LOCUS       NM_024318               3848 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor A6 (LILRA6),
            transcript variant 1, mRNA.
ACCESSION   NM_024318 XM_003960782 XM_005276655 XM_006726275 XM_024452525
            XM_047442915
VERSION     NM_024318.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3848)
  AUTHORS   Bashirova,A.A., Kasprzak,W., O'hUigin,C. and Carrington,M.
  TITLE     Distinct frequency patterns of LILRB3 and LILRA6 allelic variants
            in Europeans
  JOURNAL   Immunogenetics 75 (3), 263-267 (2023)
   PUBMED   36449053
  REMARK    GeneRIF: Distinct frequency patterns of LILRB3 and LILRA6 allelic
            variants in Europeans.
REFERENCE   2  (bases 1 to 3848)
  AUTHORS   Al-Moussawy,M., Abdelsamed,H.A. and Lakkis,F.G.
  TITLE     Immunoglobulin-like receptors and the generation of innate immune
            memory
  JOURNAL   Immunogenetics 74 (1), 179-195 (2022)
   PUBMED   35034136
  REMARK    Review article
REFERENCE   3  (bases 1 to 3848)
  AUTHORS   Hirayasu,K., Sun,J., Hasegawa,G., Hashikawa,Y., Hosomichi,K.,
            Tajima,A., Tokunaga,K., Ohashi,J. and Hanayama,R.
  TITLE     Characterization of LILRB3 and LILRA6 allelic variants in the
            Japanese population
  JOURNAL   J Hum Genet 66 (7), 739-748 (2021)
   PUBMED   33526815
  REMARK    GeneRIF: Characterization of LILRB3 and LILRA6 allelic variants in
            the Japanese population.
REFERENCE   4  (bases 1 to 3848)
  AUTHORS   Lopez-Alvarez,M.R., Jiang,W., Jones,D.C., Jayaraman,J., Johnson,C.,
            Cookson,W.O., Moffatt,M.F., Trowsdale,J. and Traherne,J.A.
  TITLE     LILRA6 copy number variation correlates with susceptibility to
            atopic dermatitis
  JOURNAL   Immunogenetics 68 (9), 743-747 (2016)
   PUBMED   27333811
  REMARK    GeneRIF: LILRA6 copy number variation correlates with
            susceptibility to atopic dermatitis.
REFERENCE   5  (bases 1 to 3848)
  AUTHORS   Bashirova,A.A., Apps,R., Vince,N., Mochalova,Y., Yu,X.G. and
            Carrington,M.
  TITLE     Diversity of the human LILRB3/A6 locus encoding a myeloid
            inhibitory and activating receptor pair
  JOURNAL   Immunogenetics 66 (1), 1-8 (2014)
   PUBMED   24096970
  REMARK    GeneRIF: LILRA6 copy number variation may influence the level of
            the activating receptor on the cell surface, potentially affecting
            signaling upon LILRB3/A6 ligation
REFERENCE   6  (bases 1 to 3848)
  AUTHORS   Mosbruger,T.L., Duggal,P., Goedert,J.J., Kirk,G.D., Hoots,W.K.,
            Tobler,L.H., Busch,M., Peters,M.G., Rosen,H.R., Thomas,D.L. and
            Thio,C.L.
  TITLE     Large-scale candidate gene analysis of spontaneous clearance of
            hepatitis C virus
  JOURNAL   J Infect Dis 201 (9), 1371-1380 (2010)
   PUBMED   20331378
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3848)
  AUTHORS   Pfistershammer,K., Lawitschka,A., Klauser,C., Leitner,J., Weigl,R.,
            Heemskerk,M.H., Pickl,W.F., Majdic,O., Bohmig,G.A., Fischer,G.F.,
            Greinix,H.T. and Steinberger,P.
  TITLE     Allogeneic disparities in immunoglobulin-like transcript 5 induce
            potent antibody responses in hematopoietic stem cell transplant
            recipients
  JOURNAL   Blood 114 (11), 2323-2332 (2009)
   PUBMED   19617579
  REMARK    GeneRIF: Allogeneic disparities in immunoglobulin-like transcript 5
            induce potent antibody responses in hematopoietic stem cell
            transplant recipients
REFERENCE   8  (bases 1 to 3848)
  AUTHORS   Wende,H., Volz,A. and Ziegler,A.
  TITLE     Extensive gene duplications and a large inversion characterize the
            human leukocyte receptor cluster
  JOURNAL   Immunogenetics 51 (8-9), 703-713 (2000)
   PUBMED   10941842
  REMARK    Erratum:[Immunogenetics 2001;52(3-4):308]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245052.3.
            
            On or before Mar 2, 2023 this sequence version replaced
            XM_047442915.1, NM_024318.4.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            CCDS Note: This CCDS representation lacks full-length transcript
            support that is specifically derived from the annotated location.
            The represented exon combination is inferred from a mixture of
            partial best hit transcript alignments and paralogous transcript
            alignments, e.g., from the related LILRA2 locus.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KC918865.1, KC918869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396365.7/ ENSP00000379651.2
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC245052.3         171258-171330       c
            74-109              AC245052.3         171059-171094       c
            110-394             AC245052.3         170566-170850       c
            395-697             AC245052.3         170116-170418       c
            698-994             AC245052.3         169371-169667       c
            995-1297            AC245052.3         168814-169116       c
            1298-1348           AC245052.3         168441-168491       c
            1349-3848           AC245052.3         165130-167629       c
FEATURES             Location/Qualifiers
     source          1..3848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3848
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /note="leukocyte immunoglobulin like receptor A6"
                     /db_xref="GeneID:79168"
                     /db_xref="HGNC:HGNC:15495"
     exon            1..73
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1485
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte immunoglobulin-like receptor,
                     subfamily B (with TM and ITIM domains), member 6;
                     immunoglobulin-like transcript 8; immunoglobulin-like
                     transcript 5; leukocyte immunoglobulin-like receptor,
                     subfamily A (with TM domain), member 6; leukocyte Ig-like
                     receptor; leucocyte Ig-like receptor A6; leukocyte
                     immunoglobulin like receptor B3"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     A member 6 isoform 1 precursor"
                     /protein_id="NP_077294.3"
                     /db_xref="CCDS:CCDS42610.1"
                     /db_xref="GeneID:79168"
                     /db_xref="HGNC:HGNC:15495"
                     /translation="MTPTLAALLCLGLSLGPRTHVQAGPFPKPTLWAEPGSVISWGSP
                     VTIWCQGSLEAQEYRLDKEGSPEPWDRNNPLEPKNKARFSIPSITEHHAGRYRCHYYS
                     SAGWSEPSDPLELVMTGAYSKPTLSALPSPVVASGGNMTLQCGSQKGYHHFVLMKEGE
                     HQLPRTLDSQQLHSGGFQALFPVGPVNPSHRWRFTCYYYYMNTPRVWSHPSDPLEILP
                     SGVSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYDRFVLYKEGERDFLQRPGQQPQAGL
                     SQANFTLGPVSPSHGGQYRCYGAHNLSSEWSAPSDPLNILMAGQIYDTVSLSAQPGPT
                     VASGENVTLLCQSWWQFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAG
                     TYRCYGSYSSNPHLLSFPSEPLELMVSGHSGGSSLPPTGPPSTPASHAKDYTVENLIR
                     MGMAGLVLVFLGILLFEAQHSQRNPQDAAGR"
     exon            74..109
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     exon            110..394
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     exon            395..697
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     exon            698..994
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1297
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1348
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..3848
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3825..3830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /note="hexamer: AATAAA"
     polyA_site      3848
                     /gene="LILRA6"
                     /gene_synonym="CD85b; ILT-8; ILT5; ILT8; LILRB3; LILRB6"
                     /note="major polyA site"
ORIGIN      
        1 atccctctgc agagcccggg gtcaccagga ggagacgcca tgacccccac cctcgcagcc
       61 ctgctctgcc tagggctgag tctgggcccc aggacccacg tgcaggcagg gcccttcccc
      121 aaacccaccc tctgggctga gccaggctct gtgatcagct gggggagccc cgtgaccatc
      181 tggtgtcagg ggagcctgga ggcccaggag taccgactgg ataaagaggg aagcccagag
      241 ccctgggaca gaaataaccc actggaaccc aagaacaagg ccagattctc catcccatcc
      301 ataacagagc accatgcggg gagataccgc tgccactatt acagctctgc aggctggtca
      361 gagcccagcg accccctgga gctggtgatg acaggagcct atagcaaacc caccctctca
      421 gccctgccca gccctgtggt ggcctcaggg gggaatatga ccctccaatg tggctcacag
      481 aagggatatc accattttgt tctgatgaag gaaggagaac accagctccc ccggaccctg
      541 gactcacagc agctccacag tggggggttc caggccctgt tccctgtggg ccccgtgaac
      601 cccagccaca ggtggaggtt cacatgctat tactattata tgaacacccc ccgggtgtgg
      661 tcccacccca gtgaccccct ggagattctg ccctcaggcg tgtctaggaa gccctccctc
      721 ctgaccctgc agggccctgt cctggcccct gggcagagcc tgaccctcca gtgtggctct
      781 gatgtcggct acgacagatt tgttctgtat aaggaggggg aacgtgactt cctccagcgc
      841 cctggccagc agccccaggc tgggctctcc caggccaact tcaccctggg ccctgtgagc
      901 ccctcccacg ggggccagta caggtgctat ggtgcacaca acctctcctc cgagtggtcg
      961 gcccccagcg accccctgaa catcctgatg gcaggacaga tctatgacac cgtctccctg
     1021 tcagcacagc cgggccccac agtggcctca ggagagaacg tgaccctgct gtgtcagtca
     1081 tggtggcagt ttgacacttt ccttctgacc aaagaagggg cagcccatcc cccactgcgt
     1141 ctgagatcaa tgtacggagc tcataagtac caggctgaat tccccatgag tcctgtgacc
     1201 tcagcccacg cggggaccta caggtgctac ggctcataca gctccaaccc ccacctgctg
     1261 tctttcccca gtgagcccct ggaactcatg gtctcaggac actctggagg ctccagcctc
     1321 ccacccacag ggccgccctc cacacctgcc tcacacgcca aggattacac agtggagaat
     1381 ctcatccgca tgggcatggc aggcttggtc ctggtgttcc tcgggattct gttatttgag
     1441 gctcagcaca gccagagaaa cccccaagat gcagccggga ggtgaacagc ggagaggaca
     1501 atgcaccctt cagcgtggtg gagcctcagg gacagatctg atgatcccag aaggctctgg
     1561 aggacaatct aggacctcca gaggggggtg agatttcagg ccacacactg tggaaggtaa
     1621 tcatgtctga tcacaaattt tgggtctcca ccttacttcc aatctatgtt gtgaatgccc
     1681 agttgagacc cacggaaaag agctcatggg tgagtgtgaa gtgcttctct gtcttaagtt
     1741 cccagagatc cttgcctctt ggaggccagc aaacactaac tcttgaggaa ttcatgacaa
     1801 tatcatctga ttcctccttc ccagcttgta tggcagtctc ccaccctcat gtgttcaatc
     1861 tgatgatccc aggaggttct ggaacaaaat ctacagccta tgctttctgg actatctgtc
     1921 gatcattcct gaagagaggg atcaatgttg aggtattcat ttcacatgat gaaaatgaca
     1981 atatcaaatg tcagaggtag tagggctcac gtagaaatcc aatacatcca tggtaggact
     2041 gcaaattact tgaatcaatt tggggaaaat atcagaagta cccagtgaaa aagaagaaac
     2101 atggccgggc gcggtggctc atgcctgtaa tcccagcact ttgggaggct gaggcgggcg
     2161 gacacgagtt caggaattcg agtccagctt ggccaacata gtgaaacccc gtctctacta
     2221 aaaatacaaa acattagctg ggcgtggtgg caggtgcctg taatttcagc tactcaggag
     2281 gctgaggcag gagaattgct tgaacctggg agacggaagc aagttggcgc cagttggtgc
     2341 agtgagccaa ggtggcgcca ttgcactccg gcccaggtga cagtacgaga cttcatctaa
     2401 aaaaaaaaga aaaaaaaaaa gaagagacac acagctatga acacaaagca cagaacctag
     2461 aggaaaatgt gttcatatgg tgaggtttca ttcacaacaa catggacagg actgctgctc
     2521 atattacaca acagccataa aacccaaaaa tacatctaaa acaaaggaaa catatgtggt
     2581 tcaattccac caagggatac tacgaggccg tgcagaggca cagacaaaat ctacaaagag
     2641 caatgcaaac caaccttcca tcatgatgtt gagtaaagaa acaagagtat aaaaagaagg
     2701 tgtgcacatg aagctcaaaa agaggcagca tttattttct agggaggcaa actcaaaata
     2761 gaccccataa ataaaggaaa tagattatgt aatccaaaat agtgcttgca catcaggaaa
     2821 tactggaggg ttctgttcaa catggaaact ccaaggacca ctggacgcgg gcactggaac
     2881 gctgactttc atttggtgac cctcaatcca cttcgagtta ttggtaaatc acataatttt
     2941 aatttgatac ggaataatca tacatgtttc ttgggagcat gtggtaatct gattcatcca
     3001 tgcaatgtgt aacgatccaa taaaggttcc caggacattc atcaccctga acatttgtta
     3061 ttatggttat tattttgaga cagagtcttg cactgtcgcc cagctggcgt gcagtggcag
     3121 gatcttggct cactgcaaac tctgcctccc gggttcaagc agttttcctg tctcagcctc
     3181 ctgagtagct aggattacag gcatgcacca tcacacctcg ctaatttttg tatttttatt
     3241 acagacgggg tttcaccatg ttgctctggc tggtctcgaa ctcctgacct aaggtgatcc
     3301 accagcgtcg gctttccata gtgctgggat tacaggtgtg agccactatg cctggccaac
     3361 ttttataatt tctgtgctgg gaacattcca aatcttcatt tctcactcat gtggaaaata
     3421 caataatctg ttgctaacta tggtcaccct actgagctct caggccctgg aacttactcc
     3481 ttctctccac ctgtatttct gcacccgtcc accaacctct ctccatccct gtcctccaca
     3541 ctcccttgcc agcctctgtt gacaaccatt ctactctctg ccatcacaag gcccactttt
     3601 gtagcttccg cgtgagtgag aacatgctcc tctttctggg cctggcttat ttcactgaac
     3661 ataatgtctt ccagattcat ctgtgttgct gaacatggta caatttcctt ctttttatgc
     3721 ctgaatatta tttcattgtg tatatagacc acatgttcct tatccattca tccattgatg
     3781 gacataggtt gattccatat cttggctatt gtgaatactg ctgcaataaa catggcaatg
     3841 cagacacc
//
