaag aaaacagcac cctggattac acggatccca
      421 caggagcttg tgaagaaggg ccagttcccc atcccatcca tcacctggga acacacaggg
      481 cggtatcgct gttactatgg tagcgacact gcaggccgct cagagagcag tgaccccctg
      541 gagctggtgg tgacaggagc ctacatcaaa cccaccctct cagcccagcc cagccccgtg
      601 gtgaactcag gagggaatgt aaccctccag tgtgactcac aggtggcatt tgatggcttc
      661 attctgtgta aggaaggaga agatgaacac ccacaatgcc tgaactccca gccccatgcc
      721 cgtgggtcgt cccgcgccat cttctccgtg ggccccgtga gcccgagtcg caggtggtgg
      781 tacaggtgct atgcttatga ctcgaactct ccctatgagt ggtctctacc cagtgatctc
      841 ctggagctcc tggtcctagg tgtttctaag aagccatcac tctcagtgca gccaggtcct
      901 atcgtggccc ctgaggagac cctgactctg cagtgtggct ctgatgctgg ctacaacaga
      961 tttgttctgt ataaggacgg ggaacgtgac ttccttcagc tcgctggcgc acagccccag
     1021 gctgggctct cccaggccaa cttcaccctg ggccctgtga gccgctccta cgggggccag
     1081 tacagatgct acggtgcaca caacctctcc tccgagtggt cggcccccag cgaccccctg
     1141 gacatcctga tcgcaggaca gttctatgac agagtctccc tctcggtgca gccgggcccc
     1201 acggtggcct caggagagaa cgtgaccctg ctgtgtcagt cacagggatg gatgcaaact
     1261 ttccttctga ccaaggaggg ggcagctgat gacccatggc gtctaagatc aacgtaccaa
     1321 tctcaaaaat accaggctga attccccatg ggtcctgtga cctcagccca tgcggggacc
     1381 tacaggtgct acggctcaca gagctccaaa ccctacctgc tgactcaccc cagtgacccc
     1441 ctggagctcg tggtctcagg accgtctggg ggccccagct ccccgacaac aggccccacc
     1501 tccacatctg caggccctga ggaccagccc ctcaccccca ccgggtcgga tccccagagt
     1561 ggtctgggaa ggcacctggg ggttgtgatc ggcatcttgg tggccgtcat cctactgctc
     1621 ctcctcctcc tcctcctctt cctcatcctc cgacatcgac gtcagggcaa acactggaca
     1681 tcgacccaga gaaaggctga tttccaacat cctgcagggg ctgtggggcc agagcccaca
     1741 gacagaggcc tgcagtggag gtccagccca gctgccgatg cccaggaaga aaacctctat
     1801 gctgccgtga agcacacaca gcctgaggat ggggtggaga tggacactcg gcagagccca
     1861 cacgatgaag acccccaggc agtgacgtat gccgaggtga aacactccag acctaggaga
     1921 gaaatggcct ctcctccttc cccactgtct ggggaattcc tggacacaaa ggacagacag
     1981 gcggaagagg acaggcagat ggacactgag gctgctgcat ctgaagcccc ccaggatgtg
     2041 acctacgccc agctgcacag cttgaccctc agacgggagg caactgagcc tcctccatcc
     2101 caggaagggc cctctccagc tgtgcccagc atctacgcca ctctggccat ccactagccc
     2161 agggggggac gcagacccca cactccatgg agtctggaat gcatgggagc tgccccccca
     2221 gtggacacca ttggacccca cccagcctgg atctacccca ggagactctg ggaactttta
     2281 ggggtcactc aattctgcag tataaataac taatgtctct acaattttga aataaagcaa
     2341 cagacttctc aataatcaat gaagtagctg agaaaactaa gtcagaaagt gcattaaact
     2401 gaatcacaat gtaaatatta cacatcaagc gatgaaactg gaaaactaca agccacgaat
     2461 gaatgaatta ggaaagaaaa aaagtaggaa atgaatgatc ttggctttcc tataagaaat
     2521 ttagggcagg gcacggtggc tcacgcctgt aattccagca ctttgggagg ccgaggcggg
     2581 cagatcacga gttcaggaga tcgagaccat cttggccaac atggtgaaac cctgtctctc
     2641 ctaaaaatac aaaaattagc tggatgtggt ggcagtgcct gtaatcccag ctatttggga
     2701 ggctgaggca ggagaatcgc ttgaaccagg gagtcagagg tttcagtgag ccaagatcgc
     2761 accactgctc tccagcctgg cgacagaggg agactccatc tcaaattaaa aaaaaaaaaa
     2821 aaaaagaaag aaaaagagaa aaaagaaatt tagaagaata acaagttatt ccaaatgaag
     2881 gcgtaagaaa gggaataata acaataataa gaggagttgt tcatgaggaa aaaccaaagc
     2941 ttgaaaattc aacaaagcca gtgaagctca ttcttgaaaa catgaatcac actcatgaat
     3001 tctaactaca atgaaaaaga gaaagaaaga gcaggcatgc atttccatat gggagtgagc
     3061 cagcagacag ccctacagat cgtacacacg ttttccaaaa ctaacaatgg aacaggcggc
     3121 aaacctatgc caatatacta gaaattgcag attaaataga tgaaatattc taaactggag
     3181 tttacataat gaacataaga gtaatcagag aatctgactc attttagatg tgtgtgtgtg
     3241 tgtatatata tgtgtgtgtg tgtgaaaaac attgactata ataaaaataa tctcgagttc
     3301 a
//
