LOCUS       NM_012276               1956 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor A4 (LILRA4),
            mRNA.
ACCESSION   NM_012276
VERSION     NM_012276.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Tavano,B. and Boasso,A.
  TITLE     Effect of immunoglobin-like transcript 7 cross-linking on
            plasmacytoid dendritic cells differentiation into
            antigen-presenting cells
  JOURNAL   PLoS One 9 (2), e89414 (2014)
   PUBMED   24586760
  REMARK    GeneRIF: Crosslinked ILT7 favours the differentiation of immature
            plasmacytoid dendritic cells into antigen-presenting cells rather
            than IPC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Tavano,B., Galao,R.P., Graham,D.R., Neil,S.J., Aquino,V.N.,
            Fuchs,D. and Boasso,A.
  TITLE     Ig-like transcript 7, but not bone marrow stromal cell antigen 2
            (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid
            dendritic cell function in primary human blood leukocytes
  JOURNAL   J Immunol 190 (6), 2622-2630 (2013)
   PUBMED   23401591
  REMARK    GeneRIF: ILT7 may exert its immunomodulatory activity only on
            immature circulating plasmacytoid dendritic cells (pDCs), providing
            a basic homeostatic mechanism rather than negative feedback control
            on activated pDCs.
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Angelot-Delettre,F., Biichle,S., Ferrand,C., Seilles,E.,
            Gaugler,B., Harrivel,V., Rosenthal-Allieri,M.A., Deconinck,E.,
            Saas,P. and Garnache-Ottou,F.
  TITLE     Intracytoplasmic detection of TCL1--but not ILT7-by flow cytometry
            is useful for blastic plasmacytoid dendritic cell leukemia
            diagnosis
  JOURNAL   Cytometry A 81 (8), 718-724 (2012)
   PUBMED   22674796
  REMARK    GeneRIF: Intracellular expression of the TCL1 as well as membrane
            and intracellular expression of ILT7 in plasmacytoid dendritic cell
            leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were
            tested.
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Cao,W. and Bover,L.
  TITLE     Signaling and ligand interaction of ILT7: receptor-mediated
            regulatory mechanisms for plasmacytoid dendritic cells
  JOURNAL   Immunol Rev 234 (1), 163-176 (2010)
   PUBMED   20193018
  REMARK    Review article
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Tsukamoto,N., Okada,S., Onami,Y., Sasaki,Y., Umezawa,K. and
            Kawakami,Y.
  TITLE     Impairment of plasmacytoid dendritic cells for IFN production by
            the ligand for immunoglobulin-like transcript 7 expressed on human
            cancer cells
  JOURNAL   Clin Cancer Res 15 (18), 5733-5743 (2009)
   PUBMED   19723650
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Ju,X.S., Hacker,C., Scherer,B., Redecke,V., Berger,T., Schuler,G.,
            Wagner,H., Lipford,G.B. and Zenke,M.
  TITLE     Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed
            by human dendritic cells and down-regulated following activation
  JOURNAL   Gene 331, 159-164 (2004)
   PUBMED   15094202
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Tedla,N., Bandeira-Melo,C., Tassinari,P., Sloane,D.E.,
            Samplaski,M., Cosman,D., Borges,L., Weller,P.F. and Arm,J.P.
  TITLE     Activation of human eosinophils through leukocyte
            immunoglobulin-like receptor 7
  JOURNAL   Proc Natl Acad Sci U S A 100 (3), 1174-1179 (2003)
   PUBMED   12529506
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Rissoan,M.C., Duhen,T., Bridon,J.M., Bendriss-Vermare,N.,
            Peronne,C., de Saint Vis,B., Briere,F. and Bates,E.E.
  TITLE     Subtractive hybridization reveals the expression of
            immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel
            transcripts in human plasmacytoid dendritic cells
  JOURNAL   Blood 100 (9), 3295-3303 (2002)
   PUBMED   12384430
  REMARK    GeneRIF: the expression of immunoglobulin-like transcript 7, in
            plasmacytoid dendritic cells
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Young,N.T., Canavez,F., Uhrberg,M., Shum,B.P. and Parham,P.
  TITLE     Conserved organization of the ILT/LIR gene family within the
            polymorphic human leukocyte receptor complex
  JOURNAL   Immunogenetics 53 (4), 270-278 (2001)
   PUBMED   11491530
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Wende,H., Volz,A. and Ziegler,A.
  TITLE     Extensive gene duplications and a large inversion characterize the
            human leukocyte receptor cluster
  JOURNAL   Immunogenetics 51 (8-9), 703-713 (2000)
   PUBMED   10941842
  REMARK    Erratum:[Immunogenetics 2001;52(3-4):308]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA983933.1, AC245884.3,
            AF283989.1 and BI834628.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012276.4.
            
            Summary: This gene encodes an immunoglobulin-like cell surface
            protein that is expressed predominantly on plasmacytoid dendritic
            cells (PDCs) and modulates the function of these cells in the
            immune response. Expression of this gene is downregulated by
            interleukin 3 (IL3). This gene is one of a cluster of highly
            related genes located at chromosomal region 19q13.4. [provided by
            RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2150385
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291759.5/ ENSP00000291759.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               DA983933.1         8-155
            149-170             AC245884.3         56186-56207         c
            171-1692            AF283989.1         1-1522
            1693-1956           BI834628.1         430-693
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1956
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /note="leukocyte immunoglobulin like receptor A4"
                     /db_xref="GeneID:23547"
                     /db_xref="HGNC:HGNC:15503"
                     /db_xref="MIM:607517"
     exon            1..103
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1569
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /note="leukocyte immunoglobulin-like receptor, subfamily A
                     (without TM domain), member 4; leukocyte
                     immunoglobulin-like receptor subfamily A member 4;
                     immunoglobulin-like transcript 7; CD85 antigen-like family
                     member G; leukocyte immunoglobulin-like receptor,
                     subfamily A (with TM domain), member 4; leucocyte Ig-like
                     receptor A4"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     A member 4 precursor"
                     /protein_id="NP_036408.4"
                     /db_xref="CCDS:CCDS12890.1"
                     /db_xref="GeneID:23547"
                     /db_xref="HGNC:HGNC:15503"
                     /db_xref="MIM:607517"
                     /translation="MTLILTSLLFFGLSLGPRTRVQAENLLKPILWAEPGPVITWHNP
                     VTIWCQGTLEAQGYRLDKEGNSMSRHILKTLESENKVKLSIPSMMWEHAGRYHCYYQS
                     PAGWSEPSDPLELVVTAYSRPTLSALPSPVVTSGVNVTLRCASRLGLGRFTLIEEGDH
                     RLSWTLNSHQHNHGKFQALFPMGPLTFSNRGTFRCYGYENNTPYVWSEPSDPLQLLVS
                     GVSRKPSLLTLQGPVVTPGENLTLQCGSDVGYIRYTLYKEGADGLPQRPGRQPQAGLS
                     QANFTLSPVSRSYGGQYRCYGAHNVSSEWSAPSDPLDILIAGQISDRPSLSVQPGPTV
                     TSGEKVTLLCQSWDPMFTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGT
                     YRCYGSRSSNPYLLSHPSEPLELVVSGATETLNPAQKKSDSKTAPHLQDYTVENLIRM
                     GVAGLVLLFLGILLFEAQHSQRSPPRCSQEANSRKDNAPFRVVEPWEQI"
     exon            104..139
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     exon            140..424
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     exon            425..724
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1021
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1324
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1375
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1956
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /note="hexamer: ATTAAA"
     polyA_site      1956
                     /gene="LILRA4"
                     /gene_synonym="CD85g; ILT7"
                     /note="major polyA site"
ORIGIN      
        1 gtctgtctgt gtctacgggc accgtggcca cacctgcctg cacagccagg gccaggagga
       61 ggagatgcca tgaccctcat tctcacaagc ctgctcttct ttgggctgag cctgggcccc
      121 aggacccggg tgcaggcaga aaacctactc aaacccatcc tgtgggccga gccaggtccc
      181 gtgatcacct ggcataaccc cgtgaccatc tggtgtcagg gcaccctgga ggcccagggg
      241 taccgtctgg ataaagaggg aaactcaatg tcgaggcaca tattaaaaac actggagtct
      301 gaaaacaagg tcaaactctc catcccatcc atgatgtggg aacatgcagg gcgatatcac
      361 tgttactatc agagccctgc aggctggtca gagcccagcg accccctgga gctggtggtg
      421 acagcctaca gcagacccac cctgtccgca ctgccaagcc ctgtggtgac ctcaggagtg
      481 aacgtgaccc tccggtgtgc ctcacggctg ggactgggca ggttcactct gattgaggaa
      541 ggagaccaca ggctctcctg gaccctgaac tcacaccaac acaaccatgg aaagttccag
      601 gccctgttcc ccatgggccc cctgaccttc agcaacaggg gtacattcag atgctacggc
      661 tatgaaaaca acaccccata cgtgtggtcg gaacccagtg accccctgca gctactggtg
      721 tcaggcgtgt ctaggaagcc ctccctcctg accctgcagg gccctgtcgt gacccccgga
      781 gagaatctga ccctccagtg tggctctgat gtcggctaca tcagatacac tctgtacaag
      841 gagggggccg atggcctccc ccagcgccct ggccggcagc cccaggctgg gctctcccag
      901 gccaacttca ccctgagccc tgtgagccgc tcctacgggg gccagtacag atgctacggc
      961 gcacacaacg tctcctccga gtggtcggcc cccagtgacc ccctggatat cctgatcgca
     1021 ggacagatct ctgacagacc ctccctctca gtgcagccgg gccccacggt gacctcagga
     1081 gagaaggtga ccctgctgtg tcagtcatgg gacccgatgt tcactttcct tctgaccaag
     1141 gagggggcag cccatccccc gttgcgtctg agatcaatgt acggagctca taagtaccag
     1201 gctgaattcc ccatgagtcc tgtgacctca gcccacgcgg ggacctacag gtgctacggc
     1261 tcacgcagct ccaaccccta cctgctgtct caccccagtg agcccctgga gctcgtggtc
     1321 tcaggagcaa ctgagaccct caatccagca caaaagaagt cagattccaa gactgcccca
     1381 cacctccagg attacacagt ggagaatctc atccgcatgg gtgtggctgg cttggtcctg
     1441 ctgttcctcg ggattctgtt atttgaggct cagcacagcc agagaagccc cccaaggtgc
     1501 agccaggagg caaacagcag aaaggacaat gcacccttca gagtggtgga gccttgggaa
     1561 cagatctgat gatctgagga ggttctggaa gactggggca gcagttgggg aagtgtctgc
     1621 tgagaatatc aaggggaaga agcatgggtc aggtgcagga agatgtctgg gtgtctgtag
     1681 aagatgcttc ctccattaaa ctgtggtgct ttcctcctca ttgtcgactc tccttgactg
     1741 ccccttcctt cgtttttctt ccctatgatg taaggcttca cccctatggt gggtttgggt
     1801 ccgcccctct gtgacctcat gctctgctcc actttcaggt aatacacctt tctttatttc
     1861 taactactgc attttctaat gtgtattact gggactatct cttcagctca taacatggaa
     1921 tttgcttttg ataattaaat ccatgggcaa aaatca
//
