LOCUS       NM_001130917            4482 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor A2 (LILRA2),
            transcript variant 1, mRNA.
ACCESSION   NM_001130917 XM_006726178 XM_006726299
VERSION     NM_001130917.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4482)
  AUTHORS   Zhang,Y., Zhang,L., Zhao,Y., Wang,S. and Feng,L.
  TITLE     Overexpression of LILRA2 indicated poor prognosis of ovarian
            carcinoma: A new potential biomarker and therapeutic target
  JOURNAL   Taiwan J Obstet Gynecol 62 (1), 77-88 (2023)
   PUBMED   36720556
  REMARK    GeneRIF: Overexpression of LILRA2 indicated poor prognosis of
            ovarian carcinoma: A new potential biomarker and therapeutic
            target.
REFERENCE   2  (bases 1 to 4482)
  AUTHORS   Yamazaki,R., Furukawa,A., Hirayasu,K., Yumoto,K., Fukuhara,H.,
            Arase,H. and Maenaka,K.
  TITLE     Molecular mechanism of the recognition of bacterially cleaved
            immunoglobulin by the immune regulatory receptor LILRA2
  JOURNAL   J Biol Chem 295 (28), 9531-9541 (2020)
   PUBMED   32424043
  REMARK    GeneRIF: Molecular mechanism of the recognition of bacterially
            cleaved immunoglobulin by the immune regulatory receptor LILRA2.
REFERENCE   3  (bases 1 to 4482)
  AUTHORS   Hirayasu,K., Saito,F., Suenaga,T., Shida,K., Arase,N., Oikawa,K.,
            Yamaoka,T., Murota,H., Chibana,H., Nakagawa,I., Kubori,T.,
            Nagai,H., Nakamaru,Y., Katayama,I., Colonna,M. and Arase,H.
  TITLE     Microbially cleaved immunoglobulins are sensed by the innate immune
            receptor LILRA2
  JOURNAL   Nat Microbiol 1 (6), 16054 (2016)
   PUBMED   27572839
  REMARK    GeneRIF: findings demonstrate that LILRA2 is a type of innate
            immune receptor in the host immune system that detects
            immunoglobulin abnormalities caused by microbial pathogens.
            GeneRIF: LILRA2 recognizes microbially cleaved antibodies and
            activates innate immunity, suggesting that LILRA2 detects dangerous
            immunological situations in which antibodies are destroyed by
            pathogens.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4482)
  AUTHORS   Lu,H.K., Mitchell,A., Endoh,Y., Hampartzoumian,T., Huynh,O.,
            Borges,L., Geczy,C., Bryant,K. and Tedla,N.
  TITLE     LILRA2 selectively modulates LPS-mediated cytokine production and
            inhibits phagocytosis by monocytes
  JOURNAL   PLoS One 7 (3), e33478 (2012)
   PUBMED   22479404
  REMARK    GeneRIF: LILRA2-mediated activation of monocytes is significantly
            different to LPS and that LILRA2 selectively modulates LPS-mediated
            monocyte activation and FcgammaRI-dependent phagocytosis.
            Erratum:[PLoS One. 2012;7(8). doi:
            10.1371/annotation/f4475cbd-3518-46cd-bb6b-a326008af388]
REFERENCE   5  (bases 1 to 4482)
  AUTHORS   Jones,D.C., Roghanian,A., Brown,D.P., Chang,C., Allen,R.L.,
            Trowsdale,J. and Young,N.T.
  TITLE     Alternative mRNA splicing creates transcripts encoding soluble
            proteins from most LILR genes
  JOURNAL   Eur J Immunol 39 (11), 3195-3206 (2009)
   PUBMED   19658091
REFERENCE   6  (bases 1 to 4482)
  AUTHORS   Borges,L., Kubin,M. and Kuhlman,T.
  TITLE     LIR9, an immunoglobulin-superfamily-activating receptor, is
            expressed as a transmembrane and as a secreted molecule
  JOURNAL   Blood 101 (4), 1484-1486 (2003)
   PUBMED   12393390
REFERENCE   7  (bases 1 to 4482)
  AUTHORS   Wilson,M.J., Torkar,M., Haude,A., Milne,S., Jones,T., Sheer,D.,
            Beck,S. and Trowsdale,J.
  TITLE     Plasticity in the organization and sequences of human KIR/ILT gene
            families
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4778-4783 (2000)
   PUBMED   10781084
REFERENCE   8  (bases 1 to 4482)
  AUTHORS   Nakajima,H., Samaridis,J., Angman,L. and Colonna,M.
  TITLE     Human myeloid cells express an activating ILT receptor (ILT1) that
            associates with Fc receptor gamma-chain
  JOURNAL   J Immunol 162 (1), 5-8 (1999)
   PUBMED   9886363
REFERENCE   9  (bases 1 to 4482)
  AUTHORS   Borges,L., Hsu,M.L., Fanger,N., Kubin,M. and Cosman,D.
  TITLE     A family of human lymphoid and myeloid Ig-like receptors, some of
            which bind to MHC class I molecules
  JOURNAL   J Immunol 159 (11), 5192-5196 (1997)
   PUBMED   9548455
REFERENCE   10 (bases 1 to 4482)
  AUTHORS   Samaridis,J. and Colonna,M.
  TITLE     Cloning of novel immunoglobulin superfamily receptors expressed on
            human myeloid and lymphoid cells: structural evidence for new
            stimulatory and inhibitory pathways
  JOURNAL   Eur J Immunol 27 (3), 660-665 (1997)
   PUBMED   9079806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245036.3, AK310088.1,
            U82278.1 and CB046242.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001130917.2.
            
            Summary: This gene encodes a member of a family of immunoreceptors
            that are expressed predominantly on monocytes and B cells, and at
            lower levels on dendritic cells and natural killer cells. The
            encoded protein is an activating receptor that inhibits dendritic
            cell differentiation and antigen presentation and suppresses innate
            immune response. Alternatively spliced transcript variants encoding
            different isoforms have been found. This gene is located in a
            cluster of related genes on chromosome 19 and there is a pseudogene
            for this gene on chromosome 3. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF025531.1, U82278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391738.8/ ENSP00000375618.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC245036.3         123794-123834
            42-89               AK310088.1         422-469
            90-492              U82278.1           1-403
            493-493             AC245036.3         124786-124786
            494-1562            U82278.1           405-1473
            1563-1755           CB046242.1         429-621
            1756-4482           AC245036.3         137565-140291
FEATURES             Location/Qualifiers
     source          1..4482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..4482
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /note="leukocyte immunoglobulin like receptor A2"
                     /db_xref="GeneID:11027"
                     /db_xref="HGNC:HGNC:6603"
                     /db_xref="MIM:604812"
     exon            1..123
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1541
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; leukocyte immunoglobulin-like receptor 7;
                     leukocyte immunoglobulin-like receptor subfamily A member
                     2 soluble; immunoglobulin-like transcript 1; CD85
                     antigen-like family member H; leukocyte
                     immunoglobulin-like receptor, subfamily A (with TM
                     domain), member 2; leucocyte Ig-like receptor A2"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     A member 2 isoform a precursor"
                     /protein_id="NP_001124389.2"
                     /db_xref="CCDS:CCDS46179.1"
                     /db_xref="GeneID:11027"
                     /db_xref="HGNC:HGNC:6603"
                     /db_xref="MIM:604812"
                     /translation="MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVIIQGSP
                     VTLRCQGSLQAEEYHLYRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSH
                     NHSSEYSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTLQCVSQVAFDGFILCKEGED
                     EHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVP
                     GVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLS
                     QANFTLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTV
                     APGKNVTLLCQSRGQFHTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGT
                     YRCYSSLSSNPYLLSLPSDPLELVVSEAAETLSPSQNKTDSTTTSLGQHPQDYTVENL
                     IRMGVAGLVLVVLGILLFEAQHSQRSLQDAAGR"
     exon            124..159
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     exon            160..441
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     exon            442..744
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1041
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1344
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1395
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..4482
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1724..1729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /note="hexamer: ATTAAA"
     polyA_site      1755
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /note="major polyA site"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
                     /note="hexamer: AATAAA"
     polyA_site      4482
                     /gene="LILRA2"
                     /gene_synonym="CD85H; ILT1; LIR-7; LIR7"
ORIGIN      
        1 ctccgagtgt ccacaccctg tgcgtctctc tgtcctgcca gcactgaggg ctcatccatc
       61 cgcagagcag ggcagtggga ggagacgcca tgacccccat cctcacggtc ctgatctgtc
      121 tcgggctgag tctgggcccc aggacccacg tgcaggcagg gcacctcccc aagcccaccc
      181 tctgggctga gccaggctct gtgatcatcc agggaagtcc tgtgaccctc aggtgtcagg
      241 ggagccttca ggctgaggag taccatctat atagggaaaa caaatcagca tcctgggtta
      301 gacggataca agagcctggg aagaatggcc agttccccat cccatccatc acctgggaac
      361 acgcagggcg gtatcactgt cagtactaca gccacaatca ctcatcagag tacagtgacc
      421 ccctggagct ggtggtgaca ggagcctaca gcaaacccac cctctcagct ctgcccagcc
      481 ctgtggtgac ctcaggaggg aacgtgaccc tccagtgtgt ctcacaggtg gcatttgacg
      541 gcttcattct gtgtaaggaa ggagaagatg aacacccaca acgcctgaac tcccattccc
      601 atgcccgtgg gtggtcctgg gccatcttct ccgtgggccc cgtgagcccg agtcgcaggt
      661 ggtcgtacag gtgctatgct tatgactcga actctcccta tgtgtggtct ctacccagtg
      721 atctcctgga gctcctggtc ccaggtgttt ctaagaagcc atcactctca gtgcagccag
      781 gtcctatggt ggcccctggg gagagcctga ccctccagtg tgtctctgat gtcggctacg
      841 acagatttgt tctgtataag gagggagaac gtgacttcct ccagcgccct ggttggcagc
      901 cccaggctgg gctctcccag gccaacttca ccctgggccc tgtgagcccc tcccacgggg
      961 gccagtacag atgctacagt gcacacaacc tctcctccga gtggtcggcc cccagtgacc
     1021 ccctggacat cctgatcaca ggacagttct atgacagacc ctctctctcg gtgcagccgg
     1081 tccccacagt agccccagga aagaacgtga ccctgctgtg tcagtcacgg gggcagttcc
     1141 acactttcct tctgaccaag gagggggcag gccatccccc actgcatctg agatcagagc
     1201 accaagctca gcagaaccag gctgaattcc gcatgggtcc tgtgacctca gcccacgtgg
     1261 ggacctacag atgctacagc tcactcagct ccaaccccta cctgctgtct ctccccagtg
     1321 accccctgga gctcgtggtc tcagaagcag ctgagaccct cagcccatca caaaacaaga
     1381 cagactccac gactacatcc ctaggccaac acccccagga ttacacagtg gagaatctca
     1441 tccgcatggg tgtggctggc ttggtcctgg tggtcctcgg gattctgcta tttgaggctc
     1501 agcacagcca gagaagccta caagatgcag ccgggaggtg aacagcagag aggacaatgc
     1561 atccttcagc gtggtggagc ctcagggaca gatctgatga tcccaggagg ctctggagga
     1621 caatctagga cctacattat ctggactgta tgctggtcat ttctagagac agcaatcaat
     1681 atttgagtgt aaggaaactg tctggggtga ttcctagaag atcattaaac tgtggtacat
     1741 ttttttgtct atgaatgttg acttcccttg actggatccc ctttttttcc catccccaga
     1801 catgaggctc catcccacat ggcaccgttg ggtccacacc tccacacacc tgtgtgctct
     1861 ggtccacggc atgtgacaca gtcttcctta ttcctcattg tcacactcct tgatgtcact
     1921 tactgagtcc ccgtctcttc agttcagaga tccaaacctg aaccaccaac taaatcaacg
     1981 acaggagatc agattccaac caggaaaaca taaatccacc ctgctgccct gacaccctct
     2041 ctgtacctta tgagcccttc cctctttctc agatgctatc tgtgtaattt ctcctgaaat
     2101 atcaccactt ggaatcatca cactggcatt tcaagtgaca ccacagctat gctgattcag
     2161 aaaaagacat ctctaaaata ctgtaattag tggtatctac caatttctgt gacataaata
     2221 tttttctcat ggcccaaatc aaggtgccaa tgggttctca ctgaatacag ggttgggaag
     2281 caagggacag aactgtcttc actaatgagc accagggacc tgtggcacat cccactgaga
     2341 gctcacccat atacctacag tcctttctat ttcagaggca atgatcactt ctacttcagt
     2401 gttatggcac aggtcaaatg aaattctgac actgttatcc tagcatatcc acaaaagaca
     2461 aacctattaa tatctgatgt gggagataac acggctcacc taaaaatcaa agtacatgcc
     2521 gggcgcggtg gctcacgcct gtaatcccag cactttggga ggccaaggca ggcagatcac
     2581 gaggtcagga gatctagacc atcctggcta acatggtgaa accccgtctc tactaaatac
     2641 acaaaaaaat attggccggg cgtggtggtg ggcgcctgta gtcccagcta ctcaggaggc
     2701 tgaggcagga gaatggcgtg aacctgggag gcggagcttg caatgggccg agattgcgac
     2761 actgccctcc agcctgggcg acagagcaag actccgtctc aaaaaaaaaa aaaaatccaa
     2821 gtacaacata agaaaaatgt taacagaact atgcagtttc gatgaaagaa ttttttttga
     2881 gatggagttt tgctttgttg cccaggctgg agtgcaatgg tgcaatctcg gctcactgca
     2941 acctccactt cccaggttca agcaattctc ctgcctctgc ctcccgagtt actggactac
     3001 aggtgtgcac caccattccc ggctattttt tgtattttta gtagagacgg gggtctcgcc
     3061 atgttagtga ggctggtctt gaactcctga cctcaggtta tccacctgcc tcagcctccc
     3121 agagtgctgg gattacaggt gtaagccact gtgcccggct gatggaagaa ttcttaaatg
     3181 actcgttcta ctttctgctg gtccaggcac tccttggctt ggggcagcat cccaccagtt
     3241 tctgcctcca tcttctcaat gcttacacct acctggttgc ctctgtcttc acacccattc
     3301 ttctgtgtgt gtcttttctc ttcttcagat tatgatatca ctcagatcag attaggactc
     3361 atcctaattc gttatgatcc cttgatcata acttaaatgc atttgcaaag actctatttc
     3421 caactatgtt cacatttata gctaatgggg ctcaggattt caacgtgtat attaggggga
     3481 acaagtcaat ttatgacagt gtctacaaga aaagtatgca tagaaataca tttaaccaaa
     3541 tacaaaaatt aggtgggtgt ggtggtacac gcctgtaatc ccagctactc aggaggctga
     3601 gacaggagaa tcgcgtcaac ccaggaaaca gaggttgcag tgagctgaga tcttgccatt
     3661 gcactccagc ctgggcaaca gagtgagact ctgtctcaaa aaaagagaaa tacatttaac
     3721 caaagagatg caatacgtat acattgacaa ttttaaaata ctgctcaaag aaataacaaa
     3781 agacctaaat gaggaaaaag tcatcccagt atcataaatc aaaaggctta aaattagtta
     3841 tctccctcta gggaacctag actaatacac tcaccccgtc tccttgttcg gaggctctcc
     3901 tgcctatcag cttttctcct ctgtgctttc catgtccctg tggttctctg gtgagcccca
     3961 tcatgctgtc ctagaagatc cacttagaat ttcggtattt actcaccatt ttgactcctc
     4021 ttaacgagac aggcacatgc cagctgtttc cattcatcca acctgaacct gagcccccga
     4081 tcattttttc taccactttt cagtcctggg aaactcagtc ccaatgtgct tgtcattcat
     4141 ttgagaataa ttttcatttt ctccagtagt tttaaaatta ctttgtatct attctagata
     4201 tcgtttgctc tatcatagtt aagacattaa tgttatttat gaatttgtgc acattaaact
     4261 catgatcttt catttctgta aaaatgtcaa ctatttcctt tgcaagtatt tattgactaa
     4321 catactcctt atttccttca ttctgaaagt gtgacacata gagatatatc tgtttcctct
     4381 tctcactcta ttctttgtgt gcattaatta tcttttctat ttttttcatt tctagttttt
     4441 ctccgatgac taatgaaaaa tttaataaat attctacacc aa
//
