LOCUS       NM_001127671           10553 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens LIF receptor subunit alpha (LIFR), transcript variant
            1, mRNA.
ACCESSION   NM_001127671
VERSION     NM_001127671.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10553)
  AUTHORS   Zhang,F., Li,J., Xu,J., Jiang,X., Chen,S. and Nasser,Q.A.
  TITLE     Circular RNA circLIFR suppresses papillary thyroid cancer
            progression by modulating the miR-429/TIMP2 axis
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 323 (2024)
   PUBMED   38914806
  REMARK    GeneRIF: Circular RNA circLIFR suppresses papillary thyroid cancer
            progression by modulating the miR-429/TIMP2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10553)
  AUTHORS   Di Giorgio,C., Morretta,E., Lupia,A., Bellini,R., Massa,C.,
            Urbani,G., Bordoni,M., Marchiano,S., Lachi,G., Rapacciuolo,P.,
            Finamore,C., Sepe,V., Chiara Monti,M., Moraca,F., Natalizi,N.,
            Graziosi,L., Distrutti,E., Biagioli,M., Catalanotti,B., Donini,A.,
            Zampella,A. and Fiorucci,S.
  TITLE     Bile acids serve as endogenous antagonists of the Leukemia
            inhibitory factor (LIF) receptor in oncogenesis
  JOURNAL   Biochem Pharmacol 223, 116134 (2024)
   PUBMED   38494064
  REMARK    GeneRIF: Bile acids serve as endogenous antagonists of the Leukemia
            inhibitory factor (LIF) receptor in oncogenesis.
REFERENCE   3  (bases 1 to 10553)
  AUTHORS   Hu,H., Zhao,Q., Sang,Y., Xiao,Y. and Jiang,N.
  TITLE     Role and mechanism of leukemia inhibitory factor receptor in
            cervical cancer invasion and metastasis
  JOURNAL   J Int Med Res 51 (6), 3000605231182557 (2023)
   PUBMED   37357760
  REMARK    GeneRIF: Role and mechanism of leukemia inhibitory factor receptor
            in cervical cancer invasion and metastasis.
REFERENCE   4  (bases 1 to 10553)
  AUTHORS   Ali,R., Iqbal,M.U.N., Rehman,R. and Khan,T.A.
  TITLE     Interplay of 'leukemia inhibitory factor receptor gene' (rs3099124)
            polymorphism, leukemia inhibitory factor and ovarian steroids with
            unexplained infertility
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 42 (9), 718-730 (2023)
   PUBMED   36924393
  REMARK    GeneRIF: Interplay of 'leukemia inhibitory factor receptor gene'
            (rs3099124) polymorphism, leukemia inhibitory factor and ovarian
            steroids with unexplained infertility.
REFERENCE   5  (bases 1 to 10553)
  AUTHORS   Bartik,Z.I., Sillen,U., Djos,A., Lindholm,A. and Fransson,S.
  TITLE     Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations
            in familial vesicoureteral reflux
  JOURNAL   PLoS One 17 (11), e0277524 (2022)
   PUBMED   36417404
  REMARK    GeneRIF: Whole exome sequencing identifies KIF26B, LIFR and LAMC1
            mutations in familial vesicoureteral reflux.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10553)
  AUTHORS   Schiemann,W.P., Graves,L.M., Baumann,H., Morella,K.K.,
            Gearing,D.P., Nielsen,M.D., Krebs,E.G. and Nathanson,N.M.
  TITLE     Phosphorylation of the human leukemia inhibitory factor (LIF)
            receptor by mitogen-activated protein kinase and the regulation of
            LIF receptor function by heterologous receptor activation
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5361-5365 (1995)
   PUBMED   7777512
REFERENCE   7  (bases 1 to 10553)
  AUTHORS   Gearing,D.P., Druck,T., Huebner,K., Overhauser,J., Gilbert,D.J.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     The leukemia inhibitory factor receptor (LIFR) gene is located
            within a cluster of cytokine receptor loci on mouse chromosome 15
            and human chromosome 5p12-p13
  JOURNAL   Genomics 18 (1), 148-150 (1993)
   PUBMED   8276403
REFERENCE   8  (bases 1 to 10553)
  AUTHORS   Gearing,D.P., Comeau,M.R., Friend,D.J., Gimpel,S.D., Thut,C.J.,
            McGourty,J., Brasher,K.K., King,J.A., Gillis,S., Mosley,B. et al.
  TITLE     The IL-6 signal transducer, gp130: an oncostatin M receptor and
            affinity converter for the LIF receptor
  JOURNAL   Science 255 (5050), 1434-1437 (1992)
   PUBMED   1542794
REFERENCE   9  (bases 1 to 10553)
  AUTHORS   Gearing,D.P. and Bruce,A.G.
  TITLE     Oncostatin M binds the high-affinity leukemia inhibitory factor
            receptor
  JOURNAL   New Biol 4 (1), 61-65 (1992)
   PUBMED   1536831
REFERENCE   10 (bases 1 to 10553)
  AUTHORS   Gearing,D.P., Thut,C.J., VandeBos,T., Gimpel,S.D., Delaney,P.B.,
            King,J., Price,V., Cosman,D. and Beckmann,M.P.
  TITLE     Leukemia inhibitory factor receptor is structurally related to the
            IL-6 signal transducer, gp130
  JOURNAL   EMBO J 10 (10), 2839-2848 (1991)
   PUBMED   1915266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290059.1, BP219669.1 and
            AC010457.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001127671.1.
            
            Summary: This gene encodes a protein that belongs to the type I
            cytokine receptor family. This protein combines with a
            high-affinity converter subunit, gp130, to form a receptor complex
            that mediates the action of the leukemia inhibitory factor, a
            polyfunctional cytokine that is involved in cellular
            differentiation, proliferation and survival in the adult and the
            embryo. Mutations in this gene cause Schwartz-Jampel syndrome type
            2, a disease belonging to the group of the bent-bone dysplasias. A
            translocation that involves the promoter of this gene,
            t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated
            with salivary gland pleiomorphic adenoma, a common type of benign
            epithelial tumor of the salivary gland. Multiple splice variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2018].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290059.1, SRR14038194.1176263.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453190.7/ ENSP00000398368.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1053              AK290059.1         1-1053
            1054-1061           BP219669.1         387-394
            1062-3558           AK290059.1         1062-3558
            3559-10258          AC010457.7         44671-51370         c
            10259-10553         AC010457.7         44376-44670         c
FEATURES             Location/Qualifiers
     source          1..10553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..10553
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /note="LIF receptor subunit alpha"
                     /db_xref="GeneID:3977"
                     /db_xref="HGNC:HGNC:6597"
                     /db_xref="MIM:151443"
     exon            1..313
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            314..474
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..3626
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CD118 antigen; leukemia inhibitory factor
                     receptor alpha; LIF receptor alpha"
                     /codon_start=1
                     /product="leukemia inhibitory factor receptor isoform a
                     precursor"
                     /protein_id="NP_001121143.1"
                     /db_xref="CCDS:CCDS3927.1"
                     /db_xref="GeneID:3977"
                     /db_xref="HGNC:HGNC:6597"
                     /db_xref="MIM:151443"
                     /translation="MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNS
                     QKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPA
                     LSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDR
                     GSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFV
                     EIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEK
                     VLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPD
                     TPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES
                     YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK
                     LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFR
                     IRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANG
                     KILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASM
                     EIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNST
                     ETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSI
                     LVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRI
                     ADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSI
                     LCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETR
                     SAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQV
                     IYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRP
                     QANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFT
                     NFFQNKPND"
     exon            475..589
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            590..729
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            730..893
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1068
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1323
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1453
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1623
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1769
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1932
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2003
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2217
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2397
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2499
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2667
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2829
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2923
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3002
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..10553
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5395..5400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /note="hexamer: AATATA"
     polyA_site      5422
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
     regulatory      10234..10239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /note="hexamer: AATAAA"
     polyA_site      10258
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /note="major polyA site"
     regulatory      10359..10364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /note="hexamer: AATACA"
     polyA_site      10379
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
     regulatory      10530..10535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
                     /note="hexamer: AATAAA"
     polyA_site      10553
                     /gene="LIFR"
                     /gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
ORIGIN      
        1 agtcccggct ggagcgactc ggccgtggcg gtggccgtta ccgttgcctc tgggaggctc
       61 tggcggcggc ggcggcccgc ggggttcgcg gagcgcagcg ggccgccctt cgcccgtggc
      121 cgcctcaagc agcctcgcgc cgacacaggg gaggcgagac ggcggctgcg gaggcggcgg
      181 cgcattgtgc ccggccccct ccttggcggc tcctgccccc gggcggctgt gggatctggg
      241 cagccccggg gcggcggccg aggctacaga gccggcggca ggggatggca agatagcggc
      301 gcgggagcgt accgactgac tgcattgcac agatgatgga tatttacgta tgtttgaaac
      361 gaccatcctg gatggtggac aataaaagaa tgaggactgc ttcaaatttc cagtggctgt
      421 tatcaacatt tattcttcta tatctaatga atcaagtaaa tagccagaaa aagggggctc
      481 ctcatgattt gaagtgtgta actaacaatt tgcaagtgtg gaactgttct tggaaagcac
      541 cctctggaac aggccgtggt actgattatg aagtttgcat tgaaaacagg tcccgttctt
      601 gttatcagtt ggagaaaacc agtattaaaa ttccagctct ttcacatggt gattatgaaa
      661 taacaataaa ttctctacat gattttggaa gttctacaag taaattcaca ctaaatgaac
      721 aaaacgtttc cttaattcca gatactccag agatcttgaa tttgtctgct gatttctcaa
      781 cctctacatt atacctaaag tggaacgaca ggggttcagt ttttccacac cgctcaaatg
      841 ttatctggga aattaaagtt ctacgtaaag agagtatgga gctcgtaaaa ttagtgaccc
      901 acaacacaac tctgaatggc aaagatacac ttcatcactg gagttgggcc tcagatatgc
      961 ccttggaatg tgccattcat tttgtggaaa ttagatgcta cattgacaat cttcattttt
     1021 ctggtctcga agagtggagt gactggagcc ctgtgaagaa catttcttgg atacctgatt
     1081 ctcagactaa ggtttttcct caagataaag tgatacttgt aggctcagac ataacatttt
     1141 gttgtgtgag tcaagaaaaa gtgttatcag cactgattgg ccatacaaac tgccccttga
     1201 tccatcttga tggggaaaat gttgcaatca agattcgtaa tatttctgtt tctgcaagta
     1261 gtggaacaaa tgtagttttt acaaccgaag ataacatatt tggaaccgtt atttttgctg
     1321 gatatccacc agatactcct caacaactga attgtgagac acatgattta aaagaaatta
     1381 tatgtagttg gaatccagga agggtgacag cgttggtggg cccacgtgct acaagctaca
     1441 ctttagttga aagtttttca ggaaaatatg ttagacttaa aagagctgaa gcacctacaa
     1501 acgaaagcta tcaattatta tttcaaatgc ttccaaatca agaaatatat aattttactt
     1561 tgaatgctca caatccgctg ggtcgatcac aatcaacaat tttagttaat ataactgaaa
     1621 aagtttatcc ccatactcct acttcattca aagtgaagga tattaattca acagctgtta
     1681 aactttcttg gcatttacca ggcaactttg caaagattaa ttttttatgt gaaattgaaa
     1741 ttaagaaatc taattcagta caagagcagc ggaatgtcac aatcaaagga gtagaaaatt
     1801 caagttatct tgttgctctg gacaagttaa atccatacac tctatatact tttcggattc
     1861 gttgttctac tgaaactttc tggaaatgga gcaaatggag caataaaaaa caacatttaa
     1921 caacagaagc cagtccttca aaggggcctg atacttggag agagtggagt tctgatggaa
     1981 aaaatttaat aatctattgg aagcctttac ccattaatga agctaatgga aaaatacttt
     2041 cctacaatgt atcgtgttca tcagatgagg aaacacagtc cctttctgaa atccctgatc
     2101 ctcagcacaa agcagagata cgacttgata agaatgacta catcatcagc gtagtggcta
     2161 aaaattctgt gggctcatca ccaccttcca aaatagcgag tatggaaatt ccaaatgatg
     2221 atctcaaaat agaacaagtt gttgggatgg gaaaggggat tctcctcacc tggcattacg
     2281 accccaacat gacttgcgac tacgtcatta agtggtgtaa ctcgtctcgg tcggaaccat
     2341 gccttatgga ctggagaaaa gttccctcaa acagcactga aactgtaata gaatctgatg
     2401 agtttcgacc aggtataaga tataattttt tcctgtatgg atgcagaaat caaggatatc
     2461 aattattacg ctccatgatt ggatatatag aagaattggc tcccattgtt gcaccaaatt
     2521 ttactgttga ggatacttct gcagattcga tattagtaaa atgggaagac attcctgtgg
     2581 aagaacttag aggcttttta agaggatatt tgttttactt tggaaaagga gaaagagaca
     2641 catctaagat gagggtttta gaatcaggtc gttctgacat aaaagttaag aatattactg
     2701 acatatccca gaagacactg agaattgctg atcttcaagg taaaacaagt taccacctgg
     2761 tcttgcgagc ctatacagat ggtggagtgg gcccggagaa gagtatgtat gtggtgacaa
     2821 aggaaaattc tgtgggatta attattgcca ttctcatccc agtggcagtg gctgtcattg
     2881 ttggagtggt gacaagtatc ctttgctatc ggaaacgaga atggattaaa gaaaccttct
     2941 accctgatat tccaaatcca gaaaactgta aagcattaca gtttcaaaag agtgtctgtg
     3001 agggaagcag tgctcttaaa acattggaaa tgaatccttg taccccaaat aatgttgagg
     3061 ttctggaaac tcgatcagca tttcctaaaa tagaagatac agaaataatt tccccagtag
     3121 ctgagcgtcc tgaagatcgc tctgatgcag agcctgaaaa ccatgtggtt gtgtcctatt
     3181 gtccacccat cattgaggaa gaaataccaa acccagccgc agatgaagct ggagggactg
     3241 cacaggttat ttacattgat gttcagtcga tgtatcagcc tcaagcaaaa ccagaagaag
     3301 aacaagaaaa tgaccctgta ggaggggcag gctataagcc acagatgcac ctccccatta
     3361 attctactgt ggaagatata gctgcagaag aggacttaga taaaactgcg ggttacagac
     3421 ctcaggccaa tgtaaataca tggaatttag tgtctccaga ctctcctaga tccatagaca
     3481 gcaacagtga gattgtctca tttggaagtc catgctccat taattcccga caatttttga
     3541 ttcctcctaa agatgaagac tctcctaaat ctaatggagg agggtggtcc tttacaaact
     3601 tttttcagaa caaaccaaac gattaacagt gtcaccgtgt cacttcagtc agccatctca
     3661 ataagctctt actgctagtg ttgctacatc agcactgggc attcttggag ggatcctgtg
     3721 aagtattgtt aggaggtgaa cttcactaca tgttaagtta cactgaaagt gttcatgtgc
     3781 ttttaatgta gtctaaaagc caaagtatag tgactcagaa tcctcaatcc acaaaactca
     3841 agattgggag ctctttgtga tcaagccaaa gaattctcat gtactctacc ttcaagaagc
     3901 atttcaaggc taatacctac ttgtacgtac atgtaaaaca aatcccgccg caactgtttt
     3961 ctgttctgtt gtttgtggtt ttctcatgtg tatacttggt ggaattgtaa gtggatttgc
     4021 aggccaggga gaaaatgtcc aagtaacagg tgaagtttat ttgcctgacg tttactcctt
     4081 tctagatgaa aaccaagcac agattttaaa acttctaaga ttattctcct ctatccacag
     4141 cattcacaaa aattaatata atttttaatg tagtgacagc gatttagtgt tttgtttgat
     4201 aaagtatgct tatttctgtg cctactgtat aatggttatc aaacagttgt ctcaggggta
     4261 caaactttga aaacaagtgt gacactgacc agcccaaatc ataatcatgt tttcttgctg
     4321 tgataggttt tgcaagcctt ttcattattt tttagctttt atgcttgctt ccattatttc
     4381 agttggttgc cctaatattt aaaatttaca cttctaagac tagagaccca cattttttaa
     4441 aaatcatttt attttgtgat acagtgacag ctttatatga gcaaattcaa tattattcat
     4501 aagcatgtaa ttccagtgac ttactatgtg agatgactac taagcaatat ctagcagcgt
     4561 tagctgtcca tatagttctg attggatttc gttcctcctg aggagaccat gccgttgagc
     4621 ttggctaccc aggcagtggt gatctttgac accttctggt ggatgttcct cccactcatg
     4681 agtcttttca tcatgccaca ttatctgatc cagtcctcac atttttaaat ataaaactaa
     4741 agagagaatg cttcttacag gaacagttac ccaagggctg tttcttagta actgtcataa
     4801 actgatctga atccatgggc atacctgtgt tgcaggtgca gcaattgctt ggtgagctgt
     4861 gcagaattga ttgccttcag cacagcatcc tctgcccacc cttgtttctc ataagcgatg
     4921 tctggagtga ttgtggttct tggaaaagca gaaggaaaaa ctaaaaagtg tatcttgtat
     4981 tttccctgcc ctcaggttgc ctatgtattt taccttttca tatttaaggc aaaagtactt
     5041 gaaaatttta agtgtccgaa taagatatgt cttttttgtt tgtttttttt ggttgtttgt
     5101 ttgtttttta tcatctgaga ttctgtaatg tatttgcaaa taatggatca attaattttt
     5161 tttgaagctc atattgtatc tttttaaaaa ccatgttgtg gaaaaaagcc agagtgacaa
     5221 gtgacaaaat ctatttaggt tctctgtgta tgaatcctga ttttaactgc taggattcag
     5281 ctaaatttct gagctttatg atctgtggaa atttggaatg aaatgcaatt cattttgtac
     5341 atacatagta tattaaaact atataatagt tcatagaaat gttcagtaat gaaaaatata
     5401 tccaatcaga gccatcccta aagagtgttc tcttgtcttc ctttgtatcc tctttggctc
     5461 cttcccttag cttccacccc agacatcaga cctggggctg ccttctctcc ctgccaaagc
     5521 ttgctgttag cattgtctgc ttgccctcaa ctcctgcctt gttccctgtt gaaatgtatc
     5581 aatcccgtac tttatctctc caggacaagg ataagtgtgg ctacagtaaa agtttattgc
     5641 tctaaacggc gctaacctga gataatgaga aaaggccaga agagattgtt tgatctctgt
     5701 ctgtcaatat atatgcattt caactgtgac catctggatc cagggccctt tctaacctat
     5761 ataacgactc atttgtttgg ttaatgatga atatcactgg ggctcttaag tcctttcgtt
     5821 ctatccaaga cttcattgtt tttttctgta tgaaaaaagt gcagaatatc actcaccttt
     5881 cccctacttt tggatcccct acacgaggat cactagctta atgagaagca gagtaacgct
     5941 attaagtctg ggcaagctcc ttataagttg ctgtgtgctt aaaagaatgt gatttatgtc
     6001 tggggccaaa gcagttttcc ttcttttccc tcattgaatt caagacagct agacccttgt
     6061 gtagatccca ggatattacc tctactcccc ccaacctgtg tgtgtaggga gagtaacaac
     6121 acgggaagag gggagggaag ttggaaggag attggtcaca tgttcagttg tctgagatac
     6181 tggtaaatgt gcgctgtttg tcaatgaagg ttgcatgcct gcatttacaa ggtggtctca
     6241 tactgattgt gctctgtcca gttagattcg tggcttctcc cttggaagct acaattaagg
     6301 actagttaga agcagaggct agatgtgttc tctccagccc ttactaactg ggaaaataat
     6361 tgagaaatcc ctcttttcct cagtgaaagc ccagtcattg gttagaaaaa tctaattgtc
     6421 aaactagcat tatgttccat catatctgtg ggatagtaat tcatgtaaga cacattttta
     6481 cctctcttac aagtcaattc acttacaagc cagtttcaaa tcaagcttcc cttgcgagga
     6541 atggagatca ttatggggct tattatgact acatttcttt tatgagtgac cattttaaat
     6601 aattaatatt ttatttaata ttaaattatt aaagacttag ctagactttt aacattagat
     6661 gaaccttgtg aatcatatat tgcatagatt agcacatgta tgcaatctag gtcatcaatt
     6721 tgttgaattt atacagccct agatttgaga ttgtggccct gagtatctgg atagttgagt
     6781 tgtgtgttta tgtgcttata tgatagaggt gctttgttcc tgcagcttag aaacagaagc
     6841 agccattcac tgagaagctt aagagaggaa gtatcaacct cattttccaa accagcatta
     6901 ctttcaccgc tcgtggatct gaaagattac atttagaaca tttagtacta ttacactctc
     6961 agaaactgtg gtaaaaagtc acattttcaa aacttcatgc atattgtatt cttgttggaa
     7021 ataagtccta tagtttctta attgtcttca tgccgtccat atttaacaaa cattgcaagt
     7081 cctttttata tttgggtaat tatttgtaat ttagtgaagg agactagggg atgttttctt
     7141 ccaaagggaa tttaaaatca attttatggt attttgaaag taaaatactc cttaacgtgt
     7201 caatattttt aaaatgttat ctcgaagttt tctattgctc aggtatataa tctaataaaa
     7261 ttttttgttt gctctaaggt tatttttgct attctctatt ttgaattatg ttaaaatttg
     7321 tgtgcatttt atgaaatgcc ttttttctta ttttgaaagt gtaaaattgg gcatctcaga
     7381 gtaaaatgtg ggattattag ctacaaagac taggcacatc gtgaaagctc agtaactaat
     7441 tttcttgact gagtcctatc ccagagtgtc acagattcaa cagaattttc ctgaagggtg
     7501 atacacacca aaatctagct tgtgtggatc tgagactatt gactcaaaga ttcaaatcta
     7561 cttcggaagt gactccacgg tttgagtgaa aactgaggaa ggactcatgc ctgtatatca
     7621 ctagatatct tatttctcca taattttaag tgttcataat ttcttcttct ttgatgggtg
     7681 tgcaactggg gcatgtttgt accagccagc atgtgttctg cccaacagtg tgtccgtgtg
     7741 tgaggttaac tgattcagaa ctcattctct tgataaacta tttcttgaaa gcatttattt
     7801 taagtcttta tttcctgctg aaatgaagtt tcatgctgtc atgcccatct tatttattct
     7861 agaagaaaat tttcatagaa gaaaatgatt tatggccaaa gttacagaac attcatcttt
     7921 tagacttagc cttagaatat cattggaaat tacttggctt gaatttggtt cgtttttatc
     7981 tttatggatt atgtaccagg gctattaata atacttaaac cccttatttt gctatggtgg
     8041 ttagattttt ttattccttt tcaattagtg ctattaatta ttacatggtc gtattcatgc
     8101 ttattacaga tgaactattt ttagtgccag tgtaaaggat taagaataac attcaattag
     8161 ttggctattt caggctttat tgtacatggt aatgtttcag ggagtgtgat ttggtctaga
     8221 atatatccag atccttgtaa ttatgatatt gggttatgac aggattctat tatttttagc
     8281 tatgaatggt gcttattttt ccctatatta ggaatgttaa tatttggatt atcagagtcc
     8341 atgttataaa cagaatttac ctatgcaaga caaattctaa ctgtgcaaca ttttcatgag
     8401 aattaaaagt tgtgtgttaa ggggaaaacc ctctgaatgt ttttatgtgt aagtgcctaa
     8461 agaaccgtag aaacagtaca tcaaaagctc ttataaaaga aaaactgatt gaacattagc
     8521 cagaaacaaa atatgattta catttttttt tttggttgct gggactgaat accctaaaaa
     8581 ctaagagatg tgagtgggga aaatgtctaa ttgataagaa agttgattta tattatattt
     8641 acatgcatct tctaagattg cctttacagt agccaatcag aactttaaaa aaaaaaaagc
     8701 taacaacata gatcctatgt gttgccctta agactaaaat actttgcaca cgtgattgaa
     8761 tggctcactt aagttgttga atttccttat acatttaaag tgtacttccg ttaagaatta
     8821 ttccatttta aatgggtaac tttcagcttc cgaactattt tcctaaacat tccagttgtg
     8881 tattataaaa gatcaaaata tctctaggtg gtagtacaat tttcatttat aacgtggaaa
     8941 agttaactgt taggtttaac attagtatta gtgtttttgc aattgctcat agaaaagaac
     9001 actgaataat ggttttcata caatttttgt aaaacattct tctcccagtt tgattccaaa
     9061 tgcttttccc caaattgtct aatatatcat aagctagtgt ttccttgtat ttaatttttc
     9121 cttccaacac aatatttagg aaaaatatga ataacattgt gagtagcggg agacaacacg
     9181 aaaaagaaac ctttcattgt tgtggagggg taggtgttat gtgattgatg cccttcctgg
     9241 cgtttgtttt atcctgttat tttctcaaaa aagagcacgg ctttttctta aatacattta
     9301 aattcagaat tgcttgcaaa agattggcct ggatagatag acatcctaga tttaagatag
     9361 taccatctta aaagtatgtt gaaaggtaaa ataaatcatt tcaaaatact taactttcct
     9421 aataaggatg ttaggttttc ttctctttca ttagctggcc ataagtcaag gtccttataa
     9481 cactaggaaa ttaccttttt ttactttcaa aattgcatta tagtgaatta ctgtttacaa
     9541 aatacacata ctgtgaacag atataagttt ctgtctttta taaggtttgt agaatgaatg
     9601 tttttttaaa gtgagtatta tatgttaaat attttaagtt ttttataaat actagtaact
     9661 gtttactaat ttttgtttgg tcaaatgctt gtaaatgtag ctgaaagaag atagggagaa
     9721 actgcggatc ccaaactgtt ccctttttca tttcttgaaa tgttaccact acagacattt
     9781 ttttaaggtg aataaacagt tgtgatgtgc tgtacctaaa atcatgttta atcgtataag
     9841 gaaacatttc aatacactta tacaggaaga aaactataga tgaagtacat gtgtgtgatt
     9901 cagtctgatt cacagaattc tgagagtaat atggaataaa acaactccac ttagatgata
     9961 actgaagcat ttcctgcctt gtgaaaattt ggattttaaa ttgctgttag aatgggaaat
    10021 ttggacactt tatatcattg tataatttca gaatttagtt tctgtatctt ttggaaaaca
    10081 tgattatagc aaaaacatag aaaataatct attactaaaa caccataaat gtaaaactag
    10141 tatgcttggc tgttaactct aaagatgtta cttatgtctg tttttaaaac atgcatgtat
    10201 ttaacaattt tatcatagta ttgtcatgga aaaaataaat atattttctt acatcttaca
    10261 ctgacagact tgggcattat tgggtttttc cccatgttac acacttagga gaagtggctc
    10321 tgctttgttg ttgtattttt ttgttctatc ccgtaagaaa tacagtggtt gtaaagcaat
    10381 cacatagcgc tatggatgta tttttaacat ttgagtacat tgctgtgcca ttggtgtaac
    10441 atccatctgt ccattaagtc attattgttt acctgagaag ttagcatcaa aataatcaaa
    10501 tagtgggaat ccaacattag caaataaata ataaatactg gtctttaaag taa
//
