LOCUS       NM_002309               3871 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens LIF interleukin 6 family cytokine (LIF), transcript
            variant 1, mRNA.
ACCESSION   NM_002309
VERSION     NM_002309.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3871)
  AUTHORS   Shen,J., Wu,W., Zhang,X., Xie,X., Shen,W. and Wang,Q.
  TITLE     Cancer-associated fibroblasts promote the malignant development of
            lung cancer through the FOXO1 protein/LIF signaling
  JOURNAL   Int J Biol Macromol 276 (Pt 2), 133987 (2024)
   PUBMED   39032875
  REMARK    GeneRIF: Cancer-associated fibroblasts promote the malignant
            development of lung cancer through the FOXO1 protein/LIF signaling.
REFERENCE   2  (bases 1 to 3871)
  AUTHORS   Xie,H., Jiang,Y., Xiang,Y., Wu,B., Zhao,J., Huang,R., Wang,M.,
            Wang,Y., Liu,J., Wu,D., Tian,D. and Bian,E.
  TITLE     Super-enhancer-driven LIF promotes the mesenchymal transition in
            glioblastoma by activating ITGB2 signaling feedback in microglia
  JOURNAL   Neuro Oncol 26 (8), 1438-1452 (2024)
   PUBMED   38554116
  REMARK    GeneRIF: Super-enhancer-driven LIF promotes the mesenchymal
            transition in glioblastoma by activating ITGB2 signaling feedback
            in microglia.
REFERENCE   3  (bases 1 to 3871)
  AUTHORS   Diallo,M., Pimenta,C., Murtinheira,F., Martins-Alves,D.,
            Pinto,F.R., da Costa,A.A., Letra-Vilela,R., Martin,V.,
            Rodriguez,C., Rodrigues,M.S. and Herrera,F.
  TITLE     Asymmetric post-translational modifications regulate the nuclear
            translocation of STAT3 homodimers in response to leukemia
            inhibitory factor
  JOURNAL   Cell Oncol (Dordr) 47 (3), 1065-1070 (2024)
   PUBMED   38150153
  REMARK    GeneRIF: Asymmetric post-translational modifications regulate the
            nuclear translocation of STAT3 homodimers in response to leukemia
            inhibitory factor.
REFERENCE   4  (bases 1 to 3871)
  AUTHORS   Wang,H., Lin,Y., Chen,R., Zhu,Y., Wang,H., Li,S., Yu,L., Zhang,K.,
            Liu,Y., Jing,T. and Sun,F.
  TITLE     Human Seminal Extracellular Vesicles Enhance Endometrial
            Receptivity Through Leukemia Inhibitory Factor
  JOURNAL   Endocrinology 165 (5) (2024)
   PUBMED   38518755
  REMARK    GeneRIF: Human Seminal Extracellular Vesicles Enhance Endometrial
            Receptivity Through Leukemia Inhibitory Factor.
REFERENCE   5  (bases 1 to 3871)
  AUTHORS   Chen,Y., Gong,Y., Qin,H., Wei,S., Wei,Y., Yu,Y., Lin,X., Shuai,P.,
            Wang,T., Guo,C., Wang,Q., Li,G., Meng,L. and Yi,L.
  TITLE     MDM2-p53 mediate a miR-181c-3p/LIF axis to regulate low dose-rate
            radiation-induced DNA damage in human B lymphocytes
  JOURNAL   Ecotoxicol Environ Saf 270, 115848 (2024)
   PUBMED   38134636
  REMARK    GeneRIF: MDM2-p53 mediate a miR-181c-3p/LIF axis to regulate low
            dose-rate radiation-induced DNA damage in human B lymphocytes.
REFERENCE   6  (bases 1 to 3871)
  AUTHORS   Bazan,J.F.
  TITLE     Neuropoietic cytokines in the hematopoietic fold
  JOURNAL   Neuron 7 (2), 197-208 (1991)
   PUBMED   1714745
REFERENCE   7  (bases 1 to 3871)
  AUTHORS   Stahl,J., Gearing,D.P., Willson,T.A., Brown,M.A., King,J.A. and
            Gough,N.M.
  TITLE     Structural organization of the genes for murine and human leukemia
            inhibitory factor. Evolutionary conservation of coding and
            non-coding regions
  JOURNAL   J Biol Chem 265 (15), 8833-8841 (1990)
   PUBMED   1692837
REFERENCE   8  (bases 1 to 3871)
  AUTHORS   Lowe,D.G., Nunes,W., Bombara,M., McCabe,S., Ranges,G.E., Henzel,W.,
            Tomida,M., Yamamoto-Yamaguchi,Y., Hozumi,M. and Goeddel,D.V.
  TITLE     Genomic cloning and heterologous expression of human
            differentiation-stimulating factor
  JOURNAL   DNA 8 (5), 351-359 (1989)
   PUBMED   2475312
REFERENCE   9  (bases 1 to 3871)
  AUTHORS   Mori,M., Yamaguchi,K. and Abe,K.
  TITLE     Purification of a lipoprotein lipase-inhibiting protein produced by
            a melanoma cell line associated with cancer cachexia
  JOURNAL   Biochem Biophys Res Commun 160 (3), 1085-1092 (1989)
   PUBMED   2730639
REFERENCE   10 (bases 1 to 3871)
  AUTHORS   Sutherland,G.R., Baker,E., Hyland,V.J., Callen,D.F., Stahl,J. and
            Gough,N.M.
  TITLE     The gene for human leukemia inhibitory factor (LIF) maps to 22q12
  JOURNAL   Leukemia 3 (1), 9-13 (1989)
   PUBMED   2491897
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN409458.1, AC004264.1 and
            AI796373.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002309.4.
            
            Summary: The protein encoded by this gene is a pleiotropic cytokine
            with roles in several different systems. It is involved in the
            induction of hematopoietic differentiation in normal and myeloid
            leukemia cells, induction of neuronal cell differentiation,
            regulator of mesenchymal to epithelial conversion during kidney
            development, and may also have a role in immune tolerance at the
            maternal-fetal interface. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP287018.1, X13967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249075.4/ ENSP00000249075.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               CN409458.1         93-692
            601-3586            AC004264.1         5441-8426           c
            3587-3871           AI796373.1         25-309              c
FEATURES             Location/Qualifiers
     source          1..3871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..3871
                     /gene="LIF"
                     /gene_synonym="CDF; DIA; HILDA; MLPLI"
                     /note="LIF interleukin 6 family cytokine"
                     /db_xref="GeneID:3976"
                     /db_xref="HGNC:HGNC:6596"
                     /db_xref="MIM:159540"
     exon            1..83
                     /gene="LIF"
                     /gene_synonym="CDF; DIA; HILDA; MLPLI"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..673
                     /gene="LIF"
                     /gene_synonym="CDF; DIA; HILDA; MLPLI"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cholinergic differentiation factor; human
                     interleukin in DA cells; differentiation-inducing factor;
                     hepatocyte-stimulating factor III; differentiation
                     inhibitory activity; D factor; melanoma-derived LPL
                     inhibitor; differentiation-stimulating factor; leukemia
                     inhibitory factor"
                     /codon_start=1
                     /product="leukemia inhibitory factor isoform 1 precursor"
                     /protein_id="NP_002300.1"
                     /db_xref="CCDS:CCDS13872.1"
                     /db_xref="GeneID:3976"
                     /db_xref="HGNC:HGNC:6596"
                     /db_xref="MIM:159540"
                     /translation="MKVLAAGVVPLLLVLHWKHGAGSPLPITPVNATCAIRHPCHNNL
                     MNQIRSQLAQLNGSANALFILYYTAQGEPFPNNLDKLCGPNVTDFPPFHANGTEKAKL
                     VELYRIVVYLGTSLGNITRDQKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYH
                     VGHVDVTYGPDTSGKDVFQKKKLGCQLLGKYKQIIAVLAQAF"
     exon            84..262
                     /gene="LIF"
                     /gene_synonym="CDF; DIA; HILDA; MLPLI"
                     /inference="alignment:Splign:2.1.0"
     exon            263..3871
                     /gene="LIF"
                     /gene_synonym="CDF; DIA; HILDA; MLPLI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3853..3858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIF"
                     /gene_synonym="CDF; DIA; HILDA; MLPLI"
                     /note="hexamer: AATAAA"
     polyA_site      3871
                     /gene="LIF"
                     /gene_synonym="CDF; DIA; HILDA; MLPLI"
                     /note="major polyA site"
ORIGIN      
        1 atgaacctct gaaaactgcc ggcatctgag gtttcctcca aggccctctg aagtgcagcc
       61 cataatgaag gtcttggcgg caggagttgt gcccctgctg ttggttctgc actggaaaca
      121 tggggcgggg agccccctcc ccatcacccc tgtcaacgcc acctgtgcca tacgccaccc
      181 atgtcacaac aacctcatga accagatcag gagccaactg gcacagctca atggcagtgc
      241 caatgccctc tttattctct attacacagc ccagggggag ccgttcccca acaacctgga
      301 caagctatgt ggccccaacg tgacggactt cccgcccttc cacgccaacg gcacggagaa
      361 ggccaagctg gtggagctgt accgcatagt cgtgtacctt ggcacctccc tgggcaacat
      421 cacccgggac cagaagatcc tcaaccccag tgccctcagc ctccacagca agctcaacgc
      481 caccgccgac atcctgcgag gcctccttag caacgtgctg tgccgcctgt gcagcaagta
      541 ccacgtgggc catgtggacg tgacctacgg ccctgacacc tcgggtaagg atgtcttcca
      601 gaagaagaag ctgggctgtc aactcctggg gaagtataag cagatcatcg ccgtgttggc
      661 ccaggccttc tagcaggagg tcttgaagtg tgctgtgaac cgagggatct caggagttgg
      721 gtccagatgt gggggcctgt ccaagggtgg ctggggccca gggcatcgct aaacccaaat
      781 gggggctgct ggcagacccc gagggtgcct ggccagtcca ctccactctg ggctgggctg
      841 tgatgaagct gagcagagtg gaaacttcca tagggaggga gctagaagaa ggtgcccctt
      901 cctctgggag attgtggact ggggagcgtg ggctggactt ctgcctctac ttgtcccttt
      961 ggccccttgc tcactttgtg cagtgaacaa actacacaag tcatctacaa gagccctgac
     1021 cacagggtga gacagcaggg cccaggggag tggaccagcc cccagcaaat tatcaccatc
     1081 tgtgcctttg ctgcccctta ggttgggact taggtgggcc agaggggcta ggatcccaaa
     1141 ggactccttg tcccctagaa gtttgatgag tggaagatag agaggggcct ctgggatgga
     1201 aggctgtctt cttttgagga tgatcagaga acttgggcat aggaacaatc tggcagaagt
     1261 ttccagaagg aggtcacttg gcattcaggc tcttggggag gcagagaagc caccttcagg
     1321 cctgggaagg aagacactgg gaggaggaga ggcctggaaa gctttggtag gttcttcgtt
     1381 ctcttccccg tgatcttccc tgcagcctgg gatggccagg gtctgatggc tggacctgca
     1441 gcaggggttt gtggaggtgg gtagggcagg ggcaggttgc taagtcaggt gcagaggttc
     1501 tgagggaccc aggctcttcc tctgggtaaa ggtctgtaag aaggggctgg ggtagctcag
     1561 agtagcagct cacatctgag gccctgggag gccttgtgag gtcacacaga ggtacttgag
     1621 ggggactgga ggccgtctct ggtccccagg gcaagggaac agcagaactt agggtcaggg
     1681 tctcagggaa ccctgagctc caagcgtgct gtgcgtctga cctggcatga tttctattta
     1741 ttatgatatc ctatttatat taacttattg gtgctttcag tggccaagtt aattcccctt
     1801 tccctggtcc ctactcaaca aaatatgatg atggctcccg acacaagcgc cagggccagg
     1861 gcttagcagg gcctggtctg gaagtcgaca atgttacaag tggaataagc cttacgggtg
     1921 aagctcagag aagggtcgga tctgagagaa tggggaggcc tgagtgggag tggggggcct
     1981 tgctccaccc ccccccatcc cctactgtga cttgctttag ggtgtcaggg tccaggctgc
     2041 aggggctggg ccaatttgtg gagaggccgg gtgcctttct gtcttgattc cagggggctg
     2101 gttcacactg ttcttgggcg ccccagcatt gtgttgtgag gcgcactgtt cctggcagat
     2161 attgtgcccc ctggagcagt gggcaagaca gtccttgtgg cccaccctgt ccttgtttct
     2221 gtgtccccat gctgcctctg aaatagcgcc ctggaacaac cctgcccctg cacccagcat
     2281 gctccgacac agcagggaag ctcctcctgt ggcccggaca cccatagacg gtgcgggggg
     2341 cctggctggg ccagacccca ggaaggtggg gtagactggg gggatcagct gcccattgct
     2401 cccaagagga ggagagggag gctgcagatg cctgggactc agaccaggaa gctgtgggcc
     2461 ctcctgctcc acccccatcc cactcccacc catgtctggg ctcccaggca gggaacccga
     2521 tctcttcctt tgtgctgggg ccaggcgagt ggagaaacgc cctccagtct gagagcaggg
     2581 gagggaagga ggcagcagag ttggggcagc tgctcagagc agtgttctgg cttcttctca
     2641 aaccctgagc gggctgccgg cctccaagtt cctccgacaa gatgatggta ctaattatgg
     2701 tacttttcac tcactttgca cctttccctg tcgctctcta agcactttac ctggatggcg
     2761 cgtgggcagt gtgcaggcag gtcctgaggc ctggggttgg ggtggagggt gcggcccgga
     2821 gttgtccatc tgtccatccc aacagcaaga cgaggatgtg gctgttgaga tgtgggccac
     2881 actcaccctt gtccaggatg cagggactgc cttctccttc ctgcttcatc cggcttagct
     2941 tggggctggc tgcattcccc caggatgggc ttcgagaaag acaaacttgt ctggaaacca
     3001 gagttgctga ttccacccgg ggggcccggc tgactcgccc atcacctcat ctccctgtgg
     3061 acttgggagc tctgtgccag gcccaccttg cggccctggc tctgagtcgc tctcccaccc
     3121 agcctggact tggccccatg ggacccatcc tcagtgctcc ctccagatcc cgtccggcag
     3181 cttggcgtcc accctgcaca gcatcactga atcacagagc ctttgcgtga aacagctctg
     3241 ccaggccggg agctgggttt ctcttccctt tttatctgct ggtgtggacc acacctgggc
     3301 ctggccggag gaagagagag tttaccaaga gagatgtctc cgggccctta tttattattt
     3361 aaacattttt ttaaaaagca ctgctagttt acttgtctct cctccccatc gtccccatcg
     3421 tcctccttgt ccctgacttg gggcacttcc accctgaccc agccagtcca gctctgcctt
     3481 gccggctctc cagagtagac atagtgtgtg gggttggagc tctggcaccc ggggaggtag
     3541 catttccctg cagatggtac agatgttcct gccttagagt catctctagt tccccacctc
     3601 aatcccggca tccagccttc agtcccgccc acgtgctagc tccgtgggcc caccgtgcgg
     3661 ccttagaggt ttccctcctt cctttccact gaaaagcaca tggccttggg tgacaaattc
     3721 ctctttgatg aatgtaccct gtggggatgt ttcatactga cagattattt ttatttattc
     3781 aatgtcatat ttaaaatatt tattttttat accaaatgaa tacttttttt tttaagaaaa
     3841 aaaagagaaa tgaataaaga atctactctt g
//
