LOCUS       NM_006863               3232 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leukocyte immunoglobulin like receptor A1 (LILRA1),
            transcript variant 1, mRNA.
ACCESSION   NM_006863
VERSION     NM_006863.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3232)
  AUTHORS   Wang,K.S., Liu,X., Aragam,N., Mullersman,J.E., Jian,X., Pan,Y. and
            Liu,Y.
  TITLE     Polymorphisms in ABLIM1 are associated with personality traits and
            alcohol dependence
  JOURNAL   J Mol Neurosci 46 (2), 265-271 (2012)
   PUBMED   21547531
REFERENCE   2  (bases 1 to 3232)
  AUTHORS   Ryu,M., Chen,Y., Qi,J., Liu,J., Fan,Z., Nam,G., Shi,Y., Cheng,H.
            and Gao,G.F.
  TITLE     LILRA3 binds both classical and non-classical HLA class I molecules
            but with reduced affinities compared to LILRB1/LILRB2: structural
            evidence
  JOURNAL   PLoS One 6 (4), e19245 (2011)
   PUBMED   21559424
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3232)
  AUTHORS   Tedla,N., An,H., Borges,L., Vollmer-Conna,U., Bryant,K., Geczy,C.
            and McNeil,H.P.
  TITLE     Expression of activating and inhibitory leukocyte
            immunoglobulin-like receptors in rheumatoid synovium: correlations
            to disease activity
  JOURNAL   Tissue Antigens 77 (4), 305-316 (2011)
   PUBMED   21388353
REFERENCE   4  (bases 1 to 3232)
  AUTHORS   Jones,D.C., Kosmoliaptsis,V., Apps,R., Lapaque,N., Smith,I.,
            Kono,A., Chang,C., Boyle,L.H., Taylor,C.J., Trowsdale,J. and
            Allen,R.L.
  TITLE     HLA class I allelic sequence and conformation regulate leukocyte
            Ig-like receptor binding
  JOURNAL   J Immunol 186 (5), 2990-2997 (2011)
   PUBMED   21270408
REFERENCE   5  (bases 1 to 3232)
  AUTHORS   Pilsbury,L.E., Allen,R.L. and Vordermeier,M.
  TITLE     Modulation of Toll-like receptor activity by leukocyte Ig-like
            receptors and their effects during bacterial infection
  JOURNAL   Mediators Inflamm 2010, 536478 (2010)
   PUBMED   20634939
  REMARK    Review article
REFERENCE   6  (bases 1 to 3232)
  AUTHORS   Brown,D., Trowsdale,J. and Allen,R.
  TITLE     The LILR family: modulators of innate and adaptive immune pathways
            in health and disease
  JOURNAL   Tissue Antigens 64 (3), 215-225 (2004)
   PUBMED   15304001
  REMARK    Review article
REFERENCE   7  (bases 1 to 3232)
  AUTHORS   Allen,R.L., Raine,T., Haude,A., Trowsdale,J. and Wilson,M.J.
  TITLE     Leukocyte receptor complex-encoded immunomodulatory receptors show
            differing specificity for alternative HLA-B27 structures
  JOURNAL   J Immunol 167 (10), 5543-5547 (2001)
   PUBMED   11698424
REFERENCE   8  (bases 1 to 3232)
  AUTHORS   Liu,W.R., Kim,J., Nwankwo,C., Ashworth,L.K. and Arm,J.P.
  TITLE     Genomic organization of the human leukocyte immunoglobulin-like
            receptors within the leukocyte receptor complex on chromosome
            19q13.4
  JOURNAL   Immunogenetics 51 (8-9), 659-669 (2000)
   PUBMED   10941837
REFERENCE   9  (bases 1 to 3232)
  AUTHORS   Wilson,M.J., Torkar,M., Haude,A., Milne,S., Jones,T., Sheer,D.,
            Beck,S. and Trowsdale,J.
  TITLE     Plasticity in the organization and sequences of human KIR/ILT gene
            families
  JOURNAL   Proc Natl Acad Sci U S A 97 (9), 4778-4783 (2000)
   PUBMED   10781084
REFERENCE   10 (bases 1 to 3232)
  AUTHORS   Borges,L., Hsu,M.L., Fanger,N., Kubin,M. and Cosman,D.
  TITLE     A family of human lymphoid and myeloid Ig-like receptors, some of
            which bind to MHC class I molecules
  JOURNAL   J Immunol 159 (11), 5192-5196 (1997)
   PUBMED   9548455
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA999265.1, AF025530.1,
            BC101514.1 and AC245036.3.
            
            On May 17, 2019 this sequence version replaced NM_006863.3.
            
            Summary: This gene encodes an activating member of the leukocyte
            immunoglobulin-like receptor (LIR) family, which is found in a gene
            cluster at chromosomal region 19q13.4. The encoded protein is
            predominantly expressed in B cells, interacts with major
            histocompatibility complex class I ligands, and contributes to the
            regulation of immune responses. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, May 2013].
            
            Transcript Variant: This variant (1, also known as LIR6a)
            represents the longest transcript and encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290919.1, AF025530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal (PMID:9548455)
            MANE Ensembl match               :: ENST00000251372.8/
                                                ENSP00000251372.3
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA999265.1         57-72
            17-170              AF025530.1         1-154
            171-1764            BC101514.1         1-1594
            1765-3232           AC245036.3         150918-152385
FEATURES             Location/Qualifiers
     source          1..3232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3232
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="leukocyte immunoglobulin like receptor A1"
                     /db_xref="GeneID:11024"
                     /db_xref="HGNC:HGNC:6602"
                     /db_xref="MIM:604810"
     exon            1..150
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            151..232
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1668
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte immunoglobulin-like receptor 6; CD85
                     antigen-like family member I; leukocyte
                     immunoglobulin-like receptor, subfamily A (with TM
                     domain), member 1; leucocyte Ig-like receptor A1;
                     leukocyte immunoglobulin-like receptor subfamily A member
                     1"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     A member 1 isoform 1 precursor"
                     /protein_id="NP_006854.1"
                     /db_xref="CCDS:CCDS12901.1"
                     /db_xref="GeneID:11024"
                     /db_xref="HGNC:HGNC:6602"
                     /db_xref="MIM:604810"
                     /translation="MTPIVTVLICLRLSLGPRTHVQAGTLPKPTLWAEPGSVITQGSP
                     VTLWCQGILETQEYRLYREKKTAPWITRIPQEIVKKGQFPIPSITWEHTGRYRCFYGS
                     HTAGWSEPSDPLELVVTGAYIKPTLSALPSPVVTSGGNVTLHCVSQVAFGSFILCKEG
                     EDEHPQCLNSQPRTHGWSRAIFSVGPVSPSRRWSYRCYAYDSNSPHVWSLPSDLLELL
                     VLGVSKKPSLSVQPGPIVAPGESLTLQCVSDVSYDRFVLYKEGERDFLQLPGPQPQAG
                     LSQANFTLGPVSRSYGGQYRCSGAYNLSSEWSAPSDPLDILIAGQFRGRPFISVHPGP
                     TVASGENVTLLCQSWGPFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHS
                     GTYRCYGSLSSNPYLLSHPSDSLELMVSGAAETLSPPQNKSDSKAGAANTLSPSQNKT
                     ASHPQDYTVENLIRMGIAGLVLVVLGILLFEAQHSQRSL"
     exon            233..268
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            269..556
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            557..859
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1156
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1459
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1510
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1549
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..3232
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2880..2885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="hexamer: AAGAAA"
     polyA_site      2900
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="major polyA site"
     regulatory      2917..2922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="hexamer: AAGAAA"
     polyA_site      2941
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="hexamer: AAGAAA"
     polyA_site      2978
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="hexamer: AAGAAA"
     polyA_site      3087
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
                     /note="hexamer: AAGAAA"
     polyA_site      3232
                     /gene="LILRA1"
                     /gene_synonym="CD85I; LIR-6; LIR6"
ORIGIN      
        1 gcatttctcc tctgtgctca ctgccacacg cagctcaacc tgagctacac agccagatgc
       61 gagatgcttc tctgctgatc tgagtctgcc tgcagcatgg accttggtct tccctgaagc
      121 atctccaggg ctggagggac gactgccatg caccgagggc tcatccatcc gcagagcagg
      181 gcagtgggag gagacgctat gacccccatc gtcacagtcc tgatctgtct caggctgagt
      241 ctgggccccc ggacccacgt gcaggcaggg accctcccca agcccacact ctgggctgag
      301 ccaggctctg tgatcaccca ggggagtccc gtgaccctct ggtgtcaggg gatcctggag
      361 acccaggagt accgtctgta tagagaaaag aaaacagcac cctggattac acggatccca
      421 caggagattg tgaagaaggg ccagttcccc atcccatcca tcacctggga acacacaggg
      481 cggtatcgct gtttctacgg tagccacact gcaggctggt cagagcccag tgaccccctg
      541 gagctggtgg tgacaggagc ctacatcaaa cccaccctct cagctctacc cagccctgtg
      601 gtgacctcag gagggaacgt gaccctccat tgtgtctcac aggtggcatt tggcagcttc
      661 attctgtgta aggaaggaga agatgaacac ccacaatgcc tgaactcaca gccccgtacc
      721 catgggtggt cccgggccat cttctctgtg ggccccgtga gcccgagtcg caggtggtcg
      781 tacaggtgct atgcttatga ctcgaactct ccccatgtgt ggtctctacc cagtgatctc
      841 ctggagctcc tggtcctagg tgtttctaag aagccatcac tctcagtgca gccaggtcct
      901 atagtggccc ctggggagag cctgaccctc cagtgtgttt ctgatgtcag ctacgacaga
      961 tttgttctgt ataaggaggg agaacgtgac ttcctccagc tccctggccc acagccccag
     1021 gctgggctct cccaggccaa cttcaccctg ggccctgtga gccgctccta cgggggccag
     1081 tacagatgct ccggtgcata caacctctcc tccgagtggt cggcccccag cgaccccctg
     1141 gacatcctga tcgcaggaca gttccgtggc agacccttca tctcggtgca tccgggcccc
     1201 acggtggcct caggagagaa cgtgaccctg ctgtgtcagt catgggggcc gttccacact
     1261 ttccttctga ccaaggcggg agcagctgat gcccccctcc gtctcagatc aatacacgaa
     1321 tatcctaagt accaggctga attccctatg agtcctgtga cctcagccca ctcggggacc
     1381 tacaggtgct acggctcact cagctccaac ccctacctgc tgtctcaccc cagtgactcc
     1441 ctggagctca tggtctcagg agcagctgag accctcagcc caccacaaaa caagtccgat
     1501 tccaaggctg gagcagctaa caccctcagc ccatcacaaa acaagactgc ctcacacccc
     1561 caggattaca cagtggagaa tctcatccgc atgggcatag ctggcttggt cctggtggtc
     1621 ctcgggattc tgctatttga ggctcagcac agccagagaa gcctctgaga tgcagccggg
     1681 aggtgaacag cagagagaag aatgtaccct tcagagtggt ggagccttgg gaacagatct
     1741 gatgatgcca ggaggttccg ggagacaatt tagggctgat gctatctgga ctgtctgcca
     1801 atcattttta gagggaggaa tcagtgttgg attgcagaga cattttctgg agtgatccat
     1861 gaaggaccat taacctgtga tacctttcct ctctattaat gttgacttcc cttggttgga
     1921 tcctcttctt tccccacccc cagacagaca tgaggctaca tcccacatgg cagcgttggg
     1981 tccacacctc tgcacatctg tgtgctctgg tccatggtgt gtaacacagt cttctttatt
     2041 actcattgcc atactccctg gtgtgcttta ctgagcctcc atctcttcaa ttcagagttc
     2101 caaacgtgct tcagtaacta aatcaatggg agagtatcgg atttcaacca ggaaaagata
     2161 aatccaccct gatgccctga caccctctct gaaccctacg agcccttccc tccttctcac
     2221 atgctacctg tgcagcttct ccttagatca ttgtgtaacc atcactgcca tcctgttcca
     2281 cacatggtca tcaccctaca cccattcagc agccactccc cattccctct tccctccagc
     2341 acctgctaac cacaaatgtg ctttctgtct ctacggattt gcctattctg tctgaaaaca
     2401 tttcaatctc ctttgacctg tgagctcctc acttcgagac ttcctgcctt tccaggcaga
     2461 accaaagtac accacgtcaa aagcaatgat aggcatttgc agtgtgttgg tgatccacga
     2521 aaggaaaatc acggaagcag gatagaaatc cagctgcaga caagacctca ggtcgatgaa
     2581 tcttgacaag cagttgagct gtttttttct actcacctag gacagtcagg cagaagtatg
     2641 caaaatgact ggggctgatt cttttctgaa ttgtcgcaaa cagcaagagg acttgagtcc
     2701 tagcattaaa gagttcaaca tgtctaggtc caagaccact gttgtgtttg aaggatgtaa
     2761 aaccctgctg cataggatgg aatatttgga gggaggatcc tgaaaaacat gagggatcaa
     2821 atagtcctca actttctagg acaaagggag cagctatttg ccatctaccc tccagaataa
     2881 agaaatctta tcattcacca tctaccctct agaataaaga aatcttatca ttcgccatct
     2941 accctgtaga ataaagaaat cttatcattc accgtctacc ctctagagta aacaaatctt
     3001 atcattcacc atctaccctc tagaataaag aaatcttatc attcgccatc taccctctag
     3061 aataaagaaa tcttatcatt caccgtctac cctctagagt aaacaaatct tatcattcgc
     3121 catctaccct ctagaataga gaaatcttat cattcatcat ctaccctcca gaataaagaa
     3181 atgttatcat ttgccatcta ccctctagaa taaagaaatc ttattaagga ca
//
