LOCUS       NM_001013672            1841 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ligand of ATE1 (LIAT1), mRNA.
ACCESSION   NM_001013672 XM_375387
VERSION     NM_001013672.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Arva,A., Kasu,Y.A.T., Duncan,J., Alkhatatbeh,M.A. and Brower,C.S.
  TITLE     The Ligand of Ate1 is intrinsically disordered and participates in
            nucleolar phase separation regulated by Jumonji Domain Containing 6
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33443146
  REMARK    GeneRIF: The Ligand of Ate1 is intrinsically disordered and
            participates in nucleolar phase separation regulated by Jumonji
            Domain Containing 6.
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Brower,C.S., Rosen,C.E., Jones,R.H., Wadas,B.C., Piatkov,K.I. and
            Varshavsky,A.
  TITLE     Liat1, an arginyltransferase-binding protein whose evolution among
            primates involved changes in the numbers of its 10-residue repeats
  JOURNAL   Proc Natl Acad Sci U S A 111 (46), E4936-E4945 (2014)
   PUBMED   25369936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141424.4, AK128660.1, BC141806.1, BC070116.1 and BG056786.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001013672.4.
            
            CCDS Note: The coding region has been updated to remove a 30-nt
            insert that is absent in the GRCh37 reference genome assembly. The
            CDS of this locus includes a tandem repeat sequence that is present
            17 times in the reference genome assembly; the removed 30-nt insert
            corresponds to an additional repeat. Transcript data indicate that
            alleles contain variable copy numbers of this tandem repeat.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KR780251.1, SRR3476690.385415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360127.7/ ENSP00000353245.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC141424.4         28247-28248
            3-3                 AK128660.1         1-1
            4-76                BC141806.1         1-73
            77-1453             BC070116.1         1-1377
            1454-1738           BC141806.1         1451-1735
            1739-1841           BG056786.1         3-105               c
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..1841
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
                     /note="ligand of ATE1"
                     /db_xref="GeneID:400566"
                     /db_xref="HGNC:HGNC:33800"
     exon            1..322
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1290
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
                     /note="ligand of ATE1 protein"
                     /codon_start=1
                     /product="protein LIAT1"
                     /protein_id="NP_001013694.4"
                     /db_xref="CCDS:CCDS32519.2"
                     /db_xref="GeneID:400566"
                     /db_xref="HGNC:HGNC:33800"
                     /translation="METRGPGLAVRAESRRLVGIGPRAPPGRVGLQPSGRLDRRGGAG
                     TMGYKDNDGEEEEREGGAAGPRGSRLPPITGGASELAKRKVKKKKRKKKTKGSGKGDD
                     KHQSQSLKSQPLSSSFHDILSPCKERGPKPEHRQSKVEKKHLPSDSSTVSLPDFAEIE
                     NLANRINESLRWDGILADPEAEKERIRIYKLNRRKRYRCLALKGFHPDPEALKGFHPD
                     PDALKGFHPDPEALKGFHPDPEALKGIHPDPEALKGFHPDPEALKGFHPDPEALKGFH
                     TDPEALKGFHIDPEALKGFHPDPKALKGFHPDPKALKGFHTDPEALKGFHPDPKALKG
                     FHPDPEALKGFHPDPEALKGFHPDPEALKGFHTDPNAEEAPENLPYLSDKDGSSSHRQ
                     PTSKAECPNLCFEGNLTPKLLHSDLAPTLLE"
     exon            323..1841
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
                     /note="hexamer: ATTAAA"
     polyA_site      1753
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
                     /note="major polyA site"
     regulatory      1820..1825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
                     /note="hexamer: CATAAA"
     polyA_site      1841
                     /gene="LIAT1"
                     /gene_synonym="C17orf97; CK20"
ORIGIN      
        1 gcagcagggg tggtcgccat ggagacgcgt ggccctggcc tggcggtccg cgctgagagt
       61 cgccgattag tcggcatcgg gcctcgggcg cccccggggc gggttgggtt gcagcccagc
      121 gggcggctgg accgccgcgg tggggcgggg acaatggggt acaaggacaa cgacggcgag
      181 gaggaggagc gggagggcgg cgccgcgggc ccgcgggggt ctagactgcc ccccatcaca
      241 ggcggcgcct ccgagctggc caaacggaag gtgaagaaga aaaaaaggaa gaagaagacc
      301 aaggggtctg gcaaggggga cgataaacat cagagtcaga gcctgaagag ccagccgctt
      361 tcttcctcct ttcatgacat cttaagtcct tgcaaagagc gtggcccgaa accagagcac
      421 agacagagca aagtggaaaa gaagcacctc ccttctgact cctccaccgt cagcctcccc
      481 gactttgccg aaatagagaa ccttgcgaat cggatcaacg aaagtctgcg ttgggatgga
      541 attcttgctg acccggaggc agagaaggaa aggattcgca tctataaact gaatcggaga
      601 aaacggtacc ggtgcttggc cctcaagggc ttccaccccg accccgaggc cctcaagggc
      661 ttccaccccg accccgacgc cctcaagggc ttccaccccg accccgaggc cctcaagggc
      721 ttccaccccg accccgaggc cctcaagggc atccaccccg accccgaggc tctcaagggc
      781 ttccaccccg accccgaggc cctcaagggc ttccaccccg accctgaggc cctcaagggt
      841 ttccacactg accccgaggc cctcaagggt ttccacattg accccgaggc cctcaagggc
      901 ttccaccccg accccaaggc cctcaagggc ttccaccccg accccaaggc cctcaagggt
      961 ttccacactg accccgaggc cctcaagggc ttccaccccg accccaaggc cctcaagggc
     1021 ttccaccccg accccgaggc cctcaagggc ttccaccccg accccgaggc cctcaagggc
     1081 ttccaccccg accccgaggc cctcaagggc ttccacactg accccaatgc cgaggaggcc
     1141 cctgagaact taccctacct ctcggacaaa gatggcagct ccagccacag gcagcccacg
     1201 tcgaaagccg agtgccccaa tctctgtttt gaaggaaacc ttaccccaaa gcttctacac
     1261 tctgacttag ctcctactct gctggagtga aaatctaccc acgacgctca caaacttata
     1321 attcctcctc accacaagtt tatgtgttaa aaaccatcat cataaaagga aatgagaccc
     1381 gtatctgaag gaaacagatg ttcggtacac ggacgacgcc gactctccca tcaccaagct
     1441 gccctcggtt gcccaggaga gccacagtgc cttgagaaca taagcaattt agtgaacaga
     1501 gttcttttca gaatttcctt tttcttaagt aagcatctct gttacttaat ttctcaccac
     1561 agctagatgt ctataatctg ccccaaaaag aaaagaaagc gtgtagatga tttacctctt
     1621 aagtctcaat ctcatggtga aactcctcac acggtacctg cttctgttgg ccggaggacg
     1681 atgccctgaa cctcttggag cctttttctg ttttaattaa atgcatggcc tgcctttata
     1741 tggcctcaaa taagtgggtt ccagaactcc atccctggga agttaccatg ggaagtccca
     1801 agaggaatac tgcttctttc ataaacatgg tcctctccta a
//
